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Protein

Integrin alpha-6

Gene

ITGA6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells. It plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi318 – 326Sequence analysis9
Calcium bindingi380 – 388Sequence analysis9
Calcium bindingi438 – 446Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-6
Alternative name(s):
VLA-6
Cleaved into the following 2 chains:
Gene namesi
Name:ITGA6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1010ExtracellularSequence analysisAdd BLAST992
Transmembranei1011 – 1036HelicalSequence analysisAdd BLAST26
Topological domaini1037 – 1072CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001626419 – 1072Integrin alpha-6Add BLAST1054
ChainiPRO_000001626519 – 898Integrin alpha-6 heavy chainSequence analysisAdd BLAST880
ChainiPRO_0000016266902 – 1072Integrin alpha-6 light chainSequence analysisAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 88By similarity
Disulfide bondi125 ↔ 148By similarity
Disulfide bondi169 ↔ 182By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi498 ↔ 557By similarity
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 631By similarity
Disulfide bondi725 ↔ 736By similarity
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi880 ↔ 927Interchain (between heavy and light chains)By similarity
Disulfide bondi933 ↔ 938By similarity
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi1038S-palmitoyl cysteine; by DHHC3By similarity1
Modified residuei1070Phosphoserine; by CaMK2Sequence analysis1

Post-translational modificationi

Phosphorylated in vivo.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP26007
PRIDEiP26007

Expressioni

Developmental stagei

Alpha-6 levels decrease with age.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015231

Structurei

3D structure databases

ProteinModelPortaliP26007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 88FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati94 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST67
Repeati170 – 223FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati238 – 295FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati296 – 357FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati358 – 413FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati414 – 476FG-GAP 7PROSITE-ProRule annotationAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1039 – 1043GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
HOGENOMiHOG000015786
HOVERGENiHBG108011
InParanoidiP26007
KOiK06485
PhylomeDBiP26007

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALLLYLP LLPGLAGAFN LDAENVIGRR GEPGSLFGFS LAMHRQLQPQ
60 70 80 90 100
EKRLLLVGAP REKAFPSQQA NRTGGLYSCD ITSSDTRCTR VVFDEDTDPK
110 120 130 140 150
MESKEDQWMG VTVQSQGPGG NVVTCAHRYE KRQYVNTVQE TRDIIGRCYV
160 170 180 190 200
LSQDLTIKDD MDNGVWSFCD GRLRGHEKFG SCQQGVAATF TRDYHYIVFG
210 220 230 240 250
APGTYNWKGV VRAEQKNQTF YDLGIFDDGP YEVGDESRQD KNLVPVPANS
260 270 280 290 300
YLGFSLDSGK GIVSQDEMTF VSGAPRANHS GAVVLLKKEK NQRALSLEHM
310 320 330 340 350
FEGEGLASSF GYDVAVVDLN SDGWQDIVVG APQYFDRSGD IGGAVYIYIN
360 370 380 390 400
QRGKWEGIKP IRLNGTADSM FGLAVENVGD INQDGYPDIA VGAPYDGFGK
410 420 430 440 450
VYIYHGSKNG INTEPAQILD GEKTGTNFFG YSIAGNMDLD KNSYPDIAVG
460 470 480 490 500
SLSDSVSVFR SRPVISITKS ITVQPDKLDL KKKNPEDPSE IWMDVKACFQ
510 520 530 540 550
YTANPRNLNP RIKINYTFEA ENERRQLGLP SRVRFKDYLS DQFTASTTLI
560 570 580 590 600
GQNSKRCVTA KLVLQEKIKD KLRPIPIAVS VNIAGLESGS SSTRKERALP
610 620 630 640 650
DLIPILNSNE SETKITKVEF LKEGCGEDNE CHSNLKLQYR FCTREGNEDR
660 670 680 690 700
FTYLPIENGI PVLVLKDQKD IALEITVTNN PSDARNPQKD GEDAYEAKLI
710 720 730 740 750
ATFPDSLTYS AFREMRGYPE KQLTCGANQN GSQAECELGN PFKRNSNVTF
760 770 780 790 800
YLILSTTKVN VDTTDLDINL KLETTSTQVN STAITASAKV VLELLLSLTG
810 820 830 840 850
VAKPSQVYFG GNIVGESAMK SEDNIGNLIE YEFRVTNLGR PLKTFGTASL
860 870 880 890 900
DIQWPKEISN GKWLLYLMKI ESKGLEKVSC QPQNEINVLH VAESHNSRRK
910 920 930 940 950
REIAEKQLTD SKTFSLFSER KYKTLDCKVN AQCVDIRCPL KGFDSKASIL
960 970 980 990 1000
LRSRLWNSTF LEEFSKMNYL DILVRASISV PAAAKNVKLT NEAAQVRVTV
1010 1020 1030 1040 1050
FPAKPVALYT GVPWWIIAVA IFAGVLMLAL LVFLLWKCGF FKRSKKDHYD
1060 1070
ATYHKAEIHA QPSDKERLTS DA
Length:1,072
Mass (Da):119,200
Last modified:May 1, 1992 - v1
Checksum:i6DE2B99ECD8B3E44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56559 mRNA Translation: CAA39909.1
PIRiA38457
RefSeqiNP_990620.1, NM_205289.1
UniGeneiGga.44589

Genome annotation databases

GeneIDi396226
KEGGigga:396226

Similar proteinsi

Entry informationi

Entry nameiITA6_CHICK
AccessioniPrimary (citable) accession number: P26007
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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