Bmi1

Functionⁱ

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	18 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		40

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 16359901
- 24105743
promoter-specific chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 22770845
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17107999
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 20956546
ubiquitin-protein transferase activator activity
Source: MGI
Inferred from direct assayⁱ
- 16359901
zinc ion binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 7926765
cellular process
Source: MGI
Traceable author statementⁱ
- 7926765
cellular response to dexamethasone stimulus Source: Ensembl
cellular response to interleukin-1 Source: Ensembl
chromatin silencing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA methylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 24105743
embryonic skeletal system development
Source: MGI
Inferred from genetic interactionⁱ
- 11290297
embryonic skeletal system morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 11290297
hematopoietic stem cell homeostasis Source: MGI
histone acetylation
Source: MGI
Inferred from genetic interactionⁱ
- 16687444
histone H2A-K119 monoubiquitination Source: UniProtKB
histone ubiquitination
Source: MGI
Inferred from direct assayⁱ
- 16359901
humoral immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 7926765
in utero embryonic development
Source: MGI
Inferred from genetic interactionⁱ
- 11290297
negative regulation of apoptotic signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 11290297
negative regulation of gene expression, epigenetic Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 9312051
- 9367786
positive regulation of B cell proliferation
Source: HGNC
Inferred from mutant phenotypeⁱ
- 15964995
positive regulation of immature T cell proliferation in thymus
Source: HGNC
Inferred from mutant phenotypeⁱ
- 15964995
positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
regulation of adaxial/abaxial pattern formation
Source: MGI
Inferred from genetic interactionⁱ
- 17107999
rostrocaudal neural tube patterning
Source: MGI
Inferred from mutant phenotypeⁱ
- 8887324
skeletal system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 7926765
somatic stem cell division
Source: MGI
Inferred from mutant phenotypeⁱ
- 12714971

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-3108214 SUMOylation of DNA damage response and repair proteins R-MMU-3899300 SUMOylation of transcription cofactors R-MMU-4551638 SUMOylation of chromatin organization proteins R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724 Regulation of PTEN gene transcription R-MMU-8953750 Transcriptional Regulation by E2F6

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription
R-MMU-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polycomb complex protein BMI-1 Alternative name(s): Polycomb group RING finger protein 4
Gene namesⁱ	Name:Bmi1 Synonyms:Bmi-1, Pcgf4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:88174 Bmi1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055988	1 – 324	Polycomb complex protein BMI-1Add BLAST		324

Post-translational modificationⁱ

May be polyubiquitinated; which does not lead to proteasomal degradation (By similarity). Monoubiquitinated.By similarity1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	P25916
PaxDbⁱ	P25916
PeptideAtlas More...PeptideAtlasⁱ	P25916
PRIDEⁱ	P25916

PTM databases

iPTMnetⁱ	P25916
PhosphoSitePlusⁱ	P25916

Expressionⁱ

Tissue specificityⁱ

Detected in most organs with high expression levels in thymus, heart, brain and testis.

Gene expression databases

Bgeeⁱ	ENSMUSG00000026739 Expressed in 364 organ(s), highest expression level in embryo
CleanExⁱ	MM_BMI1
ExpressionAtlasⁱ	P25916 baseline and differential
Genevisibleⁱ	P25916 MM

Interactionⁱ

Subunit structureⁱ

Component of a PRC1-like complex (PubMed:16359901). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3, RING1 and RNF2 (By similarity). Interacts with RNF2/RING2 (PubMed:16359901, PubMed:16710298). Interacts with RING1 (PubMed:16359901, PubMed:16710298). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. Interacts with CBX7 and CBX8 (PubMed:16359901). Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1 (By similarity). Interacts with PHC2 (PubMed:16359901).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Cbx8	Q9QXV1	3	EBI-927401,EBI-1216641
Dnmt3b	O88509	2	EBI-927401,EBI-7987547
Hells	Q60848	2	EBI-927401,EBI-3043887
PHC2	Q8IXK0	2	EBI-927401,EBI-713786	From Homo sapiens.
Phc2	Q9QWH1	3	EBI-927401,EBI-642357
Ring1	O35730	4	EBI-927401,EBI-929310
Rnf2	Q9CQJ4	17	EBI-927401,EBI-927321

Protein-protein interaction databases

BioGridⁱ	198359, 26 interactors
CORUMⁱ	P25916
Database of interacting proteins More...DIPⁱ	DIP-132N
IntActⁱ	P25916, 21 interactors
Molecular INTeraction database More...MINTⁱ	P25916
STRINGⁱ	10090.ENSMUSP00000028071

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 12	Combined sources	4
Helixⁱ	13 – 15	Combined sources	3
Turnⁱ	19 – 21	Combined sources	3
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	26 – 31	Combined sources	6
Turnⁱ	32 – 34	Combined sources	3
Beta strandⁱ	37 – 39	Combined sources	3
Helixⁱ	40 – 47	Combined sources	8
Turnⁱ	54 – 56	Combined sources	3
Helixⁱ	65 – 68	Combined sources	4
Beta strandⁱ	69 – 71	Combined sources	3
Helixⁱ	73 – 82	Combined sources	10
Helixⁱ	86 – 100	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P25916
SMRⁱ	P25916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P25916

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	160 – 180	Interaction with PHC2By similarityAdd BLAST		21
Regionⁱ	162 – 226	Interaction with E4F1By similarityAdd BLAST		65

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	81 – 95	Nuclear localization signalSequence analysisAdd BLAST		15

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	249 – 324	Pro/Ser-richAdd BLAST		76

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	18 – 57	RING-typePROSITE-ProRule annotationAdd BLAST		40

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2660 Eukaryota ENOG410XPCN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074463
HOGENOMⁱ	HOG000231945
HOVERGENⁱ	HBG052826
InParanoidⁱ	P25916
KEGG Orthology (KO) More...KOⁱ	K11459
OMAⁱ	QVANKRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09IB
PhylomeDBⁱ	P25916
TreeFamⁱ	TF324206

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039642 E3_Ub_ligase/polycomb_RING IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
PANTHERⁱ	PTHR10825 PTHR10825, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16207 RAWUL, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P25916-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS 
        60         70         80         90        100
KYCPICDVQV HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA 
       110        120        130        140        150
HPSADAANGS NEDRGEVADE EKRIITDDEI ISLSIEFFDQ SRLDRKVNKE 
       160        170        180        190        200
KPKEEVNDKR YLRCPAAMTV MHLRKFLRSK MDIPNTFQID VMYEEEPLKD 
       210        220        230        240        250
YYTLMDIAYI YTWRRNGPLP LKYRVRPTCK RMKMSHQRDG LTNAGELESD 
       260        270        280        290        300
SGSDKANSPA GGVPSTSSCL PSPSTPVQSP HPQFPHISST MNGTSNSPSA 
       310        320 
NHQSSFASRP RKSSLNGSSA TSSG

Length:324

Mass (Da):36,708

Last modified:May 1, 1992 - v1

Checksum:ⁱAD7DECDB6B29DCE5

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2ASR6	A2ASR6_MOUSE	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	Bmi1	105	Annotation score:
A2ASR8	A2ASR8_MOUSE	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	Bmi1	197	Annotation score:
A2ASR5	A2ASR5_MOUSE	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	Bmi1	75	Annotation score:
A2ASR7	A2ASR7_MOUSE	Polycomb complex protein BMI-1 Polycomb complex protein BMI-1	Bmi1	159	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64067 Genomic DNA Translation: AAA37299.1 M64068 Genomic DNA Translation: AAA37301.1 Sequence problems. M64279 mRNA Translation: AAA37300.1 BC053708 mRNA Translation: AAH53708.1 BC056384 mRNA Translation: AAH56384.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15711.1
PIRⁱ	A39523
NCBI Reference Sequences More...RefSeqⁱ	NP_031578.2, NM_007552.4 XP_006497374.1, XM_006497311.2 XP_006497375.1, XM_006497312.3
UniGeneⁱ	Mm.289584

Genome annotation databases

Ensemblⁱ	ENSMUST00000028071; ENSMUSP00000028071; ENSMUSG00000026739 ENSMUST00000051929; ENSMUSP00000110300; ENSMUSG00000026739
GeneIDⁱ	12151
KEGGⁱ	mmu:12151
UCSC genome browser More...UCSCⁱ	uc008ily.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25916	MCG9550, isoform CRA_a		MOUSE		324	UniRef100_P25916
Polycomb complex protein BMI-1 (Fragment)		MOUSE		197
Polycomb complex protein BMI-1 (Fragment)		MOUSE		159

