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Protein

Rhombotin-1

Gene

LMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SIGNORiP25800

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:LMO1
Synonyms:RBTN1, RHOM1, TTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166407.13
HGNCiHGNC:6641 LMO1
MIMi186921 gene+phenotype
neXtProtiNX_P25800

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4004
MalaCardsiLMO1
MIMi186921 gene+phenotype
OpenTargetsiENSG00000166407
Orphaneti635 Neuroblastoma
PharmGKBiPA30407

Polymorphism and mutation databases

BioMutaiLMO1
DMDMi132532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758941 – 156Rhombotin-1Add BLAST156

Proteomic databases

EPDiP25800
MaxQBiP25800
PaxDbiP25800
PeptideAtlasiP25800
PRIDEiP25800
ProteomicsDBi54297

PTM databases

iPTMnetiP25800
PhosphoSitePlusiP25800

Miscellaneous databases

PMAP-CutDBiP25800

Expressioni

Tissue specificityi

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.1 Publication

Gene expression databases

BgeeiENSG00000166407 Expressed in 89 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LMO1
ExpressionAtlasiP25800 baseline and differential
GenevisibleiP25800 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110190, 60 interactors
IntActiP25800, 106 interactors
MINTiP25800
STRINGi9606.ENSP00000338207

Structurei

3D structure databases

ProteinModelPortaliP25800
SMRiP25800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini88 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP25800
OMAiCPRTGRP
OrthoDBiEOG091G0LKW
PhylomeDBiP25800
TreeFamiTF351071

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P25800-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK
60 70 80 90 100
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM
110 120 130 140 150
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQM DYEEGQLNGT

FESQVQ
Length:156
Mass (Da):17,828
Last modified:May 1, 1992 - v1
Checksum:i6BAFBE1F870CCAAC
GO
Isoform 2 (identifier: P25800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MMVLDKEDG → MVLDQEDG

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,697
Checksum:iD18E9D3F21705F4A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK83E9PK83_HUMAN
Rhombotin-1
LMO1
145Annotation score:

Sequence cautioni

The sequence AAH39512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0466641 – 9MMVLDKEDG → MVLDQEDG in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26682 mRNA Translation: AAA36819.1
AJ277662 Genomic DNA Translation: CAC14587.1
AC091013 Genomic DNA No translation available.
BC039512 mRNA Translation: AAH39512.1 Different initiation.
BC069673 mRNA Translation: AAH69673.1
BC069752 mRNA Translation: AAH69752.1
BC069793 mRNA Translation: AAH69793.1
BC096056 mRNA Translation: AAH96056.1
BC096057 mRNA Translation: AAH96057.1
CCDSiCCDS44534.1 [P25800-1]
CCDS58118.1 [P25800-2]
PIRiA32795
RefSeqiNP_001257357.1, NM_001270428.1 [P25800-2]
NP_002306.1, NM_002315.2 [P25800-1]
UniGeneiHs.654426

Genome annotation databases

EnsembliENST00000335790; ENSP00000338207; ENSG00000166407 [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407 [P25800-2]
GeneIDi4004
KEGGihsa:4004
UCSCiuc001mgg.3 human [P25800-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26682 mRNA Translation: AAA36819.1
AJ277662 Genomic DNA Translation: CAC14587.1
AC091013 Genomic DNA No translation available.
BC039512 mRNA Translation: AAH39512.1 Different initiation.
BC069673 mRNA Translation: AAH69673.1
BC069752 mRNA Translation: AAH69752.1
BC069793 mRNA Translation: AAH69793.1
BC096056 mRNA Translation: AAH96056.1
BC096057 mRNA Translation: AAH96057.1
CCDSiCCDS44534.1 [P25800-1]
CCDS58118.1 [P25800-2]
PIRiA32795
RefSeqiNP_001257357.1, NM_001270428.1 [P25800-2]
NP_002306.1, NM_002315.2 [P25800-1]
UniGeneiHs.654426

3D structure databases

ProteinModelPortaliP25800
SMRiP25800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110190, 60 interactors
IntActiP25800, 106 interactors
MINTiP25800
STRINGi9606.ENSP00000338207

PTM databases

iPTMnetiP25800
PhosphoSitePlusiP25800

Polymorphism and mutation databases

BioMutaiLMO1
DMDMi132532

Proteomic databases

EPDiP25800
MaxQBiP25800
PaxDbiP25800
PeptideAtlasiP25800
PRIDEiP25800
ProteomicsDBi54297

Protocols and materials databases

DNASUi4004
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335790; ENSP00000338207; ENSG00000166407 [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407 [P25800-2]
GeneIDi4004
KEGGihsa:4004
UCSCiuc001mgg.3 human [P25800-1]

Organism-specific databases

CTDi4004
DisGeNETi4004
EuPathDBiHostDB:ENSG00000166407.13
GeneCardsiLMO1
HGNCiHGNC:6641 LMO1
MalaCardsiLMO1
MIMi186921 gene+phenotype
neXtProtiNX_P25800
OpenTargetsiENSG00000166407
Orphaneti635 Neuroblastoma
PharmGKBiPA30407
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP25800
OMAiCPRTGRP
OrthoDBiEOG091G0LKW
PhylomeDBiP25800
TreeFamiTF351071

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SIGNORiP25800

Miscellaneous databases

ChiTaRSiLMO1 human
GeneWikiiLMO1
GenomeRNAii4004
PMAP-CutDBiP25800
PROiPR:P25800
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166407 Expressed in 89 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LMO1
ExpressionAtlasiP25800 baseline and differential
GenevisibleiP25800 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBTN1_HUMAN
AccessioniPrimary (citable) accession number: P25800
Secondary accession number(s): E9PSF5, Q4VBC5, Q8IXR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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