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Protein

Metallothionein-like protein 2A

Gene

MT2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn) (PubMed:18287486). Plays a role in Cu homeostasis, specifically in the remobilization of Cu from senescing leaves. The mobilization of Cu from internal sources is important for seed development (PubMed:24635746).Curated2 Publications

GO - Molecular functioni

  • copper ion binding Source: TAIR

GO - Biological processi

  • cellular copper ion homeostasis Source: TAIR

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 2A
Short name:
MT-2A
Short name:
MT-K
Alternative name(s):
MT-1G
Gene namesi
Name:MT2A
Ordered Locus Names:At3g09390
ORF Names:F3L24.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09390
TAIRilocus:2083519 AT3G09390

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973861 – 81Metallothionein-like protein 2AAdd BLAST81

Proteomic databases

PaxDbiP25860

Expressioni

Tissue specificityi

Abundant in leaves, inflorescences and roots of mature plants. Also detected in roots of young plants, and in siliques (PubMed:7565594). Expressed in leaf mesophyll cells, filaments, stigma and tips of elongating lateral roots (Ref. 8).2 Publications

Inductioni

Strongly induced in seedlings by CuSO4.1 Publication

Gene expression databases

ExpressionAtlasiP25860 baseline and differential
GenevisibleiP25860 AT

Interactioni

Protein-protein interaction databases

BioGridi5432, 2 interactors
STRINGi3702.AT3G09390.1

Structurei

3D structure databases

ProteinModelPortaliP25860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J5R6 Eukaryota
ENOG410Z616 LUCA
HOGENOMiHOG000220916
InParanoidiP25860
OMAiANCTCNP
OrthoDBiEOG0936118M
PhylomeDBiP25860

Family and domain databases

InterProiView protein in InterPro
IPR000347 Metalthion_15p
PANTHERiPTHR33543 PTHR33543, 1 hit
PfamiView protein in Pfam
PF01439 Metallothio_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25860-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCCGGNCGC GSGCKCGNGC GGCKMYPDLG FSGETTTTET FVLGVAPAMK
60 70 80
NQYEASGESN NAENDACKCG SDCKCDPCTC K
Length:81
Mass (Da):8,163
Last modified:November 1, 1997 - v2
Checksum:iB2639167E56854EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64N → S in BAA01990 (Ref. 1) Curated1
Sequence conflicti64N → S in CAA44630 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11394 Genomic DNA Translation: BAA01990.1
X62818 mRNA Translation: CAA44630.1
U15108 mRNA Translation: AAA50250.1
AC011436 Genomic DNA Translation: AAF14034.1
CP002686 Genomic DNA Translation: AEE74760.1
CP002686 Genomic DNA Translation: ANM65194.1
AY037263 mRNA Translation: AAK59864.1
AY077669 mRNA Translation: AAL76147.1
Z26416 mRNA Translation: CAA81248.1
PIRiS18069 SMMUL
S57861
RefSeqiNP_001327181.1, NM_001337815.1
NP_187550.1, NM_111773.4
UniGeneiAt.24444
At.42166
At.67557

Genome annotation databases

EnsemblPlantsiAT3G09390.1; AT3G09390.1; AT3G09390
AT3G09390.2; AT3G09390.2; AT3G09390
GeneIDi820098
GrameneiAT3G09390.1; AT3G09390.1; AT3G09390
AT3G09390.2; AT3G09390.2; AT3G09390
KEGGiath:AT3G09390

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11394 Genomic DNA Translation: BAA01990.1
X62818 mRNA Translation: CAA44630.1
U15108 mRNA Translation: AAA50250.1
AC011436 Genomic DNA Translation: AAF14034.1
CP002686 Genomic DNA Translation: AEE74760.1
CP002686 Genomic DNA Translation: ANM65194.1
AY037263 mRNA Translation: AAK59864.1
AY077669 mRNA Translation: AAL76147.1
Z26416 mRNA Translation: CAA81248.1
PIRiS18069 SMMUL
S57861
RefSeqiNP_001327181.1, NM_001337815.1
NP_187550.1, NM_111773.4
UniGeneiAt.24444
At.42166
At.67557

3D structure databases

ProteinModelPortaliP25860
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5432, 2 interactors
STRINGi3702.AT3G09390.1

Proteomic databases

PaxDbiP25860

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G09390.1; AT3G09390.1; AT3G09390
AT3G09390.2; AT3G09390.2; AT3G09390
GeneIDi820098
GrameneiAT3G09390.1; AT3G09390.1; AT3G09390
AT3G09390.2; AT3G09390.2; AT3G09390
KEGGiath:AT3G09390

Organism-specific databases

AraportiAT3G09390
TAIRilocus:2083519 AT3G09390

Phylogenomic databases

eggNOGiENOG410J5R6 Eukaryota
ENOG410Z616 LUCA
HOGENOMiHOG000220916
InParanoidiP25860
OMAiANCTCNP
OrthoDBiEOG0936118M
PhylomeDBiP25860

Miscellaneous databases

PROiPR:P25860

Gene expression databases

ExpressionAtlasiP25860 baseline and differential
GenevisibleiP25860 AT

Family and domain databases

InterProiView protein in InterPro
IPR000347 Metalthion_15p
PANTHERiPTHR33543 PTHR33543, 1 hit
PfamiView protein in Pfam
PF01439 Metallothio_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT2A_ARATH
AccessioniPrimary (citable) accession number: P25860
Secondary accession number(s): P43391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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