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Entry version 191 (31 Jul 2019)
Sequence version 2 (05 May 2009)
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Protein

Tyrosine-protein phosphatase non-receptor type 3

Gene

PTPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei811SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei842Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei886SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-182971 EGFR downregulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P26045

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase H1
Short name:
PTP-H1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN3
Synonyms:PTPH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9655 PTPN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176877 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26045

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5774

MalaCards human disease database

More...
MalaCardsi
PTPN3

Open Targets

More...
OpenTargetsi
ENSG00000070159

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
70567 Cholangiocarcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33999

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2396509

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462761

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194331 – 913Tyrosine-protein phosphatase non-receptor type 3Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei357PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P26045

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P26045

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26045

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26045

PeptideAtlas

More...
PeptideAtlasi
P26045

PRoteomics IDEntifications database

More...
PRIDEi
P26045

ProteomicsDB human proteome resource

More...
ProteomicsDBi
17113
20397
54312 [P26045-1]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P26045

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26045

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26045

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000070159 Expressed in 202 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P26045 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26045 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038343
HPA046728

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111740, 41 interactors

Database of interacting proteins

More...
DIPi
DIP-38839N

Protein interaction database and analysis system

More...
IntActi
P26045, 53 interactors

Molecular INTeraction database

More...
MINTi
P26045

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363667

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P26045

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1913
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26045

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26045

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 312FERMPROSITE-ProRule annotationAdd BLAST284
Domaini510 – 582PDZPROSITE-ProRule annotationAdd BLAST73
Domaini646 – 901Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni842 – 848Substrate bindingBy similarity7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KDUQ Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157888

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26045

KEGG Orthology (KO)

More...
KOi
K18027

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMAYNHL

Database of Orthologous Groups

More...
OrthoDBi
96595at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26045

TreeFam database of animal gene trees

More...
TreeFami
TF315900

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd13189 FERM_C_PTPN4_PTPN3_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR041783 PTPN3/4_FERM_C
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000927 Tyr-Ptase_nr3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935 BAND41
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P26045-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSRLRALGG RINNIRTSEL PKEKTRSEVI CSIHFLDGVV QTFKVTKQDT
60 70 80 90 100
GQVLLDMVHN HLGVTEKEYF GLQHDDDSVD SPRWLEASKA IRKQLKGGFP
110 120 130 140 150
CTLHFRVRFF IPDPNTLQQE QTRHLYFLQL KMDICEGRLT CPLNSAVVLA
160 170 180 190 200
SYAVQSHFGD YNSSIHHPGY LSDSHFIPDQ NEDFLTKVES LHEQHSGLKQ
210 220 230 240 250
SEAESCYINI ARTLDFYGVE LHSGRDLHNL DLMIGIASAG VAVYRKYICT
260 270 280 290 300
SFYPWVNILK ISFKRKKFFI HQRQKQAESR EHIVAFNMLN YRSCKNLWKS
310 320 330 340 350
CVEHHTFFQA KKLLPQEKNV LSQYWTMGSR NTKKSVNNQY CKKVIGGMVW
360 370 380 390 400
NPAMRRSLSV EHLETKSLPS RSPPITPNWR SPRLRHEIRK PRHSSADNLA
410 420 430 440 450
NEMTYITETE DVFYTYKGSL APQDSDSEVS QNRSPHQESL SENNPAQSYL
460 470 480 490 500
TQKSSSSVSP SSNAPGSCSP DGVDQQLLDD FHRVTKGGST EDASQYYCDK
510 520 530 540 550
NDNGDSYLVL IRITPDEDGK FGFNLKGGVD QKMPLVVSRI NPESPADTCI
560 570 580 590 600
PKLNEGDQIV LINGRDISEH THDQVVMFIK ASRESHSREL ALVIRRRAVR
610 620 630 640 650
SFADFKSEDE LNQLFPEAIF PMCPEGGDTL EGSMAQLKKG LESGTVLIQF
660 670 680 690 700
EQLYRKKPGL AITFAKLPQN LDKNRYKDVL PYDTTRVLLQ GNEDYINASY
710 720 730 740 750
VNMEIPAANL VNKYIATQGP LPHTCAQFWQ VVWDQKLSLI VMLTTLTERG
760 770 780 790 800
RTKCHQYWPD PPDVMNHGGF HIQCQSEDCT IAYVSREMLV TNTQTGEEHT
810 820 830 840 850
VTHLQYVAWP DHGVPDDSSD FLEFVNYVRS LRVDSEPVLV HCSAGIGRTG
860 870 880 890 900
VLVTMETAMC LTERNLPIYP LDIVRKMRDQ RAMMVQTSSQ YKFVCEAILR
910
VYEEGLVQML DPS
Length:913
Mass (Da):103,990
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44FBBFA35A5F2AFF
GO
Isoform 2 (identifier: P26045-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Note: No experimental confirmation available.
Show »
Length:782
Mass (Da):88,814
Checksum:i00302B9F06B3568B
GO
Isoform 3 (identifier: P26045-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     335-379: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):83,723
Checksum:i6A9CCF192920EDE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KN34J3KN34_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN3
839Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti814V → I in AAA35647 (PubMed:1648725).Curated1
Sequence conflicti814V → I in AAB22439 (PubMed:1626183).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05525277D → N. Corresponds to variant dbSNP:rs35285139Ensembl.1
Natural variantiVAR_05525390A → P1 PublicationCorresponds to variant dbSNP:rs3793524Ensembl.1
Natural variantiVAR_055254409T → A. Corresponds to variant dbSNP:rs10979858Ensembl.1
Natural variantiVAR_055255605F → L. Corresponds to variant dbSNP:rs7859962Ensembl.1
Natural variantiVAR_055256763D → N. Corresponds to variant dbSNP:rs10116806Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463091 – 131Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_046310335 – 379Missing in isoform 3. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M64572 mRNA Translation: AAA35647.1
BX648253 mRNA No translation available.
BX648735 mRNA No translation available.
AL359963 Genomic DNA No translation available.
AL450025 Genomic DNA No translation available.
AL162733 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59046.1
BC126117 mRNA Translation: AAI26118.1
S39392 mRNA Translation: AAB22439.2
S76309 mRNA Translation: AAB33583.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48000.1 [P26045-3]
CCDS48001.1 [P26045-2]
CCDS6776.1 [P26045-1]

