UniProtKB - P25916 (BMI1_MOUSE)
Polycomb complex protein BMI-1
Bmi1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- chromatin binding Source: MGI
- promoter-specific chromatin binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- ubiquitin-protein transferase activator activity Source: MGI
- zinc ion binding Source: UniProtKB
GO - Biological processi
- brain development Source: MGI
- cellular process Source: MGI
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- chromatin silencing Source: GO_Central
- DNA methylation Source: MGI
- embryonic skeletal system development Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- hematopoietic stem cell homeostasis Source: MGI
- histone acetylation Source: MGI
- histone H2A-K119 monoubiquitination Source: UniProtKB
- histone ubiquitination Source: MGI
- humoral immune response Source: MGI
- in utero embryonic development Source: MGI
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of gene expression, epigenetic Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of B cell proliferation Source: HGNC-UCL
- positive regulation of immature T cell proliferation in thymus Source: HGNC-UCL
- positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
- regulation of adaxial/abaxial pattern formation Source: MGI
- rostrocaudal neural tube patterning Source: MGI
- skeletal system development Source: MGI
- somatic stem cell division Source: MGI
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724, Regulation of PTEN gene transcription R-MMU-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Polycomb complex protein BMI-1Alternative name(s): Polycomb group RING finger protein 4 |
Gene namesi | Name:Bmi1 Synonyms:Bmi-1, Pcgf4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88174, Bmi1 |
Subcellular locationi
Nucleus
- nuclear body Source: MGI
- nucleus Source: MGI
- PcG protein complex Source: MGI
- PRC1 complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- heterochromatin Source: MGI
- ubiquitin ligase complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055988 | 1 – 324 | Polycomb complex protein BMI-1Add BLAST | 324 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | P25916 |
PaxDbi | P25916 |
PeptideAtlasi | P25916 |
PRIDEi | P25916 |
PTM databases
iPTMneti | P25916 |
PhosphoSitePlusi | P25916 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000026739, Expressed in embryo and 376 other tissues |
ExpressionAtlasi | P25916, baseline and differential |
Genevisiblei | P25916, MM |
Interactioni
Subunit structurei
Component of a PRC1-like complex (PubMed:16359901).
Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3, RING1 and RNF2 (By similarity).
Interacts with RNF2/RING2 (PubMed:16359901, PubMed:16710298).
Interacts with RING1 (PubMed:16359901, PubMed:16710298).
Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A.
Interacts with CBX7 and CBX8 (PubMed:16359901).
Interacts with SPOP.
Part of a complex consisting of BMI1, CUL3 and SPOP.
Interacts with E4F1 (By similarity).
Interacts with PHC2 (PubMed:16359901).
By similarity2 PublicationsBinary interactionsi
Hide detailsP25916
Protein-protein interaction databases
BioGRIDi | 198359, 29 interactors |
CORUMi | P25916 |
DIPi | DIP-132N |
IntActi | P25916, 21 interactors |
MINTi | P25916 |
STRINGi | 10090.ENSMUSP00000028071 |
Miscellaneous databases
RNActi | P25916, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P25916 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25916 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 180 | Interaction with PHC2By similarityAdd BLAST | 21 | |
Regioni | 162 – 226 | Interaction with E4F1By similarityAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 81 – 95 | Nuclear localization signalSequence analysisAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 249 – 324 | Pro/Ser-richAdd BLAST | 76 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 18 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | P25916 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
