UniProtKB - P26040 (EZRI_MOUSE)
Ezrin
Ezr
Functioni
Activity regulationi
GO - Molecular functioni
- actin binding Source: MGI
- actin filament binding Source: UniProtKB
- ATPase binding Source: MGI
- cell adhesion molecule binding Source: BHF-UCL
- disordered domain specific binding Source: CAFA
- identical protein binding Source: MGI
- microtubule binding Source: MGI
- protein-containing complex binding Source: MGI
- protein C-terminus binding Source: CAFA
- protein domain specific binding Source: MGI
- protein kinase A binding Source: MGI
- protein kinase A catalytic subunit binding Source: MGI
- protein kinase A regulatory subunit binding Source: MGI
- S100 protein binding Source: MGI
GO - Biological processi
- actin cytoskeleton reorganization Source: MGI
- actin filament bundle assembly Source: UniProtKB
- astral microtubule organization Source: MGI
- cellular protein-containing complex localization Source: MGI
- cellular response to cAMP Source: MGI
- cortical microtubule organization Source: MGI
- establishment of centrosome localization Source: MGI
- establishment of endothelial barrier Source: MGI
- establishment or maintenance of apical/basal cell polarity Source: MGI
- filopodium assembly Source: MGI
- intestinal D-glucose absorption Source: UniProtKB
- leukocyte cell-cell adhesion Source: Ensembl
- membrane to membrane docking Source: Ensembl
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- negative regulation of interleukin-2 production Source: MGI
- negative regulation of p38MAPK cascade Source: MGI
- negative regulation of T cell receptor signaling pathway Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- phosphatidylinositol-mediated signaling Source: MGI
- positive regulation of cellular protein catabolic process Source: MGI
- positive regulation of early endosome to late endosome transport Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of multicellular organism growth Source: UniProtKB
- positive regulation of protein localization to early endosome Source: MGI
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- positive regulation of protein secretion Source: MGI
- protein kinase A signaling Source: MGI
- protein localization to cell cortex Source: MGI
- protein localization to plasma membrane Source: MGI
- receptor internalization Source: MGI
- regulation of cell shape Source: MGI
- regulation of microvillus length Source: UniProtKB
- regulation of organelle assembly Source: MGI
- sphingosine-1-phosphate receptor signaling pathway Source: MGI
- terminal web assembly Source: UniProtKB
Keywordsi
Biological process | Cell shape |
Enzyme and pathway databases
Reactomei | R-MMU-373752, Netrin-1 signaling R-MMU-437239, Recycling pathway of L1 |
Protein family/group databases
TCDBi | 8.A.25.1.1, the ezrin/radixin/moesin (ezrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: EzrinAlternative name(s): Cytovillin Villin-2 p81 |
Gene namesi | Name:Ezr Synonyms:Vil2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98931, Ezr |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Plasma membrane
- Apical cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- microvillus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- ruffle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cell projection By similarity
- cell cortex By similarity
- microvillus 1 Publication
Note: Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Microvillar peripheral membrane protein (cytoplasmic side). Localizes to cell extensions and peripheral processes of astrocytes (By similarity).By similarity
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actin filament Source: UniProtKB
- ciliary basal body Source: MGI
Cytosol
- cytosol Source: MGI
Endosome
- endosome Source: MGI
Nucleus
- fibrillar center Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- basolateral plasma membrane Source: UniProtKB
- cytoplasmic side of apical plasma membrane Source: MGI
- immunological synapse Source: MGI
- microvillus membrane Source: MGI
- plasma membrane Source: MGI
- plasma membrane raft Source: MGI
- ruffle membrane Source: UniProtKB-SubCell
- T-tubule Source: MGI
Other locations
