Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 214 (07 Oct 2020)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Probable ATP-dependent RNA helicase DDX6

Gene

DDX6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi140 – 147ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.4.13, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P26196

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-430039, mRNA decay by 5' to 3' exoribonuclease

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P26196

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX6Curated (EC:3.6.4.131 Publication)
Alternative name(s):
ATP-dependent RNA helicase p54
DEAD box protein 6
Oncogene RCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX6
Synonyms:HLR2, RCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110367.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2747, DDX6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600326, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26196

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder with impaired language and dysmorphic facies (IDDILF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by intellectual disability, developmental delay, impaired language development, and dysmorphic features including telecanthus, epicanthus, arched eyebrows and low-set ears. Additional features include feeding difficulties, mild cardiac or genitourinary defects, and distal skeletal anomalies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083368372H → R in IDDILF. 1 Publication1
Natural variantiVAR_083369373R → Q in IDDILF; decreased P-body assembly; decreased interaction with LSM14A; decreased interaction with LSM14B; decreased interaction with EIF4ENIF1/4E-T; decreased interaction with PATL1. 1 Publication1
Natural variantiVAR_083370390C → R in IDDILF; decreased P-body assembly; decreased interaction with LSM14A; decreased interaction with LSM14B; decreased interaction with EIF4ENIF1/4E-T. 1 Publication1
Natural variantiVAR_083371391T → I in IDDILF; decreased P-body assembly. 1 Publication1
Natural variantiVAR_083372391T → P in IDDILF; decreased P-body assembly. 1 Publication1
A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi247E → Q: Abolished helicase activity and ability to regulate RNA metabolism. 1 Publication1
Mutagenesisi320Q → A: Abolishes interaction with EDC3; when associated with A-323; A-327 and A-331. 1 Publication1
Mutagenesisi323H → A: Abolishes interaction with EDC3; when associated with A-320; A-327 and A-331. 1 Publication1
Mutagenesisi327T → A: Abolishes interaction with EDC3; when associated with A-320; A-323 and A-331. 1 Publication1
Mutagenesisi331R → A: Abolishes interaction with EDC3; when associated with A-320; A-323 and A-327. 1 Publication1
Mutagenesisi386R → E: Abolished ability to regulate RNA metabolism. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
1656

MalaCards human disease database

More...
MalaCardsi
DDX6
MIMi618653, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000110367

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
528084, Non-specific syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27229

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P26196, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105783

Drug and drug target database

More...
DrugBanki
DB01694, D-tartaric acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241327

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000549831 – 483Probable ATP-dependent RNA helicase DDX6Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated (PubMed:26184334).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P26196

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P26196

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P26196

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26196

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26196

PeptideAtlas

More...
PeptideAtlasi
P26196

PRoteomics IDEntifications database

More...
PRIDEi
P26196

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54313

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P26196

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P26196, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26196

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P26196

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26196

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P26196

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in most tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110367, Expressed in forebrain and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P26196, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26196, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110367, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LSM14A, LSM14B, EIF4ENIF1/4E-T, PATL1, EDC3 and EDC4 (PubMed:26027925, PubMed:31422817, PubMed:27342281, PubMed:28216671, PubMed:32354837, PubMed:26489469, PubMed:29510985).

Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948).

Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046).

Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599).

Interacts with RC3H1 (By similarity).

Interacts with ATXN2L (PubMed:23209657).

Interacts with MCRIP1 (PubMed:26184334).

Interacts with MCRIP2 (PubMed:26184334).

Interacts with NUFIP2 (PubMed:26184334).

Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

By similarity14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P26196
With#Exp.IntAct
AGO2 [Q9UKV8]14EBI-351257,EBI-528269
ATXN2 [Q99700]7EBI-351257,EBI-697691
BEGAIN [Q9BUH8]3EBI-351257,EBI-742722
BEND7 - isoform 2 [Q8N7W2-2]3EBI-351257,EBI-10181188
BHLHB9 [Q6PI77]3EBI-351257,EBI-11519926
BIRC7 [Q96CA5]7EBI-351257,EBI-517623
CALCOCO2 [Q13137]6EBI-351257,EBI-739580
CCDC14 - isoform 3 [Q49A88-3]3EBI-351257,EBI-12105646
CEP70 [Q8NHQ1]6EBI-351257,EBI-739624
CEP76 [Q8TAP6]3EBI-351257,EBI-742887
CNKSR3 [Q6P9H4]3EBI-351257,EBI-10253274
DCP1A [Q9NPI6]8EBI-351257,EBI-374238
DDX17 [Q92841]3EBI-351257,EBI-746012
DES [P17661]3EBI-351257,EBI-1055572
DISC1 - isoform 2 [Q9NRI5-2]3EBI-351257,EBI-11988027
EDC3 [Q96F86]14EBI-351257,EBI-997311
EFHC2 [Q5JST6]3EBI-351257,EBI-2349927
EIF4ENIF1 [Q9NRA8]6EBI-351257,EBI-301024
ENTR1 - isoform 2 [Q96C92-2]3EBI-351257,EBI-10178036
FCHO1 [A0A0C3SFZ9]3EBI-351257,EBI-11977403
FXR1 - isoform 2 [P51114-2]3EBI-351257,EBI-11022345
GIGYF1 [O75420]3EBI-351257,EBI-947774
GOLGA2 [Q08379]6EBI-351257,EBI-618309
HOOK2 - isoform 2 [Q96ED9-2]3EBI-351257,EBI-10961706
IK [Q13123]3EBI-351257,EBI-713456
IKZF1 [Q13422]3EBI-351257,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-351257,EBI-11522367
INKA1 [Q96EL1]3EBI-351257,EBI-10285157
JAKMIP1 [Q96N16]3EBI-351257,EBI-2680803
JUP [P14923]3EBI-351257,EBI-702484
KRT34 [O76011]5EBI-351257,EBI-1047093
KRT40 [Q6A162]3EBI-351257,EBI-10171697
KRTAP10-8 [P60410]6EBI-351257,EBI-10171774
LRRC6 [Q86X45]3EBI-351257,EBI-9379658
LZTS1 [Q9Y250]3EBI-351257,EBI-1216080
MAGED1 [Q9Y5V3]3EBI-351257,EBI-716006
MAPT - isoform Tau-F [P10636-8]7EBI-351257,EBI-366233
MESD [Q14696]3EBI-351257,EBI-6165891
MTUS2 - isoform 2 [Q5JR59-3]4EBI-351257,EBI-11522433
NAB2 [Q15742]3EBI-351257,EBI-8641936
NONO - isoform 2 [Q15233-2]3EBI-351257,EBI-10203843
PAK5 [Q9P286]3EBI-351257,EBI-741896
PDLIM7 [Q9NR12]3EBI-351257,EBI-350517
PICK1 [Q9NRD5]3EBI-351257,EBI-79165
PNMA5 [Q96PV4]3EBI-351257,EBI-10171633
POU6F2 [P78424]3EBI-351257,EBI-12029004
PRPH [P41219]3EBI-351257,EBI-752074
RBM11 [P57052]3EBI-351257,EBI-741332
REL - isoform 2 [Q04864-2]3EBI-351257,EBI-10829018
RUNDC3A [Q59EK9]3EBI-351257,EBI-747225
SCYL1 - isoform 4 [Q96KG9-4]5EBI-351257,EBI-12023020
SHMT1 [P34896]3EBI-351257,EBI-715117
SIPA1L2 - isoform 2 [Q9P2F8-2]5EBI-351257,EBI-10326741
SLAIN1 [Q8ND83]3EBI-351257,EBI-10269374
SORBS3 [O60504]3EBI-351257,EBI-741237
SPATA6 - isoform 2 [Q9NWH7-2]3EBI-351257,EBI-17860101
TCF12 - isoform 3 [Q99081-3]3EBI-351257,EBI-11952764
TCF4 [P15884]3EBI-351257,EBI-533224
TCF4 - isoform SEF2-1D [P15884-3]3EBI-351257,EBI-13636688
TLE5 [Q08117]3EBI-351257,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-351257,EBI-11741437
TP53BP2 [Q05BL1]3EBI-351257,EBI-11952721
TRAF2 [Q12933]3EBI-351257,EBI-355744
TRIM27 [P14373]6EBI-351257,EBI-719493
TRIM37 [O94972]3EBI-351257,EBI-741602
TRIM54 [Q9BYV2]3EBI-351257,EBI-2130429
USH1G [Q495M9]3EBI-351257,EBI-8601749
VPS52 [Q8N1B4]6EBI-351257,EBI-2799833
ZBTB10 - isoform 3 [Q96DT7-3]3EBI-351257,EBI-12017160
ZBTB14 [O43829]3EBI-351257,EBI-10176632
ZBTB43 [O43298]3EBI-351257,EBI-740718
ZBTB8A [Q96BR9]6EBI-351257,EBI-742740
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-351257,EBI-14104088
ZNF24 [P17028]3EBI-351257,EBI-707773
ZRANB1 [Q9UGI0]3EBI-351257,EBI-527853

