UniProtKB - P26255 (ADRB3_RAT)
Protein
Beta-3 adrenergic receptor
Gene
Adrb3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 114 | Agonist or antagonistBy similarity | 1 | |
Binding sitei | 119 | Agonist or antagonistBy similarity | 1 |
GO - Molecular functioni
- beta3-adrenergic receptor activity Source: HGNC-UCL
- beta-3 adrenergic receptor binding Source: RGD
- beta-adrenergic receptor activity Source: HGNC-UCL
- epinephrine binding Source: RGD
- G protein-coupled receptor activity Source: GO_Central
- norepinephrine binding Source: RGD
- protein homodimerization activity Source: HGNC-UCL
GO - Biological processi
- activation of adenylate cyclase activity Source: HGNC-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- aging Source: RGD
- brown fat cell differentiation Source: RGD
- diet induced thermogenesis Source: RGD
- eating behavior Source: RGD
- heat generation Source: RGD
- negative regulation of multicellular organism growth Source: RGD
- norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: RGD
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of MAPK cascade Source: HGNC-UCL
- response to antibiotic Source: RGD
- response to cold Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-390696, Adrenoceptors |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-3 adrenergic receptorAlternative name(s): Beta-3 adrenoreceptor Short name: Beta-3 adrenoceptor |
Gene namesi | Name:Adrb3 Synonyms:Adrb3r |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2061, Adrb3 |
Subcellular locationi
Plasma membrane
Nucleus
- nucleus Source: RGD
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- membrane Source: RGD
- receptor complex Source: HGNC-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularBy similarityAdd BLAST | 36 | |
Transmembranei | 37 – 60 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 61 – 69 | CytoplasmicBy similarity | 9 | |
Transmembranei | 70 – 88 | Helical; Name=2By similarityAdd BLAST | 19 | |
Topological domaini | 89 – 108 | ExtracellularBy similarityAdd BLAST | 20 | |
Transmembranei | 109 – 130 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 131 – 152 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 153 – 175 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 176 – 200 | ExtracellularBy similarityAdd BLAST | 25 | |
Transmembranei | 201 – 222 | Helical; Name=5By similarityAdd BLAST | 22 | |
Topological domaini | 223 – 289 | CytoplasmicBy similarityAdd BLAST | 67 | |
Transmembranei | 290 – 311 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 312 – 323 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 324 – 344 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 345 – 400 | CytoplasmicBy similarityAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069148 | 1 – 400 | Beta-3 adrenergic receptorAdd BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 107 ↔ 193 | PROSITE-ProRule annotation | ||
Disulfide bondi | 186 ↔ 192 | PROSITE-ProRule annotation | ||
Lipidationi | 358 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P26255 |
PRIDEi | P26255 |
PTM databases
GlyGeni | P26255, 2 sites |
iPTMneti | P26255 |
PhosphoSitePlusi | P26255 |
Expressioni
Tissue specificityi
White and brown adipose tissues, and digestive tract.
Gene expression databases
Bgeei | ENSRNOG00000012674, Expressed in colon and 14 other tissues |
Genevisiblei | P26255, RN |
Interactioni
Subunit structurei
Interacts with ARRDC3.
By similarityGO - Molecular functioni
- beta-3 adrenergic receptor binding Source: RGD
- protein homodimerization activity Source: HGNC-UCL
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016907 |
Chemistry databases
BindingDBi | P26255 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 195 – 209 | Agonist and antagonist bindingBy similarityAdd BLAST | 15 | |
Regioni | 302 – 309 | Agonist and antagonist bindingBy similarity | 8 | |
Regioni | 329 – 333 | Agonist and antagonist bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158663 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P26255 |
OMAi | APIMSKW |
OrthoDBi | 614199at2759 |
PhylomeDBi | P26255 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000681, ADRB3_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00563, ADRENRGCB3AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P26255-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPWPHKNGS LAFWSDAPTL DPSAANTSGL PGVPWAAALA GALLALATVG
60 70 80 90 100
GNLLVITAIA RTPRLQTITN VFVTSLATAD LVVGLLVMPP GATLALTGHW
110 120 130 140 150
PLGATGCELW TSVDVLCVTA SIETLCALAV DRYLAVTNPL RYGTLVTKRR
160 170 180 190 200
ARAAVVLVWI VSATVSFAPI MSQWWRVGAD AEAQECHSNP RCCSFASNMP
210 220 230 240 250
YALLSSSVSF YLPLLVMLFV YARVFVVAKR QRRLLRRELG RFPPEESPRS
260 270 280 290 300
PSRSPSPATV GTPTASDGVP SCGRRPARLL PLGEHRALRT LGLIMGIFSL
310 320 330 340 350
CWLPFFLANV LRALVGPSLV PSGVFIALNW LGYANSAFNP LIYCRSPDFR
360 370 380 390 400
DAFRRLLCSY GGRGPEEPRV VTFPASPVAS RQNSPLNRFD GYEGERPFPT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 234 – 235 | LL → FV in AAA74470 (PubMed:1721063).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74716 mRNA Translation: AAA74470.1 S73473 mRNA Translation: AAB20702.1 S56481 mRNA Translation: AAB25520.1 S56152 Genomic DNA Translation: AAB25521.1 |
PIRi | A41679 A53281 |
RefSeqi | NP_037240.2, NM_013108.2 |
Genome annotation databases
Ensembli | ENSRNOT00000016907; ENSRNOP00000016907; ENSRNOG00000012674 |
GeneIDi | 25645 |
KEGGi | rno:25645 |
UCSCi | RGD:2061, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74716 mRNA Translation: AAA74470.1 S73473 mRNA Translation: AAB20702.1 S56481 mRNA Translation: AAB25520.1 S56152 Genomic DNA Translation: AAB25521.1 |
PIRi | A41679 A53281 |
RefSeqi | NP_037240.2, NM_013108.2 |
3D structure databases
SMRi | P26255 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016907 |
Chemistry databases
BindingDBi | P26255 |
ChEMBLi | CHEMBL4031 |
DrugCentrali | P26255 |
GuidetoPHARMACOLOGYi | 30 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P26255, 2 sites |
iPTMneti | P26255 |
PhosphoSitePlusi | P26255 |
Proteomic databases
PaxDbi | P26255 |
PRIDEi | P26255 |
Genome annotation databases
Ensembli | ENSRNOT00000016907; ENSRNOP00000016907; ENSRNOG00000012674 |
GeneIDi | 25645 |
KEGGi | rno:25645 |
UCSCi | RGD:2061, rat |
Organism-specific databases
CTDi | 155 |
RGDi | 2061, Adrb3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158663 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | P26255 |
OMAi | APIMSKW |
OrthoDBi | 614199at2759 |
PhylomeDBi | P26255 |
TreeFami | TF316350 |
Enzyme and pathway databases
Reactomei | R-RNO-390696, Adrenoceptors |
Miscellaneous databases
PROi | PR:P26255 |
Gene expression databases
Bgeei | ENSRNOG00000012674, Expressed in colon and 14 other tissues |
Genevisiblei | P26255, RN |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000681, ADRB3_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00563, ADRENRGCB3AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADRB3_RAT | |
Accessioni | P26255Primary (citable) accession number: P26255 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries