Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pentraxin-related protein PTX3

Gene

PTX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.By similarity

GO - Molecular functioni

  • (1->3)-beta-D-glucan binding Source: Ensembl
  • complement component C1q binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • virion binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SIGNORiP26022

Names & Taxonomyi

Protein namesi
Recommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor alpha-induced protein 5
Short name:
TNF alpha-induced protein 5
Tumor necrosis factor-inducible gene 14 protein
Short name:
TSG-14
Gene namesi
Name:PTX3
Synonyms:TNFAIP5, TSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163661.3
HGNCiHGNC:9692 PTX3
MIMi602492 gene
neXtProtiNX_P26022

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5806
OpenTargetsiENSG00000163661
PharmGKBiPA34036

Polymorphism and mutation databases

BioMutaiPTX3
DMDMi296452984

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002354518 – 381Pentraxin-related protein PTX3Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47Interchain1 Publication
Disulfide bondi49Interchain1 Publication
Disulfide bondi103Interchain1 Publication
Disulfide bondi179 ↔ 3571 Publication
Disulfide bondi210 ↔ 271PROSITE-ProRule annotation1 Publication
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317Interchain1 Publication
Disulfide bondi318Interchain1 Publication

Post-translational modificationi

Glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP26022
MaxQBiP26022
PaxDbiP26022
PeptideAtlasiP26022
PRIDEiP26022
ProteomicsDBi54310

PTM databases

GlyConnecti704
iPTMnetiP26022
PhosphoSitePlusiP26022
UniCarbKBiP26022

Expressioni

Inductioni

By IL1B/interleukin-1 beta and TNF.

Gene expression databases

BgeeiENSG00000163661 Expressed in 176 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_PTX3
GenevisibleiP26022 HS

Organism-specific databases

HPAiHPA069320

Interactioni

Subunit structurei

Homooctamer; disulfide-linked. Binds to C1q (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111770, 8 interactors
IntActiP26022, 9 interactors
STRINGi9606.ENSP00000295927

Structurei

3D structure databases

ProteinModelPortaliP26022
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 381Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 101Sequence analysisAdd BLAST28
Coiled coili143 – 167Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IHCT Eukaryota
ENOG410XRG6 LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247046
HOVERGENiHBG008331
InParanoidiP26022
OMAiCHIRGNI
OrthoDBiEOG091G0AHP
PhylomeDBiP26022
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR006558 LamG-like
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00560 LamGL, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG
60 70 80 90 100
QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA
110 120 130 140 150
RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA
160 170 180 190 200
AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR
210 220 230 240 250
PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG
260 270 280 290 300
GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH
310 320 330 340 350
IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE
360 370 380
TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S
Length:381
Mass (Da):41,976
Last modified:May 18, 2010 - v3
Checksum:i09BCE02E2A62D62A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202M → L in AAA61234 (PubMed:7679696).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04314039H → Q. Corresponds to variant dbSNP:rs34655398Ensembl.1
Natural variantiVAR_04314148A → D4 PublicationsCorresponds to variant dbSNP:rs3816527Ensembl.1
Natural variantiVAR_043142290A → V. Corresponds to variant dbSNP:rs35415718Ensembl.1
Natural variantiVAR_043143313E → K. Corresponds to variant dbSNP:rs4478039Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63613 mRNA Translation: CAA45158.1
X63053 mRNA Translation: CAA44778.1
M31166 mRNA Translation: AAA61234.1
DQ207368 Genomic DNA Translation: ABA64467.1
AK312705 mRNA Translation: BAG35583.1
AC020630 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78708.1
BC039733 mRNA Translation: AAH39733.1
CCDSiCCDS3180.1
PIRiA44323
RefSeqiNP_002843.2, NM_002852.3
UniGeneiHs.591286

Genome annotation databases

EnsembliENST00000295927; ENSP00000295927; ENSG00000163661
GeneIDi5806
KEGGihsa:5806
UCSCiuc003fbl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63613 mRNA Translation: CAA45158.1
X63053 mRNA Translation: CAA44778.1
M31166 mRNA Translation: AAA61234.1
DQ207368 Genomic DNA Translation: ABA64467.1
AK312705 mRNA Translation: BAG35583.1
AC020630 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78708.1
BC039733 mRNA Translation: AAH39733.1
CCDSiCCDS3180.1
PIRiA44323
RefSeqiNP_002843.2, NM_002852.3
UniGeneiHs.591286

3D structure databases

ProteinModelPortaliP26022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111770, 8 interactors
IntActiP26022, 9 interactors
STRINGi9606.ENSP00000295927

PTM databases

GlyConnecti704
iPTMnetiP26022
PhosphoSitePlusiP26022
UniCarbKBiP26022

Polymorphism and mutation databases

BioMutaiPTX3
DMDMi296452984

Proteomic databases

EPDiP26022
MaxQBiP26022
PaxDbiP26022
PeptideAtlasiP26022
PRIDEiP26022
ProteomicsDBi54310

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295927; ENSP00000295927; ENSG00000163661
GeneIDi5806
KEGGihsa:5806
UCSCiuc003fbl.5 human

Organism-specific databases

CTDi5806
DisGeNETi5806
EuPathDBiHostDB:ENSG00000163661.3
GeneCardsiPTX3
H-InvDBiHIX0024325
HGNCiHGNC:9692 PTX3
HPAiHPA069320
MIMi602492 gene
neXtProtiNX_P26022
OpenTargetsiENSG00000163661
PharmGKBiPA34036
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHCT Eukaryota
ENOG410XRG6 LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247046
HOVERGENiHBG008331
InParanoidiP26022
OMAiCHIRGNI
OrthoDBiEOG091G0AHP
PhylomeDBiP26022
TreeFamiTF330208

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SIGNORiP26022

Miscellaneous databases

GeneWikiiPTX3
GenomeRNAii5806
PROiPR:P26022
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163661 Expressed in 176 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_PTX3
GenevisibleiP26022 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR006558 LamG-like
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00560 LamGL, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTX3_HUMAN
AccessioniPrimary (citable) accession number: P26022
Secondary accession number(s): B2R6T6, Q38M82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again