UniProtKB - P25786 (PSA1_HUMAN)
Proteasome subunit alpha type-1
PSMA1
Functioni
GO - Molecular functioni
- endopeptidase activity Source: GO_Central
- lipopolysaccharide binding Source: Ensembl
- RNA binding Source: ProtInc
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasomal protein catabolic process Source: GO_Central
- proteasomal ubiquitin-independent protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | P25786 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Protein family/group databases
MEROPSi | T01.976 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alpha type-1Alternative name(s): 30 kDa prosomal protein Short name: PROS-30 Macropain subunit C2 Multicatalytic endopeptidase complex subunit C2 Proteasome component C2 Proteasome nu chain |
Gene namesi | Name:PSMA1 Synonyms:HC2, NU, PROS30, PSC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000129084.17 |
HGNCi | HGNC:9530, PSMA1 |
MIMi | 602854, gene |
neXtProti | NX_P25786 |
Subcellular locationi
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- polysome Source: ProtInc
- proteasome complex Source: UniProtKB
- proteasome core complex Source: UniProtKB
- proteasome core complex, alpha-subunit complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5682 |
OpenTargetsi | ENSG00000129084 |
PharmGKBi | PA33875 |
Miscellaneous databases
Pharosi | P25786, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
DrugCentrali | P25786 |
Polymorphism and mutation databases
BioMutai | PSMA1 |
DMDMi | 130848 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124060 | 1 – 263 | Proteasome subunit alpha type-1Add BLAST | 263 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 110 | Phosphoserine; alternateCombined sources | 1 | |
Glycosylationi | 110 | O-linked (GlcNAc) serine; alternateBy similarity | 1 | |
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 177 | PhosphoserineCombined sources | 1 | |
Cross-linki | 208 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P25786 |
jPOSTi | P25786 |
MassIVEi | P25786 |
MaxQBi | P25786 |
PaxDbi | P25786 |
PeptideAtlasi | P25786 |
PRIDEi | P25786 |
ProteomicsDBi | 54287 [P25786-1] 54288 [P25786-2] |
TopDownProteomicsi | P25786-1 [P25786-1] |
2D gel databases
OGPi | P25786 |
REPRODUCTION-2DPAGEi | IPI00016832 |
PTM databases
GlyGeni | P25786, 1 site |
iPTMneti | P25786 |
MetOSitei | P25786 |
PhosphoSitePlusi | P25786 |
SwissPalmi | P25786 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000129084, Expressed in left adrenal gland and 126 other tissues |
ExpressionAtlasi | P25786, baseline and differential |
Genevisiblei | P25786, HS |
Organism-specific databases
HPAi | ENSG00000129084, Low tissue specificity |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
Interacts with NOTCH3.
Interacts with ZFAND1 (PubMed:29804830).
7 PublicationsBinary interactionsi
P25786
Protein-protein interaction databases
BioGRIDi | 111655, 348 interactors |
CORUMi | P25786 |
DIPi | DIP-29369N |
IntActi | P25786, 231 interactors |
MINTi | P25786 |
STRINGi | 9606.ENSP00000414359 |
Chemistry databases
BindingDBi | P25786 |
Miscellaneous databases
RNActi | P25786, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P25786 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0863, Eukaryota |
GeneTreei | ENSGT00550000074855 |
HOGENOMi | CLU_035750_8_0_1 |
InParanoidi | P25786 |
OMAi | TQEMVAC |
OrthoDBi | 1222564at2759 |
PhylomeDBi | P25786 |
TreeFami | TF106206 |
Family and domain databases
CDDi | cd03749, proteasome_alpha_type_1, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR035144, Proteasome_alpha1 IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b |
PANTHERi | PTHR11599:SF12, PTHR11599:SF12, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK
60 70 80 90 100
RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD
110 120 130 140 150
RPLPVSRLVS LIGSKTQIPT QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS
160 170 180 190 200
ANYFDCRAMS IGARSQSART YLERHMSEFM ECNLNELVKH GLRALRETLP
210 220 230 240 250
AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP QRKAQPAQPA
