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Protein

Collagen alpha-3(V) chain

Gene

COL5A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • heparin binding Source: GO_Central
  • proteoglycan binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-3(V) chain
Gene namesi
Name:COL5A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000080573.6
HGNCiHGNC:14864 COL5A3
MIMi120216 gene
neXtProtiNX_P25940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi50509
OpenTargetsiENSG00000080573
PharmGKBiPA26726

Chemistry databases

ChEMBLiCHEMBL2364188

Polymorphism and mutation databases

BioMutaiCOL5A3
DMDMi281185497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000584530 – 1745Collagen alpha-3(V) chainAdd BLAST1716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1544InterchainPROSITE-ProRule annotation
Disulfide bondi1567InterchainPROSITE-ProRule annotation
Disulfide bondi1576InterchainPROSITE-ProRule annotation
Disulfide bondi1585 ↔ 1742PROSITE-ProRule annotation
Disulfide bondi1651 ↔ 1696PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

EPDiP25940
MaxQBiP25940
PaxDbiP25940
PeptideAtlasiP25940
PRIDEiP25940
ProteomicsDBi54301

PTM databases

GlyConnecti1138
iPTMnetiP25940
PhosphoSitePlusiP25940

Expressioni

Gene expression databases

BgeeiENSG00000080573 Expressed in 185 organ(s), highest expression level in esophagus
CleanExiHS_COL5A3
GenevisibleiP25940 HS

Organism-specific databases

HPAiHPA048256

Interactioni

Subunit structurei

Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1728 Collagen type V trimer variant 2
STRINGi9606.ENSP00000264828

Structurei

3D structure databases

ProteinModelPortaliP25940
SMRiP25940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 224Laminin G-likeAdd BLAST163
Domaini391 – 440Collagen-like 1Add BLAST50
Domaini482 – 538Collagen-like 2Add BLAST57
Domaini824 – 877Collagen-like 3Add BLAST54
Domaini905 – 950Collagen-like 4Add BLAST46
Domaini951 – 989Collagen-like 5Add BLAST39
Domaini1430 – 1488Collagen-like 6Add BLAST59
Domaini1514 – 1744Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 391Nonhelical regionAdd BLAST181
Regioni392 – 1489Triple-helical regionAdd BLAST1098

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOGENOMiHOG000085654
HOVERGENiHBG004933
InParanoidiP25940
KOiK19721
OMAiQSFTYSC
OrthoDBiEOG091G01AE
PhylomeDBiP25940
TreeFamiTF323987

