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Entry version 232 (07 Oct 2020)
Sequence version 1 (01 May 1992)
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Protein

Proteasome subunit alpha type-1

Gene

PSMA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P25786

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534, Vpu mediated degradation of CD4
R-HSA-180585, Vif-mediated degradation of APOBEC3G
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-202424, Downstream TCR signaling
R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562, Regulation of ornithine decarboxylase (ODC)
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641257, Degradation of AXIN
R-HSA-4641258, Degradation of DVL
R-HSA-5358346, Hedgehog ligand biogenesis
R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684, Hedgehog 'on' state
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-5678895, Defective CFTR causes cystic fibrosis
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-5689603, UCH proteinases
R-HSA-5689880, Ub-specific processing proteases
R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949, Orc1 removal from chromatin
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481, G2/M Checkpoints
R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-8951664, Neddylation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

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MEROPSi
T01.976

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome subunit alpha type-1
Alternative name(s):
30 kDa prosomal protein
Short name:
PROS-30
Macropain subunit C2
Multicatalytic endopeptidase complex subunit C2
Proteasome component C2
Proteasome nu chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSMA1
Synonyms:HC2, NU, PROS30, PSC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000129084.17

Human Gene Nomenclature Database

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HGNCi
HGNC:9530, PSMA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602854, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P25786

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
5682

Open Targets

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OpenTargetsi
ENSG00000129084

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33875

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P25786, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2364701
CHEMBL3831201

Drug and drug target database

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DrugBanki
DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE

DrugCentral

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DrugCentrali
P25786

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PSMA1

Domain mapping of disease mutations (DMDM)

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DMDMi
130848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001240601 – 263Proteasome subunit alpha type-1Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei110Phosphoserine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110O-linked (GlcNAc) serine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei177PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P25786

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P25786

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P25786

MaxQB - The MaxQuant DataBase

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MaxQBi
P25786

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P25786

PeptideAtlas

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PeptideAtlasi
P25786

PRoteomics IDEntifications database

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PRIDEi
P25786

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54287 [P25786-1]
54288 [P25786-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P25786-1 [P25786-1]

2D gel databases

USC-OGP 2-DE database

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OGPi
P25786

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00016832

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P25786, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P25786

MetOSite database of methionine sulfoxide sites

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MetOSitei
P25786

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P25786

SwissPalm database of S-palmitoylation events

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SwissPalmi
P25786

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in breast cancer tissue (at protein level). Up-regulated in liver tumor tissues.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000129084, Expressed in left adrenal gland and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P25786, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P25786, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000129084, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

Interacts with NOTCH3.

Interacts with ZFAND1 (PubMed:29804830).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P25786
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-359352,EBI-11096309
ABI3 [Q9P2A4]3EBI-359352,EBI-742038
ACTN2 [P35609]3EBI-359352,EBI-77797
AGR2 [O95994]3EBI-359352,EBI-712648
APIP [Q96GX9]3EBI-359352,EBI-359248
BANF2 - isoform 2 [Q9H503-2]6EBI-359352,EBI-11977289
BLZF1 [Q9H2G9]3EBI-359352,EBI-2548012
C22orf39 [Q6P5X5]3EBI-359352,EBI-7317823
CABP5 [Q9NP86]3EBI-359352,EBI-10311131
CALCOCO2 [Q13137]4EBI-359352,EBI-739580
CBS [P35520]4EBI-359352,EBI-740135
CCDC102B [Q68D86]6EBI-359352,EBI-10171570
CCDC153 - isoform 2 [Q494R4-2]3EBI-359352,EBI-11974185
CCNH [P51946]9EBI-359352,EBI-741406
CDA [P32320]3EBI-359352,EBI-9250559
CDKN2D [P55273]3EBI-359352,EBI-745859
CDR2 [Q01850]3EBI-359352,EBI-1181367
CEP70 [Q8NHQ1]6EBI-359352,EBI-739624
CEP72 [Q9P209]5EBI-359352,EBI-739498
CFAP206 [Q8IYR0]3EBI-359352,EBI-749051
CHMP1A [Q9HD42]3EBI-359352,EBI-1057156
CINP [Q9BW66]3EBI-359352,EBI-739784
COG4 [Q9H9E3]3EBI-359352,EBI-368382
COG6 [Q9Y2V7]3EBI-359352,EBI-3866319
CRX [O43186]3EBI-359352,EBI-748171
DCTD [P32321]3EBI-359352,EBI-739870
DCTPP1 [Q9H773]3EBI-359352,EBI-723569
DDIT4L [Q96D03]3EBI-359352,EBI-742054
DEF6 [Q9H4E7]3EBI-359352,EBI-745369
DYDC1 [Q8WWB3]3EBI-359352,EBI-740680
DYNLT1 [P63172]3EBI-359352,EBI-1176455
EHMT2 [A2ABF9]3EBI-359352,EBI-10174566
EIF4A3 [P38919]3EBI-359352,EBI-299104
EMSY - isoform 5 [Q7Z589-5]3EBI-359352,EBI-11989522
FNDC11 [Q9BVV2]5EBI-359352,EBI-744935
GNPTAB [Q3T906]3EBI-359352,EBI-1104907
GOLGA2 [Q08379]6EBI-359352,EBI-618309
GOLGA6A [Q9NYA3]3EBI-359352,EBI-11163335
GPHN - isoform 2 [Q9NQX3-2]3EBI-359352,EBI-11043087
GSDMD [P57764]3EBI-359352,EBI-2798865
GUCD1 - isoform 2 [Q96NT3-2]3EBI-359352,EBI-11978177
HEL-S-70 [V9HW80]3EBI-359352,EBI-10175326
HEXIM2 [Q96MH2]3EBI-359352,EBI-5460660
HOMER3 [Q9NSC5]11EBI-359352,EBI-748420
HOOK2 - isoform 2 [Q96ED9-2]3EBI-359352,EBI-10961706
HOXC11 [O43248]3EBI-359352,EBI-2652631
HSD17B14 [Q9BPX1]3EBI-359352,EBI-742664
HSF2BP [O75031]3EBI-359352,EBI-7116203
IFT20 [Q8IY31]3EBI-359352,EBI-744203
IKZF1 [Q13422]3EBI-359352,EBI-745305
IKZF3 [Q9UKT9]3EBI-359352,EBI-747204
INO80E [Q8NBZ0]3EBI-359352,EBI-769401
IPO13 [O94829]3EBI-359352,EBI-747310
KAZN - isoform 2 [Q674X7-2]6EBI-359352,EBI-12024294
KCTD1 [Q719H9]3EBI-359352,EBI-9027502
KCTD13 [Q8WZ19]3EBI-359352,EBI-742916
KCTD6 [Q8NC69]6EBI-359352,EBI-2511344
KCTD7 - isoform 2 [Q96MP8-2]3EBI-359352,EBI-11954971
KCTD9 [Q7L273]6EBI-359352,EBI-4397613
KHDRBS3 [O75525]3EBI-359352,EBI-722504
KRT13 [P13646]3EBI-359352,EBI-1223876
KRT15 [P19012]4EBI-359352,EBI-739566
KRT19 [P08727]3EBI-359352,EBI-742756
KRT31 [Q15323]3EBI-359352,EBI-948001
KRT34 [O76011]3EBI-359352,EBI-1047093
KRT37 [O76014]3EBI-359352,EBI-1045716
KRT38 [O76015]6EBI-359352,EBI-1047263
KRT40 [Q6A162]3EBI-359352,EBI-10171697
KRTAP1-1 [Q07627]3EBI-359352,EBI-11959885
KRTAP4-1 [A0A087WY89]3EBI-359352,EBI-11957260
KRTAP5-9 [P26371]6EBI-359352,EBI-3958099
LDOC1 [O95751]8EBI-359352,EBI-740738
LMO2 - isoform 3 [P25791-3]3EBI-359352,EBI-11959475
LONRF1 [Q17RB8]3EBI-359352,EBI-2341787
LZTFL1 [Q9NQ48]3EBI-359352,EBI-2824799
LZTS1 [Q9Y250]3EBI-359352,EBI-1216080
LZTS2 [Q9BRK4]3EBI-359352,EBI-741037
MAD1L1 [Q9Y6D9]3EBI-359352,EBI-742610
MAPK1 [P28482]3EBI-359352,EBI-959949
MAPRE1 [Q15691]6EBI-359352,EBI-1004115
MAPRE3 [Q9UPY8]4EBI-359352,EBI-726739
MID2 - isoform 2 [Q9UJV3-2]6EBI-359352,EBI-10172526
MIEF1 [Q9NQG6]3EBI-359352,EBI-740987
MKNK2 - isoform 2 [Q9HBH9-2]3EBI-359352,EBI-14141314
MKRN3 [Q13064]6EBI-359352,EBI-2340269
MLH1 [P40692]5EBI-359352,EBI-744248
MRFAP1L1 [Q96HT8]4EBI-359352,EBI-748896
MSANTD4 [Q8NCY6]3EBI-359352,EBI-7850168
MTUS2 [Q5JR59]6EBI-359352,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-359352,EBI-11522433
NAB2 [Q15742]3EBI-359352,EBI-8641936
NME7 [Q9Y5B8]3EBI-359352,EBI-744782
NOTCH2NLA [Q7Z3S9]3EBI-359352,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-359352,EBI-22310682
PCBD1 [P61457]3EBI-359352,EBI-740475
PCYT2 [Q99447]3EBI-359352,EBI-750317
PICK1 [Q9NRD5]3EBI-359352,EBI-79165
PM20D2 [Q8IYS1]3EBI-359352,EBI-11339910
PNMA1 [Q8ND90]6EBI-359352,EBI-302345
PNMA2 [Q9UL42]4EBI-359352,EBI-302355
PNMA5 [Q96PV4]3EBI-359352,EBI-10171633
POLR1C [O15160]3EBI-359352,EBI-1055079
PRDM14 [Q9GZV8]3EBI-359352,EBI-3957793
PRIMPOL [Q96LW4]3EBI-359352,EBI-10044038
PRPH [P41219]3EBI-359352,EBI-752074
PSMA2 [P25787]12EBI-359352,EBI-603262
PSMA3 [P25788]15EBI-359352,EBI-348380
PSMA4 [P25789]8EBI-359352,EBI-359310
PSMA7 [O14818]15EBI-359352,EBI-603272
PSMB1 [P20618]9EBI-359352,EBI-372273
PSMB2 [P49721]8EBI-359352,EBI-359335
RBCK1 [Q9BYM8]3EBI-359352,EBI-2340624
REL [Q04864]3EBI-359352,EBI-307352
RFC2 - isoform 2 [P35250-2]3EBI-359352,EBI-12936957
RGS19 [P49795]3EBI-359352,EBI-874907
ROPN1 [Q9HAT0]6EBI-359352,EBI-1378139
SAT1 [P21673]3EBI-359352,EBI-711613
SH3GLB1 [Q9Y371]3EBI-359352,EBI-2623095
SLF2 [Q8IX21]3EBI-359352,EBI-2682240
SPDEF [O95238]3EBI-359352,EBI-12811275
SSX2IP [Q9Y2D8]3EBI-359352,EBI-2212028
TCF12 [Q99081]4EBI-359352,EBI-722877
TCF4 [P15884]3EBI-359352,EBI-533224
TEKT4 [Q8WW24]3EBI-359352,EBI-750487
TNFAIP1 [Q13829]3EBI-359352,EBI-2505861
TNR [A1L306]3EBI-359352,EBI-10182881
TRAF1 [Q13077]3EBI-359352,EBI-359224
TRAF5 [O00463]3EBI-359352,EBI-523498
TRIM10 [Q9UDY6]4EBI-359352,EBI-6427325
TRIM23 [P36406]5EBI-359352,EBI-740098
TRIM27 [P14373]6EBI-359352,EBI-719493
TRIM42 [Q8IWZ5]3EBI-359352,EBI-5235829
TRIM54 [Q9BYV2]3EBI-359352,EBI-2130429
UBXN11 [Q5T124]3EBI-359352,EBI-746004
UBXN11 - isoform 6 [Q5T124-6]3EBI-359352,EBI-11524408
VCP [P55072]3EBI-359352,EBI-355164
VMAC [Q2NL98]3EBI-359352,EBI-2803134
WTAP [Q15007]3EBI-359352,EBI-751647
YPEL5 [P62699]3EBI-359352,EBI-11721624
ZMYND19 [Q96E35]3EBI-359352,EBI-746595

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111655, 344 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P25786

Database of interacting proteins

More...
DIPi
DIP-29369N

Protein interaction database and analysis system

More...
IntActi
P25786, 231 interactors

Molecular INTeraction database

More...
MINTi
P25786

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000414359

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P25786

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P25786, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25786

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0863, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074855

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035750_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25786

KEGG Orthology (KO)

More...
KOi
K02725

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQEMVAC

Database of Orthologous Groups

More...
OrthoDBi
1222564at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25786

TreeFam database of animal gene trees

More...
TreeFami
TF106206

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03749, proteasome_alpha_type_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR023332, Proteasome_alpha-type
IPR035144, Proteasome_alpha1
IPR000426, Proteasome_asu_N
IPR001353, Proteasome_sua/b

The PANTHER Classification System

More...
PANTHERi
PTHR11599:SF12, PTHR11599:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00227, Proteasome, 1 hit
PF10584, Proteasome_A_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00948, Proteasome_A_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00388, PROTEASOME_ALPHA_1, 1 hit
PS51475, PROTEASOME_ALPHA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Short (identifier: P25786-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK
60 70 80 90 100
RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD
110 120 130 140 150
RPLPVSRLVS LIGSKTQIPT QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS
160 170 180 190 200
ANYFDCRAMS IGARSQSART YLERHMSEFM ECNLNELVKH GLRALRETLP
210 220 230 240 250
AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP QRKAQPAQPA
260
DEPAEKADEP MEH
Length:263
Mass (Da):29,556
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F159C5BCEFE8DED
GO
Isoform Long (identifier: P25786-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQLSKVK

Show »
Length:269
Mass (Da):30,239
Checksum:iDB7435F82890F923
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX11F5GX11_HUMAN
Proteasome endopeptidase complex
PSMA1
238Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H112F5H112_HUMAN
Proteasome subunit alpha type-1
PSMA1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14 – 15SP → TA in AAA92734 (PubMed:1398136).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06745437G → V2 PublicationsCorresponds to variant dbSNP:rs17850016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0052791M → MQLSKVK in isoform Long. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X61969 mRNA Translation: CAA43961.1
D00759 mRNA Translation: BAA00656.1
M64992 mRNA Translation: AAA92734.1
BT006647 mRNA Translation: AAP35293.1
AK290765 mRNA Translation: BAF83454.1
CH471064 Genomic DNA Translation: EAW68479.1
BC002577 mRNA Translation: AAH02577.1
BC005932 mRNA Translation: AAH05932.1
BC008472 mRNA Translation: AAH08472.1
BC009576 mRNA Translation: AAH09576.1
BC015105 mRNA Translation: AAH15105.1
BC015356 mRNA Translation: AAH15356.1
BC022372 mRNA Translation: AAH22372.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31431.1 [P25786-2]
CCDS7816.1 [P25786-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC1445

NCBI Reference Sequences

More...
RefSeqi
NP_002777.1, NM_002786.3 [P25786-1]
NP_683877.1, NM_148976.2 [P25786-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396394; ENSP00000379676; ENSG00000129084 [P25786-1]
ENST00000418988; ENSP00000414359; ENSG00000129084 [P25786-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5682

UCSC genome browser

More...
UCSCi
uc001mlk.4, human [P25786-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61969 mRNA Translation: CAA43961.1
D00759 mRNA Translation: BAA00656.1
M64992 mRNA Translation: AAA92734.1
BT006647 mRNA Translation: AAP35293.1
AK290765 mRNA Translation: BAF83454.1
CH471064 Genomic DNA Translation: EAW68479.1
BC002577 mRNA Translation: AAH02577.1
BC005932 mRNA Translation: AAH05932.1
BC008472 mRNA Translation: AAH08472.1
BC009576 mRNA Translation: AAH09576.1
BC015105 mRNA Translation: AAH15105.1
BC015356 mRNA Translation: AAH15356.1
BC022372 mRNA Translation: AAH22372.1
CCDSiCCDS31431.1 [P25786-2]
CCDS7816.1 [P25786-1]
PIRiJC1445
RefSeqiNP_002777.1, NM_002786.3 [P25786-1]
NP_683877.1, NM_148976.2 [P25786-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R3OX-ray2.60F/T4-241[»]
4R67X-ray2.89F/T/h/v4-241[»]
5A0Qelectron microscopy3.50F/T1-263[»]
5GJQelectron microscopy4.50G/m1-263[»]
5GJRelectron microscopy3.50G/m1-263[»]
5L4Gelectron microscopy4.02F/S1-263[»]
5LE5X-ray1.80E/S1-263[»]
5LEXX-ray2.20E/S1-263[»]
5LEYX-ray1.90E/S1-263[»]
5LEZX-ray2.19E/S1-263[»]
5LF0X-ray2.41E/S1-263[»]
5LF1X-ray2.00E/S1-263[»]
5LF3X-ray2.10E/S1-263[»]
5LF4X-ray1.99E/S1-263[»]
5LF6X-ray2.07E/S1-263[»]
5LF7X-ray2.00E/S1-263[»]
5LN3electron microscopy6.80F1-263[»]
5M32electron microscopy3.80E/S2-239[»]
5T0Celectron microscopy3.80AL/BL2-263[»]
5T0Gelectron microscopy4.40L2-263[»]
5T0Helectron microscopy6.80L2-263[»]
5T0Ielectron microscopy8.00L2-263[»]
5T0Jelectron microscopy8.00L2-263[»]
5VFOelectron microscopy3.50L/l4-241[»]
5VFPelectron microscopy4.20L/l4-241[»]
5VFQelectron microscopy4.20L/l4-241[»]
5VFRelectron microscopy4.90L/l4-241[»]
5VFSelectron microscopy3.60L/l4-241[»]
5VFTelectron microscopy7.00L/l4-241[»]
5VFUelectron microscopy5.80L/l4-241[»]
6AVOelectron microscopy3.80G/L1-263[»]
6E5BX-ray2.77E/S1-263[»]
6KWYelectron microscopy2.72E/S1-263[»]
6MSBelectron microscopy3.00L/l2-263[»]
6MSDelectron microscopy3.20L/l2-263[»]
6MSEelectron microscopy3.30Z56-234[»]
6MSGelectron microscopy3.50L/l2-263[»]
6MSHelectron microscopy3.60L/l2-263[»]
6MSJelectron microscopy3.30L/l2-263[»]
6MSKelectron microscopy3.20L/l2-263[»]
6R70electron microscopy3.50E/S2-239[»]
6REYelectron microscopy3.00F/T1-263[»]
6RGQelectron microscopy2.60F/T1-263[»]
6XMJelectron microscopy3.00F4-241[»]
SMRiP25786
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111655, 344 interactors
CORUMiP25786
DIPiDIP-29369N
IntActiP25786, 231 interactors
MINTiP25786
STRINGi9606.ENSP00000414359

Chemistry databases

BindingDBiP25786
ChEMBLiCHEMBL2364701
CHEMBL3831201
DrugBankiDB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
DrugCentraliP25786

Protein family/group databases

MEROPSiT01.976

PTM databases

GlyGeniP25786, 1 site
iPTMnetiP25786
MetOSiteiP25786
PhosphoSitePlusiP25786
SwissPalmiP25786

Polymorphism and mutation databases

BioMutaiPSMA1
DMDMi130848

2D gel databases

OGPiP25786
REPRODUCTION-2DPAGEiIPI00016832

Proteomic databases

EPDiP25786
jPOSTiP25786
MassIVEiP25786
MaxQBiP25786
PaxDbiP25786
PeptideAtlasiP25786
PRIDEiP25786
ProteomicsDBi54287 [P25786-1]
54288 [P25786-2]
TopDownProteomicsiP25786-1 [P25786-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11977, 341 antibodies

The DNASU plasmid repository

More...
DNASUi
5682

Genome annotation databases

EnsembliENST00000396394; ENSP00000379676; ENSG00000129084 [P25786-1]
ENST00000418988; ENSP00000414359; ENSG00000129084 [P25786-2]
GeneIDi5682
KEGGihsa:5682
UCSCiuc001mlk.4, human [P25786-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5682
DisGeNETi5682
EuPathDBiHostDB:ENSG00000129084.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSMA1
HGNCiHGNC:9530, PSMA1
HPAiENSG00000129084, Low tissue specificity
MIMi602854, gene
neXtProtiNX_P25786
OpenTargetsiENSG00000129084
PharmGKBiPA33875

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0863, Eukaryota
GeneTreeiENSGT00550000074855
HOGENOMiCLU_035750_8_0_1
InParanoidiP25786
KOiK02725
OMAiTQEMVAC
OrthoDBi1222564at2759
PhylomeDBiP25786
TreeFamiTF106206

Enzyme and pathway databases

PathwayCommonsiP25786
ReactomeiR-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534, Vpu mediated degradation of CD4
R-HSA-180585, Vif-mediated degradation of APOBEC3G
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253, Degradation of beta-catenin by the destruction complex
R-HSA-202424, Downstream TCR signaling
R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562, Regulation of ornithine decarboxylase (ODC)
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641257, Degradation of AXIN
R-HSA-4641258, Degradation of DVL
R-HSA-5358346, Hedgehog ligand biogenesis
R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-5610780, Degradation of GLI1 by the proteasome
R-HSA-5610783, Degradation of GLI2 by the proteasome
R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684, Hedgehog 'on' state
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-5678895, Defective CFTR causes cystic fibrosis
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-5689603, UCH proteinases
R-HSA-5689880, Ub-specific processing proteases
R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949, Orc1 removal from chromatin
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69481, G2/M Checkpoints
R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902, Regulation of RUNX2 expression and activity
R-HSA-8941858, Regulation of RUNX3 expression and activity
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-8951664, Neddylation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9020702, Interleukin-1 signaling
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5682, 749 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PSMA1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Proteasome_(prosome,_macropain)_subunit,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5682
PharosiP25786, Tclin

Protein Ontology

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PROi
PR:P25786
RNActiP25786, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000129084, Expressed in left adrenal gland and 126 other tissues
ExpressionAtlasiP25786, baseline and differential
GenevisibleiP25786, HS

Family and domain databases

CDDicd03749, proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR023332, Proteasome_alpha-type
IPR035144, Proteasome_alpha1
IPR000426, Proteasome_asu_N
IPR001353, Proteasome_sua/b
PANTHERiPTHR11599:SF12, PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227, Proteasome, 1 hit
PF10584, Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948, Proteasome_A_N, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388, PROTEASOME_ALPHA_1, 1 hit
PS51475, PROTEASOME_ALPHA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25786
Secondary accession number(s): A8K400, Q53YE8, Q9BRV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 7, 2020
This is version 232 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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