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Protein

Neuropeptide Y receptor type 1

Gene

NPY1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: ProtInc
  • pancreatic polypeptide receptor activity Source: GO_Central
  • peptide YY receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP25929

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:NPY1R
Synonyms:NPYR, NPYY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164128.6
HGNCiHGNC:7956 NPY1R
MIMi162641 gene
neXtProtiNX_P25929

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 76CytoplasmicSequence analysisAdd BLAST11
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 116ExtracellularSequence analysisAdd BLAST19
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 154CytoplasmicSequence analysisAdd BLAST17
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 211ExtracellularSequence analysisAdd BLAST36
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 260CytoplasmicSequence analysisAdd BLAST28
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 299ExtracellularSequence analysisAdd BLAST18
Transmembranei300 – 320Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini321 – 384CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4886
OpenTargetsiENSG00000164128
PharmGKBiPA258

Chemistry databases

ChEMBLiCHEMBL4777
DrugBankiDB05004 AC162352
GuidetoPHARMACOLOGYi305

Polymorphism and mutation databases

BioMutaiNPY1R
DMDMi128997

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699201 – 384Neuropeptide Y receptor type 1Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 198PROSITE-ProRule annotation
Lipidationi338S-palmitoyl cysteineSequence analysis1
Modified residuei368PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP25929
PeptideAtlasiP25929
PRIDEiP25929
ProteomicsDBi54300

PTM databases

iPTMnetiP25929
PhosphoSitePlusiP25929

Expressioni

Gene expression databases

BgeeiENSG00000164128 Expressed in 153 organ(s), highest expression level in adipose tissue
CleanExiHS_NPY1R
ExpressionAtlasiP25929 baseline and differential
GenevisibleiP25929 HS

Organism-specific databases

HPAiHPA029903

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-372227,EBI-6655667

Protein-protein interaction databases

BioGridi110946, 3 interactors
IntActiP25929, 5 interactors
STRINGi9606.ENSP00000354652

Chemistry databases

BindingDBiP25929

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25929
SMRiP25929
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG105676
InParanoidiP25929
KOiK04204
OMAiQVENHSI
OrthoDBiEOG091G0A5E
PhylomeDBiP25929
TreeFamiTF315303

Family and domain databases

CDDicd15395 7tmA_NPY1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000351 NPY1_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR43916:SF5 PTHR43916:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01013 NRPEPTIDEY1R
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P25929-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTLFSQVE NHSVHSNFSE KNAQLLAFEN DDCHLPLAMI FTLALAYGAV
60 70 80 90 100
IILGVSGNLA LIIIILKQKE MRNVTNILIV NLSFSDLLVA IMCLPFTFVY
110 120 130 140 150
TLMDHWVFGE AMCKLNPFVQ CVSITVSIFS LVLIAVERHQ LIINPRGWRP
160 170 180 190 200
NNRHAYVGIA VIWVLAVASS LPFLIYQVMT DEPFQNVTLD AYKDKYVCFD
210 220 230 240 250
QFPSDSHRLS YTTLLLVLQY FGPLCFIFIC YFKIYIRLKR RNNMMDKMRD
260 270 280 290 300
NKYRSSETKR INIMLLSIVV AFAVCWLPLT IFNTVFDWNH QIIATCNHNL
310 320 330 340 350
LFLLCHLTAM ISTCVNPIFY GFLNKNFQRD LQFFFNFCDF RSRDDDYETI
360 370 380
AMSTMHTDVS KTSLKQASPV AFKKINNNDD NEKI
Length:384
Mass (Da):44,392
Last modified:May 1, 1992 - v1
Checksum:i582B0DDB04490316
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DKL9B4DKL9_HUMAN
cDNA FLJ51985, highly similar to Ne...
NPY1R
141Annotation score:
D6REY0D6REY0_HUMAN
Neuropeptide Y receptor type 1
NPY1R
99Annotation score:
D6R9D0D6R9D0_HUMAN
Neuropeptide Y receptor type 1
NPY1R
64Annotation score:
D6RI97D6RI97_HUMAN
Neuropeptide Y receptor type 1
NPY1R
61Annotation score:
D6RHH6D6RHH6_HUMAN
Neuropeptide Y receptor type 1
NPY1R
60Annotation score:
D6RC44D6RC44_HUMAN
Neuropeptide Y receptor type 1
NPY1R
24Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96F → L in AAA59920 (PubMed:1321422).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014681374K → T. Corresponds to variant dbSNP:rs5578Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88461 mRNA Translation: AAA73215.1
M84755 mRNA Translation: AAA59920.1
L07614 mRNA No translation available.
L07615 mRNA Translation: AAA59947.1
AY548168 mRNA Translation: AAS55647.1
AK312578 mRNA Translation: BAG35472.1
CH471056 Genomic DNA Translation: EAX04841.1
BC036657 mRNA Translation: AAH36657.1
BC071720 mRNA Translation: AAH71720.1
CCDSiCCDS34089.1
PIRiA45490
RefSeqiNP_000900.1, NM_000909.5
XP_005263088.1, XM_005263031.3
XP_011530312.1, XM_011532010.2
UniGeneiHs.519057
Hs.733329