260
DEPAEKADEP MEH
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MQLSKVK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GX11 | F5GX11_HUMAN | Proteasome subunit alpha type-1 | PSMA1 | 238 | Annotation score: | ||
F5H112 | F5H112_HUMAN | Proteasome subunit alpha type-1 | PSMA1 | 14 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 – 15 | SP → TA in AAA92734 (PubMed:1398136).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067454 | 37 | G → V2 PublicationsCorresponds to variant dbSNP:rs17850016Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005279 | 1 | M → MQLSKVK in isoform Long. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61969 mRNA Translation: CAA43961.1 D00759 mRNA Translation: BAA00656.1 M64992 mRNA Translation: AAA92734.1 BT006647 mRNA Translation: AAP35293.1 AK290765 mRNA Translation: BAF83454.1 CH471064 Genomic DNA Translation: EAW68479.1 BC002577 mRNA Translation: AAH02577.1 BC005932 mRNA Translation: AAH05932.1 BC008472 mRNA Translation: AAH08472.1 BC009576 mRNA Translation: AAH09576.1 BC015105 mRNA Translation: AAH15105.1 BC015356 mRNA Translation: AAH15356.1 BC022372 mRNA Translation: AAH22372.1 |
CCDSi | CCDS31431.1 [P25786-2] CCDS7816.1 [P25786-1] |
PIRi | JC1445 |
RefSeqi | NP_002777.1, NM_002786.3 [P25786-1] NP_683877.1, NM_148976.2 [P25786-2] |
Genome annotation databases
Ensembli | ENST00000396394; ENSP00000379676; ENSG00000129084 [P25786-1] ENST00000418988; ENSP00000414359; ENSG00000129084 [P25786-2] |
GeneIDi | 5682 |
KEGGi | hsa:5682 |
UCSCi | uc001mlk.4, human [P25786-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61969 mRNA Translation: CAA43961.1 D00759 mRNA Translation: BAA00656.1 M64992 mRNA Translation: AAA92734.1 BT006647 mRNA Translation: AAP35293.1 AK290765 mRNA Translation: BAF83454.1 CH471064 Genomic DNA Translation: EAW68479.1 BC002577 mRNA Translation: AAH02577.1 BC005932 mRNA Translation: AAH05932.1 BC008472 mRNA Translation: AAH08472.1 BC009576 mRNA Translation: AAH09576.1 BC015105 mRNA Translation: AAH15105.1 BC015356 mRNA Translation: AAH15356.1 BC022372 mRNA Translation: AAH22372.1 |
CCDSi | CCDS31431.1 [P25786-2] CCDS7816.1 [P25786-1] |
PIRi | JC1445 |
RefSeqi | NP_002777.1, NM_002786.3 [P25786-1] NP_683877.1, NM_148976.2 [P25786-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3O | X-ray | 2.60 | F/T | 4-241 | [»] | |
4R67 | X-ray | 2.89 | F/T/h/v | 4-241 | [»] | |
5A0Q | electron microscopy | 3.50 | F/T | 1-263 | [»] | |
5GJQ | electron microscopy | 4.50 | G/m | 1-263 | [»] | |
5GJR | electron microscopy | 3.50 | G/m | 1-263 | [»] | |
5L4G | electron microscopy | 4.02 | F/S | 1-263 | [»] | |
5LE5 | X-ray | 1.80 | E/S | 1-263 | [»] | |
5LEX | X-ray | 2.20 | E/S | 1-263 | [»] | |
5LEY | X-ray | 1.90 | E/S | 1-263 | [»] | |
5LEZ | X-ray | 2.19 | E/S | 1-263 | [»] | |
5LF0 | X-ray | 2.41 | E/S | 1-263 | [»] | |
5LF1 | X-ray | 2.00 | E/S | 1-263 | [»] | |
5LF3 | X-ray | 2.10 | E/S | 1-263 | [»] | |
5LF4 | X-ray | 1.99 | E/S | 1-263 | [»] | |
5LF6 | X-ray | 2.07 | E/S | 1-263 | [»] | |
5LF7 | X-ray | 2.00 | E/S | 1-263 | [»] | |
5LN3 | electron microscopy | 6.80 | F | 1-263 | [»] | |
5M32 | electron microscopy | 3.80 | E/S | 2-239 | [»] | |
5T0C | electron microscopy | 3.80 | AL/BL | 2-263 | [»] | |
5T0G | electron microscopy | 4.40 | L | 2-263 | [»] | |
5T0H | electron microscopy | 6.80 | L | 2-263 | [»] | |
5T0I | electron microscopy | 8.00 | L | 2-263 | [»] | |
5T0J | electron microscopy | 8.00 | L | 2-263 | [»] | |
5VFO | electron microscopy | 3.50 | L/l | 4-241 | [»] | |
5VFP | electron microscopy | 4.20 | L/l | 4-241 | [»] | |
5VFQ | electron microscopy | 4.20 | L/l | 4-241 | [»] | |
5VFR | electron microscopy | 4.90 | L/l | 4-241 | [»] | |
5VFS | electron microscopy | 3.60 | L/l | 4-241 | [»] | |
5VFT | electron microscopy | 7.00 | L/l | 4-241 | [»] | |
5VFU | electron microscopy | 5.80 | L/l | 4-241 | [»] | |
6AVO | electron microscopy | 3.80 | G/L | 1-263 | [»] | |
6E5B | X-ray | 2.77 | E/S | 1-263 | [»] | |
6KWY | electron microscopy | 2.72 | E/S | 1-263 | [»] | |
6MSB | electron microscopy | 3.00 | L/l | 2-263 | [»] | |
6MSD | electron microscopy | 3.20 | L/l | 2-263 | [»] | |
6MSE | electron microscopy | 3.30 | Z | 56-234 | [»] | |
6MSG | electron microscopy | 3.50 | L/l | 2-263 | [»] | |
6MSH | electron microscopy | 3.60 | L/l | 2-263 | [»] | |
6MSJ | electron microscopy | 3.30 | L/l | 2-263 | [»] | |
6MSK | electron microscopy | 3.20 | L/l | 2-263 | [»] | |
6R70 | electron microscopy | 3.50 | E/S | 2-239 | [»] | |
6REY | electron microscopy | 3.00 | F/T | 1-263 | [»] | |
6RGQ | electron microscopy | 2.60 | F/T | 1-263 | [»] | |
6WJD | electron microscopy | 4.80 | L/l | 2-263 | [»] | |
6WJN | electron microscopy | 5.70 | L/l | 4-241 | [»] | |
6XMJ | electron microscopy | 3.00 | F | 4-241 | [»] | |
SMRi | P25786 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111655, 348 interactors |
CORUMi | P25786 |
DIPi | DIP-29369N |
IntActi | P25786, 231 interactors |
MINTi | P25786 |
STRINGi | 9606.ENSP00000414359 |
Chemistry databases
BindingDBi | P25786 |
ChEMBLi | CHEMBL2364701 CHEMBL3831201 |
DrugBanki | DB08515, (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE |
DrugCentrali | P25786 |
Protein family/group databases
MEROPSi | T01.976 |
PTM databases
GlyGeni | P25786, 1 site |
iPTMneti | P25786 |
MetOSitei | P25786 |
PhosphoSitePlusi | P25786 |
SwissPalmi | P25786 |
Polymorphism and mutation databases
BioMutai | PSMA1 |
DMDMi | 130848 |
2D gel databases
OGPi | P25786 |
REPRODUCTION-2DPAGEi | IPI00016832 |
Proteomic databases
EPDi | P25786 |
jPOSTi | P25786 |
MassIVEi | P25786 |
MaxQBi | P25786 |
PaxDbi | P25786 |
PeptideAtlasi | P25786 |
PRIDEi | P25786 |
ProteomicsDBi | 54287 [P25786-1] 54288 [P25786-2] |
TopDownProteomicsi | P25786-1 [P25786-1] |
Protocols and materials databases
Antibodypediai | 11977, 341 antibodies |
DNASUi | 5682 |
Genome annotation databases
Ensembli | ENST00000396394; ENSP00000379676; ENSG00000129084 [P25786-1] ENST00000418988; ENSP00000414359; ENSG00000129084 [P25786-2] |
GeneIDi | 5682 |
KEGGi | hsa:5682 |
UCSCi | uc001mlk.4, human [P25786-1] |
Organism-specific databases
CTDi | 5682 |
DisGeNETi | 5682 |
EuPathDBi | HostDB:ENSG00000129084.17 |
GeneCardsi | PSMA1 |
HGNCi | HGNC:9530, PSMA1 |
HPAi | ENSG00000129084, Low tissue specificity |
MIMi | 602854, gene |
neXtProti | NX_P25786 |
OpenTargetsi | ENSG00000129084 |
PharmGKBi | PA33875 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0863, Eukaryota |
GeneTreei | ENSGT00550000074855 |
HOGENOMi | CLU_035750_8_0_1 |
InParanoidi | P25786 |
OMAi | TQEMVAC |
OrthoDBi | 1222564at2759 |
PhylomeDBi | P25786 |
TreeFami | TF106206 |
Enzyme and pathway databases
PathwayCommonsi | P25786 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 5682, 750 hits in 848 CRISPR screens |
ChiTaRSi | PSMA1, human |
GeneWikii | Proteasome_(prosome,_macropain)_subunit,_alpha_1 |
GenomeRNAii | 5682 |
Pharosi | P25786, Tclin |
PROi | PR:P25786 |
RNActi | P25786, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129084, Expressed in left adrenal gland and 126 other tissues |
ExpressionAtlasi | P25786, baseline and differential |
Genevisiblei | P25786, HS |
Family and domain databases
CDDi | cd03749, proteasome_alpha_type_1, 1 hit |
Gene3Di | 3.60.20.10, 1 hit |
InterProi | View protein in InterPro IPR029055, Ntn_hydrolases_N IPR023332, Proteasome_alpha-type IPR035144, Proteasome_alpha1 IPR000426, Proteasome_asu_N IPR001353, Proteasome_sua/b |
PANTHERi | PTHR11599:SF12, PTHR11599:SF12, 1 hit |
Pfami | View protein in Pfam PF00227, Proteasome, 1 hit PF10584, Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948, Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235, SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388, PROTEASOME_ALPHA_1, 1 hit PS51475, PROTEASOME_ALPHA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSA1_HUMAN | |
Accessioni | P25786Primary (citable) accession number: P25786 Secondary accession number(s): A8K400, Q53YE8, Q9BRV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 233 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries