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Entry version 190 (13 Feb 2019)
Sequence version 3 (21 Feb 2006)
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Protein

Cathepsin S

Gene

CTSS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. EC:3.4.22.27

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei139By similarity1
Active sitei278By similarity1
Active sitei298By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.27 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P25774

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I29.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin S (EC:3.4.22.27)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163131.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2545 CTSS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116845 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25774

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1520

Open Targets

More...
OpenTargetsi
ENSG00000163131

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27041

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2954

Drug and drug target database

More...
DrugBanki
DB08195 (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE
DB03837 Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide
DB03984 Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide
DB03767 Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide
DB08752 N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
DB08755 N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2353

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
88984046

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002631317 – 114Activation peptideAdd BLAST98
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000026314115 – 331Cathepsin SAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi126 ↔ 2241 Publication
Disulfide bondi136 ↔ 1801 Publication
Disulfide bondi170 ↔ 2131 Publication
Disulfide bondi272 ↔ 3201 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P25774

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P25774

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P25774

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25774

PeptideAtlas

More...
PeptideAtlasi
P25774

PRoteomics IDEntifications database

More...
PRIDEi
P25774

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54285
54286 [P25774-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25774

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P25774

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P25774

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163131 Expressed in 207 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P25774 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25774 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000460
HPA002988

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107900, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-61077N

Protein interaction database and analysis system

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IntActi
P25774, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357981

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P25774

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXFmodel-A115-331[»]
1GLOX-ray2.20A115-331[»]
1MS6X-ray1.90A115-331[»]
1NPZX-ray2.00A/B115-331[»]
1NQCX-ray1.80A115-331[»]
2C0YX-ray2.10A17-331[»]
2F1GX-ray1.90A/B112-331[»]
2FQ9X-ray1.65A/B114-331[»]
2FRAX-ray1.90A/B114-330[»]
2FRQX-ray1.60A/B114-331[»]
2FT2X-ray1.70A/B114-331[»]
2FUDX-ray1.95A/B114-331[»]
2FYEX-ray2.20A115-331[»]
2G6DX-ray2.50A115-331[»]
2G7YX-ray2.00A/B114-330[»]
2H7JX-ray1.50A/B112-331[»]
2HH5X-ray1.80A/B112-331[»]
2HHNX-ray1.55A/B112-331[»]
2HXZX-ray1.90A/B/C112-331[»]
2OP3X-ray1.60A/B112-331[»]
2R9MX-ray1.97A/B115-331[»]
2R9NX-ray2.00A/B115-331[»]
2R9OX-ray2.00A/B115-331[»]
3IEJX-ray2.18A/B115-331[»]
3N3GX-ray1.60A/B115-331[»]
3N4CX-ray1.90A/B115-331[»]
3OVXX-ray1.49A/B114-331[»]
4P6EX-ray1.80A/B109-331[»]
4P6GX-ray1.58A/B/C/D114-331[»]
5QBUX-ray2.78A/B114-331[»]
5QBVX-ray1.80A/B115-331[»]
5QBWX-ray3.01A114-331[»]
5QBXX-ray2.10A/B114-331[»]
5QBYX-ray2.25A/B114-331[»]
5QBZX-ray2.80A114-331[»]
5QC0X-ray1.90A/B114-331[»]
5QC1X-ray2.08A/B114-331[»]
5QC2X-ray2.26A/B114-331[»]
5QC3X-ray2.00A/B114-331[»]
5QC4X-ray2.00A/B115-331[»]
5QC5X-ray2.40A/B114-331[»]
5QC6X-ray2.10A/B114-331[»]
5QC7X-ray1.90A/B114-331[»]
5QC8X-ray1.74A/B114-331[»]
5QC9X-ray2.00A/B114-331[»]
5QCAX-ray2.29A/B114-331[»]
5QCBX-ray2.20A/B114-331[»]
5QCCX-ray1.80A/B114-331[»]
5QCDX-ray1.95A114-331[»]
5QCEX-ray2.78A/B114-331[»]
5QCFX-ray2.10A114-331[»]
5QCGX-ray2.69A/B114-331[»]
5QCHX-ray2.20A/B/C/D114-331[»]
5QCIX-ray2.18A114-331[»]
5QCJX-ray2.00A/B/C114-331[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P25774

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P25774

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P25774

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1543 Eukaryota
COG4870 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155176

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230774

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG011513

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25774

KEGG Orthology (KO)

More...
KOi
K01368

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYDPSCT

Database of Orthologous Groups

More...
OrthoDBi
1275401at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25774

TreeFam database of animal gene trees

More...
TreeFami
TF313739

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02248 Peptidase_C1A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29

The PANTHER Classification System

More...
PANTHERi
PTHR12411 PTHR12411, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00705 PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P25774-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL
60 70 80 90 100
IWEKNLKFVM LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ
110 120 130 140 150
WQRNITYKSN PNRILPDSVD WREKGCVTEV KYQGSCGACW AFSAVGALEA
160 170 180 190 200
QLKLKTGKLV SLSAQNLVDC STEKYGNKGC NGGFMTTAFQ YIIDNKGIDS
210 220 230 240 250
DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE AVANKGPVSV
260 270 280 290 300
GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW
310 320 330
GHNFGEEGYI RMARNKGNHC GIASFPSYPE I
Length:331
Mass (Da):37,496
Last modified:February 21, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86093619DB6F0269
GO
Isoform 2 (identifier: P25774-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-133: Missing.

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):31,626
Checksum:iC0445894FAD89713
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPS4U3KPS4_HUMAN
Cathepsin S
CTSS
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQE7U3KQE7_HUMAN
Cathepsin S
CTSS
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92M → T (PubMed:1373132).Curated1
Sequence conflicti92M → T (PubMed:8157683).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025385113R → W3 PublicationsCorresponds to variant dbSNP:rs2230061Ensembl.1
Natural variantiVAR_025386161S → T2 PublicationsCorresponds to variant dbSNP:rs1059604Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04271284 – 133Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S93414 mRNA Translation: AAB22005.1
M86553 mRNA Translation: AAA35655.1
M90696 mRNA Translation: AAC37592.1
U07374
, U07370, U07371, U07372, U07373 Genomic DNA Translation: AAB60643.2
CR541676 mRNA Translation: CAG46477.1
AK301472 mRNA Translation: BAG62991.1
AK314482 mRNA Translation: BAG37086.1
AL356292 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53518.1
CH471121 Genomic DNA Translation: EAW53519.1
BC002642 mRNA Translation: AAH02642.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55634.1 [P25774-2]
CCDS968.1 [P25774-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A42482

NCBI Reference Sequences

More...
RefSeqi
NP_001186668.1, NM_001199739.1 [P25774-2]
NP_004070.3, NM_004079.4 [P25774-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.181301

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368985; ENSP00000357981; ENSG00000163131 [P25774-1]
ENST00000448301; ENSP00000408414; ENSG00000163131 [P25774-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1520

UCSC genome browser

More...
UCSCi
uc001evn.3 human [P25774-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S93414 mRNA Translation: AAB22005.1
M86553 mRNA Translation: AAA35655.1
M90696 mRNA Translation: AAC37592.1
U07374
, U07370, U07371, U07372, U07373 Genomic DNA Translation: AAB60643.2
CR541676 mRNA Translation: CAG46477.1
AK301472 mRNA Translation: BAG62991.1
AK314482 mRNA Translation: BAG37086.1
AL356292 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53518.1
CH471121 Genomic DNA Translation: EAW53519.1
BC002642 mRNA Translation: AAH02642.1
CCDSiCCDS55634.1 [P25774-2]
CCDS968.1 [P25774-1]
PIRiA42482
RefSeqiNP_001186668.1, NM_001199739.1 [P25774-2]
NP_004070.3, NM_004079.4 [P25774-1]
UniGeneiHs.181301