Protein sequence database of the Protein Information Resource

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PIRi
A41109

NCBI Reference Sequences

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RefSeqi
NP_001138840.1, NM_001145368.1
NP_001138841.1, NM_001145369.1 [P26045-2]
NP_001138842.1, NM_001145370.1 [P26045-3]
NP_001138843.1, NM_001145371.1
NP_002820.3, NM_002829.3 [P26045-1]
XP_006717262.1, XM_006717199.3 [P26045-1]
XP_006717267.1, XM_006717204.3 [P26045-2]
XP_011517191.1, XM_011518889.2 [P26045-1]
XP_016870444.1, XM_017014955.1 [P26045-1]
XP_016870446.1, XM_017014957.1 [P26045-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000374541; ENSP00000363667; ENSG00000070159 [P26045-1]
ENST00000412145; ENSP00000416654; ENSG00000070159 [P26045-2]
ENST00000446349; ENSP00000395384; ENSG00000070159 [P26045-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5774

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5774

UCSC genome browser

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UCSCi
uc004beb.2 human [P26045-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64572 mRNA Translation: AAA35647.1
BX648253 mRNA No translation available.
BX648735 mRNA No translation available.
AL359963 Genomic DNA No translation available.
AL450025 Genomic DNA No translation available.
AL162733 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59046.1
BC126117 mRNA Translation: AAI26118.1
S39392 mRNA Translation: AAB22439.2
S76309 mRNA Translation: AAB33583.1
CCDSiCCDS48000.1 [P26045-3]
CCDS48001.1 [P26045-2]
CCDS6776.1 [P26045-1]
PIRiA41109
RefSeqiNP_001138840.1, NM_001145368.1
NP_001138841.1, NM_001145369.1 [P26045-2]
NP_001138842.1, NM_001145370.1 [P26045-3]
NP_001138843.1, NM_001145371.1
NP_002820.3, NM_002829.3 [P26045-1]
XP_006717262.1, XM_006717199.3 [P26045-1]
XP_006717267.1, XM_006717204.3 [P26045-2]
XP_011517191.1, XM_011518889.2 [P26045-1]
XP_016870444.1, XM_017014955.1 [P26045-1]
XP_016870446.1, XM_017014957.1 [P26045-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B49X-ray1.54A628-913[»]
4QUMX-ray2.52A628-909[»]
4QUNX-ray1.86A/B628-909[»]
4RH5X-ray1.60A628-909[»]
4RH9X-ray1.60A628-909[»]
4RHGX-ray1.58A628-909[»]
4RI4X-ray1.60A/B628-909[»]
4RI5X-ray1.26A/B628-909[»]
4S0GX-ray1.72A628-909[»]
6HKSX-ray2.19A/B/C/D/E/F489-597[»]
SMRiP26045
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111740, 41 interactors
DIPiDIP-38839N
IntActiP26045, 53 interactors
MINTiP26045
STRINGi9606.ENSP00000363667

Chemistry databases

BindingDBiP26045
ChEMBLiCHEMBL2396509

PTM databases

DEPODiP26045
iPTMnetiP26045
PhosphoSitePlusiP26045

Polymorphism and mutation databases

BioMutaiPTPN3
DMDMi229462761

Proteomic databases

EPDiP26045
jPOSTiP26045
MaxQBiP26045
PaxDbiP26045
PeptideAtlasiP26045
PRIDEiP26045
ProteomicsDBi17113
20397
54312 [P26045-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5774
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374541; ENSP00000363667; ENSG00000070159 [P26045-1]
ENST00000412145; ENSP00000416654; ENSG00000070159 [P26045-2]
ENST00000446349; ENSP00000395384; ENSG00000070159 [P26045-3]
GeneIDi5774
KEGGihsa:5774
UCSCiuc004beb.2 human [P26045-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5774
DisGeNETi5774

GeneCards: human genes, protein and diseases

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GeneCardsi
PTPN3
HGNCiHGNC:9655 PTPN3
HPAiHPA038343
HPA046728
MalaCardsiPTPN3
MIMi176877 gene
neXtProtiNX_P26045
OpenTargetsiENSG00000070159
Orphaneti70567 Cholangiocarcinoma
PharmGKBiPA33999

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000157888
HOGENOMiHOG000007048
InParanoidiP26045
KOiK18027
OMAiDMAYNHL
OrthoDBi96595at2759
PhylomeDBiP26045
TreeFamiTF315900

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-182971 EGFR downregulation
SIGNORiP26045

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PTPN3 human
EvolutionaryTraceiP26045

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTPN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5774

Protein Ontology

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PROi
PR:P26045

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000070159 Expressed in 202 organ(s), highest expression level in oocyte
ExpressionAtlasiP26045 baseline and differential
GenevisibleiP26045 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13189 FERM_C_PTPN4_PTPN3_like, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR041783 PTPN3/4_FERM_C
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26045
Secondary accession number(s): A0AUW9, E7EN99, E9PGU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 5, 2009
Last modified: July 31, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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