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Protein

Pentraxin-related protein PTX3

Gene

PTX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • (1->3)-beta-D-glucan binding Source: Ensembl
  • complement component C1q binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • virion binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P26022

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor alpha-induced protein 5
Short name:
TNF alpha-induced protein 5
Tumor necrosis factor-inducible gene 14 protein
Short name:
TSG-14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTX3
Synonyms:TNFAIP5, TSG14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163661.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9692 PTX3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602492 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5806

Open Targets

More...
OpenTargetsi
ENSG00000163661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34036

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTX3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452984

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002354518 – 381Pentraxin-related protein PTX3Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47Interchain1 Publication
Disulfide bondi49Interchain1 Publication
Disulfide bondi103Interchain1 Publication
Disulfide bondi179 ↔ 3571 Publication
Disulfide bondi210 ↔ 271PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317Interchain1 Publication
Disulfide bondi318Interchain1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P26022

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P26022

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26022

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26022

PeptideAtlas

More...
PeptideAtlasi
P26022

PRoteomics IDEntifications database

More...
PRIDEi
P26022

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54310

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
704

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26022

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26022

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P26022

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL1B/interleukin-1 beta and TNF.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163661 Expressed in 176 organ(s), highest expression level in smooth muscle tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTX3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26022 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA069320

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooctamer; disulfide-linked. Binds to C1q (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111770, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P26022, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295927

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P26022

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 381Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 101Sequence analysisAdd BLAST28
Coiled coili143 – 167Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHCT Eukaryota
ENOG410XRG6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247046

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008331

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26022

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLARPCA

Database of Orthologous Groups

More...
OrthoDBi
770812at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26022

TreeFam database of animal gene trees

More...
TreeFami
TF330208

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00152 PTX, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR006558 LamG-like
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00354 Pentaxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00895 PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00560 LamGL, 1 hit
SM00159 PTX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P26022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG
60 70 80 90 100
QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA
110 120 130 140 150
RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA
160 170 180 190 200
AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR
210 220 230 240 250
PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG
260 270 280 290 300
GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH
310 320 330 340 350
IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE
360 370 380
TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S
Length:381
Mass (Da):41,976
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09BCE02E2A62D62A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202M → L in AAA61234 (PubMed:7679696).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04314039H → Q. Corresponds to variant dbSNP:rs34655398Ensembl.1
Natural variantiVAR_04314148A → D4 PublicationsCorresponds to variant dbSNP:rs3816527Ensembl.1
Natural variantiVAR_043142290A → V. Corresponds to variant dbSNP:rs35415718Ensembl.1
Natural variantiVAR_043143313E → K. Corresponds to variant dbSNP:rs4478039Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X63613 mRNA Translation: CAA45158.1
X63053 mRNA Translation: CAA44778.1
M31166 mRNA Translation: AAA61234.1
DQ207368 Genomic DNA Translation: ABA64467.1
AK312705 mRNA Translation: BAG35583.1
AC020630 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78708.1
BC039733 mRNA Translation: AAH39733.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3180.1

Protein sequence database of the Protein Information Resource

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PIRi
A44323

NCBI Reference Sequences

More...
RefSeqi
NP_002843.2, NM_002852.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591286

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295927; ENSP00000295927; ENSG00000163661

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5806

UCSC genome browser

More...
UCSCi
uc003fbl.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63613 mRNA Translation: CAA45158.1
X63053 mRNA Translation: CAA44778.1
M31166 mRNA Translation: AAA61234.1
DQ207368 Genomic DNA Translation: ABA64467.1
AK312705 mRNA Translation: BAG35583.1
AC020630 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78708.1
BC039733 mRNA Translation: AAH39733.1
CCDSiCCDS3180.1
PIRiA44323
RefSeqiNP_002843.2, NM_002852.3
UniGeneiHs.591286

3D structure databases

ProteinModelPortaliP26022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111770, 8 interactors
IntActiP26022, 10 interactors
STRINGi9606.ENSP00000295927

PTM databases

GlyConnecti704
iPTMnetiP26022
PhosphoSitePlusiP26022
UniCarbKBiP26022

Polymorphism and mutation databases

BioMutaiPTX3
DMDMi296452984

Proteomic databases

EPDiP26022
jPOSTiP26022
MaxQBiP26022
PaxDbiP26022
PeptideAtlasiP26022
PRIDEiP26022
ProteomicsDBi54310

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295927; ENSP00000295927; ENSG00000163661
GeneIDi5806
KEGGihsa:5806
UCSCiuc003fbl.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5806
DisGeNETi5806
EuPathDBiHostDB:ENSG00000163661.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTX3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0024325
HGNCiHGNC:9692 PTX3
HPAiHPA069320
MIMi602492 gene
neXtProtiNX_P26022
OpenTargetsiENSG00000163661
PharmGKBiPA34036

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHCT Eukaryota
ENOG410XRG6 LUCA
GeneTreeiENSGT00940000154867
HOGENOMiHOG000247046
HOVERGENiHBG008331
InParanoidiP26022
OMAiSLARPCA
OrthoDBi770812at2759
PhylomeDBiP26022
TreeFamiTF330208

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SIGNORiP26022

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5806

Protein Ontology

More...
PROi
PR:P26022

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163661 Expressed in 176 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_PTX3
GenevisibleiP26022 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR006558 LamG-like
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00560 LamGL, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTX3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26022
Secondary accession number(s): B2R6T6, Q38M82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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