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Protein

Rhombotin-2

Gene

LMO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

SIGNOR Signaling Network Open Resource

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SIGNORi
P25791

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhombotin-2
Alternative name(s):
Cysteine-rich protein TTG-2
LIM domain only protein 2
Short name:
LMO-2
T-cell translocation protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMO2
Synonyms:RBTN2, RBTNL1, RHOM2, TTG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135363.11

Human Gene Nomenclature Database

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HGNCi
HGNC:6642 LMO2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
180385 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25791

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
4005

Open Targets

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OpenTargetsi
ENSG00000135363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30408

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3217402

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LMO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
132533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758961 – 158Rhombotin-2Add BLAST158

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P25791

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P25791

PeptideAtlas

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PeptideAtlasi
P25791

PRoteomics IDEntifications database

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PRIDEi
P25791

ProteomicsDB human proteome resource

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ProteomicsDBi
54294
54295 [P25791-3]
54296 [P25791-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P25791

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P25791

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135363 Expressed in 236 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

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CleanExi
HS_LMO2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P25791 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB016258
HPA029285

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-739696,EBI-743598
ABI2Q9NYB9-24EBI-11959475,EBI-11096309
ADAMTSL4Q6UY14-33EBI-739696,EBI-10173507
AESQ081173EBI-739696,EBI-717810
AGTRAPQ6RW133EBI-739696,EBI-741181
AIMP2Q131554EBI-11959475,EBI-745226
BANPQ8N9N53EBI-739696,EBI-744695
BCAS2O759344EBI-11959475,EBI-1050106
BLZF1Q9H2G93EBI-739696,EBI-2548012
C1orf94Q6P1W53EBI-739696,EBI-946029
CALCOCO2Q131373EBI-739696,EBI-739580
CCDC36Q8IYA83EBI-739696,EBI-8638439
CDX4O146273EBI-739696,EBI-10181162
CLHC1Q8NHS43EBI-739696,EBI-10203156
CMTM5Q96DZ93EBI-739696,EBI-2548702
DBF4BQ8NFT63EBI-739696,EBI-749662
DDIT3P35638-23EBI-739696,EBI-10173632
DRAP1Q149193EBI-739696,EBI-712941
FHL3Q136433EBI-739696,EBI-741101
GFAPP141363EBI-739696,EBI-744302
GOLGA2Q083793EBI-739696,EBI-618309
GRB2P629933EBI-739696,EBI-401755
HDAC5Q9UQL64EBI-11959475,EBI-715576
HNRNPCP079103EBI-739696,EBI-357966
HNRNPMP522724EBI-739696,EBI-486809
HOOK1Q9UJC33EBI-739696,EBI-746704
IFT43Q96FT93EBI-739696,EBI-10189681
IKZF3Q9UKT93EBI-739696,EBI-747204
INCA1Q0VD864EBI-11959475,EBI-6509505
KANK2Q63ZY33EBI-739696,EBI-2556193
KRT15P190123EBI-739696,EBI-739566
KRT40Q6A1623EBI-739696,EBI-10171697
KRTAP10-7P604093EBI-739696,EBI-10172290
LDB1Q86U706EBI-739696,EBI-677177
LDB1Q86U70-24EBI-11959475,EBI-11979761
LZTS2Q9BRK43EBI-739696,EBI-741037
MAGEA8P433613EBI-739696,EBI-10182930
MAPRE1Q156916EBI-739696,EBI-1004115
MAPRE2Q155554EBI-739696,EBI-739717
MAPRE3Q9UPY85EBI-739696,EBI-726739
MBIPQ9NS73-53EBI-739696,EBI-10182361
MRFAP1L1Q96HT83EBI-739696,EBI-748896
MTUS2Q5JR593EBI-739696,EBI-742948
N4BP2L2Q928023EBI-739696,EBI-2514973
NIF3L1Q9GZT83EBI-739696,EBI-740897
NOTCH2NLAQ7Z3S93EBI-739696,EBI-945833
NUP62P371983EBI-739696,EBI-347978
NUTM1Q86Y263EBI-739696,EBI-10178410
PDE9AO760833EBI-739696,EBI-742764
PHC2Q8IXK04EBI-739696,EBI-713786
PRKG1Q139763EBI-739696,EBI-3952014
RELQ048643EBI-739696,EBI-307352
RELAQ042063EBI-739696,EBI-73886
RINT1Q6NUQ13EBI-739696,EBI-726876
ROCK1Q134643EBI-739696,EBI-876651
SAXO1Q8IYX73EBI-739696,EBI-3957636
SKP1P632083EBI-739696,EBI-307486
SOX5P357113EBI-739696,EBI-3505701
SPERTQ8NA613EBI-739696,EBI-741724
SSX2IPQ9Y2D83EBI-739696,EBI-2212028
STAT3P407633EBI-739696,EBI-518675
TFPTP0C1Z6-23EBI-739696,EBI-10178002
TRIM23P364063EBI-739696,EBI-740098
TRIM54Q9BYV23EBI-739696,EBI-2130429
TRIP6Q156543EBI-739696,EBI-742327
TSC22D4Q9Y3Q83EBI-739696,EBI-739485
TUFT1Q9NNX13EBI-739696,EBI-2557363
UBE2IQ7KZS03EBI-739696,EBI-10180829
ZFP64Q9NTW73EBI-739696,EBI-745730
ZNF24P170283EBI-739696,EBI-707773

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110191, 152 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P25791

Protein interaction database and analysis system

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IntActi
P25791, 165 interactors

Molecular INTeraction database

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MINTi
P25791

STRING: functional protein association networks

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STRINGi
9606.ENSP00000257818

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XJYX-ray2.40A26-156[»]
2XJZX-ray2.80A/B/C/D/E26-156[»]
2YPAX-ray2.80C25-156[»]
4KFZX-ray2.80A/B9-158[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P25791

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P25791

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P25791

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 89LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini94 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second LIM zinc-binding domain interacts with KDM5A.

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0490 Eukaryota
ENOG410YIJ3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232175

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054231

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P25791

KEGG Orthology (KO)

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KOi
K15612

Identification of Orthologs from Complete Genome Data

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OMAi
RIRAFEM

Database of Orthologous Groups

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OrthoDBi
1307952at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P25791

TreeFam database of animal gene trees

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TreeFami
TF351071

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001781 Znf_LIM

Pfam protein domain database

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Pfami
View protein in Pfam
PF00412 LIM, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00132 LIM, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P25791-1) [UniParc]FASTAAdd to basket
Also known as: LMO2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW
60 70 80 90 100
HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR
110 120 130 140 150
IRAYEMTMRV KDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIYE

WTKINGMI
Length:158
Mass (Da):18,358
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B4FF02505528C93
GO
Isoform 3 (identifier: P25791-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEGSAVTVLERGGASSPAERRSKRRRRSGGDGGGGGGARAPEGVRAPAAGQPRATKGAPPPPGTPPPSPM

Show »
Length:227
Mass (Da):25,036
Checksum:iF80DBD6392880361
GO
Isoform 2 (identifier: P25791-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: E → SLKGSQVRCPVWPKTISDPRCWSHSGEAVPDAWPSLQGTSG
     16-158: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:55
Mass (Da):5,941
Checksum:i0576C718F35DABF3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF98804 differs from that shown. Intron retention.Curated
The sequence AAH73973 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAA43430 differs from that shown. Reason: Frameshift at several positions.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389611M → MEGSAVTVLERGGASSPAER RSKRRRRSGGDGGGGGGARA PEGVRAPAAGQPRATKGAPP PPGTPPPSPM in isoform 3. 1 Publication1
Alternative sequenceiVSP_03896215E → SLKGSQVRCPVWPKTISDPR CWSHSGEAVPDAWPSLQGTS G in isoform 2. 1 Publication1
Alternative sequenceiVSP_03896316 – 158Missing in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X61118 mRNA Translation: CAA43430.1 Frameshift.
BC034041 mRNA Translation: AAH34041.1
BC035607 mRNA Translation: AAH35607.1
BC042426 mRNA Translation: AAH42426.1
BC073973 mRNA Translation: AAH73973.1 Sequence problems.
AF257211 mRNA Translation: AAF98804.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44567.1 [P25791-1]
CCDS7888.2 [P25791-3]

