UniProtKB - P26011 (ITB7_MOUSE)
Protein
Integrin beta-7
Gene
Itgb7
Organism
Mus musculus (Mouse)
Status
Functioni
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.
GO - Molecular functioni
- cell adhesion molecule binding Source: MGI
- integrin binding Source: GO_Central
- signaling receptor activity Source: InterPro
GO - Biological processi
- cell adhesion mediated by integrin Source: GO_Central
- cell-matrix adhesion Source: MGI
- cell-matrix adhesion involved in ameboidal cell migration Source: MGI
- cell migration Source: GO_Central
- heterotypic cell-cell adhesion Source: MGI
- integrin-mediated signaling pathway Source: MGI
- leukocyte migration Source: MGI
- leukocyte tethering or rolling Source: MGI
- receptor clustering Source: MGI
- substrate adhesion-dependent cell spreading Source: MGI
- T cell migration Source: MGI
Keywordsi
Molecular function | Integrin, Receptor |
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083, Integrin cell surface interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Integrin beta-7Alternative name(s): Integrin beta-P M290 IEL antigen |
Gene namesi | Name:Itgb7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96616, Itgb7 |
Subcellular locationi
Other locations
Plasma Membrane
- integrin alpha4-beta7 complex Source: MGI
Other locations
- cell surface Source: MGI
- focal adhesion Source: GO_Central
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 724 | ExtracellularSequence analysisAdd BLAST | 705 | |
Transmembranei | 725 – 745 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 746 – 806 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000016353 | 20 – 806 | Integrin beta-7Add BLAST | 787 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 476 | By similarity | ||
Disulfide bondi | 51 ↔ 61 | By similarity | ||
Disulfide bondi | 54 ↔ 91 | By similarity | ||
Disulfide bondi | 64 ↔ 80 | By similarity | ||
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 216 ↔ 223 | By similarity | ||
Glycosylationi | 250 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 271 ↔ 311 | By similarity | ||
Glycosylationi | 279 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 412 ↔ 428 | By similarity | ||
Glycosylationi | 434 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 448 ↔ 688 | By similarity | ||
Disulfide bondi | 474 ↔ 478 | By similarity | ||
Disulfide bondi | 488 ↔ 500 | By similarity | ||
Disulfide bondi | 497 ↔ 537 | By similarity | ||
Disulfide bondi | 502 ↔ 511 | By similarity | ||
Disulfide bondi | 513 ↔ 527 | By similarity | ||
Glycosylationi | 531 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 543 ↔ 548 | By similarity | ||
Disulfide bondi | 545 ↔ 574 | By similarity | ||
Disulfide bondi | 550 ↔ 559 | By similarity | ||
Disulfide bondi | 561 ↔ 566 | By similarity | ||
Disulfide bondi | 580 ↔ 585 | By similarity | ||
Disulfide bondi | 582 ↔ 613 | By similarity | ||
Disulfide bondi | 587 ↔ 596 | By similarity | ||
Glycosylationi | 590 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 598 ↔ 605 | By similarity | ||
Disulfide bondi | 619 ↔ 624 | By similarity | ||
Disulfide bondi | 621 ↔ 666 | By similarity | ||
Disulfide bondi | 626 ↔ 635 | By similarity | ||
Disulfide bondi | 638 ↔ 641 | By similarity | ||
Disulfide bondi | 645 ↔ 654 | By similarity | ||
Glycosylationi | 665 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 674 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P26011 |
jPOSTi | P26011 |
MaxQBi | P26011 |
PaxDbi | P26011 |
PeptideAtlasi | P26011 |
PRIDEi | P26011 |
PTM databases
GlyGeni | P26011, 8 sites |
iPTMneti | P26011 |
PhosphoSitePlusi | P26011 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001281, Expressed in mesenteric lymph node and 157 other tissues |
ExpressionAtlasi | P26011, baseline and differential |
Genevisiblei | P26011, MM |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E.
Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23).
