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Entry version 215 (18 Sep 2019)
Sequence version 1 (01 May 1992)
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Protein

NF-kappa-B inhibitor alpha

Gene

NFKBIA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-202424 Downstream TCR signaling
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-4755510 SUMOylation of immune response proteins
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P25963

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P25963

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P25963

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-kappa-B inhibitor alpha
Alternative name(s):
I-kappa-B-alpha
Short name:
IkB-alpha
Short name:
IkappaBalpha
Major histocompatibility complex enhancer-binding protein MAD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFKBIA
Synonyms:IKBA, MAD3, NFKBI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7797 NFKBIA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164008 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25963

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ectodermal dysplasia and immunodeficiency 2 (EDAID2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. EDAID2 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03487132S → I in EDAID2. 1 PublicationCorresponds to variant dbSNP:rs28933100EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21K → R: Little change in Tax-stimulated transactivation. No sumoylation. Greatly reduced Tax- or cytokine-stimulated transactivation and decrease in ubiquitination and degradation; when associated with R-22. 4 Publications1
Mutagenesisi22K → R: Little change in Tax-stimulated transactivation. No sumoylation. Greatly reduced Tax- or cytokine-stimulated transactivation and decrease in ubiquitination and degradation; when associated with R-21. 4 Publications1
Mutagenesisi31D → A: Loss of phosphorylation; when associated with A-35. 1 Publication1
Mutagenesisi32S → A: Loss of phosphorylation, ubiquitination and degradation; when associated with A-36. 2 Publications1
Mutagenesisi32S → T: Decrease in phosphorylation and degradation; when associated with T-36. 2 Publications1
Mutagenesisi35D → A: Loss in phosphorylation; when associated with A-31. 1 Publication1
Mutagenesisi35D → G: No change neither in phosphorylation, nor on degradation. 1 Publication1
Mutagenesisi36S → A: Loss of phosphorylation, ubiquitination, and degradation; when associated with A-32. 2 Publications1
Mutagenesisi36S → T: Decrease in phosphorylation and degradation; when associated with T-32. 2 Publications1
Mutagenesisi38K → R: No change in Tax-stimulated transactivation. No change in Tax-stimulated transactivation; when associated with R-47. 1 Publication1
Mutagenesisi42Y → F: No phosphorylation. 1 Publication1
Mutagenesisi45 – 52MVKELQEI → AAKEAQEA: No nuclear export. 1 Publication8
Mutagenesisi47K → R: Little change in Tax-stimulated transactivation. No change in Tax-stimulated transactivation; when associated with R-38. 1 Publication1
Mutagenesisi115 – 120LHLAVI → AHAAVA: Greatly reduced nuclear localization. Great reduction in its ability to inhibit DNA binding of RELA. 1 Publication6
Mutagenesisi210N → A: Almost abolished ability to inhibit NF-kappa-B DNA-binding activity; when associated with A-244. 1 Publication1
Mutagenesisi234S → A: No inducible ubiquitination nor protein degradation. 1 Publication1
Mutagenesisi244N → A: Almost abolished ability to inhibit NF-kappa-B DNA-binding activity; when associated with A-210. 1 Publication1
Mutagenesisi262S → A: No inducible ubiquitination nor protein degradation. 1 Publication1
Mutagenesisi263T → A: No inducible ubiquitination nor protein degradation. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia

Organism-specific databases

DisGeNET

More...
DisGeNETi
4792

MalaCards human disease database

More...
MalaCardsi
NFKBIA
MIMi612132 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100906

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251579 Giant cell glioblastoma
251576 Gliosarcoma
98813 Hypohidrotic ectodermal dysplasia with immunodeficiency
150 Nasopharyngeal carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31601

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2898

Drug and drug target database

More...
DrugBanki
DB00945 Acetylsalicylic acid
DB06543 Astaxanthin
DB05983 Bardoxolone methyl

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFKBIA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669991 – 317NF-kappa-B inhibitor alphaAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO or ubiquitin); alternate2 Publications
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32Phosphoserine; by IKKA and IKKE2 Publications1
Modified residuei36Phosphoserine; by IKKA, IKKB, IKKE and TBK12 Publications1
Modified residuei42Phosphotyrosine; by Tyr-kinases1 Publication1
Modified residuei210(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei244(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei283Phosphoserine; by CK22 Publications1
Modified residuei288Phosphoserine; by CK21 Publication1
Modified residuei291Phosphothreonine; by CK22 Publications1
Modified residuei293Phosphoserine; by CK21 Publication1
Modified residuei299Phosphothreonine; by CK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation.3 Publications
Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability.3 Publications
Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-36.5 Publications
Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with NFKBIA degradation and impairs subsequent NF-kappa-B activation.

Keywords - PTMi

Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P25963

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P25963

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P25963

MaxQB - The MaxQuant DataBase

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MaxQBi
P25963

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P25963

PeptideAtlas

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PeptideAtlasi
P25963

PRoteomics IDEntifications database

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PRIDEi
P25963

ProteomicsDB human proteome resource

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ProteomicsDBi
54304

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25963

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P25963

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P25963

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in adherent monocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100906 Expressed in 237 organ(s), highest expression level in vena cava

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P25963 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P25963 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB003815
HPA029207

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RELA; the interaction requires the nuclear import signal.

Interacts with NKIRAS1 and NKIRAS2.

Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14.

Interacts with isoform 1 and isoform 2 of RWDD3; the interaction enhances sumoylation.

Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC.

Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA.

Interacts with PRMT2.

Interacts with PRKACA in platelets; this interaction is disrupted by thrombin and collagen.

Interacts with HIF1AN.

Interacts with MEFV.

Interacts with DDRGK1; positively regulates NFKBIA phosphorylation and degradation.

9 Publications

(Microbial infection)

Interacts with HBV protein X.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110859, 154 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P25963

Database of interacting proteins

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DIPi
DIP-139N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P25963

Protein interaction database and analysis system

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IntActi
P25963, 93 interactors

Molecular INTeraction database

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MINTi
P25963

STRING: functional protein association networks

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STRINGi
9606.ENSP00000216797

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P25963

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P25963

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P25963

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 103ANK 1Add BLAST31
Repeati110 – 139ANK 2Add BLAST30
Repeati143 – 172ANK 3Add BLAST30
Repeati182 – 211ANK 4Add BLAST30
Repeati216 – 245ANK 5Add BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi30 – 36Destruction motif7
Motifi45 – 54Nuclear export signal10
Motifi110 – 120Nuclear import signalAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059576

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P25963

KEGG Orthology (KO)

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KOi
K04734

Identification of Orthologs from Complete Genome Data

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OMAi
DWAMEGP

Database of Orthologous Groups

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OrthoDBi
1341288at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P25963

TreeFam database of animal gene trees

More...
TreeFami
TF320166

Family and domain databases

Database of protein disorder

More...
DisProti
DP00468

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P25963-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ
60 70 80 90 100
EIRLEPQEVP RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD
110 120 130 140 150
LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL
160 170 180 190 200
ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE
210 220 230 240 250
LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG
260 270 280 290 300
YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE
310
DELPYDDCVF GGQRLTL
Length:317
Mass (Da):35,609
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i088B313226786395
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3I4G3V3I4_HUMAN
NF-kappa-B inhibitor alpha
NFKBIA
274Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2A2G3V2A2_HUMAN
NF-kappa-B inhibitor alpha
NFKBIA
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V286G3V286_HUMAN
NF-kappa-B inhibitor alpha
NFKBIA
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3K1G3V3K1_HUMAN
NF-kappa-B inhibitor alpha
NFKBIA
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03487132S → I in EDAID2. 1 PublicationCorresponds to variant dbSNP:rs28933100EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M69043 mRNA Translation: AAA16489.1
AJ249294
, AJ249295, AJ249283, AJ249284, AJ249285, AJ249286 Genomic DNA Translation: CAB65556.2
AY033600 mRNA Translation: AAK51149.1
BT007091 mRNA Translation: AAP35754.1
AY496422 Genomic DNA Translation: AAR29599.1
AK313421 mRNA Translation: BAG36213.1
AL133163 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65875.1
BC002601 mRNA Translation: AAH02601.1
BC004983 mRNA Translation: AAH04983.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9656.1

Protein sequence database of the Protein Information Resource

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PIRi
A39935

NCBI Reference Sequences

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RefSeqi
NP_065390.1, NM_020529.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000216797; ENSP00000216797; ENSG00000100906

Database of genes from NCBI RefSeq genomes

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GeneIDi
4792

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4792

UCSC genome browser

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UCSCi
uc001wtf.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NFKBIAbase

NFKBIA mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69043 mRNA Translation: AAA16489.1
AJ249294
, AJ249295, AJ249283, AJ249284, AJ249285, AJ249286 Genomic DNA Translation: CAB65556.2
AY033600 mRNA Translation: AAK51149.1
BT007091 mRNA Translation: AAP35754.1
AY496422 Genomic DNA Translation: AAR29599.1
AK313421 mRNA Translation: BAG36213.1
AL133163 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65875.1
BC002601 mRNA Translation: AAH02601.1
BC004983 mRNA Translation: AAH04983.1
CCDSiCCDS9656.1
PIRiA39935
RefSeqiNP_065390.1, NM_020529.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IKNX-ray2.30D67-302[»]
1NFIX-ray2.70E/F70-282[»]
SMRiP25963
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110859, 154 interactors
CORUMiP25963
DIPiDIP-139N
ELMiP25963
IntActiP25963, 93 interactors
MINTiP25963
STRINGi9606.ENSP00000216797

Chemistry databases

BindingDBiP25963
ChEMBLiCHEMBL2898
DrugBankiDB00945 Acetylsalicylic acid
DB06543 Astaxanthin
DB05983 Bardoxolone methyl

PTM databases

iPTMnetiP25963
PhosphoSitePlusiP25963

Polymorphism and mutation databases

BioMutaiNFKBIA
DMDMi126682

Proteomic databases

EPDiP25963
jPOSTiP25963
MassIVEiP25963
MaxQBiP25963
PaxDbiP25963
PeptideAtlasiP25963
PRIDEiP25963
ProteomicsDBi54304

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4792
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216797; ENSP00000216797; ENSG00000100906
GeneIDi4792
KEGGihsa:4792
UCSCiuc001wtf.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4792
DisGeNETi4792

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NFKBIA
HGNCiHGNC:7797 NFKBIA
HPAiCAB003815
HPA029207
MalaCardsiNFKBIA
MIMi164008 gene
612132 phenotype
neXtProtiNX_P25963
OpenTargetsiENSG00000100906
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
98813 Hypohidrotic ectodermal dysplasia with immunodeficiency
150 Nasopharyngeal carcinoma
PharmGKBiPA31601

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000162733
HOGENOMiHOG000059576
InParanoidiP25963
KOiK04734
OMAiDWAMEGP
OrthoDBi1341288at2759
PhylomeDBiP25963
TreeFamiTF320166

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-202424 Downstream TCR signaling
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-4755510 SUMOylation of immune response proteins
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
SABIO-RKiP25963
SignaLinkiP25963
SIGNORiP25963

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NFKBIA human
EvolutionaryTraceiP25963

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
I%CE%BAB%CE%B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4792

Pharos

More...
Pharosi
P25963
PMAP-CutDBiP25963

Protein Ontology

More...
PROi
PR:P25963

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100906 Expressed in 237 organ(s), highest expression level in vena cava
ExpressionAtlasiP25963 baseline and differential
GenevisibleiP25963 HS

Family and domain databases

DisProtiDP00468
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIKBA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25963
Secondary accession number(s): B2R8L6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 18, 2019
This is version 215 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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