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Protein

Collagen alpha-3(V) chain

Gene

COL5A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • heparin binding Source: GO_Central
  • proteoglycan binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-3(V) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000080573.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14864 COL5A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120216 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25940

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50509

Open Targets

More...
OpenTargetsi
ENSG00000080573

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26726

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL5A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
281185497

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000584530 – 1745Collagen alpha-3(V) chainAdd BLAST1716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1544InterchainPROSITE-ProRule annotation
Disulfide bondi1567InterchainPROSITE-ProRule annotation
Disulfide bondi1576InterchainPROSITE-ProRule annotation
Disulfide bondi1585 ↔ 1742PROSITE-ProRule annotation
Disulfide bondi1651 ↔ 1696PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P25940

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P25940

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25940

PeptideAtlas

More...
PeptideAtlasi
P25940

PRoteomics IDEntifications database

More...
PRIDEi
P25940

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54301

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1138

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25940

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P25940

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000080573 Expressed in 185 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_COL5A3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25940 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048256

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1728 Collagen type V trimer variant 2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P25940

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25940

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 224Laminin G-likeAdd BLAST163
Domaini391 – 440Collagen-like 1Add BLAST50
Domaini482 – 538Collagen-like 2Add BLAST57
Domaini824 – 877Collagen-like 3Add BLAST54
Domaini905 – 950Collagen-like 4Add BLAST46
Domaini951 – 989Collagen-like 5Add BLAST39
Domaini1430 – 1488Collagen-like 6Add BLAST59
Domaini1514 – 1744Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 391Nonhelical regionAdd BLAST181
Regioni392 – 1489Triple-helical regionAdd BLAST1098

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085654

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P25940

KEGG Orthology (KO)

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KOi
K19721

Identification of Orthologs from Complete Genome Data

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OMAi
QSFTYSC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01AE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25940

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 2 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P25940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNRRDLGQP RAGLCLLLAA LQLLPGTQAD PVDVLKALGV QGGQAGVPEG
60 70 80 90 100
PGFCPQRTPE GDRAFRIGQA STLGIPTWEL FPEGHFPENF SLLITLRGQP
110 120 130 140 150
ANQSVLLSIY DERGARQLGL ALGPALGLLG DPFRPLPQQV NLTDGRWHRV
160 170 180 190 200
AVSIDGEMVT LVADCEAQPP VLGHGPRFIS IAGLTVLGTQ DLGEKTFEGD
210 220 230 240 250
IQELLISPDP QAAFQACERY LPDCDNLAPA ATVAPQGEPE TPRPRRKGKG
260 270 280 290 300
KGRKKGRGRK GKGRKKNKEI WTSSPPPDSA ENQTSTDIPK TETPAPNLPP
310 320 330 340 350
TPTPLVVTST VTTGLNATIL ERSLDPDSGT ELGTLETKAA REDEEGDDST
360 370 380 390 400
MGPDFRAAEY PSRTQFQIFP GAGEKGAKGE PAVIEKGQQF EGPPGAPGPQ
410 420 430 440 450
GVVGPSGPPG PPGFPGDPGP PGPAGLPGIP GIDGIRGPPG TVIMMPFQFA
460 470 480 490 500
GGSFKGPPVS FQQAQAQAVL QQTQLSMKGP PGPVGLTGRP GPVGLPGHPG
510 520 530 540 550
LKGEEGAEGP QGPRGLQGPH GPPGRVGKMG RPGADGARGL PGDTGPKGDR
560 570 580 590 600
GFDGLPGLPG EKGQRGDFGH VGQPGPPGED GERGAEGPPG PTGQAGEPGP
610 620 630 640 650
RGLLGPRGSP GPTGRPGVTG IDGAPGAKGN VGPPGEPGPP GQQGNHGSQG
660 670 680 690 700
LPGPQGLIGT PGEKGPPGNP GIPGLPGSDG PLGHPGHEGP TGEKGAQGPP
710 720 730 740 750
GSAGPPGYPG PRGVKGTSGN RGLQGEKGEK GEDGFPGFKG DVGLKGDQGK
760 770 780 790 800
PGAPGPRGED GPEGPKGQAG QAGEEGPPGS AGEKGKLGVP GLPGYPGRPG
810 820 830 840 850
PKGSIGFPGP LGPIGEKGKS GKTGQPGLEG ERGPPGSRGE RGQPGATGQP
860 870 880 890 900
GPKGDVGQDG APGIPGEKGL PGLQGPPGFP GPKGPPGHQG KDGRPGHPGQ
910 920 930 940 950
RGELGFQGQT GPPGPAGVLG PQGKTGEVGP LGERGPPGPP GPPGEQGLPG
960 970 980 990 1000
LEGREGAKGE LGPPGPLGKE GPAGLRGFPG PKGGPGDPGP TGLKGDKGPP
1010 1020 1030 1040 1050
GPVGANGSPG ERGPLGPAGG IGLPGQSGSE GPVGPAGKKG SRGERGPPGP
1060 1070 1080 1090 1100
TGKDGIPGPL GPLGPPGAAG PSGEEGDKGD VGAPGHKGSK GDKGDAGPPG
1110 1120 1130 1140 1150
QPGIRGPAGH PGPPGADGAQ GRRGPPGLFG QKGDDGVRGF VGVIGPPGLQ
1160 1170 1180 1190 1200
GLPGPPGEKG EVGDVGSMGP HGAPGPRGPQ GPTGSEGTPG LPGGVGQPGA
1210 1220 1230 1240 1250
VGEKGERGDA GDPGPPGAPG IPGPKGDIGE KGDSGPSGAA GPPGKKGPPG
1260 1270 1280 1290 1300
EDGAKGSVGP TGLPGDLGPP GDPGVSGIDG SPGEKGDPGD VGGPGPPGAS
1310 1320 1330 1340 1350
GEPGAPGPPG KRGPSGHMGR EGREGEKGAK GEPGPDGPPG RTGPMGARGP
1360 1370 1380 1390 1400
PGRVGPEGLR GIPGPVGEPG LLGAPGQMGP PGPLGPSGLP GLKGDTGPKG
1410 1420 1430 1440 1450
EKGHIGLIGL IGPPGEAGEK GDQGLPGVQG PPGPKGDPGP PGPIGSLGHP
1460 1470 1480 1490 1500
GPPGVAGPLG QKGSKGSPGS MGPRGDTGPA GPPGPPGAPA ELHGLRRRRR
1510 1520 1530 1540 1550
FVPVPLPVVE GGLEEVLASL TSLSLELEQL RRPPGTAERP GLVCHELHRN
1560 1570 1580 1590 1600
HPHLPDGEYW IDPNQGCARD SFRVFCNFTA GGETCLYPDK KFEIVKLASW
1610 1620 1630 1640 1650
SKEKPGGWYS TFRRGKKFSY VDADGSPVNV VQLNFLKLLS ATARQNFTYS
1660 1670 1680 1690 1700
CQNAAAWLDE ATGDYSHSAR FLGTNGEELS FNQTTAATVS VPQDGCRLRK
1710 1720 1730 1740
GQTKTLFEFS SSRAGFLPLW DVAATDFGQT NQKFGFELGP VCFSS
Length:1,745
Mass (Da):172,121
Last modified:December 15, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F5644D2A919D864
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1687A → T in AAF59902 (PubMed:10722718).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020015134R → H. Corresponds to variant dbSNP:rs2303098Ensembl.1
Natural variantiVAR_060789322R → G1 PublicationCorresponds to variant dbSNP:rs2287803Ensembl.1
Natural variantiVAR_0556781042R → P. Corresponds to variant dbSNP:rs2161468Ensembl.1
Natural variantiVAR_0200161207R → P. Corresponds to variant dbSNP:rs2287813Ensembl.1
Natural variantiVAR_0200171428V → M. Corresponds to variant dbSNP:rs3815746Ensembl.1
Natural variantiVAR_0556791488A → P. Corresponds to variant dbSNP:rs3745584Ensembl.1
Natural variantiVAR_0200181594I → M. Corresponds to variant dbSNP:rs3745581Ensembl.1
Natural variantiVAR_0200191691V → I. Corresponds to variant dbSNP:rs2277969Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177941 mRNA Translation: AAF59902.1
AC008742 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12222.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S20375