Protein	Similar proteins		Species	Score	Length	Source
P25916	Polycomb complex protein BMI-1		FELCA		326	UniRef90_P25916
MCG9550, isoform CRA_a		MOUSE		324
polycomb complex protein BMI-1 isoform X1		TURTR		341
Uncharacterized protein		RHIRO		339
Uncharacterized protein		PIG		333
+122

Protein	Similar proteins		Species	Score	Length	Source
P25916	Polycomb complex protein BMI-1		FELCA		326	UniRef50_P25916
MCG9550, isoform CRA_a		MOUSE		324
polycomb complex protein BMI-1 isoform X1		TURTR		341
Uncharacterized protein		RHIRO		339
Uncharacterized protein		PIG		333
+194

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64067 Genomic DNA Translation: AAA37299.1 M64068 Genomic DNA Translation: AAA37301.1 Sequence problems. M64279 mRNA Translation: AAA37300.1 BC053708 mRNA Translation: AAH53708.1 BC056384 mRNA Translation: AAH56384.1
CCDSⁱ	CCDS15711.1
PIRⁱ	A39523
RefSeqⁱ	NP_031578.2, NM_007552.4 XP_006497374.1, XM_006497311.2 XP_006497375.1, XM_006497312.3
UniGeneⁱ	Mm.289584

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CKL	X-ray	2.00	A	1-108	[»]
ProteinModelPortalⁱ	P25916
SMRⁱ	P25916
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198359, 26 interactors
CORUMⁱ	P25916
DIPⁱ	DIP-132N
IntActⁱ	P25916, 21 interactors
MINTⁱ	P25916
STRINGⁱ	10090.ENSMUSP00000028071

PTM databases

iPTMnetⁱ	P25916
PhosphoSitePlusⁱ	P25916

Proteomic databases

EPDⁱ	P25916
PaxDbⁱ	P25916
PeptideAtlasⁱ	P25916
PRIDEⁱ	P25916

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028071; ENSMUSP00000028071; ENSMUSG00000026739 ENSMUST00000051929; ENSMUSP00000110300; ENSMUSG00000026739
GeneIDⁱ	12151
KEGGⁱ	mmu:12151
UCSCⁱ	uc008ily.1 mouse

Organism-specific databases

CTDⁱ	648
MGIⁱ	MGI:88174 Bmi1

Phylogenomic databases

eggNOGⁱ	KOG2660 Eukaryota ENOG410XPCN LUCA
GeneTreeⁱ	ENSGT00550000074463
HOGENOMⁱ	HOG000231945
HOVERGENⁱ	HBG052826
InParanoidⁱ	P25916
KOⁱ	K11459
OMAⁱ	QVANKRY
OrthoDBⁱ	EOG091G09IB
PhylomeDBⁱ	P25916
TreeFamⁱ	TF324206

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2559580 Oxidative Stress Induced Senescence R-MMU-3108214 SUMOylation of DNA damage response and repair proteins R-MMU-3899300 SUMOylation of transcription cofactors R-MMU-4551638 SUMOylation of chromatin organization proteins R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8943724 Regulation of PTEN gene transcription R-MMU-8953750 Transcriptional Regulation by E2F6

Reactomeⁱ

R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription
R-MMU-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

EvolutionaryTraceⁱ	P25916
Protein Ontology More...PROⁱ	PR:P25916
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026739 Expressed in 364 organ(s), highest expression level in embryo
CleanExⁱ	MM_BMI1
ExpressionAtlasⁱ	P25916 baseline and differential
Genevisibleⁱ	P25916 MM

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR039642 E3_Ub_ligase/polycomb_RING IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
PANTHERⁱ	PTHR10825 PTHR10825, 1 hit
Pfamⁱ	View protein in Pfam PF16207 RAWUL, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BMI1_MOUSE
Accessionⁱ	P25916Primary (citable) accession number: P25916
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	May 1, 1992
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P25916 (BMI1_MOUSE)

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Polycomb complex protein BMI-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