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108022, 188 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P26196

Database of interacting proteins

More...
DIPi
DIP-29195N

Protein interaction database and analysis system

More...
IntActi
P26196, 134 interactors

Molecular INTeraction database

More...
MINTi
P26196

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478754

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P26196, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1483
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26196

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26196

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini127 – 298Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
Domaini308 – 468Helicase C-terminalPROSITE-ProRule annotationAdd BLAST161

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 124Q motifAdd BLAST29
Motifi246 – 249DEAD box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0326, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003041_30_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26196

KEGG Orthology (KO)

More...
KOi
K12614

Identification of Orthologs from Complete Genome Data

More...
OMAi
DWNLMSS

Database of Orthologous Groups

More...
OrthoDBi
583315at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26196

TreeFam database of animal gene trees

More...
TreeFami
TF300440

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P26196-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT
60 70 80 90 100
INNGTQQQAQ SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED
110 120 130 140 150
YCLKRELLMG IFEMGWEKPS PIQEESIPIA LSGRDILARA KNGTGKSGAY
160 170 180 190 200
LIPLLERLDL KKDNIQAMVI VPTRELALQV SQICIQVSKH MGGAKVMATT
210 220 230 240 250
GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV QMIVLDEADK
260 270 280 290 300
LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
310 320 330 340 350
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL
360 370 380 390 400
AKKISQLGYS CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI
410 420 430 440 450
QAVNVVINFD FPKLAETYLH RIGRSGRFGH LGLAINLITY DDRFNLKSIE
460 470 480
EQLGTEIKPI PSNIDKSLYV AEYHSEPVED EKP
Length:483
Mass (Da):54,417
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF802C642861793FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IV96Q8IV96_HUMAN
RNA helicase
DDX6
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293Q → E in Z11685 (PubMed:1579499).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083368372H → R in IDDILF. 1 Publication1
Natural variantiVAR_083369373R → Q in IDDILF; decreased P-body assembly; decreased interaction with LSM14A; decreased interaction with LSM14B; decreased interaction with EIF4ENIF1/4E-T; decreased interaction with PATL1. 1 Publication1
Natural variantiVAR_083370390C → R in IDDILF; decreased P-body assembly; decreased interaction with LSM14A; decreased interaction with LSM14B; decreased interaction with EIF4ENIF1/4E-T. 1 Publication1
Natural variantiVAR_083371391T → I in IDDILF; decreased P-body assembly. 1 Publication1
Natural variantiVAR_083372391T → P in IDDILF; decreased P-body assembly. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z11685 mRNA No translation available.
BC065007 mRNA Translation: AAH65007.1
D17532 mRNA Translation: BAA04482.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44751.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S22651

