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UniProtKB - P25744 (MDTG_ECOLI)
Protein
Multidrug resistance protein MdtG
Gene
mdtG
Organism
Escherichia coli (strain K12)
Status
Functioni
Confers resistance to fosfomycin and deoxycholate.
1 PublicationGO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
- response to paraquat Source: EcoCyc
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: EcoCyc
Keywordsi
Biological process | Antibiotic resistance, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:YCEE-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.2.20, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein MdtG |
Gene namesi | Name:mdtG Synonyms:yceE Ordered Locus Names:b1053, JW1040 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 319 – 339 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 378 – 398 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173334 | 1 – 408 | Multidrug resistance protein MdtGAdd BLAST | 408 |
Proteomic databases
PaxDbi | P25744 |
PRIDEi | P25744 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261506, 14 interactors |
STRINGi | 511145.b1053 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_57_3_6 |
InParanoidi | P25744 |
OMAi | VIRHNVP |
PhylomeDBi | P25744 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
HAMAPi | MF_01528, MFS_MdtG, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023692, Mutidrug-R_MdtG IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P25744-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR
RRIPQVSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59939 Genomic DNA Translation: CAA42562.1 U00096 Genomic DNA Translation: AAC74137.1 AP009048 Genomic DNA Translation: BAA35851.1 |
PIRi | B42290 |
RefSeqi | NP_415571.1, NC_000913.3 WP_000074172.1, NZ_STEB01000016.1 |
Genome annotation databases
EnsemblBacteriai | AAC74137; AAC74137; b1053 BAA35851; BAA35851; BAA35851 |
GeneIDi | 66670680 945627 |
KEGGi | ecj:JW1040 eco:b1053 |
PATRICi | fig|1411691.4.peg.1216 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59939 Genomic DNA Translation: CAA42562.1 U00096 Genomic DNA Translation: AAC74137.1 AP009048 Genomic DNA Translation: BAA35851.1 |
PIRi | B42290 |
RefSeqi | NP_415571.1, NC_000913.3 WP_000074172.1, NZ_STEB01000016.1 |
3D structure databases
AlphaFoldDBi | P25744 |
SMRi | P25744 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261506, 14 interactors |
STRINGi | 511145.b1053 |
Protein family/group databases
TCDBi | 2.A.1.2.20, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P25744 |
PRIDEi | P25744 |
Protocols and materials databases
DNASUi | 945627 |
Genome annotation databases
EnsemblBacteriai | AAC74137; AAC74137; b1053 BAA35851; BAA35851; BAA35851 |
GeneIDi | 66670680 945627 |
KEGGi | ecj:JW1040 eco:b1053 |
PATRICi | fig|1411691.4.peg.1216 |
Organism-specific databases
EchoBASEi | EB1319 |
Phylogenomic databases
eggNOGi | COG2814, Bacteria |
HOGENOMi | CLU_001265_57_3_6 |
InParanoidi | P25744 |
OMAi | VIRHNVP |
PhylomeDBi | P25744 |
Enzyme and pathway databases
BioCyci | EcoCyc:YCEE-MONOMER |
Miscellaneous databases
PROi | PR:P25744 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
HAMAPi | MF_01528, MFS_MdtG, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR023692, Mutidrug-R_MdtG IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MDTG_ECOLI | |
Accessioni | P25744Primary (citable) accession number: P25744 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families