NCBI Reference Sequences

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RefSeqi
NP_056534.2, NM_015719.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.235368

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264828; ENSP00000264828; ENSG00000080573

Database of genes from NCBI RefSeq genomes

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GeneIDi
50509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50509

UCSC genome browser

More...
UCSCi
uc002mmq.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177941 mRNA Translation: AAF59902.1
AC008742 Genomic DNA No translation available.
CCDSiCCDS12222.1
PIRiS20375
RefSeqiNP_056534.2, NM_015719.3
UniGeneiHs.235368

3D structure databases

ProteinModelPortaliP25940
SMRiP25940
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1728 Collagen type V trimer variant 2
STRINGi9606.ENSP00000264828

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

GlyConnecti1138
iPTMnetiP25940
PhosphoSitePlusiP25940

Polymorphism and mutation databases

BioMutaiCOL5A3
DMDMi281185497

Proteomic databases

EPDiP25940
MaxQBiP25940
PaxDbiP25940
PeptideAtlasiP25940
PRIDEiP25940
ProteomicsDBi54301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264828; ENSP00000264828; ENSG00000080573
GeneIDi50509
KEGGihsa:50509
UCSCiuc002mmq.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
50509
DisGeNETi50509
EuPathDBiHostDB:ENSG00000080573.6

GeneCards: human genes, protein and diseases

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GeneCardsi
COL5A3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0039977
HIX0040299
HGNCiHGNC:14864 COL5A3
HPAiHPA048256
MIMi120216 gene
neXtProtiNX_P25940
OpenTargetsiENSG00000080573
PharmGKBiPA26726

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000162394
HOGENOMiHOG000085654
HOVERGENiHBG004933
InParanoidiP25940
KOiK19721
OMAiQSFTYSC
OrthoDBiEOG091G01AE
PhylomeDBiP25940
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
COL5A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50509

Protein Ontology

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PROi
PR:P25940

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000080573 Expressed in 185 organ(s), highest expression level in esophagus
CleanExiHS_COL5A3
GenevisibleiP25940 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO5A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25940
Secondary accession number(s): Q9NZQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 15, 2009
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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