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128
GeneIDi4886
KEGGihsa:4886
UCSCiuc003iqm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88461 mRNA Translation: AAA73215.1
M84755 mRNA Translation: AAA59920.1
L07614 mRNA No translation available.
L07615 mRNA Translation: AAA59947.1
AY548168 mRNA Translation: AAS55647.1
AK312578 mRNA Translation: BAG35472.1
CH471056 Genomic DNA Translation: EAX04841.1
BC036657 mRNA Translation: AAH36657.1
BC071720 mRNA Translation: AAH71720.1
CCDSiCCDS34089.1
PIRiA45490
RefSeqiNP_000900.1, NM_000909.5
XP_005263088.1, XM_005263031.3
XP_011530312.1, XM_011532010.2
UniGeneiHs.519057
Hs.733329

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F1Umodel-A38-67[»]
B74-103[»]
C110-142[»]
D153-175[»]
E208-233[»]
F258-288[»]
G300-320[»]
2IILmodel-@1-384[»]
5ZBQX-ray2.70A2-358[»]
ProteinModelPortaliP25929
SMRiP25929
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110946, 3 interactors
IntActiP25929, 5 interactors
STRINGi9606.ENSP00000354652

Chemistry databases

BindingDBiP25929
ChEMBLiCHEMBL4777
DrugBankiDB05004 AC162352
GuidetoPHARMACOLOGYi305

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25929
PhosphoSitePlusiP25929

Polymorphism and mutation databases

BioMutaiNPY1R
DMDMi128997

Proteomic databases

PaxDbiP25929
PeptideAtlasiP25929
PRIDEiP25929
ProteomicsDBi54300

Protocols and materials databases

DNASUi4886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296533; ENSP00000354652; ENSG00000164128
GeneIDi4886
KEGGihsa:4886
UCSCiuc003iqm.3 human

Organism-specific databases

CTDi4886
DisGeNETi4886
EuPathDBiHostDB:ENSG00000164128.6
GeneCardsiNPY1R
HGNCiHGNC:7956 NPY1R
HPAiHPA029903
MIMi162641 gene
neXtProtiNX_P25929
OpenTargetsiENSG00000164128
PharmGKBiPA258
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150833
HOGENOMiHOG000050229
HOVERGENiHBG105676
InParanoidiP25929
KOiK04204
OMAiQVENHSI
OrthoDBiEOG091G0A5E
PhylomeDBiP25929
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP25929

Miscellaneous databases

GeneWikiiNeuropeptide_Y_receptor_Y1
GenomeRNAii4886
PROiPR:P25929
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164128 Expressed in 153 organ(s), highest expression level in adipose tissue
CleanExiHS_NPY1R
ExpressionAtlasiP25929 baseline and differential
GenevisibleiP25929 HS

Family and domain databases

CDDicd15395 7tmA_NPY1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000351 NPY1_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR43916:SF5 PTHR43916:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01013 NRPEPTIDEY1R
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPY1R_HUMAN
AccessioniPrimary (citable) accession number: P25929
Secondary accession number(s): B2R6H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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