By similarityGO - Molecular functioni
- cell adhesion molecule binding Source: MGI
- integrin binding Source: GO_Central
Protein-protein interaction databases
ComplexPortali | CPX-3077, integrin alpha4-beta7 complex CPX-3127, Integrin alphaE-beta7 complex |
STRINGi | 10090.ENSMUSP00000001327 |
Chemistry databases
BindingDBi | P26011 |
Miscellaneous databases
RNActi | P26011, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 150 – 389 | VWFAAdd BLAST | 240 | |
Repeati | 478 – 526 | IAdd BLAST | 49 | |
Repeati | 527 – 565 | IIAdd BLAST | 39 | |
Repeati | 566 – 604 | IIIAdd BLAST | 39 | |
Repeati | 605 – 640 | IVAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 478 – 640 | Cysteine-rich tandem repeatsAdd BLAST | 163 |
Sequence similaritiesi
Belongs to the integrin beta chain family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1226, Eukaryota |
GeneTreei | ENSGT01010000222340 |
HOGENOMi | CLU_011772_2_1_1 |
InParanoidi | P26011 |
OMAi | PLAANCS |
OrthoDBi | 473040at2759 |
PhylomeDBi | P26011 |
TreeFami | TF105392 |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR013111, EGF_extracell IPR040622, I-EGF_1 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR015437, Integrin_bsu-7 IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF36, PTHR10082:SF36, 1 hit |
Pfami | View protein in Pfam PF07974, EGF_2, 1 hit PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 4 hits PS01186, EGF_2, 1 hit PS00243, INTEGRIN_BETA, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P26011-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDSSTVLIF LLVLGGGQSE LDTKITSSGE AAEWEDPDLS LQGSCQPVPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPAQELEEPR
110 120 130 140 150
GRQEVLQDKP LSQGDRGEGA TQLAPQRIRV TLRPGEPQKF RVRFLRAAGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLHHPCPSRL ERCQPPFSFH HVLSLTGDAQ AFEREVGRQN
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGR CHLDSNGVYT NSAEFDYPSV GQVAQALTAA NIQPIFAVTG
360 370 380 390 400
ATLPVYQELR QLIPKSAVGE LSEDSSNVVQ LIMDAYDSLS STVTLEHSPL
410 420 430 440 450
PPGVSISFES HCKGPEKTEG EAGDRGQCND VRVNQTVDFW VTLQATHCLP
460 470 480 490 500
EAHVLRLWAL GFSEELTVEL HTVCDCNCGD AQPHAPYCSD GQGDLQCGIC
510 520 530 540 550
SCAPGRLGQL CECSEADLSS PDLESGCRAP NGTGPLCSGK GRCQCGRCSC
560 570 580 590 600
SGQSSGRLCE CDDASCERHE GILCGGFGHC QCGVCHCHAN HTGRACECSK
610 620 630 640 650
SVDSCVSPEG GLCSGHGYCK CNRCQCLDGY YGALCDQCLG CKSPCEQYRD
660 670 680 690 700
CAECGAFGTG PLAANCSVVC ADVNVTLTLA PNLDDGWCKE RTIDNQLFFF
710 720 730 740 750
LVEHAASGIV LRVRPQEKGV DHTRAIILGC TGGIVAVGLG LVLAYRLSVE
760 770 780 790 800
IYDRREYRRF EKEQQQLNWK QDNNPLYKSA ITTTVNPRFQ GTNGRSPSLS
LTREAD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z0L2 | D3Z0L2_MOUSE | Integrin beta-7 | Itgb7 | 83 | Annotation score: | ||
A0A2R8VI55 | A0A2R8VI55_MOUSE | Integrin beta-7 | Itgb7 | 98 | Annotation score: | ||
A0A2R8VI38 | A0A2R8VI38_MOUSE | Integrin beta-7 | Itgb7 | 10 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 81 | A → E AA sequence (PubMed:1710115).Curated | 1 | |
Sequence conflicti | 81 | A → G in AAB23193 (PubMed:1381390).Curated | 1 | |
Sequence conflicti | 124 | Missing in AAA02749 (PubMed:1559978).Curated | 1 | |
Sequence conflicti | 538 | S → C in AAB23193 (PubMed:1381390).Curated | 1 | |
