UniProtKB - P26298 (LDHD_LACPE)
Protein
D-lactate dehydrogenase
Gene
N/A
Organism
Lactobacillus pentosus
Status
Functioni
Miscellaneous
Also active on D-glycerate.
Caution
Was originally thought to originate from L.plantarum.1 Publication
Catalytic activityi
- EC:1.1.1.28
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 175 | NADBy similarity | 1 | |
Binding sitei | 212 | NADBy similarity | 1 | |
Active sitei | 235 | By similarity | 1 | |
Active sitei | 264 | By similarity | 1 | |
Active sitei | 296 | Proton donorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 155 – 156 | NADBy similarity | 2 | |
Nucleotide bindingi | 206 – 207 | NADBy similarity | 2 | |
Nucleotide bindingi | 233 – 235 | NADBy similarity | 3 |
GO - Molecular functioni
- D-lactate dehydrogenase activity Source: UniProtKB-EC
- NAD binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
SABIO-RKi | P26298 |
Names & Taxonomyi
Protein namesi | Recommended name: D-lactate dehydrogenase (EC:1.1.1.28)Short name: D-LDH Alternative name(s): D-specific 2-hydroxyacid dehydrogenase |
Organismi | Lactobacillus pentosus |
Taxonomic identifieri | 1589 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075956 | 1 – 332 | D-lactate dehydrogenaseAdd BLAST | 332 |
Proteomic databases
PRIDEi | P26298 |
Interactioni
Subunit structurei
Homodimer.
Structurei
3D structure databases
ProteinModelPortali | P26298 |
SMRi | P26298 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P26298-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIIAYAVRD DERPFFDTWM KENPDVEVKL VPELLTEDNV DLAKGFDGAD
60 70 80 90 100
VYQQKDYTAE VLNKLADEGV KNISLRNVGV DNLDVPTVKA RGLNISNVPA
110 120 130 140 150
YSPNAIAELS VTQLMQLLRQ TPMFNKKLAK QDFRWAPDIA KELNTMTVGV
160 170 180 190 200
IGTGRIGRAA IDIFKGFGAK VIGYDVYRNA ELEKEGMYVD TLDELYAQAD
210 220 230 240 250
VITLHVPALK DNYHMLNADA FSKMKDGAYI LNFARGTLID SEDLIKALDS
260 270 280 290 300
GKVAGAALVT YEYETKIFNK DLEGQTIDDK VFMNLFNRDN VLITPHTAFY
310 320 330
TETAVHNMVH VSMNSNKQFI ETGKADTQVK FD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90339 Genomic DNA Translation: BAA14352.1 |
PIRi | A40885 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90339 Genomic DNA Translation: BAA14352.1 |
PIRi | A40885 |
3D structure databases
ProteinModelPortali | P26298 |
SMRi | P26298 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P26298 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Enzyme and pathway databases
SABIO-RKi | P26298 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LDHD_LACPE | |
Accessioni | P26298Primary (citable) accession number: P26298 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 5, 2018 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |