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Entry version 107 (08 May 2019)
Sequence version 2 (23 Jan 2002)
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Protein

Putative surface-exposed virulence protein BigA

Gene

bigA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SENT99287:STM3478-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.12.5.5 the autotransporter-1 (at-1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative surface-exposed virulence protein BigA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bigA
Ordered Locus Names:STM3478
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002080828 – 1953Putative surface-exposed virulence protein BigAAdd BLAST1926

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25927

PRoteomics IDEntifications database

More...
PRIDEi
P25927

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati101 – 1031; truncated3
Repeati104 – 1132; truncated10
Repeati114 – 1223; truncated9
Repeati123 – 1334Add BLAST11
Repeati134 – 1445Add BLAST11
Repeati145 – 1556Add BLAST11
Repeati156 – 1667Add BLAST11
Repeati167 – 1778Add BLAST11
Repeati178 – 1889Add BLAST11
Repeati189 – 19910Add BLAST11
Repeati200 – 21011Add BLAST11
Repeati211 – 22112Add BLAST11
Repeati222 – 23213Add BLAST11
Repeati233 – 24314Add BLAST11
Repeati244 – 25215; truncated9
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1649 – 1952AutotransporterPROSITE-ProRule annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 25215 X 11 AA tandem repeatsAdd BLAST152

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107EF2 Bacteria
ENOG410ZHQ7 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000120520

KEGG Orthology (KO)

More...
KOi
K12516

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCETSTR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869 Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515 SSF103515, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P25927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPMQKKKLI SIAIALTLQS YYIPAIAAEN NDDEKECPSN ISSLPKEKRA
60 70 80 90 100
KLSPTCLATP ENDNHWGWVA GGVAALVAGV AIGVENNGGG DSNHSYTPPK
110 120 130 140 150
PDNGGDVTPP DDGGNVTPPD DGGNVTPPDD GGDDNVTPPD DSGDDDVAPP
160 170 180 190 200
DDSGDDDVTP PDDSGDDDVT PPDDSGDGDV TPPDDSGDDD VTPPDDSGDD
210 220 230 240 250
DVTPPDDSGD DDVTPPDDSG DDDVTPPDDS GDDDVTPPDD SGDDDDTPPD
260 270 280 290 300
DSVITFSNGV TIDKGKDTLT FDSFKLDNGS VLEGAVWNYS EQDNQWQLTT
310 320 330 340 350
ADGKTLNVTG WDVTDANAAV IEGTQENGLY WKYDSRGYLI IADDNTTVIS
360 370 380 390 400
GDDQAHNSDR GMDISGQDRT GVIISGDRTV NTLTGDSSVT DGATGMVISG
410 420 430 440 450
DGTTNTISGH STVDNATGAL ISGNGTTTNF AGDIAVSGGG TAIIIDGDNA
460 470 480 490 500
TIKNTGTSDI SGAGSTGTVI DGNNARVNND GDMTITDGGT GGHITGDNVV
510 520 530 540 550
IDNAGSTTVS GADATALYIE GDNALVINEG NQTISGGAVG TRIDGDDAHT
560 570 580 590 600
TNTGDIAVDG AGSAAVIING DNGSLTQAGD LLVTDGAMGI ITYGTGNEAK
610 620 630 640 650
NTGNATVRDA DSVGFVVAGE KNTFKNKGDI DVSLNGTGAL VSGDMSQVTL
660 670 680 690 700
DGDINVVSVQ DSEGVFSSAT GVSVSGDSNA VDITGNVNIS ADYGQDDLAA
710 720 730 740 750
GAPPLTGVVV GGNGNTVTLN GALNIDDNDL SATGGQYLDV VGLSVTGDDN
760 770 780 790 800
DVEIDGGINI THSEDPLDGT SADITGISVS GNSTVTLNGH STIDTNTVVG
810 820 830 840 850
GHVVLARVNN GGSLILGDDS VVDVNVSYIP TGYYTYNALL MADGEGTSIE
860 870 880 890 900
NKGDITSHGV YSVIRADNGS EVSNSGDILV YATSSNSSED RAAITRASGE
910 920 930 940 950
GSAVHNKAGG DITLISDQTP QGSGGIEVYP LKWYTHTFYA MMASDYGDVV
960 970 980 990 1000
NDEGATIHLQ GAGVYGVTAS RGKALNEGNI YLDGLVPTLD DENNITSTSY
1010 1020 1030 1040 1050
WQPSSLYLTS SGMVAGSTDA DGDATAINTG NITVNNAGFG MMALNGGTAI
1060 1070 1080 1090 1100
NQGVITLTAD DGVTGQADEL VGMAALNGGV VINDTSGVIN IDADYGQAFL
1110 1120 1130 1140 1150
SDSSSYIINN GSINLNGSPM DDTDSHMGGT PTDKIWIQSL PGSGDSDTRT
1160 1170 1180 1190 1200
SDTGFFTAGT LANYGTETLN GDVDVNGGWL YNEAGASLTV NGTVTINGGA
1210 1220 1230 1240 1250
NALANYGTLD ADAISTWHSL FNEADGSITT DLLTLNGDVT FYNNGDFTGS
1260 1270 1280 1290 1300
IAGTSYQQEI VNTGDMTVAE DGKSLVSGSF YFYNEEDATL TNSGSAVEGG
1310 1320 1330 1340 1350
ENTIINLTRA NDSLTQVNSG TITATNGYSA ITTVNGSNDP KWIWNTATGV
1360 1370 1380 1390 1400
INGINPDAPL INLGRGYNFG NQGTINVQGD NAVAISGGTS SYVINLVNSG
1410 1420 1430 1440 1450
TINVGTEQGK EDGTNGTGLI GIKGNGNATT INNTADGVIN VYADDSYAFG
1460 1470 1480 1490 1500
GKTKAIINNG EINLLCDSGC DIYAPGTTGT QNDHNGTADI VIPDATTAPT
1510 1520 1530 1540 1550
EGSIPTPPAD PNAPQQLSNY IVGTNADGSS GTLKANNLVI GDNVKVDTGF
1560 1570 1580 1590 1600
TSGTADTTVV VDNAFTGSNI QGADNITSTS VVWNAQGSQD ADGNVDVTMT
1610 1620 1630 1640 1650
KNAYADVATD SSVSDVAQAL DAGYTNNELY TSLNVGTTAE LNSALKQVSG
1660 1670 1680 1690 1700
AQATTVFREA RVLSNRFTML ADAAPQIKDG LAFNVVAKGD PRAELGNDTQ
1710 1720 1730 1740 1750
YDMLALRQTL DLTASQNLTL EYGIARLDGD GSKTAGDNGL TGGYSQFFGL
1760 1770 1780 1790 1800
KHSMAFDEGL AWNNSLRYDV HNLDSSRSVA YGDVNKIADS DMRQQYLEFR
1810 1820 1830 1840 1850
SEGAKTFTMM GDALKVTPYA GVKFRHTMED GYKERSAGDF NLSMNSGNET
1860 1870 1880 1890 1900
AVDSIVGLKL DYAGKDGWSA TATLEGGPNL SYSKSQRTAS LQGAAGQSFG
1910 1920 1930 1940 1950
VDDGQKGGGV NGLATIGVKY SSNDTALHLD AYQWKEDGIS DKGFMLNVKK