- apical part of cell Source: MGI
- astrocyte projection Source: MGI
- brush border Source: UniProtKB
- cell body Source: MGI
- cell cortex Source: UniProtKB-SubCell
- cell periphery Source: MGI
- cell projection Source: MGI
- cell tip Source: MGI
- cytoplasm Source: MGI
- extrinsic component of membrane Source: UniProtKB
- filopodium Source: MGI
- focal adhesion Source: Ensembl
- membrane raft Source: MGI
- microspike Source: MGI
- microvillus Source: UniProtKB
- myelin sheath Source: UniProtKB
- perinuclear region of cytoplasm Source: MGI
- protein-containing complex Source: MGI
- ruffle Source: MGI
- Schwann cell microvillus Source: MGI
- uropod Source: MGI
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219409 | 1 – 586 | EzrinAdd BLAST | 586 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 146 | Phosphotyrosine; by PDGFRBy similarity | 1 | |
Modified residuei | 354 | Phosphotyrosine; by PDGFRBy similarity | 1 | |
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 478 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 535 | PhosphoserineCombined sources | 1 | |
Modified residuei | 567 | Phosphothreonine; by ROCK2 and PKC/PRKCI1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
CPTACi | non-CPTAC-3807 |
EPDi | P26040 |
jPOSTi | P26040 |
PaxDbi | P26040 |
PeptideAtlasi | P26040 |
PRIDEi | P26040 |
ProteomicsDBi | 275709 |
2D gel databases
REPRODUCTION-2DPAGEi | P26040 |
PTM databases
iPTMneti | P26040 |
PhosphoSitePlusi | P26040 |
SwissPalmi | P26040 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000052397, Expressed in epithelium of stomach and 388 other tissues |
ExpressionAtlasi | P26040, baseline and differential |
Genevisiblei | P26040, MM |
Interactioni
Subunit structurei
Interacts with MPP5 and SLC9A3R2.
Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity).
Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B.
Interacts (when phosphorylated) with FES/FPS.
Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (PubMed:21745462). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity).
Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition (By similarity).
Interacts with SPN (PubMed:9472040, PubMed:21289089).
Interacts with CD44 and ICAM2 (PubMed:9472040).
By similarity3 PublicationsGO - Molecular functioni
- actin binding Source: MGI
- actin filament binding Source: UniProtKB
- ATPase binding Source: MGI
- cell adhesion molecule binding Source: BHF-UCL
- disordered domain specific binding Source: CAFA
- identical protein binding Source: MGI
- microtubule binding Source: MGI
- protein C-terminus binding Source: CAFA
- protein domain specific binding Source: MGI
- protein kinase A binding Source: MGI
- protein kinase A catalytic subunit binding Source: MGI
- protein kinase A regulatory subunit binding Source: MGI
- S100 protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204522, 37 interactors |
CORUMi | P26040 |
IntActi | P26040, 15 interactors |
MINTi | P26040 |
STRINGi | 10090.ENSMUSP00000063734 |
Miscellaneous databases
RNActi | P26040, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 295 | FERMPROSITE-ProRule annotationAdd BLAST | 294 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 244 – 586 | Interaction with SCYL3By similarityAdd BLAST | 343 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 115 – 120 | [IL]-x-C-x-x-[DE] motifBy similarity | 6 |
Domaini
Phylogenomic databases
eggNOGi | KOG3529, Eukaryota |
GeneTreei | ENSGT00960000186596 |
HOGENOMi | CLU_003623_6_2_1 |
InParanoidi | P26040 |
OMAi | QRVMEQH |
OrthoDBi | 627741at2759 |
PhylomeDBi | P26040 |
TreeFami | TF313935 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13194, FERM_C_ERM, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR011174, ERM IPR011259, ERM_C_dom IPR041789, ERM_FERM_C IPR000798, Ez/rad/moesin-like IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR008954, Moesin_tail_sf IPR011993, PH-like_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00769, ERM, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit |
PIRSFi | PIRSF002305, ERM, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF48678, SSF48678, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV
60 70 80 90 100
DNKGFPTWLK LDKKVSAQEV RKENPVQFKF RAKFYPEDVA EELIQDITQK
110 120 130 140 150
LFFLQVKDGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE MHKSGYLSSE
160 170 180 190 200
RLIPQRVMDQ HKLSRDQWED RIQVWHAEHR GMLKDSAMLE YLKIAQDLEM
210 220 230 240 250
YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF
260 270 280 290 300
NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI
310 320 330 340 350
EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM LREKEELMLR
360 370 380 390 400
LQDYEQKTKR AEKELSEQIE KALQLEEERR RAQEEAERLE ADRMAALRAK
410 420 430 440 450
EELERQAQDQ IKSQEQLAAE LAEYTAKIAL LEEARRRKED EVEEWQHRAK
460 470 480 490 500
EAQDDLVKTK EELHLVMTAP PPPPPPVYEP VNYHVQEGLQ DEGAEPMGYS
510 520 530 540 550
AELSSEGILD DRNEEKRITE AEKNERVQRQ LLTLSNELSQ ARDENKRTHN
560 570 580
DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | Q → P in CAA43086 (PubMed:1955455).Curated | 1 | |
Sequence conflicti | 325 | T → A in CAA43086 (PubMed:1955455).Curated | 1 | |
Sequence conflicti | 570 | Q → R in BAB22341 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60671 mRNA Translation: CAA43086.1 AK002766 mRNA Translation: BAB22341.1 BC048181 mRNA Translation: AAH48181.2 |
CCDSi | CCDS37428.1 |
PIRi | B41129 |
RefSeqi | NP_033536.2, NM_009510.2 |
Genome annotation databases
Ensembli | ENSMUST00000064234; ENSMUSP00000063734; ENSMUSG00000052397 |
GeneIDi | 22350 |
KEGGi | mmu:22350 |
UCSCi | uc008ahv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60671 mRNA Translation: CAA43086.1 AK002766 mRNA Translation: BAB22341.1 BC048181 mRNA Translation: AAH48181.2 |
CCDSi | CCDS37428.1 |
PIRi | B41129 |
RefSeqi | NP_033536.2, NM_009510.2 |
3D structure databases
BMRBi | P26040 |
SMRi | P26040 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204522, 37 interactors |
CORUMi | P26040 |
IntActi | P26040, 15 interactors |
MINTi | P26040 |
STRINGi | 10090.ENSMUSP00000063734 |
Chemistry databases
ChEMBLi | CHEMBL3102687 |
Protein family/group databases
TCDBi | 8.A.25.1.1, the ezrin/radixin/moesin (ezrin) family |
PTM databases
iPTMneti | P26040 |
PhosphoSitePlusi | P26040 |
SwissPalmi | P26040 |
2D gel databases
REPRODUCTION-2DPAGEi | P26040 |
Proteomic databases
CPTACi | non-CPTAC-3807 |
EPDi | P26040 |
jPOSTi | P26040 |
PaxDbi | P26040 |
PeptideAtlasi | P26040 |
PRIDEi | P26040 |
ProteomicsDBi | 275709 |
Protocols and materials databases
Antibodypediai | 3417, 1471 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000064234; ENSMUSP00000063734; ENSMUSG00000052397 |
GeneIDi | 22350 |
KEGGi | mmu:22350 |
UCSCi | uc008ahv.1, mouse |
Organism-specific databases
CTDi | 7430 |
MGIi | MGI:98931, Ezr |
Phylogenomic databases
eggNOGi | KOG3529, Eukaryota |
GeneTreei | ENSGT00960000186596 |
HOGENOMi | CLU_003623_6_2_1 |
InParanoidi | P26040 |
OMAi | QRVMEQH |
OrthoDBi | 627741at2759 |
PhylomeDBi | P26040 |
TreeFami | TF313935 |
Enzyme and pathway databases
Reactomei | R-MMU-373752, Netrin-1 signaling R-MMU-437239, Recycling pathway of L1 |
Miscellaneous databases
BioGRID-ORCSi | 22350, 0 hits in 55 CRISPR screens |
ChiTaRSi | Ezr, mouse |
PROi | PR:P26040 |
RNActi | P26040, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052397, Expressed in epithelium of stomach and 388 other tissues |
ExpressionAtlasi | P26040, baseline and differential |
Genevisiblei | P26040, MM |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13194, FERM_C_ERM, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR011174, ERM IPR011259, ERM_C_dom IPR041789, ERM_FERM_C IPR000798, Ez/rad/moesin-like IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR008954, Moesin_tail_sf IPR011993, PH-like_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00769, ERM, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit |
PIRSFi | PIRSF002305, ERM, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF48678, SSF48678, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EZRI_MOUSE | |
Accessioni | P26040Primary (citable) accession number: P26040 Secondary accession number(s): Q80ZT8, Q9DCI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 199 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot