UniProtKB - P25961 (PTH1R_RAT)
Parathyroid hormone/parathyroid hormone-related peptide receptor
Pth1r
Functioni
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
1 PublicationGO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: BHF-UCL
- peptide hormone binding Source: BHF-UCL
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: BHF-UCL
- aging Source: RGD
- bone mineralization Source: RGD
- bone resorption Source: RGD
- cell maturation Source: RGD
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: RGD
- chondrocyte differentiation Source: RGD
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
- in utero embryonic development Source: RGD
- negative regulation of cell population proliferation Source: RGD
- ossification Source: RGD
- osteoblast development Source: RGD
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of inositol phosphate biosynthetic process Source: BHF-UCL
- skeletal system development Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-373080, Class B/2 (Secretin family receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Parathyroid hormone/parathyroid hormone-related peptide receptorAlternative name(s): PTH/PTHrP type I receptor Short name: PTH/PTHr receptor Parathyroid hormone 1 receptor Short name: PTH1 receptor |
Gene namesi | Name:Pth1r Synonyms:Pthr, Pthr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3442, Pth1r |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Nucleus
- nucleus Source: RGD
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- basolateral plasma membrane Source: BHF-UCL
- brush border membrane Source: RGD
- integral component of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 188 | ExtracellularSequence analysisAdd BLAST | 162 | |
Transmembranei | 189 – 212 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 213 – 219 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 220 – 239 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 240 – 282 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 283 – 306 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 307 – 320 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 321 – 342 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 343 – 361 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 362 – 382 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 409 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 410 – 428 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 429 – 440 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 441 – 463 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 464 – 591 | CytoplasmicSequence analysisAdd BLAST | 128 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL6038 |
DrugCentrali | P25961 |
GuidetoPHARMACOLOGYi | 331 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012848 | 27 – 591 | Parathyroid hormone/parathyroid hormone-related peptide receptorAdd BLAST | 565 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 117 | By similarity | ||
Disulfide bondi | 108 ↔ 148 | By similarity | ||
Disulfide bondi | 131 ↔ 170 | By similarity | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P25961 |
PTM databases
GlyGeni | P25961, 4 sites |
iPTMneti | P25961 |
PhosphoSitePlusi | P25961 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000020948, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | P25961, RN |
Interactioni
Subunit structurei
Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:1313566). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (By similarity).
By similarity1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- protein self-association Source: RGD
Protein-protein interaction databases
BioGRIDi | 248587, 1 interactor |
CORUMi | P25961 |
DIPi | DIP-46025N |
STRINGi | 10116.ENSRNOP00000028435 |
Chemistry databases
BindingDBi | P25961 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 104 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 516 – 544 | DisorderedSequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 474 – 477 | Important for interaction with G proteinsBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 104 | Basic and acidic residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | CLU_002753_4_3_1 |
InParanoidi | P25961 |
OMAi | ESDKGWM |
OrthoDBi | 651627at2759 |
PhylomeDBi | P25961 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGAARIAPSL ALLLCCPVLS SAYALVDADD VFTKEEQIFL LHRAQAQCDK
60 70 80 90 100
LLKEVLHTAA NIMESDKGWT PASTSGKPRK EKASGKFYPE SKENKDVPTG
110 120 130 140 150
SRRRGRPCLP EWDNIVCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWEVVPGH NRTWANYSEC LKFMTNETRE REVFDRLGMI YTVGYSMSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHMFLSF MLRAASIFVK DAVLYSGFTL
260 270 280 290 300
DEAERLTEEE LHIIAQVPPP PAAAAVGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTIFGWG LPAVFVAVWV GVRATLANTG
360 370 380 390 400
CWDLSSGHKK WIIQVPILAS VVLNFILFIN IIRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLRST LVLVPLFGVH YTVFMALPYT EVSGTLWQIQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI RKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RAGLSLPLSP RLPPATTNGH SQLPGHAKPG APATETETLP
560 570 580 590
VTMAVPKDDG FLNGSCSGLD EEASGSARPP PLLQEEWETV M
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I5ZQF2 | A0A8I5ZQF2_RAT | Parathyroid hormone/parathyroid hor... | Pth1r | 585 | Annotation score: | ||
A0A8I6AIQ2 | A0A8I6AIQ2_RAT | Parathyroid hormone/parathyroid hor... | Pth1r | 600 | Annotation score: | ||
A0A8I6GBX8 | A0A8I6GBX8_RAT | Parathyroid hormone/parathyroid hor... | Pth1r | 583 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77184 mRNA Translation: AAA41811.1 L19475 mRNA Translation: AAA68098.1 |
PIRi | I54195 |
RefSeqi | NP_064458.1, NM_020073.2 XP_006244060.1, XM_006243998.3 XP_006244061.1, XM_006243999.2 |
Genome annotation databases
Ensembli | ENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948 |
GeneIDi | 56813 |
KEGGi | rno:56813 |
UCSCi | RGD:3442, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77184 mRNA Translation: AAA41811.1 L19475 mRNA Translation: AAA68098.1 |
PIRi | I54195 |
RefSeqi | NP_064458.1, NM_020073.2 XP_006244060.1, XM_006243998.3 XP_006244061.1, XM_006243999.2 |
3D structure databases
AlphaFoldDBi | P25961 |
SMRi | P25961 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248587, 1 interactor |
CORUMi | P25961 |
DIPi | DIP-46025N |
STRINGi | 10116.ENSRNOP00000028435 |
Chemistry databases
BindingDBi | P25961 |
ChEMBLi | CHEMBL6038 |
DrugCentrali | P25961 |
GuidetoPHARMACOLOGYi | 331 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P25961, 4 sites |
iPTMneti | P25961 |
PhosphoSitePlusi | P25961 |
Proteomic databases
PaxDbi | P25961 |
Genome annotation databases
Ensembli | ENSRNOT00000028435; ENSRNOP00000028435; ENSRNOG00000020948 |
GeneIDi | 56813 |
KEGGi | rno:56813 |
UCSCi | RGD:3442, rat |
Organism-specific databases
CTDi | 5745 |
RGDi | 3442, Pth1r |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
HOGENOMi | CLU_002753_4_3_1 |
InParanoidi | P25961 |
OMAi | ESDKGWM |
OrthoDBi | 651627at2759 |
PhylomeDBi | P25961 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-RNO-373080, Class B/2 (Secretin family receptors) |
Miscellaneous databases
PROi | PR:P25961 |
Gene expression databases
Bgeei | ENSRNOG00000020948, Expressed in adult mammalian kidney and 21 other tissues |
Genevisiblei | P25961, RN |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTH1R_RAT | |
Accessioni | P25961Primary (citable) accession number: P25961 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families