NCBI Reference Sequences

More...
RefSeqi
NP_001244120.1, NM_001257191.2
NP_004388.2, NM_004397.5
XP_005271474.1, XM_005271417.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000526070; ENSP00000433704; ENSG00000110367
ENST00000534980; ENSP00000442266; ENSG00000110367
ENST00000620157; ENSP00000478754; ENSG00000110367

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1656

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1656

UCSC genome browser

More...
UCSCi
uc031ygs.2, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11685 mRNA No translation available.
BC065007 mRNA Translation: AAH65007.1
D17532 mRNA Translation: BAA04482.1
CCDSiCCDS44751.1
PIRiS22651
RefSeqiNP_001244120.1, NM_001257191.2
NP_004388.2, NM_004397.5
XP_005271474.1, XM_005271417.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VECX-ray2.01A/B94-299[»]
2WAXX-ray2.30A/C296-483[»]
2WAYX-ray2.30A/C296-483[»]
4CRWX-ray1.75B307-483[»]
4CT4X-ray2.30B/D95-469[»]
4CT5X-ray3.00A/B95-469[»]
5ANRX-ray2.10B95-469[»]
6F9SX-ray3.03A301-469[»]
6S8SX-ray2.21A/C295-483[»]
SMRiP26196
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108022, 188 interactors
CORUMiP26196
DIPiDIP-29195N
IntActiP26196, 134 interactors
MINTiP26196
STRINGi9606.ENSP00000478754

Chemistry databases

ChEMBLiCHEMBL4105783
DrugBankiDB01694, D-tartaric acid

PTM databases

GlyGeniP26196, 1 site
iPTMnetiP26196
MetOSiteiP26196
PhosphoSitePlusiP26196
SwissPalmiP26196

Polymorphism and mutation databases

BioMutaiDDX6
DMDMi116241327

2D gel databases

DOSAC-COBS-2DPAGEiP26196

Proteomic databases

EPDiP26196
jPOSTiP26196
MassIVEiP26196
MaxQBiP26196
PaxDbiP26196
PeptideAtlasiP26196
PRIDEiP26196
ProteomicsDBi54313

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3315, 415 antibodies

The DNASU plasmid repository

More...
DNASUi
1656

Genome annotation databases

EnsembliENST00000526070; ENSP00000433704; ENSG00000110367
ENST00000534980; ENSP00000442266; ENSG00000110367
ENST00000620157; ENSP00000478754; ENSG00000110367
GeneIDi1656
KEGGihsa:1656
UCSCiuc031ygs.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1656
DisGeNETi1656
EuPathDBiHostDB:ENSG00000110367.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DDX6
HGNCiHGNC:2747, DDX6
HPAiENSG00000110367, Low tissue specificity
MalaCardsiDDX6
MIMi600326, gene
618653, phenotype
neXtProtiNX_P26196
OpenTargetsiENSG00000110367
Orphaneti528084, Non-specific syndromic intellectual disability
PharmGKBiPA27229

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0326, Eukaryota
GeneTreeiENSGT00900000141067
HOGENOMiCLU_003041_30_0_1
InParanoidiP26196
KOiK12614
OMAiDWNLMSS
OrthoDBi583315at2759
PhylomeDBiP26196
TreeFamiTF300440

Enzyme and pathway databases

BRENDAi3.6.4.13, 2681
PathwayCommonsiP26196
ReactomeiR-HSA-430039, mRNA decay by 5' to 3' exoribonuclease
SIGNORiP26196

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1656, 556 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DDX6, human
EvolutionaryTraceiP26196

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DDX6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1656
PharosiP26196, Tbio

Protein Ontology

More...
PROi
PR:P26196
RNActiP26196, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110367, Expressed in forebrain and 233 other tissues
ExpressionAtlasiP26196, baseline and differential
GenevisibleiP26196, HS

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR000629, RNA-helicase_DEAD-box_CS
IPR014014, RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039, DEAD_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51195, Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26196
Secondary accession number(s): Q5D048
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 17, 2006
Last modified: October 7, 2020
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again