Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High affinity immunoglobulin gamma Fc receptor I

Gene

Fcgr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.2 Publications

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

GO - Molecular functioni

  • IgG binding Source: MGI
  • IgG receptor activity Source: MGI
  • leukotriene receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin gamma Fc receptor I
Short name:
IgG Fc receptor I
Alternative name(s):
Fc-gamma RI
Short name:
FcRI
CD_antigen: CD64
Gene namesi
Name:Fcgr1
Synonyms:Fcg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95498 Fcgr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 297ExtracellularSequence analysisAdd BLAST273
Transmembranei298 – 320HelicalSequence analysisAdd BLAST23
Topological domaini321 – 404CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

According to PubMed:11911823, mice display altered endocytosis of monomeric IgG and impaired antibody-dependent killing of cells by macrophage. Antigen presentation is also affected and those mice develop only reduced inflammatory responses. An increased in IgG responses is also detected associated with an increased number of antibody-forming cells. PubMed:11911824, also reported that a variety of IgG2a-immune complex-dependent immune functions like protection against bacterial infection were impaired.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001514025 – 404High affinity immunoglobulin gamma Fc receptor IAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 95PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 177PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 269PROSITE-ProRule annotation
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei347PhosphoserineCombined sources1
Modified residuei368PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated on serine residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP26151
PaxDbiP26151
PeptideAtlasiP26151
PRIDEiP26151

PTM databases

iPTMnetiP26151
PhosphoSitePlusiP26151

Expressioni

Tissue specificityi

Macrophage-specific.

Gene expression databases

BgeeiENSMUSG00000015947 Expressed in 136 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FCGR1
ExpressionAtlasiP26151 baseline and differential
GenevisibleiP26151 MM

Interactioni

Subunit structurei

Interacts with FCERG1; forms a functional signaling complex (By similarity). Interacts with FLNA; prevents FCGR1A degradation (By similarity). Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199618, 1 interactor
STRINGi10090.ENSMUSP00000029748

Structurei

3D structure databases

ProteinModelPortaliP26151
SMRiP26151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 111Ig-like C2-type 1Add BLAST80
Domaini117 – 194Ig-like C2-type 2Add BLAST78
Domaini201 – 286Ig-like C2-type 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 342Interaction with EPB41L2By similarityAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK2 Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP26151
KOiK06498
OMAiVTLTCHG
OrthoDBiEOG091G0ETN
PhylomeDBiP26151
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P26151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILTSFGDDM WLLTTLLLWV PVGGEVVNAT KAVITLQPPW VSIFQKENVT
60 70 80 90 100
LWCEGPHLPG DSSTQWFING TAVQISTPSY SIPEASFQDS GEYRCQIGSS
110 120 130 140 150
MPSDPVQLQI HNDWLLLQAS RRVLTEGEPL ALRCHGWKNK LVYNVVFYRN
160 170 180 190 200
GKSFQFSSDS EVAILKTNLS HSGIYHCSGT GRHRYTSAGV SITVKELFTT
210 220 230 240 250
PVLRASVSSP FPEGSLVTLN CETNLLLQRP GLQLHFSFYV GSKILEYRNT
260 270 280 290 300
SSEYHIARAE REDAGFYWCE VATEDSSVLK RSPELELQVL GPQSSAPVWF
310 320 330 340 350
HILFYLSVGI MFSLNTVLYV KIHRLQREKK YNLEVPLVSE QGKKANSFQQ
360 370 380 390 400
VRSDGVYEEV TATASQTTPK EAPDGPRSSV GDCGPEQPEP LPPSDSTGAQ

TSQS
Length:404
Mass (Da):44,888
Last modified:May 1, 1992 - v1
Checksum:i1C4F0033842767E7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JE74A0A0G2JE74_MOUSE
High affinity immunoglobulin gamma ...
Fcgr1
50Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31314 mRNA Translation: AAA40056.1
CCDSiCCDS17639.1
PIRiA46480
RefSeqiNP_034316.1, NM_010186.5
UniGeneiMm.150

Genome annotation databases

EnsembliENSMUST00000029748; ENSMUSP00000029748; ENSMUSG00000015947
GeneIDi14129
KEGGimmu:14129
UCSCiuc008qmr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31314 mRNA Translation: AAA40056.1
CCDSiCCDS17639.1
PIRiA46480
RefSeqiNP_034316.1, NM_010186.5
UniGeneiMm.150

3D structure databases

ProteinModelPortaliP26151
SMRiP26151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199618, 1 interactor
STRINGi10090.ENSMUSP00000029748

PTM databases

iPTMnetiP26151
PhosphoSitePlusiP26151

Proteomic databases

MaxQBiP26151
PaxDbiP26151
PeptideAtlasiP26151
PRIDEiP26151

Protocols and materials databases

DNASUi14129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029748; ENSMUSP00000029748; ENSMUSG00000015947
GeneIDi14129
KEGGimmu:14129
UCSCiuc008qmr.1 mouse

Organism-specific databases

CTDi14129
MGIiMGI:95498 Fcgr1

Phylogenomic databases

eggNOGiENOG410IVK2 Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP26151
KOiK06498
OMAiVTLTCHG
OrthoDBiEOG091G0ETN
PhylomeDBiP26151
TreeFamiTF335097

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis

Miscellaneous databases

PROiPR:P26151
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015947 Expressed in 136 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_FCGR1
ExpressionAtlasiP26151 baseline and differential
GenevisibleiP26151 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR1_MOUSE
AccessioniPrimary (citable) accession number: P26151
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again