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BXFmodel-A115-331[»]
1GLOX-ray2.20A115-331[»]
1MS6X-ray1.90A115-331[»]
1NPZX-ray2.00A/B115-331[»]
1NQCX-ray1.80A115-331[»]
2C0YX-ray2.10A17-331[»]
2F1GX-ray1.90A/B112-331[»]
2FQ9X-ray1.65A/B114-331[»]
2FRAX-ray1.90A/B114-330[»]
2FRQX-ray1.60A/B114-331[»]
2FT2X-ray1.70A/B114-331[»]
2FUDX-ray1.95A/B114-331[»]
2FYEX-ray2.20A115-331[»]
2G6DX-ray2.50A115-331[»]
2G7YX-ray2.00A/B114-330[»]
2H7JX-ray1.50A/B112-331[»]
2HH5X-ray1.80A/B112-331[»]
2HHNX-ray1.55A/B112-331[»]
2HXZX-ray1.90A/B/C112-331[»]
2OP3X-ray1.60A/B112-331[»]
2R9MX-ray1.97A/B115-331[»]
2R9NX-ray2.00A/B115-331[»]
2R9OX-ray2.00A/B115-331[»]
3IEJX-ray2.18A/B115-331[»]
3N3GX-ray1.60A/B115-331[»]
3N4CX-ray1.90A/B115-331[»]
3OVXX-ray1.49A/B114-331[»]
4P6EX-ray1.80A/B109-331[»]
4P6GX-ray1.58A/B/C/D114-331[»]
5QBUX-ray2.78A/B114-331[»]
5QBVX-ray1.80A/B115-331[»]
5QBWX-ray3.01A114-331[»]
5QBXX-ray2.10A/B114-331[»]
5QBYX-ray2.25A/B114-331[»]
5QBZX-ray2.80A114-331[»]
5QC0X-ray1.90A/B114-331[»]
5QC1X-ray2.08A/B114-331[»]
5QC2X-ray2.26A/B114-331[»]
5QC3X-ray2.00A/B114-331[»]
5QC4X-ray2.00A/B115-331[»]
5QC5X-ray2.40A/B114-331[»]
5QC6X-ray2.10A/B114-331[»]
5QC7X-ray1.90A/B114-331[»]
5QC8X-ray1.74A/B114-331[»]
5QC9X-ray2.00A/B114-331[»]
5QCAX-ray2.29A/B114-331[»]
5QCBX-ray2.20A/B114-331[»]
5QCCX-ray1.80A/B114-331[»]
5QCDX-ray1.95A114-331[»]
5QCEX-ray2.78A/B114-331[»]
5QCFX-ray2.10A114-331[»]
5QCGX-ray2.69A/B114-331[»]
5QCHX-ray2.20A/B/C/D114-331[»]
5QCIX-ray2.18A114-331[»]
5QCJX-ray2.00A/B/C114-331[»]
ProteinModelPortaliP25774
SMRiP25774
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107900, 3 interactors
DIPiDIP-61077N
IntActiP25774, 7 interactors
STRINGi9606.ENSP00000357981

Chemistry databases

BindingDBiP25774
ChEMBLiCHEMBL2954
DrugBankiDB08195 (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE
DB03837 Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide
DB03984 Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide
DB03767 Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide
DB08752 N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
DB08755 N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
GuidetoPHARMACOLOGYi2353

Protein family/group databases

MEROPSiI29.004

PTM databases

iPTMnetiP25774
PhosphoSitePlusiP25774

Polymorphism and mutation databases

BioMutaiCTSS
DMDMi88984046

Proteomic databases

EPDiP25774
jPOSTiP25774
MaxQBiP25774
PaxDbiP25774
PeptideAtlasiP25774
PRIDEiP25774
ProteomicsDBi54285
54286 [P25774-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1520
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368985; ENSP00000357981; ENSG00000163131 [P25774-1]
ENST00000448301; ENSP00000408414; ENSG00000163131 [P25774-2]
GeneIDi1520
KEGGihsa:1520
UCSCiuc001evn.3 human [P25774-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1520
DisGeNETi1520
EuPathDBiHostDB:ENSG00000163131.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTSS
HGNCiHGNC:2545 CTSS
HPAiCAB000460
HPA002988
MIMi116845 gene
neXtProtiNX_P25774
OpenTargetsiENSG00000163131
PharmGKBiPA27041

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00940000155176
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiP25774
KOiK01368
OMAiYYDPSCT
OrthoDBi1275401at2759
PhylomeDBiP25774
TreeFamiTF313739

Enzyme and pathway databases

BRENDAi3.4.22.27 2681
ReactomeiR-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
SIGNORiP25774

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTSS human
EvolutionaryTraceiP25774

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cathepsin_S

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1520
PMAP-CutDBiP25774

Protein Ontology

More...
PROi
PR:P25774

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163131 Expressed in 207 organ(s), highest expression level in leukocyte
ExpressionAtlasiP25774 baseline and differential
GenevisibleiP25774 HS

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25774
Secondary accession number(s): B4DWC9
, D3DV05, Q5T5I0, Q6FHS5, Q9BUG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 21, 2006
Last modified: February 13, 2019
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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