TFR
Length:1,953
Mass (Da):200,151
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i611B3F1C954D91AE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA27042 differs from that shown. Reason: Frameshift at positions 415 and 732.Curated
The sequence AAA27042 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA27043 differs from that shown. Reason: Frameshift at positions 415 and 732.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207D → DRGDDDVTPPDD in AAD39458 (Ref. 1) Curated1
Sequence conflicti514A → R in AAA27043 (PubMed:1987123).Curated1
Sequence conflicti1698D → N in AAD39458 (Ref. 1) Curated1
Sequence conflicti1795 – 1798QYLE → ITLQ in AAD39458 (Ref. 1) Curated4
Sequence conflicti1836 – 1837SA → T in AAD39458 (Ref. 1) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF133696 Genomic DNA Translation: AAD39458.1
AE006468 Genomic DNA Translation: AAL22340.1
M64606 Genomic DNA Translation: AAA27042.1 Sequence problems.
M64606 Genomic DNA Translation: AAA27043.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
C39200
D39200

NCBI Reference Sequences

More...
RefSeqi
NP_462381.1, NC_003197.2
WP_010989077.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL22340; AAL22340; STM3478

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1255001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM3478

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.3676

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133696 Genomic DNA Translation: AAD39458.1
AE006468 Genomic DNA Translation: AAL22340.1
M64606 Genomic DNA Translation: AAA27042.1 Sequence problems.
M64606 Genomic DNA Translation: AAA27043.1 Frameshift.
PIRiC39200
D39200
RefSeqiNP_462381.1, NC_003197.2
WP_010989077.1, NC_003197.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.B.12.5.5 the autotransporter-1 (at-1) family

Proteomic databases

PaxDbiP25927
PRIDEiP25927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22340; AAL22340; STM3478
GeneIDi1255001
KEGGistm:STM3478
PATRICifig|99287.12.peg.3676

Phylogenomic databases

eggNOGiENOG4107EF2 Bacteria
ENOG410ZHQ7 LUCA
HOGENOMiHOG000120520
KOiK12516
OMAiVCETSTR

Enzyme and pathway databases

BioCyciSENT99287:STM3478-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIGA_SALTY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25927
Secondary accession number(s): P25928, Q9XCQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2002
Last modified: May 8, 2019
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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