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Protein

Peptidase 1

Gene

EURM1

Organism
Euroglyphus maynei (Mayne's house dust mite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable thiol protease.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133By similarity1
Active sitei269By similarity1
Active sitei289By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.073

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase 1 (EC:3.4.22.65)
Alternative name(s):
Allergen Eur m I
Mite group 1 allergen Eur m 1
Allergen: Eur m 1
Gene namesi
Name:EURM1
OrganismiEuroglyphus maynei (Mayne's house dust mite)
Taxonomic identifieri6958 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaePyroglyphinaeEuroglyphus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1359 Eur m 1.0101
1360 Eur m 1.0102
338 Eur m 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002637819 – 98Add BLAST80
ChainiPRO_000002637999 – 321Peptidase 1Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 170By similarity
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP25780
SMRiP25780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25780-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIILAIASL LVLSAVYARP ASIKTFEEFK KAFNKTYATP EKEEVARKNF
60 70 80 90 100
LESLKYVESN KGAINHLSDL SLDEFKNQFL MNANAFEQLK TQFDLNAETY
110 120 130 140 150
ACSINSVSLP SELDLRSLRT VTPIRMQGGC GSCWAFSGVA STESAYLAYR
160 170 180 190 200
NMSLDLAEQE LVDCASQNGC HGDTIPRGIE YIQQNGVVQE HYYPYVAREQ
210 220 230 240 250
SCHRPNAQRY GLKNYCQISP PDSNKIRQAL TQTHTAVAVI IGIKDLNAFR
260 270 280 290 300
HYDGRTIMQH DNGYQPNYHA VNIVGYGNTQ GVDYWIVRNS WDTTWGDNGY
310 320
GYFAANINLM MIEQYPYVVM L
Length:321
Mass (Da):36,290
Last modified:June 20, 2001 - v2
Checksum:i6CFD44FEC725999E
GO

Sequence cautioni

The sequence AAC82352 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36T → S in Eur m 1.0102. 1
Natural varianti126M → N in Eur m 1.0102. 1
Natural varianti320M → I in Eur m 1.0102. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047610 mRNA Translation: AAC82351.1
AF047611 mRNA Translation: AAC82352.1 Different initiation.
AF047612 mRNA Translation: AAC82353.1
X60073 Genomic DNA Translation: CAA42677.1
PIRiS21864

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047610 mRNA Translation: AAC82351.1
AF047611 mRNA Translation: AAC82352.1 Different initiation.
AF047612 mRNA Translation: AAC82353.1
X60073 Genomic DNA Translation: CAA42677.1
PIRiS21864

3D structure databases

ProteinModelPortaliP25780
SMRiP25780
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1359 Eur m 1.0101
1360 Eur m 1.0102
338 Eur m 1
MEROPSiC01.073

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT1_EURMA
AccessioniPrimary (citable) accession number: P25780
Secondary accession number(s): Q9TZZ3, Q9TZZ4, Q9UBA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 20, 2001
Last modified: September 12, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Allergens
    Nomenclature of allergens and list of entries
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