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Protein

Protein S100-P

Gene

S100P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).3 Publications

Miscellaneous

This protein binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 321; low affinityAdd BLAST14
Calcium bindingi62 – 732; high affinityAdd BLAST12

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • calcium-dependent protein binding Source: HGNC
  • calcium ion binding Source: ProtInc
  • magnesium ion binding Source: HGNC
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: InterPro
  • transition metal ion binding Source: InterPro

GO - Biological processi

  • endothelial cell migration Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • response to organic substance Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-P
Alternative name(s):
Migration-inducing gene 9 protein
Short name:
MIG9
Protein S100-E
S100 calcium-binding protein P
Gene namesi
Name:S100P
Synonyms:S100E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163993.6
HGNCiHGNC:10504 S100P
MIMi600614 gene
neXtProtiNX_P25815

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi21 – 23Missing in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with C-64, K-68 and S-73. 2 Publications3
Mutagenesisi64N → C in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, K-68 and S-73. 2 Publications1
Mutagenesisi68Q → K in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and S-73. 2 Publications1
Mutagenesisi73E → S in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and K-68. 2 Publications1

Organism-specific databases

DisGeNETi6286
OpenTargetsiENSG00000163993
PharmGKBiPA34913

Chemistry databases

DrugBankiDB01003 Cromoglicic acid

Polymorphism and mutation databases

BioMutaiS100P
DMDMi134142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440321 – 95Protein S100-PAdd BLAST95

Proteomic databases

EPDiP25815
MaxQBiP25815
PaxDbiP25815
PeptideAtlasiP25815
PRIDEiP25815
ProteomicsDBi54298
TopDownProteomicsiP25815

PTM databases

iPTMnetiP25815
PhosphoSitePlusiP25815

Expressioni

Tissue specificityi

Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.2 Publications

Gene expression databases

BgeeiENSG00000163993
CleanExiHS_S100P
GenevisibleiP25815 HS

Organism-specific databases

HPAiHPA019502

Interactioni

Subunit structurei

Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • calcium-dependent protein binding Source: HGNC
  • protein homodimerization activity Source: UniProtKB
  • RAGE receptor binding Source: InterPro

Protein-protein interaction databases

BioGridi112194, 23 interactors
IntActiP25815, 15 interactors
STRINGi9606.ENSP00000296370

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 18Combined sources16
Beta strandi21 – 23Combined sources3
Beta strandi25 – 28Combined sources4
Helixi30 – 40Combined sources11
Helixi44 – 46Combined sources3
Helixi53 – 61Combined sources9
Beta strandi63 – 70Combined sources8
Helixi71 – 92Combined sources22

3D structure databases

ProteinModelPortaliP25815
SMRiP25815
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25815

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J11V Eukaryota
ENOG410YX5D LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP25815
OMAiCHKYFEQ
OrthoDBiEOG091G10QT
PhylomeDBiP25815
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
IPR028494 S100P
PANTHERiPTHR11639:SF69 PTHR11639:SF69, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P25815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD
60 70 80 90
KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK
Length:95
Mass (Da):10,400
Last modified:December 1, 1992 - v2
Checksum:i786E6E3F3EACC6C1
GO

Sequence cautioni

The sequence AAS00487 differs from that shown. Sequencing error in Met-1 codon.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12I → M in AAS00487 (Ref. 4) Curated1
Sequence conflicti32E → T AA sequence (PubMed:1540168).Curated1
Sequence conflicti44F → E AA sequence (PubMed:1540168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65614 mRNA Translation: CAA46566.1
AF539739 mRNA Translation: AAO41114.1
BT007289 mRNA Translation: AAP35953.1
AY423724 mRNA Translation: AAS00487.1 Sequence problems.
BC006819 mRNA Translation: AAH06819.1
CCDSiCCDS3391.1
PIRiS24146
RefSeqiNP_005971.1, NM_005980.2
UniGeneiHs.2962

Genome annotation databases

EnsembliENST00000296370; ENSP00000296370; ENSG00000163993
GeneIDi6286
KEGGihsa:6286
UCSCiuc003gjl.4 human

Similar proteinsi

Entry informationi

Entry nameiS100P_HUMAN
AccessioniPrimary (citable) accession number: P25815
Secondary accession number(s): Q5J7W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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