PhylomeDBi | P25916 |
TreeFami | TF324206 |
Family and domain databases
DisProti | DP01316 |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS
60 70 80 90 100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA
110 120 130 140 150
HPSADAANGS NEDRGEVADE EKRIITDDEI ISLSIEFFDQ SRLDRKVNKE
160 170 180 190 200
KPKEEVNDKR YLRCPAAMTV MHLRKFLRSK MDIPNTFQID VMYEEEPLKD
210 220 230 240 250
YYTLMDIAYI YTWRRNGPLP LKYRVRPTCK RMKMSHQRDG LTNAGELESD
260 270 280 290 300
SGSDKANSPA GGVPSTSSCL PSPSTPVQSP HPQFPHISST MNGTSNSPSA
310 320
NHQSSFASRP RKSSLNGSSA TSSG
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ASR8 | A2ASR8_MOUSE | Polycomb complex protein BMI-1 | Bmi1 | 197 | Annotation score: | ||
A2ASR5 | A2ASR5_MOUSE | Polycomb complex protein BMI-1 | Bmi1 | 75 | Annotation score: | ||
A2ASR6 | A2ASR6_MOUSE | Polycomb complex protein BMI-1 | Bmi1 | 105 | Annotation score: | ||
A2ASR7 | A2ASR7_MOUSE | Polycomb complex protein BMI-1 | Bmi1 | 159 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64067 Genomic DNA Translation: AAA37299.1 M64068 Genomic DNA Translation: AAA37301.1 Sequence problems. M64279 mRNA Translation: AAA37300.1 BC053708 mRNA Translation: AAH53708.1 BC056384 mRNA Translation: AAH56384.1 |
CCDSi | CCDS15711.1 |
PIRi | A39523 |
RefSeqi | NP_031578.2, NM_007552.4 XP_006497374.1, XM_006497311.2 XP_006497375.1, XM_006497312.3 |
Genome annotation databases
Ensembli | ENSMUST00000028071; ENSMUSP00000028071; ENSMUSG00000026739 ENSMUST00000051929; ENSMUSP00000110300; ENSMUSG00000026739 |
GeneIDi | 12151 |
KEGGi | mmu:12151 |
UCSCi | uc008ily.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64067 Genomic DNA Translation: AAA37299.1 M64068 Genomic DNA Translation: AAA37301.1 Sequence problems. M64279 mRNA Translation: AAA37300.1 BC053708 mRNA Translation: AAH53708.1 BC056384 mRNA Translation: AAH56384.1 |
CCDSi | CCDS15711.1 |
PIRi | A39523 |
RefSeqi | NP_031578.2, NM_007552.4 XP_006497374.1, XM_006497311.2 XP_006497375.1, XM_006497312.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CKL | X-ray | 2.00 | A | 1-108 | [»] | |
SMRi | P25916 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198359, 29 interactors |
CORUMi | P25916 |
DIPi | DIP-132N |
IntActi | P25916, 21 interactors |
MINTi | P25916 |
STRINGi | 10090.ENSMUSP00000028071 |
PTM databases
iPTMneti | P25916 |
PhosphoSitePlusi | P25916 |
Proteomic databases
EPDi | P25916 |
PaxDbi | P25916 |
PeptideAtlasi | P25916 |
PRIDEi | P25916 |
Genome annotation databases
Ensembli | ENSMUST00000028071; ENSMUSP00000028071; ENSMUSG00000026739 ENSMUST00000051929; ENSMUSP00000110300; ENSMUSG00000026739 |
GeneIDi | 12151 |
KEGGi | mmu:12151 |
UCSCi | uc008ily.1, mouse |
Organism-specific databases
CTDi | 648 |
MGIi | MGI:88174, Bmi1 |
Phylogenomic databases
eggNOGi | KOG2660, Eukaryota |
GeneTreei | ENSGT00940000156042 |
HOGENOMi | CLU_046427_0_0_1 |
InParanoidi | P25916 |
OMAi | HLICALC |
OrthoDBi | 1344247at2759 |
PhylomeDBi | P25916 |
TreeFami | TF324206 |
Enzyme and pathway databases
Reactomei | R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-4551638, SUMOylation of chromatin organization proteins R-MMU-4570464, SUMOylation of RNA binding proteins R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724, Regulation of PTEN gene transcription R-MMU-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
BioGRID-ORCSi | 12151, 1 hit in 19 CRISPR screens |
EvolutionaryTracei | P25916 |
PROi | PR:P25916 |
RNActi | P25916, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026739, Expressed in embryo and 376 other tissues |
ExpressionAtlasi | P25916, baseline and differential |
Genevisiblei | P25916, MM |
Family and domain databases
DisProti | DP01316 |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443, RAWUL IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF16207, RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMI1_MOUSE | |
Accessioni | P25916Primary (citable) accession number: P25916 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references