UniProtKB - P25791 (RBTN2_HUMAN)
Rhombotin-2
LMO2
Functioni
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
GO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- transcription coactivator activity Source: BHF-UCL
- transcription coregulator binding Source: BHF-UCL
GO - Biological processi
- cellular response to thyroid hormone stimulus Source: UniProtKB
- multicellular organism development Source: ProtInc
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P25791 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P25791 |
SIGNORi | P25791 |
Names & Taxonomyi
Protein namesi | Recommended name: Rhombotin-2Alternative name(s): Cysteine-rich protein TTG-2 LIM domain only protein 2 Short name: LMO-2 T-cell translocation protein 2 |
Gene namesi | Name:LMO2 Synonyms:RBTN2, RBTNL1, RHOM2, TTG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6642, LMO2 |
MIMi | 180385, gene |
neXtProti | NX_P25791 |
VEuPathDBi | HostDB:ENSG00000135363 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
Other locations
- transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 4005 |
OpenTargetsi | ENSG00000135363 |
PharmGKBi | PA30408 |
Miscellaneous databases
Pharosi | P25791, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3217402 |
Genetic variation databases
BioMutai | LMO2 |
DMDMi | 132533 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075896 | 1 – 158 | Rhombotin-2Add BLAST | 158 |
Proteomic databases
jPOSTi | P25791 |
MassIVEi | P25791 |
MaxQBi | P25791 |
PaxDbi | P25791 |
PeptideAtlasi | P25791 |
PRIDEi | P25791 |
ProteomicsDBi | 54294 [P25791-1] 54295 [P25791-3] |
PTM databases
iPTMneti | P25791 |
PhosphoSitePlusi | P25791 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135363, Expressed in metanephric glomerulus and 247 other tissues |
Genevisiblei | P25791, HS |
Organism-specific databases
HPAi | ENSG00000135363, Low tissue specificity |
Interactioni
Subunit structurei
Interacts via its LIM domains with ELF2 and LDB1.
Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity).
Interacts with BEX2 and KDM5A.
By similarity2 PublicationsBinary interactionsi
P25791
LMO2 - isoform 3 [P25791-3]
GO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- identical protein binding Source: IntAct
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- transcription coregulator binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 110191, 251 interactors |
CORUMi | P25791 |
IntActi | P25791, 227 interactors |
MINTi | P25791 |
STRINGi | 9606.ENSP00000257818 |
Miscellaneous databases
RNActi | P25791, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P25791 |
BMRBi | P25791 |
SMRi | P25791 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25791 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 89 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 94 – 153 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 |
Domaini
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160199 |
HOGENOMi | CLU_3031687_0_0_1 |
InParanoidi | P25791 |
OMAi | TTSSECR |
OrthoDBi | 1307952at2759 |
PhylomeDBi | P25791 |
TreeFami | TF351071 |
Family and domain databases
IDEALi | IID00268 |
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW
60 70 80 90 100
HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR
110 120 130 140 150
IRAYEMTMRV KDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIYE
WTKINGMI
The sequence of this isoform differs from the canonical sequence as follows:
15-15: E → SLKGSQVRCPVWPKTISDPRCWSHSGEAVPDAWPSLQGTSG
16-158: Missing.
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038961 | 1 | M → MEGSAVTVLERGGASSPAER RSKRRRRSGGDGGGGGGARA PEGVRAPAAGQPRATKGAPP PPGTPPPSPM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_038962 | 15 | E → SLKGSQVRCPVWPKTISDPR CWSHSGEAVPDAWPSLQGTS G in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_038963 | 16 – 158 | Missing in isoform 2. 1 PublicationAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61118 mRNA Translation: CAA43430.1 Frameshift. BC034041 mRNA Translation: AAH34041.1 BC035607 mRNA Translation: AAH35607.1 BC042426 mRNA Translation: AAH42426.1 BC073973 mRNA Translation: AAH73973.1 Sequence problems. AF257211 mRNA Translation: AAF98804.1 Sequence problems. |
CCDSi | CCDS44567.1 [P25791-1] CCDS7888.2 [P25791-3] |
PIRi | S29477 |
