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Entry version 184 (13 Nov 2019)
Sequence version 2 (01 Jun 2001)
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Protein

Furin-like protease 1, isoforms 1/1-X/2

Gene

Fur1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. EC:3.4.21.75

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei372Charge relay systemPROSITE-ProRule annotation1
Active sitei413Charge relay systemPROSITE-ProRule annotation1
Active sitei587Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.75 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1592389 Activation of Matrix Metalloproteinases
R-DME-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-DME-186797 Signaling by PDGF
R-DME-2173789 TGF-beta receptor signaling activates SMADs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P26016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Furin-like protease 1, isoforms 1/1-X/2 (EC:3.4.21.75)
Short name:
Furin-1
Alternative name(s):
Kex2-like endoprotease 1
dKLIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fur1
ORF Names:CG10772
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004509 Fur1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei1233 – 1253HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000027020? – 309Sequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027021310 – 1269Furin-like protease 1, isoforms 1/1-X/2Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi430 ↔ 579By similarity
Disulfide bondi522 ↔ 552By similarity
Glycosylationi606N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi669 ↔ 695By similarity
Glycosylationi727N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi994N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26016

PRoteomics IDEntifications database

More...
PRIDEi
P26016

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adults, isoform 1-X is expressed in CNS, fat body and female reproductive tissues, and in embryos, in CNS, tracheal pits, hindgut, posterior spiracles and anal pads.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms 1-X and 2 are expressed in embryos, larvae, pupae and adults. Highest expression is in late embryos.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004509 Expressed in 48 organ(s), highest expression level in oviduct (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P26016 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26016 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
70692, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P26016, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0089026

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26016

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini340 – 654Peptidase S8PROSITE-ProRule annotationAdd BLAST315
Domaini662 – 793P/Homo BPROSITE-ProRule annotationAdd BLAST132

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family. Furin subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3525 Eukaryota
COG1404 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26016

KEGG Orthology (KO)

More...
KOi
K01349

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26016

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1-X (identifier: P26016-1) [UniParc]FASTAAdd to basket
Also known as: E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNDVVRWSR QPTSNTTNSS SSSRSDSNST HKHRSKSNKL NARQLGSNAA
60 70 80 90 100
RSCQQRSSVA TTLEDEQQTI IECDIGNFNF DCNLFKTSFL TQHKQKRSGK
110 120 130 140 150
SSSKSKSNRS RPLAKTKAVF LLALQFSAVV FLCNINVGFV AGSVATAASS
160 170 180 190 200
AGGSSPAAPS SAPSSPPTVA VPPPPPPSSA LKVDPNGQSP VLPPYVLDYE
210 220 230 240 250
TGGKAKLTPN NGKFGQSGSS GSNNNHIVGH YTHTWAVHIP NGDNGMADAV
260 270 280 290 300
AKDHGFVNLG KIFDDHYHFA HHKVSKRSLS PATHHQTRLD DDDRVHWAKQ
310 320 330 340 350
QRAKSRSKRD FIRMRPSRTS SRAMSMVDAM SFNDSKWPQM WYLNRGGGLD
360 370 380 390 400
MNVIPAWKMG ITGKGVVVTI LDDGLESDHP DIQDNYDPKA SYDVNSHDDD
410 420 430 440 450
PMPHYDMTDS NRHGTRCAGE VAATANNSFC AVGIAYGASV GGVRMLDGDV
460 470 480 490 500
TDAVEARSLS LNPQHIDIYS ASWGPDDDGK TVDGPGELAS RAFIEGTTKG
510 520 530 540 550
RGGKGSIFIW ASGNGGREQD NCNCDGYTNS IWTLSISSAT EEGHVPWYSE
560 570 580 590 600
KCSSTLATTY SSGGQGEKQV VTTDLHHSCT VSHTGTSASA PLAAGIAALV
610 620 630 640 650
LQSNQNLTWR DLQHIVVRTA KPANLKDPSW SRNGVGRRVS HSFGYGLMDA
660 670 680 690 700
AEMVRVARNW KAVPEQQRCE INAPHVDKVI PPRTHITLQL TVNHCRSVNY
710 720 730 740 750
LEHVQAKITL TSQRRGDIQL FLRSPANTSV TLLTPRIHDN SRSGFNQWPF
760 770 780 790 800
MSVHTWGESP QGNWQLEIHN EGRYMGHALL REWSLIFYGT TQSIGPNDPI
810 820 830 840 850
SVPKPSGSEA TTPNSSSTTS NLHQAYSPQY PRIPPNNFGS SPSGGSKLPL
860 870 880 890 900
GKVPPPNKSS YVTNNPLLNS APPKQGYQQI SATYGVILGK ANGKSNNNSK
910 920 930 940 950
EKTNNKGNKS NNGNKGKSGG SSGNRKEQTT QSTIIQTSTS KNKYYRISQQ
960 970 980 990 1000
QQQKNNKQDR NGVQTQRPKA NSGEKSYDEK SRKVVGEITT NSGNGSIKAA
1010 1020 1030 1040 1050
KQVKESTTTS SNSRIPKLFE RYEKIQAIFP ELEPYENSSP KGKPKQAKQG
1060 1070 1080 1090 1100
KQFEVDLFKP TNGGNSRQGN TKKSPSVPPP SQTMATLSIL PILPAGGSSF
1110 1120 1130 1140 1150
LPDQKILKKQ QLLMAAAGVM APAQVEVEME EVHATPDYEA RKDQRKEVNG
1160 1170 1180 1190 1200
PNAQITQWDM IFYGTETPAQ PDDVANPSQS NQFNLYGNDM AHNDVEYDST
1210 1220 1230 1240 1250
GQWRNMQQVG EVGMTRDHSN TAACLKWSDR KCLGLSLLFF MIMQVFFLNF
1260
KHANDNNNKN KNNIIKCIR
Length:1,269
Mass (Da):138,627
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i594E641CFB024C82
GO
Isoform 1 (identifier: P26016-2) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     776-1152: Missing.
     1208-1208: Q → QQYPFPFQ

Show »
Length:899
Mass (Da):98,797
Checksum:i0D800C3495DB918C
GO
Isoform 2 (identifier: P26016-3) [UniParc]FASTAAdd to basket
Also known as: C, D, F

The sequence of this isoform differs from the canonical sequence as follows:
     776-1152: Missing.

Show »
Length:892
Mass (Da):97,889
Checksum:i66D5C5B288C47895
GO
Isoform 1-CRR (identifier: P30430-1) [UniParc]FASTAAdd to basket
Also known as: A
The sequence of this isoform can be found in the external entry P30430.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,101
Mass (Da):120,993
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KHV0A0A0B4KHV0_DROME
Furin 1, isoform J
Fur1 Dfur1, dFur1, dFurin 1, Dfurin1, dKLIP-1
1,478Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KI15A0A0B4KI15_DROME
Furin 1, isoform H
Fur1 Dfur1, dFur1, dFurin 1, Dfurin1, dKLIP-1
864Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F0JAG0F0JAG0_DROME
Furin 1, isoform G
Fur1 Dfur1, dFur1, dFurin 1, Dfurin1, dKLIP-1
285Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005424776 – 1152Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST377
Alternative sequenceiVSP_0080421208Q → QQYPFPFQ in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X59384 mRNA Translation: CAA42027.1
L12370, L12369 Genomic DNA Translation: AAA28546.1
L12370, L12369 Genomic DNA Translation: AAA28547.1
L12375 mRNA Translation: AAA28550.1
L12376 mRNA Translation: AAA28549.1
AE014297 Genomic DNA Translation: AAF56463.2
AE014297 Genomic DNA Translation: AAF56464.1
AE014297 Genomic DNA Translation: AAN14052.1
AE014297 Genomic DNA Translation: AAS65215.1
AE014297 Genomic DNA Translation: AAS65216.1
AY069590 mRNA Translation: AAL39735.1

Protein sequence database of the Protein Information Resource

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PIRi
S17546
S35366

NCBI Reference Sequences

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RefSeqi
NP_524885.1, NM_080146.3 [P26016-1]
NP_733103.1, NM_170655.2 [P26016-3]
NP_733104.1, NM_170656.2 [P26016-3]
NP_996293.1, NM_206570.2 [P26016-3]
NP_996294.2, NM_206571.2 [P26016-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089983; FBpp0089026; FBgn0004509 [P26016-1]
FBtr0089984; FBpp0089027; FBgn0004509 [P26016-3]
FBtr0089985; FBpp0089028; FBgn0004509 [P26016-3]
FBtr0089987; FBpp0089030; FBgn0004509 [P26016-3]
FBtr0336805; FBpp0307776; FBgn0004509 [P26016-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
47220

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG10772

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59384 mRNA Translation: CAA42027.1
L12370, L12369 Genomic DNA Translation: AAA28546.1
L12370, L12369 Genomic DNA Translation: AAA28547.1
L12375 mRNA Translation: AAA28550.1
L12376 mRNA Translation: AAA28549.1
AE014297 Genomic DNA Translation: AAF56463.2
AE014297 Genomic DNA Translation: AAF56464.1
AE014297 Genomic DNA Translation: AAN14052.1
AE014297 Genomic DNA Translation: AAS65215.1
AE014297 Genomic DNA Translation: AAS65216.1
AY069590 mRNA Translation: AAL39735.1
PIRiS17546
S35366
RefSeqiNP_524885.1, NM_080146.3 [P26016-1]
NP_733103.1, NM_170655.2 [P26016-3]
NP_733104.1, NM_170656.2 [P26016-3]
NP_996293.1, NM_206570.2 [P26016-3]
NP_996294.2, NM_206571.2 [P26016-3]

3D structure databases

SMRiP26016
ModBaseiSearch...

Protein-protein interaction databases

BioGridi70692, 5 interactors
IntActiP26016, 3 interactors
STRINGi7227.FBpp0089026

Proteomic databases

PaxDbiP26016
PRIDEiP26016

Genome annotation databases

EnsemblMetazoaiFBtr0089983; FBpp0089026; FBgn0004509 [P26016-1]
FBtr0089984; FBpp0089027; FBgn0004509 [P26016-3]
FBtr0089985; FBpp0089028; FBgn0004509 [P26016-3]
FBtr0089987; FBpp0089030; FBgn0004509 [P26016-3]
FBtr0336805; FBpp0307776; FBgn0004509 [P26016-3]
GeneIDi47220
KEGGidme:Dmel_CG10772

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
47220
FlyBaseiFBgn0004509 Fur1

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
InParanoidiP26016
KOiK01349
PhylomeDBiP26016

Enzyme and pathway databases

BRENDAi3.4.21.75 1994
ReactomeiR-DME-1592389 Activation of Matrix Metalloproteinases
R-DME-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-DME-186797 Signaling by PDGF
R-DME-2173789 TGF-beta receptor signaling activates SMADs
SignaLinkiP26016

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fur1 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
47220

Gene expression databases

BgeeiFBgn0004509 Expressed in 48 organ(s), highest expression level in oviduct (Drosophila)
ExpressionAtlasiP26016 differential
GenevisibleiP26016 DM

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUR11_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26016
Secondary accession number(s): A4V3E2, Q05817, Q27436
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 1, 2001
Last modified: November 13, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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