Sequence conflicti | 557 | R → H in AAA02749 (PubMed:1559978).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68903 mRNA Translation: AAA02749.1 M95632 mRNA Translation: AAA39323.1 M95633 mRNA Translation: AAA39324.1 S44607 mRNA Translation: AAB23193.1 AK078871 mRNA Translation: BAC37433.1 AK154766 mRNA Translation: BAE32815.1 AK155207 mRNA Translation: BAE33119.1 BC011184 mRNA Translation: AAH11184.1 S63504 Genomic DNA Translation: AAB27396.1 |
CCDSi | CCDS49740.1 |
PIRi | A46271 I54754 |
RefSeqi | NP_038594.2, NM_013566.2 |
Genome annotation databases
Ensembli | ENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281 |
GeneIDi | 16421 |
KEGGi | mmu:16421 |
UCSCi | uc012aaa.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68903 mRNA Translation: AAA02749.1 M95632 mRNA Translation: AAA39323.1 M95633 mRNA Translation: AAA39324.1 S44607 mRNA Translation: AAB23193.1 AK078871 mRNA Translation: BAC37433.1 AK154766 mRNA Translation: BAE32815.1 AK155207 mRNA Translation: BAE33119.1 BC011184 mRNA Translation: AAH11184.1 S63504 Genomic DNA Translation: AAB27396.1 |
CCDSi | CCDS49740.1 |
PIRi | A46271 I54754 |
RefSeqi | NP_038594.2, NM_013566.2 |
3D structure databases
SMRi | P26011 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3077, integrin alpha4-beta7 complex CPX-3127, Integrin alphaE-beta7 complex |
STRINGi | 10090.ENSMUSP00000001327 |
Chemistry databases
BindingDBi | P26011 |
ChEMBLi | CHEMBL2111481 |
PTM databases
GlyGeni | P26011, 8 sites |
iPTMneti | P26011 |
PhosphoSitePlusi | P26011 |
Proteomic databases
EPDi | P26011 |
jPOSTi | P26011 |
MaxQBi | P26011 |
PaxDbi | P26011 |
PeptideAtlasi | P26011 |
PRIDEi | P26011 |
Protocols and materials databases
Antibodypediai | 26942, 511 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000001327; ENSMUSP00000001327; ENSMUSG00000001281 |
GeneIDi | 16421 |
KEGGi | mmu:16421 |
UCSCi | uc012aaa.1, mouse |
Organism-specific databases
CTDi | 3695 |
MGIi | MGI:96616, Itgb7 |
Phylogenomic databases
eggNOGi | KOG1226, Eukaryota |
GeneTreei | ENSGT01010000222340 |
HOGENOMi | CLU_011772_2_1_1 |
InParanoidi | P26011 |
OMAi | PLAANCS |
OrthoDBi | 473040at2759 |
PhylomeDBi | P26011 |
TreeFami | TF105392 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083, Integrin cell surface interactions |
Miscellaneous databases
BioGRID-ORCSi | 16421, 1 hit in 18 CRISPR screens |
ChiTaRSi | Itgb7, mouse |
PROi | PR:P26011 |
RNActi | P26011, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001281, Expressed in mesenteric lymph node and 157 other tissues |
ExpressionAtlasi | P26011, baseline and differential |
Genevisiblei | P26011, MM |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR013111, EGF_extracell IPR040622, I-EGF_1 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR015437, Integrin_bsu-7 IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF36, PTHR10082:SF36, 1 hit |
Pfami | View protein in Pfam PF07974, EGF_2, 1 hit PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 4 hits PS01186, EGF_2, 1 hit PS00243, INTEGRIN_BETA, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITB7_MOUSE | |
Accessioni | P26011Primary (citable) accession number: P26011 Secondary accession number(s): Q3U2M1, Q64656 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families