UniProtKB - P26051 (CD44_RAT)
CD44 antigen
Cd44
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 44 | HyaluronanBy similarity | 1 | |
Binding sitei | 81 | HyaluronanBy similarity | 1 | |
Binding sitei | 82 | HyaluronanBy similarity | 1 | |
Binding sitei | 108 | HyaluronanBy similarity | 1 |
GO - Molecular functioni
- epidermal growth factor receptor binding Source: RGD
- hyaluronic acid binding Source: RGD
- phosphoprotein binding Source: RGD
- protein kinase binding Source: RGD
- transmembrane signaling receptor activity Source: GO_Central
- type II transforming growth factor beta receptor binding Source: RGD
GO - Biological processi
- blood vessel maturation Source: RGD
- branching involved in prostate gland morphogenesis Source: RGD
- branching involved in ureteric bud morphogenesis Source: RGD
- cartilage development Source: RGD
- cell adhesion Source: RGD
- cell migration Source: RGD
- cellular response to fibroblast growth factor stimulus Source: RGD
- cytokine-mediated signaling pathway Source: GOC
- hyaluronan catabolic process Source: RGD
- inflammatory response Source: RGD
- macrophage fusion Source: RGD
- monocyte aggregation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: RGD
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
- negative regulation of DNA damage response, signal transduction by p53 class mediator Source: RGD
- negative regulation of inflammatory response Source: RGD
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: RGD
- negative regulation of mature B cell apoptotic process Source: RGD
- negative regulation of regulatory T cell differentiation Source: RGD
- neuron projection development Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of heterotypic cell-cell adhesion Source: RGD
- positive regulation of kinase activity Source: RGD
- positive regulation of monocyte aggregation Source: RGD
- positive regulation of neutrophil apoptotic process Source: RGD
- positive regulation of peptidyl-serine phosphorylation Source: RGD
- positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
- regulation of cell growth Source: RGD
- regulation of lamellipodium morphogenesis Source: UniProtKB
- response to nutrient levels Source: RGD
- response to organic cyclic compound Source: RGD
- response to vitamin A Source: RGD
- T cell activation Source: RGD
- Wnt signaling pathway Source: RGD
- wound healing, spreading of cells Source: UniProtKB
- wound healing involved in inflammatory response Source: RGD
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix R-RNO-202733, Cell surface interactions at the vascular wall R-RNO-216083, Integrin cell surface interactions R-RNO-2160916, Hyaluronan uptake and degradation R-RNO-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenAlternative name(s): Extracellular matrix receptor III Short name: ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Phagocytic glycoprotein 1 Short name: PGP-1 Phagocytic glycoprotein I Short name: PGP-I CD_antigen: CD44 |
Gene namesi | Name:Cd44 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2307, Cd44 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- microvillus By similarity
Note: Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli.By similarity
Nucleus
- nucleus Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
- basolateral plasma membrane Source: RGD
- external side of plasma membrane Source: RGD
- lamellipodium membrane Source: UniProtKB
- plasma membrane Source: RGD
Other locations
- cell projection Source: UniProtKB
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
- macrophage migration inhibitory factor receptor complex Source: RGD
- microvillus Source: UniProtKB
- protein-containing complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 410 | ExtracellularSequence analysisAdd BLAST | 389 | |
Transmembranei | 411 – 431 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 432 – 503 | CytoplasmicSequence analysisAdd BLAST | 72 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000026691 | 22 – 503 | CD44 antigenAdd BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 31 ↔ 133 | PROSITE-ProRule annotation | ||
Disulfide bondi | 56 ↔ 122 | PROSITE-ProRule annotation | ||
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 80 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 124 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 288 | Sulfotyrosine1 Publication | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 433 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 447 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 458 | PhosphoserineBy similarity | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, SulfationPTM databases
GlyGeni | P26051, 8 sites |
iPTMneti | P26051 |
PhosphoSitePlusi | P26051 |
Interactioni
Subunit structurei
Interacts with PKN2 (By similarity).
Interacts with TIAM1 and TIAM2 (By similarity).
Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment.
Interacts with UNC119.
Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (By similarity).
Interacts with RDX, EZR and MSN (By similarity).
Interacts with EGFR (By similarity).
Interacts with CD74; this complex is essential for the MIF-induced signaling cascade that results in B cell survival (By similarity).
By similarityGO - Molecular functioni
- epidermal growth factor receptor binding Source: RGD
- phosphoprotein binding Source: RGD
- protein kinase binding Source: RGD
- type II transforming growth factor beta receptor binding Source: RGD
Protein-protein interaction databases
CORUMi | P26051 |
IntActi | P26051, 1 interactor |
STRINGi | 10116.ENSRNOP00000009000 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 124 | LinkPROSITE-ProRule annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 228 – 410 | StemAdd BLAST | 183 | |
Regioni | 434 – 452 | Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 154 – 162 | Arg/Lys-rich (basic) | 9 |
Domaini
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RX7Q, Eukaryota |
InParanoidi | P26051 |
PhylomeDBi | P26051 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDKVWWHTAW GLLCLLQLSL AQQQIDLNIT CRYAGVFHVE KNGRYSISRT
60 70 80 90 100
EAADLCEAFN TTLPTMAQME LALRKGFETC RYGFIEGHVV IPRIHPNAIC
110 120 130 140 150
AANNTGVYIL LASNTSHYDT YCFNASAPLE EDCTSVTDLP NSFDGPVTIT
160 170 180 190 200
IVNRDGTRYS KKGEYRTHQE DIDASNIIDE DVSSGSTIEK STPEGYILHT
210 220 230 240 250
DLPTSQPTGD RDDAFFIGST LATIATTPWV SAHTKQNQER TQWNPIHSNP
260 270 280 290 300
EVLLQTTTRM TDIDRNSTSA HGENWTQEPQ PPFNNHEYQD EEETPHATST
310 320 330 340 350
TWADPNSTTE EAATQKEKWF ENEWQGKNPP TPSEDSHVTE GTTASAHNNH
360 370 380 390 400
PSQRMTTQSQ EDVSWTDFFD PISHPMGQGH QTESKGHSSG NQDSGVTTTS
410 420 430 440 450
GPARRPQIPE WLIILASLLA LALILAVCIA VNSRRRCGQK KKLVINSGNG
460 470 480 490 500
TVEDRKPSEL NGEASKSQEM VHLVNKEPTE TPDQFMTADE TRNLQSVDMK
IGV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LSA1 | F1LSA1_RAT | CD44 antigen | Cd44 | 779 | Annotation score: | ||
O70509 | O70509_RAT | CD44 antigen | Cd44 rCG_26920 | 364 | Annotation score: | ||
D3ZGF1 | D3ZGF1_RAT | CD44 antigen | Cd44 | 478 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | R → S in AAA97915 (Ref. 2) Curated | 1 | |
Sequence conflicti | 74 | R → S in AAA92920 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005330 | 224 – 385 | IATTP…QTESK → SDGDSSMDPRGGFDTVTHGS ELA in isoform 1. 2 PublicationsAdd BLAST | 162 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61875 mRNA Translation: AAA53532.1 M61874 mRNA Translation: AAA53534.1 U52179 mRNA Translation: AAA97915.1 U46957 mRNA Translation: AAA92920.1 |
PIRi | B38745 |
RefSeqi | XP_006234693.1, XM_006234631.3 |
Genome annotation databases
GeneIDi | 25406 |
UCSCi | RGD:2307, rat [P26051-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61875 mRNA Translation: AAA53532.1 M61874 mRNA Translation: AAA53534.1 U52179 mRNA Translation: AAA97915.1 U46957 mRNA Translation: AAA92920.1 |
PIRi | B38745 |
RefSeqi | XP_006234693.1, XM_006234631.3 |
3D structure databases
SMRi | P26051 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | P26051 |
IntActi | P26051, 1 interactor |
STRINGi | 10116.ENSRNOP00000009000 |
PTM databases
GlyGeni | P26051, 8 sites |
iPTMneti | P26051 |
PhosphoSitePlusi | P26051 |
Genome annotation databases
GeneIDi | 25406 |
UCSCi | RGD:2307, rat [P26051-1] |
Organism-specific databases
CTDi | 960 |
RGDi | 2307, Cd44 |
Phylogenomic databases
eggNOGi | ENOG502RX7Q, Eukaryota |
InParanoidi | P26051 |
PhylomeDBi | P26051 |
Enzyme and pathway databases
Reactomei | R-RNO-1474228, Degradation of the extracellular matrix R-RNO-202733, Cell surface interactions at the vascular wall R-RNO-216083, Integrin cell surface interactions R-RNO-2160916, Hyaluronan uptake and degradation R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P26051 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD44_RAT | |
Accessioni | P26051Primary (citable) accession number: P26051 Secondary accession number(s): Q99021 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |