UniProtKB - P26260 (SDC1_RAT)
Protein
Syndecan-1
Gene
Sdc1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.By similarity
GO - Molecular functioni
- extracellular matrix binding Source: RGD
- identical protein binding Source: RGD
- protein C-terminus binding Source: RGD
GO - Biological processi
- canonical Wnt signaling pathway Source: RGD
- cell adhesion Source: RGD
- cell-cell signaling Source: RGD
- cell migration Source: GO_Central
- inflammatory response Source: RGD
- myoblast development Source: RGD
- odontogenesis Source: RGD
- positive regulation of exosomal secretion Source: RGD
- positive regulation of extracellular exosome assembly Source: RGD
- response to calcium ion Source: RGD
- response to cAMP Source: RGD
- response to glucocorticoid Source: RGD
- response to hydrogen peroxide Source: RGD
- response to organic substance Source: RGD
- response to toxic substance Source: RGD
- Sertoli cell development Source: RGD
- striated muscle cell development Source: RGD
- ureteric bud development Source: RGD
- wound healing Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-RNO-2022928, HS-GAG biosynthesis R-RNO-2024096, HS-GAG degradation R-RNO-202733, Cell surface interactions at the vascular wall R-RNO-3000170, Syndecan interactions R-RNO-449836, Other interleukin signaling R-RNO-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syndecan-1Short name: SYND1 Alternative name(s): CD_antigen: CD138 |
Gene namesi | Name:Sdc1 Synonyms:Synd1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3648, Sdc1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
- extracellular exosome By similarity
Other locations
- Membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
Note: Shedding of the ectodomain produces a soluble form.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 257 | ExtracellularSequence analysisAdd BLAST | 235 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 313 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000033502 | 23 – 313 | Syndecan-1Add BLAST | 291 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | O-linked (Xyl...) (chondroitin sulfate) serineBy similarity | 1 | |
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 45 | O-linked (Xyl...) (heparan sulfate) serineBy similarity | 1 | |
Glycosylationi | 47 | O-linked (Xyl...) (heparan sulfate) serineBy similarity | 1 | |
Glycosylationi | 209 | O-linked (Xyl...) (chondroitin sulfate) serineBy similarity | 1 | |
Glycosylationi | 219 | O-linked (Xyl...) (chondroitin sulfate) serineBy similarity | 1 | |
Modified residuei | 288 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3 (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 253 – 254 | Cleavage of ectodomainSequence analysis | 2 |
Keywords - PTMi
Glycoprotein, Heparan sulfate, Phosphoprotein, ProteoglycanProteomic databases
jPOSTi | P26260 |
PaxDbi | P26260 |
PRIDEi | P26260 |
PTM databases
GlyGeni | P26260, 6 sites |
iPTMneti | P26260 |
PhosphoSitePlusi | P26260 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000059947, Expressed in esophagus and 19 other tissues |
Genevisiblei | P26260, RN |
Interactioni
Subunit structurei
Interacts with CDCP1.
Interacts (via C-terminus) with TIAM1 (via PDZ domain) (By similarity).
Interacts with MDK (PubMed:9089390).
By similarity1 PublicationBinary interactionsi
P26260
With | #Exp. | IntAct |
---|---|---|
Sdc2 [P34900] | 2 | EBI-1173127,EBI-1173032 |
GO - Molecular functioni
- identical protein binding Source: RGD
- protein C-terminus binding Source: RGD
Protein-protein interaction databases
IntActi | P26260, 4 interactors |
STRINGi | 10116.ENSRNOP00000008582 |
Family & Domainsi
Sequence similaritiesi
Belongs to the syndecan proteoglycan family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZWT, Eukaryota |
GeneTreei | ENSGT00940000161171 |
HOGENOMi | CLU_887201_0_0_1 |
InParanoidi | P26260 |
OMAi | QPAMPQI |
OrthoDBi | 1340825at2759 |
PhylomeDBi | P26260 |
TreeFami | TF320463 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031190, Syndecan-1 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF5, PTHR10915:SF5, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26260-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRAALWLWL CALALRLQPA LPQIVTANVP PEDQDGSGDD SDNFSGSGTG
60 70 80 90 100
ALPDMTLSRQ TPSTWKDVWL LTATPTAPEP TSRDTEATLT SILPAGEKPE
110 120 130 140 150
EGEPVAHVEA EPDFTARDKE KEATTRPRET TQLPVTQQAS TAARATTAQA
160 170 180 190 200
SVTSHPHGDV QPGLHETLAP TAPGQPDHQP PSVEDGGTSV IKEVVEDETT
210 220 230 240 250
NQLPAGEGSG EQDFTFETSG ENTAVAGVEP DLRNQSPVDE GATGASQGLL
260 270 280 290 300
DRKEVLGGVI AGGLVGLIFA VCLVAFMLYR MKKKDEGSYS LEEPKQANGG
310
AYQKPTKQEE FYA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | L → V (PubMed:1639809).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60651 mRNA Translation: CAA43058.1 M81785 mRNA Translation: AAA42198.1 S61865 mRNA Translation: AAB26726.1 BC061834 mRNA Translation: AAH61834.1 |
PIRi | A42853 |
RefSeqi | NP_037158.1, NM_013026.2 |
Genome annotation databases
Ensembli | ENSRNOT00000086633; ENSRNOP00000072283; ENSRNOG00000059947 |
GeneIDi | 25216 |
KEGGi | rno:25216 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60651 mRNA Translation: CAA43058.1 M81785 mRNA Translation: AAA42198.1 S61865 mRNA Translation: AAB26726.1 BC061834 mRNA Translation: AAH61834.1 |
PIRi | A42853 |
RefSeqi | NP_037158.1, NM_013026.2 |
3D structure databases
SMRi | P26260 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P26260, 4 interactors |
STRINGi | 10116.ENSRNOP00000008582 |
PTM databases
GlyGeni | P26260, 6 sites |
iPTMneti | P26260 |
PhosphoSitePlusi | P26260 |
Proteomic databases
jPOSTi | P26260 |
PaxDbi | P26260 |
PRIDEi | P26260 |
Genome annotation databases
Ensembli | ENSRNOT00000086633; ENSRNOP00000072283; ENSRNOG00000059947 |
GeneIDi | 25216 |
KEGGi | rno:25216 |
Organism-specific databases
CTDi | 6382 |
RGDi | 3648, Sdc1 |
Phylogenomic databases
eggNOGi | ENOG502RZWT, Eukaryota |
GeneTreei | ENSGT00940000161171 |
HOGENOMi | CLU_887201_0_0_1 |
InParanoidi | P26260 |
OMAi | QPAMPQI |
OrthoDBi | 1340825at2759 |
PhylomeDBi | P26260 |
TreeFami | TF320463 |
Enzyme and pathway databases
Reactomei | R-RNO-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-RNO-2022928, HS-GAG biosynthesis R-RNO-2024096, HS-GAG degradation R-RNO-202733, Cell surface interactions at the vascular wall R-RNO-3000170, Syndecan interactions R-RNO-449836, Other interleukin signaling R-RNO-975634, Retinoid metabolism and transport |
Miscellaneous databases
PROi | PR:P26260 |
Gene expression databases
Bgeei | ENSRNOG00000059947, Expressed in esophagus and 19 other tissues |
Genevisiblei | P26260, RN |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031190, Syndecan-1 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF5, PTHR10915:SF5, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SDC1_RAT | |
Accessioni | P26260Primary (citable) accession number: P26260 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families