High affinity immunoglobulin gamma Fc receptor I

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• IgG binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• IgG receptor activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• leukotriene receptor binding Source: MGI
• transmembrane signaling receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antibody-dependent cellular cytotoxicity Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• antigen processing and presentation of exogenous antigen Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• cell surface receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• innate immune response Source: UniProtKB-KW
• phagocytosis, engulfment Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• phagocytosis, recognition Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • "Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity."
    Gavin A.L., Barnes N., Dijstelbloem H.M., Hogarth P.M.
    J Immunol 160:20-23(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis, engulfment Source: MGI
• positive regulation of protein tyrosine kinase activity Source: MGI
• positive regulation of type IIa hypersensitivity Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• positive regulation of type III hypersensitivity Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• receptor-mediated endocytosis Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• regulation of immune response Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses."
    Barnes N., Gavin A.L., Tan P.S., Mottram P., Koentgen F., Hogarth P.M.
    Immunity 16:379-389(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.5

    "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
    Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.

    , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
    Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• response to bacterium Source: MGIInferred from mutant phenotypeⁱ
  • "Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages."
    Uppington H., Menager N., Boross P., Wood J., Sheppard M., Verbeek S., Mastroeni P.
    Immunology 119:147-158(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• leukotriene receptor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MILTSFGDDM WLLTTLLLWV PVGGEVVNAT KAVITLQPPW VSIFQKENVT 
        60         70         80         90        100
LWCEGPHLPG DSSTQWFING TAVQISTPSY SIPEASFQDS GEYRCQIGSS 
       110        120        130        140        150
MPSDPVQLQI HNDWLLLQAS RRVLTEGEPL ALRCHGWKNK LVYNVVFYRN 
       160        170        180        190        200
GKSFQFSSDS EVAILKTNLS HSGIYHCSGT GRHRYTSAGV SITVKELFTT 
       210        220        230        240        250
PVLRASVSSP FPEGSLVTLN CETNLLLQRP GLQLHFSFYV GSKILEYRNT 
       260        270        280        290        300
SSEYHIARAE REDAGFYWCE VATEDSSVLK RSPELELQVL GPQSSAPVWF 
       310        320        330        340        350
HILFYLSVGI MFSLNTVLYV KIHRLQREKK YNLEVPLVSE QGKKANSFQQ 
       360        370        380        390        400
VRSDGVYEEV TATASQTTPK EAPDGPRSSV GDCGPEQPEP LPPSDSTGAQ 

TSQS                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families