RefSeqi | NP_001135787.1, NM_001142315.1 [P25791-1] NP_001135788.1, NM_001142316.1 [P25791-1] NP_005565.2, NM_005574.3 [P25791-3] XP_005252978.1, XM_005252921.2 [P25791-1] XP_016873216.1, XM_017017727.1 [P25791-1] XP_016873217.1, XM_017017728.1 [P25791-1] XP_016873218.1, XM_017017729.1 [P25791-1] XP_016873219.1, XM_017017730.1 [P25791-1] XP_016873220.1, XM_017017731.1 [P25791-1] XP_016873221.1, XM_017017732.1 [P25791-1] XP_016873222.1, XM_017017733.1 [P25791-1] |
Genome annotation databases
Ensembli | ENST00000257818.3; ENSP00000257818.2; ENSG00000135363.12 [P25791-3] ENST00000395833.7; ENSP00000379175.3; ENSG00000135363.12 ENST00000411482.1; ENSP00000401967.1; ENSG00000135363.12 [P25791-4] |
GeneIDi | 4005 |
KEGGi | hsa:4005 |
MANE-Selecti | ENST00000257818.3; ENSP00000257818.2; NM_005574.4; NP_005565.2 [P25791-3] |
UCSCi | uc001mve.5, human [P25791-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61118 mRNA Translation: CAA43430.1 Frameshift. BC034041 mRNA Translation: AAH34041.1 BC035607 mRNA Translation: AAH35607.1 BC042426 mRNA Translation: AAH42426.1 BC073973 mRNA Translation: AAH73973.1 Sequence problems. AF257211 mRNA Translation: AAF98804.1 Sequence problems. |
CCDSi | CCDS44567.1 [P25791-1] CCDS7888.2 [P25791-3] |
PIRi | S29477 |
RefSeqi | NP_001135787.1, NM_001142315.1 [P25791-1] NP_001135788.1, NM_001142316.1 [P25791-1] NP_005565.2, NM_005574.3 [P25791-3] XP_005252978.1, XM_005252921.2 [P25791-1] XP_016873216.1, XM_017017727.1 [P25791-1] XP_016873217.1, XM_017017728.1 [P25791-1] XP_016873218.1, XM_017017729.1 [P25791-1] XP_016873219.1, XM_017017730.1 [P25791-1] XP_016873220.1, XM_017017731.1 [P25791-1] XP_016873221.1, XM_017017732.1 [P25791-1] XP_016873222.1, XM_017017733.1 [P25791-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XJY | X-ray | 2.40 | A | 26-156 | [»] | |
2XJZ | X-ray | 2.80 | A/B/C/D/E | 26-156 | [»] | |
2YPA | X-ray | 2.80 | C | 25-156 | [»] | |
4KFZ | X-ray | 2.80 | A/B | 9-158 | [»] | |
AlphaFoldDBi | P25791 | |||||
BMRBi | P25791 | |||||
SMRi | P25791 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110191, 251 interactors |
CORUMi | P25791 |
IntActi | P25791, 227 interactors |
MINTi | P25791 |
STRINGi | 9606.ENSP00000257818 |
Chemistry databases
ChEMBLi | CHEMBL3217402 |
PTM databases
iPTMneti | P25791 |
PhosphoSitePlusi | P25791 |
Genetic variation databases
BioMutai | LMO2 |
DMDMi | 132533 |
Proteomic databases
jPOSTi | P25791 |
MassIVEi | P25791 |
MaxQBi | P25791 |
PaxDbi | P25791 |
PeptideAtlasi | P25791 |
PRIDEi | P25791 |
ProteomicsDBi | 54294 [P25791-1] 54295 [P25791-3] |
Protocols and materials databases
ABCDi | P25791, 1 sequenced antibody |
Antibodypediai | 4265, 737 antibodies from 42 providers |
DNASUi | 4005 |
Genome annotation databases
Ensembli | ENST00000257818.3; ENSP00000257818.2; ENSG00000135363.12 [P25791-3] ENST00000395833.7; ENSP00000379175.3; ENSG00000135363.12 ENST00000411482.1; ENSP00000401967.1; ENSG00000135363.12 [P25791-4] |
GeneIDi | 4005 |
KEGGi | hsa:4005 |
MANE-Selecti | ENST00000257818.3; ENSP00000257818.2; NM_005574.4; NP_005565.2 [P25791-3] |
UCSCi | uc001mve.5, human [P25791-1] |
Organism-specific databases
CTDi | 4005 |
DisGeNETi | 4005 |
GeneCardsi | LMO2 |
HGNCi | HGNC:6642, LMO2 |
HPAi | ENSG00000135363, Low tissue specificity |
MIMi | 180385, gene |
neXtProti | NX_P25791 |
OpenTargetsi | ENSG00000135363 |
PharmGKBi | PA30408 |
VEuPathDBi | HostDB:ENSG00000135363 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160199 |
HOGENOMi | CLU_3031687_0_0_1 |
InParanoidi | P25791 |
OMAi | TTSSECR |
OrthoDBi | 1307952at2759 |
PhylomeDBi | P25791 |
TreeFami | TF351071 |
Enzyme and pathway databases
PathwayCommonsi | P25791 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P25791 |
SIGNORi | P25791 |
Miscellaneous databases
BioGRID-ORCSi | 4005, 40 hits in 1086 CRISPR screens |
ChiTaRSi | LMO2, human |
EvolutionaryTracei | P25791 |
GeneWikii | LMO2 |
GenomeRNAii | 4005 |
Pharosi | P25791, Tbio |
PROi | PR:P25791 |
RNActi | P25791, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135363, Expressed in metanephric glomerulus and 247 other tissues |
Genevisiblei | P25791, HS |
Family and domain databases
IDEALi | IID00268 |
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RBTN2_HUMAN | |
Accessioni | P25791Primary (citable) accession number: P25791 Secondary accession number(s): Q9HD58 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references