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25940-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNRRDLGQP RAGLCLLLAA LQLLPGTQAD PVDVLKALGV QGGQAGVPEG
60 70 80 90 100
PGFCPQRTPE GDRAFRIGQA STLGIPTWEL FPEGHFPENF SLLITLRGQP
110 120 130 140 150
ANQSVLLSIY DERGARQLGL ALGPALGLLG DPFRPLPQQV NLTDGRWHRV
160 170 180 190 200
AVSIDGEMVT LVADCEAQPP VLGHGPRFIS IAGLTVLGTQ DLGEKTFEGD
210 220 230 240 250
IQELLISPDP QAAFQACERY LPDCDNLAPA ATVAPQGEPE TPRPRRKGKG
260 270 280 290 300
KGRKKGRGRK GKGRKKNKEI WTSSPPPDSA ENQTSTDIPK TETPAPNLPP
310 320 330 340 350
TPTPLVVTST VTTGLNATIL ERSLDPDSGT ELGTLETKAA REDEEGDDST
360 370 380 390 400
MGPDFRAAEY PSRTQFQIFP GAGEKGAKGE PAVIEKGQQF EGPPGAPGPQ
410 420 430 440 450
GVVGPSGPPG PPGFPGDPGP PGPAGLPGIP GIDGIRGPPG TVIMMPFQFA
460 470 480 490 500
GGSFKGPPVS FQQAQAQAVL QQTQLSMKGP PGPVGLTGRP GPVGLPGHPG
510 520 530 540 550
LKGEEGAEGP QGPRGLQGPH GPPGRVGKMG RPGADGARGL PGDTGPKGDR
560 570 580 590 600
GFDGLPGLPG EKGQRGDFGH VGQPGPPGED GERGAEGPPG PTGQAGEPGP
610 620 630 640 650
RGLLGPRGSP GPTGRPGVTG IDGAPGAKGN VGPPGEPGPP GQQGNHGSQG
660 670 680 690 700
LPGPQGLIGT PGEKGPPGNP GIPGLPGSDG PLGHPGHEGP TGEKGAQGPP
710 720 730 740 750
GSAGPPGYPG PRGVKGTSGN RGLQGEKGEK GEDGFPGFKG DVGLKGDQGK
760 770 780 790 800
PGAPGPRGED GPEGPKGQAG QAGEEGPPGS AGEKGKLGVP GLPGYPGRPG
810 820 830 840 850
PKGSIGFPGP LGPIGEKGKS GKTGQPGLEG ERGPPGSRGE RGQPGATGQP
860 870 880 890 900
GPKGDVGQDG APGIPGEKGL PGLQGPPGFP GPKGPPGHQG KDGRPGHPGQ
910 920 930 940 950
RGELGFQGQT GPPGPAGVLG PQGKTGEVGP LGERGPPGPP GPPGEQGLPG
960 970 980 990 1000
LEGREGAKGE LGPPGPLGKE GPAGLRGFPG PKGGPGDPGP TGLKGDKGPP
1010 1020 1030 1040 1050
GPVGANGSPG ERGPLGPAGG IGLPGQSGSE GPVGPAGKKG SRGERGPPGP
1060 1070 1080 1090 1100
TGKDGIPGPL GPLGPPGAAG PSGEEGDKGD VGAPGHKGSK GDKGDAGPPG
1110 1120 1130 1140 1150
QPGIRGPAGH PGPPGADGAQ GRRGPPGLFG QKGDDGVRGF VGVIGPPGLQ
1160 1170 1180 1190 1200
GLPGPPGEKG EVGDVGSMGP HGAPGPRGPQ GPTGSEGTPG LPGGVGQPGA
1210 1220 1230 1240 1250
VGEKGERGDA GDPGPPGAPG IPGPKGDIGE KGDSGPSGAA GPPGKKGPPG
1260 1270 1280 1290 1300
EDGAKGSVGP TGLPGDLGPP GDPGVSGIDG SPGEKGDPGD VGGPGPPGAS
1310 1320 1330 1340 1350
GEPGAPGPPG KRGPSGHMGR EGREGEKGAK GEPGPDGPPG RTGPMGARGP
1360 1370 1380 1390 1400
PGRVGPEGLR GIPGPVGEPG LLGAPGQMGP PGPLGPSGLP GLKGDTGPKG
1410 1420 1430 1440 1450
EKGHIGLIGL IGPPGEAGEK GDQGLPGVQG PPGPKGDPGP PGPIGSLGHP
1460 1470 1480 1490 1500
GPPGVAGPLG QKGSKGSPGS MGPRGDTGPA GPPGPPGAPA ELHGLRRRRR
1510 1520 1530 1540 1550
FVPVPLPVVE GGLEEVLASL TSLSLELEQL RRPPGTAERP GLVCHELHRN
1560 1570 1580 1590 1600
HPHLPDGEYW IDPNQGCARD SFRVFCNFTA GGETCLYPDK KFEIVKLASW
1610 1620 1630 1640 1650
SKEKPGGWYS TFRRGKKFSY VDADGSPVNV VQLNFLKLLS ATARQNFTYS
1660 1670 1680 1690 1700
CQNAAAWLDE ATGDYSHSAR FLGTNGEELS FNQTTAATVS VPQDGCRLRK
1710 1720 1730 1740
GQTKTLFEFS SSRAGFLPLW DVAATDFGQT NQKFGFELGP VCFSS
Length:1,745
Mass (Da):172,121
Last modified:December 15, 2009 - v3
Checksum:i4F5644D2A919D864
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1687A → T in AAF59902 (PubMed:10722718).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020015134R → H. Corresponds to variant dbSNP:rs2303098Ensembl.1
Natural variantiVAR_060789322R → G1 PublicationCorresponds to variant dbSNP:rs2287803Ensembl.1
Natural variantiVAR_0556781042R → P. Corresponds to variant dbSNP:rs2161468Ensembl.1
Natural variantiVAR_0200161207R → P. Corresponds to variant dbSNP:rs2287813Ensembl.1
Natural variantiVAR_0200171428V → M. Corresponds to variant dbSNP:rs3815746Ensembl.1
Natural variantiVAR_0556791488A → P. Corresponds to variant dbSNP:rs3745584Ensembl.1
Natural variantiVAR_0200181594I → M. Corresponds to variant dbSNP:rs3745581Ensembl.1
Natural variantiVAR_0200191691V → I. Corresponds to variant dbSNP:rs2277969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177941 mRNA Translation: AAF59902.1
AC008742 Genomic DNA No translation available.
CCDSiCCDS12222.1
PIRiS20375
RefSeqiNP_056534.2, NM_015719.3
UniGeneiHs.235368

Genome annotation databases

EnsembliENST00000264828; ENSP00000264828; ENSG00000080573
GeneIDi50509
KEGGihsa:50509
UCSCiuc002mmq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177941 mRNA Translation: AAF59902.1
AC008742 Genomic DNA No translation available.
CCDSiCCDS12222.1
PIRiS20375
RefSeqiNP_056534.2, NM_015719.3
UniGeneiHs.235368

3D structure databases

ProteinModelPortaliP25940
SMRiP25940
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1728 Collagen type V trimer variant 2
STRINGi9606.ENSP00000264828

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

GlyConnecti1138
iPTMnetiP25940
PhosphoSitePlusiP25940

Polymorphism and mutation databases

BioMutaiCOL5A3
DMDMi281185497

Proteomic databases

EPDiP25940
MaxQBiP25940
PaxDbiP25940
PeptideAtlasiP25940
PRIDEiP25940
ProteomicsDBi54301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264828; ENSP00000264828; ENSG00000080573
GeneIDi50509
KEGGihsa:50509
UCSCiuc002mmq.1 human

Organism-specific databases

CTDi50509
DisGeNETi50509
EuPathDBiHostDB:ENSG00000080573.6
GeneCardsiCOL5A3
H-InvDBiHIX0039977
HIX0040299
HGNCiHGNC:14864 COL5A3
HPAiHPA048256
MIMi120216 gene
neXtProtiNX_P25940
OpenTargetsiENSG00000080573
PharmGKBiPA26726
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOGENOMiHOG000085654
HOVERGENiHBG004933
InParanoidiP25940
KOiK19721
OMAiQSFTYSC
OrthoDBiEOG091G01AE
PhylomeDBiP25940
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

GeneWikiiCOL5A3
GenomeRNAii50509
PROiPR:P25940
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080573 Expressed in 185 organ(s), highest expression level in esophagus
CleanExiHS_COL5A3
GenevisibleiP25940 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 2 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO5A3_HUMAN
AccessioniPrimary (citable) accession number: P25940
Secondary accession number(s): Q9NZQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 15, 2009
Last modified: November 7, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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