Protein sequence database of the Protein Information Resource

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PIRi
S29477

NCBI Reference Sequences

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RefSeqi
NP_001135787.1, NM_001142315.1 [P25791-1]
NP_001135788.1, NM_001142316.1 [P25791-1]
NP_005565.2, NM_005574.3 [P25791-3]
XP_005252978.1, XM_005252921.2 [P25791-1]
XP_016873216.1, XM_017017727.1 [P25791-1]
XP_016873217.1, XM_017017728.1 [P25791-1]
XP_016873218.1, XM_017017729.1 [P25791-1]
XP_016873219.1, XM_017017730.1 [P25791-1]
XP_016873220.1, XM_017017731.1 [P25791-1]
XP_016873221.1, XM_017017732.1 [P25791-1]
XP_016873222.1, XM_017017733.1 [P25791-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.34560

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000257818; ENSP00000257818; ENSG00000135363 [P25791-3]
ENST00000395833; ENSP00000379175; ENSG00000135363 [P25791-1]
ENST00000411482; ENSP00000401967; ENSG00000135363 [P25791-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4005

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4005

UCSC genome browser

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UCSCi
uc001mve.5 human [P25791-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61118 mRNA Translation: CAA43430.1 Frameshift.
BC034041 mRNA Translation: AAH34041.1
BC035607 mRNA Translation: AAH35607.1
BC042426 mRNA Translation: AAH42426.1
BC073973 mRNA Translation: AAH73973.1 Sequence problems.
AF257211 mRNA Translation: AAF98804.1 Sequence problems.
CCDSiCCDS44567.1 [P25791-1]
CCDS7888.2 [P25791-3]
PIRiS29477
RefSeqiNP_001135787.1, NM_001142315.1 [P25791-1]
NP_001135788.1, NM_001142316.1 [P25791-1]
NP_005565.2, NM_005574.3 [P25791-3]
XP_005252978.1, XM_005252921.2 [P25791-1]
XP_016873216.1, XM_017017727.1 [P25791-1]
XP_016873217.1, XM_017017728.1 [P25791-1]
XP_016873218.1, XM_017017729.1 [P25791-1]
XP_016873219.1, XM_017017730.1 [P25791-1]
XP_016873220.1, XM_017017731.1 [P25791-1]
XP_016873221.1, XM_017017732.1 [P25791-1]
XP_016873222.1, XM_017017733.1 [P25791-1]
UniGeneiHs.34560

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XJYX-ray2.40A26-156[»]
2XJZX-ray2.80A/B/C/D/E26-156[»]
2YPAX-ray2.80C25-156[»]
4KFZX-ray2.80A/B9-158[»]
ProteinModelPortaliP25791
SMRiP25791
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110191, 152 interactors
CORUMiP25791
IntActiP25791, 165 interactors
MINTiP25791
STRINGi9606.ENSP00000257818

Chemistry databases

ChEMBLiCHEMBL3217402

PTM databases

iPTMnetiP25791
PhosphoSitePlusiP25791

Polymorphism and mutation databases

BioMutaiLMO2
DMDMi132533

Proteomic databases

MaxQBiP25791
PaxDbiP25791
PeptideAtlasiP25791
PRIDEiP25791
ProteomicsDBi54294
54295 [P25791-3]
54296 [P25791-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4005
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257818; ENSP00000257818; ENSG00000135363 [P25791-3]
ENST00000395833; ENSP00000379175; ENSG00000135363 [P25791-1]
ENST00000411482; ENSP00000401967; ENSG00000135363 [P25791-4]
GeneIDi4005
KEGGihsa:4005
UCSCiuc001mve.5 human [P25791-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4005
DisGeNETi4005
EuPathDBiHostDB:ENSG00000135363.11

GeneCards: human genes, protein and diseases

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GeneCardsi
LMO2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0009544
HGNCiHGNC:6642 LMO2
HPAiCAB016258
HPA029285
MIMi180385 gene
neXtProtiNX_P25791
OpenTargetsiENSG00000135363
PharmGKBiPA30408

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00940000160199
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiP25791
KOiK15612
OMAiRIRAFEM
OrthoDBi1307952at2759
PhylomeDBiP25791
TreeFamiTF351071

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SIGNORiP25791

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LMO2 human
EvolutionaryTraceiP25791

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LMO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4005

Protein Ontology

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PROi
PR:P25791

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135363 Expressed in 236 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_LMO2
GenevisibleiP25791 HS

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBTN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25791
Secondary accession number(s): Q9HD58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 16, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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