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UniProtKB - P26051 (CD44_RAT)

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Protein

CD44 antigen

Gene

Cd44

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44HyaluronanBy similarity1
Binding sitei81HyaluronanBy similarity1
Binding sitei82HyaluronanBy similarity1
Binding sitei108HyaluronanBy similarity1

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • hyaluronic acid binding Source: InterPro
  • phosphoprotein binding Source: RGD
  • protein kinase binding Source: RGD
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • blood vessel maturation Source: RGD
  • cell adhesion Source: RGD
  • cell migration Source: RGD
  • inflammatory response Source: RGD
  • macrophage fusion Source: RGD
  • neuron projection development Source: RGD
  • positive regulation of neutrophil apoptotic process Source: RGD
  • regulation of cell growth Source: RGD
  • regulation of lamellipodium morphogenesis Source: UniProtKB
  • response to organic cyclic compound Source: RGD
  • response to vitamin A Source: RGD
  • wound healing, spreading of cells Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:Cd44
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2307 Cd44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 410ExtracellularSequence analysisAdd BLAST389
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 503CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002669122 – 503CD44 antigenAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi31 ↔ 133PROSITE-ProRule annotation
Disulfide bondi56 ↔ 122PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 100PROSITE-ProRule annotation
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei288Sulfotyrosine1 Publication1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei433Phosphoserine; by PKCBy similarity1
Modified residuei447PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1
Modified residuei458PhosphoserineBy similarity1
Modified residuei467PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated.By similarity
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-467 (constitutive phosphorylation site), and the phosphorylation of Ser-433.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation

Proteomic databases

PRIDEiP26051

PTM databases

iPTMnetiP26051
PhosphoSitePlusiP26051

Interactioni

Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with PKN2. Interacts with TIAM1 and TIAM2. Interacts with UNC119. Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration. Interacts with RDX, EZR and MSN.By similarity

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • phosphoprotein binding Source: RGD
  • protein kinase binding Source: RGD
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMiP26051
IntActiP26051, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP26051
SMRiP26051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 124LinkPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni228 – 410StemAdd BLAST183
Regioni434 – 452Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 162Arg/Lys-rich (basic)9

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003850
InParanoidiP26051
PhylomeDBiP26051

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom
PANTHERiPTHR10225:SF6 PTHR10225:SF6, 1 hit
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
PRINTSiPR00658 CD44
PR01265 LINKMODULE
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 2 (identifier: P26051-1) [UniParc]FASTAAdd to basket
Also known as: Long, Meta-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKVWWHTAW GLLCLLQLSL AQQQIDLNIT CRYAGVFHVE KNGRYSISRT 
        60         70         80         90        100
EAADLCEAFN TTLPTMAQME LALRKGFETC RYGFIEGHVV IPRIHPNAIC 
       110        120        130        140        150
AANNTGVYIL LASNTSHYDT YCFNASAPLE EDCTSVTDLP NSFDGPVTIT 
       160        170        180        190        200
IVNRDGTRYS KKGEYRTHQE DIDASNIIDE DVSSGSTIEK STPEGYILHT 
       210        220        230        240        250
DLPTSQPTGD RDDAFFIGST LATIATTPWV SAHTKQNQER TQWNPIHSNP 
       260        270        280        290        300
EVLLQTTTRM TDIDRNSTSA HGENWTQEPQ PPFNNHEYQD EEETPHATST 
       310        320        330        340        350
TWADPNSTTE EAATQKEKWF ENEWQGKNPP TPSEDSHVTE GTTASAHNNH 
       360        370        380        390        400
PSQRMTTQSQ EDVSWTDFFD PISHPMGQGH QTESKGHSSG NQDSGVTTTS 
       410        420        430        440        450
GPARRPQIPE WLIILASLLA LALILAVCIA VNSRRRCGQK KKLVINSGNG 
       460        470        480        490        500
TVEDRKPSEL NGEASKSQEM VHLVNKEPTE TPDQFMTADE TRNLQSVDMK 

IGV
Length:503
Mass (Da):55,946
Last modified:November 1, 1997 - v2
Checksum:iFB489D009BD4EE22
GO
Isoform 1 (identifier: P26051-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     224-385: IATTPWVSAH...MGQGHQTESK → SDGDSSMDPRGGFDTVTHGSELA

Show »
Length:364
Mass (Da):39,794
Checksum:iC45DE71B059DEA5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74R → S in AAA97915 (Ref. 2) Curated1
Sequence conflicti74R → S in AAA92920 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005330224 – 385IATTP…QTESK → SDGDSSMDPRGGFDTVTHGS ELA in isoform 1. 2 PublicationsAdd BLAST162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61875 mRNA Translation: AAA53532.1
M61874 mRNA Translation: AAA53534.1
U52179 mRNA Translation: AAA97915.1
U46957 mRNA Translation: AAA92920.1
PIRiB38745
RefSeqiXP_006234693.1, XM_006234631.3
UniGeneiRn.1120

Genome annotation databases

GeneIDi25406
UCSCiRGD:2307 rat [P26051-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCD44_RAT
AccessioniPrimary (citable) accession number: P26051
Secondary accession number(s): Q99021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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