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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Activity regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18NAD; via amide nitrogenUniRule annotation1
Binding sitei39NADUniRule annotation1
Binding sitei46NADUniRule annotation1
Binding sitei71NADUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei159Allosteric activatorUniRule annotation1
Binding sitei174Allosteric activatorUniRule annotation1
Active sitei181Proton acceptorUniRule annotation1
Binding sitei235SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 86NADUniRule annotation2
Nucleotide bindingi124 – 126NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13096
SMUT210007:G1FZX-1058-MONOMER
SABIO-RKiP26283
UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Synonyms:lct
Ordered Locus Names:SMU_1115
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683961 – 328L-lactate dehydrogenaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphotyrosineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU_1115

Structurei

3D structure databases

ProteinModelPortaliP26283
SMRiP26283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 129Substrate bindingUniRule annotation4
Regioni154 – 157Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00016
OMAiMDLMQTA
PhylomeDBiP26283

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

P26283-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTATKQHKKV ILVGDGAVGS SYAFALVNQG IAQELGIIEI PQLFEKAVGD
60 70 80 90 100
ALDLSHALAF TSPKKIYAAK YEDCADADLV VITAGAPQKP GETRLDLVGK
110 120 130 140 150
NLAINKSIVT QVIESGFNGI FLVAANPVDI LTYATWKFSG FPAEKVIGSG
160 170 180 190 200
TSLDTARFRQ ALAEKLDVDA RSVHAYIMGE HGDSEFAVWS HANVAGVNLE
210 220 230 240 250
NYLQDVQNFN GEELIDLFEG VRDAAYTIIN KKGATFYGIA VALARITKAI
260 270 280 290 300
LDDENAILPL SVFQDGQYGF NEVFIGQPAI VGAHGIVRPV NIPLNDAEKQ
310 320
KMQASAKELK AIIDEAFSKE EFAAAARN
Length:328
Mass (Da):35,245
Last modified:November 28, 2002 - v2
Checksum:i43679B8ECDDB411C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → R (PubMed:1937751).Curated1
Sequence conflicti23A → R (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72545 Genomic DNA Translation: AAA26914.1
L42474 Genomic DNA Translation: AAA67466.1
AE014133 Genomic DNA Translation: AAN58808.1
PIRiA43598
RefSeqiNP_721502.1, NC_004350.2
WP_002262228.1, NC_004350.2

Genome annotation databases

EnsemblBacteriaiAAN58808; AAN58808; SMU_1115
GeneIDi1028428
KEGGismu:SMU_1115
PATRICifig|210007.7.peg.998

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72545 Genomic DNA Translation: AAA26914.1
L42474 Genomic DNA Translation: AAA67466.1
AE014133 Genomic DNA Translation: AAN58808.1
PIRiA43598
RefSeqiNP_721502.1, NC_004350.2
WP_002262228.1, NC_004350.2

3D structure databases

ProteinModelPortaliP26283
SMRiP26283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1115

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58808; AAN58808; SMU_1115
GeneIDi1028428
KEGGismu:SMU_1115
PATRICifig|210007.7.peg.998

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00016
OMAiMDLMQTA
PhylomeDBiP26283

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

BioCyciMetaCyc:MONOMER-13096
SMUT210007:G1FZX-1058-MONOMER
SABIO-RKiP26283

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDH_STRMU
AccessioniPrimary (citable) accession number: P26283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 28, 2002
Last modified: October 10, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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