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UniProtKB - P25801 (RBTN2_MOUSE)
Protein
Rhombotin-2
Gene
Lmo2
Organism
Mus musculus (Mouse)
Status
Functioni
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
1 PublicationGO - Molecular functioni
- bHLH transcription factor binding Source: MGI
- chromatin binding Source: MGI
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- transcription coactivator activity Source: MGI
- transcription coregulator binding Source: MGI
GO - Biological processi
- cellular response to thyroid hormone stimulus Source: MGI
- embryonic hemopoiesis Source: MGI
- negative regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Names & Taxonomyi
Protein namesi | Recommended name: Rhombotin-2Alternative name(s): Cysteine-rich protein TTG-2 LIM domain only protein 2 Short name: LMO-2 T-cell translocation protein 2 |
Gene namesi | Name:Lmo2 Synonyms:Rbtn-2, Rbtn2, Rhom-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102811, Lmo2 |
VEuPathDBi | HostDB:ENSMUSG00000032698 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Other locations
- protein-containing complex Source: UniProtKB
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075897 | 1 – 158 | Rhombotin-2Add BLAST | 158 |
Proteomic databases
PaxDbi | P25801 |
PRIDEi | P25801 |
ProteomicsDBi | 254902 |
PTM databases
PhosphoSitePlusi | P25801 |
Expressioni
Tissue specificityi
Expressed in early mouse development in central nervous system, lung, kidney, liver and spleen but only very low levels occur in thymus.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032698, Expressed in bone marrow and 359 other tissues |
ExpressionAtlasi | P25801, baseline and differential |
Genevisiblei | P25801, MM |
Interactioni
Subunit structurei
Interacts with BEX2 and KDM5A (By similarity).
Interacts via its LIM domains with ELF2 and LDB1.
Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL.
By similarity3 PublicationsBinary interactionsi
P25801
GO - Molecular functioni
- bHLH transcription factor binding Source: MGI
- identical protein binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- transcription coregulator binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201179, 59 interactors |
CORUMi | P25801 |
DIPi | DIP-24247N |
IntActi | P25801, 7 interactors |
MINTi | P25801 |
STRINGi | 10090.ENSMUSP00000106770 |
Miscellaneous databases
RNActi | P25801, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P25801 |
BMRBi | P25801 |
SMRi | P25801 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25801 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 89 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 94 – 153 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 |
Domaini
The second LIM zinc-binding domain interacts with KDM5A.By similarity
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160199 |
InParanoidi | P25801 |
OMAi | TTSSECR |
Family and domain databases
IDEALi | IID50043 |
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P25801-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW
60 70 80 90 100
HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR
110 120 130 140 150
IRAYEMTMRV KDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIYE
WTKINGII
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2BHP3 | A2BHP3_MOUSE | Rhombotin-2 | Lmo2 | 228 | Annotation score: | ||
A2BHP5 | A2BHP5_MOUSE | Rhombotin-2 | Lmo2 | 220 | Annotation score: | ||
A2BHP1 | A2BHP1_MOUSE | Rhombotin-2 | Lmo2 | 156 | Annotation score: | ||
A2BHP2 | A2BHP2_MOUSE | Rhombotin-2 | Lmo2 | 144 | Annotation score: | ||
A2BHP4 | A2BHP4_MOUSE | Rhombotin-2 | Lmo2 | 59 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64360 mRNA Translation: AAA40054.1 BC057880 mRNA Translation: AAH57880.1 |
CCDSi | CCDS50652.1 |
PIRi | A39370 |
RefSeqi | NP_001135808.1, NM_001142336.1 NP_001135809.1, NM_001142337.1 XP_006498883.1, XM_006498820.3 |
Genome annotation databases
Ensembli | ENSMUST00000123437; ENSMUSP00000117703; ENSMUSG00000032698 ENSMUST00000170926; ENSMUSP00000128317; ENSMUSG00000032698 |
GeneIDi | 16909 |
KEGGi | mmu:16909 |
UCSCi | uc012caj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64360 mRNA Translation: AAA40054.1 BC057880 mRNA Translation: AAH57880.1 |
CCDSi | CCDS50652.1 |
PIRi | A39370 |
RefSeqi | NP_001135808.1, NM_001142336.1 NP_001135809.1, NM_001142337.1 XP_006498883.1, XM_006498820.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J2O | NMR | - | A | 26-87 | [»] | |
2L6Y | NMR | - | B | 84-156 | [»] | |
2L6Z | NMR | - | C | 84-156 | [»] | |
2LXD | NMR | - | A | 84-156 | [»] | |
AlphaFoldDBi | P25801 | |||||
BMRBi | P25801 | |||||
SMRi | P25801 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201179, 59 interactors |
CORUMi | P25801 |
DIPi | DIP-24247N |
IntActi | P25801, 7 interactors |
MINTi | P25801 |
STRINGi | 10090.ENSMUSP00000106770 |
PTM databases
PhosphoSitePlusi | P25801 |
Proteomic databases
PaxDbi | P25801 |
PRIDEi | P25801 |
ProteomicsDBi | 254902 |
Protocols and materials databases
Antibodypediai | 4265, 737 antibodies from 42 providers |
DNASUi | 16909 |
Genome annotation databases
Ensembli | ENSMUST00000123437; ENSMUSP00000117703; ENSMUSG00000032698 ENSMUST00000170926; ENSMUSP00000128317; ENSMUSG00000032698 |
GeneIDi | 16909 |
KEGGi | mmu:16909 |
UCSCi | uc012caj.1, mouse |
Organism-specific databases
CTDi | 4005 |
MGIi | MGI:102811, Lmo2 |
VEuPathDBi | HostDB:ENSMUSG00000032698 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160199 |
InParanoidi | P25801 |
OMAi | TTSSECR |
Enzyme and pathway databases
Reactomei | R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Miscellaneous databases
BioGRID-ORCSi | 16909, 7 hits in 74 CRISPR screens |
ChiTaRSi | Lmo2, mouse |
EvolutionaryTracei | P25801 |
PROi | PR:P25801 |
RNActi | P25801, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032698, Expressed in bone marrow and 359 other tissues |
ExpressionAtlasi | P25801, baseline and differential |
Genevisiblei | P25801, MM |
Family and domain databases
IDEALi | IID50043 |
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RBTN2_MOUSE | |
Accessioni | P25801Primary (citable) accession number: P25801 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references