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Protein

Endonuclease-1

Gene

endA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has double-strand break activity.

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.

Enzyme regulationi

Inhibited by RNA.

GO - Molecular functioni

  • deoxyribonuclease I activity Source: UniProtKB-EC
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters Source: EcoCyc
  • endonuclease activity Source: EcoCyc

GO - Biological processi

  • DNA catabolic process Source: EcoCyc

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:EG11336-MONOMER
MetaCyc:EG11336-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease-1 (EC:3.1.21.1)
Alternative name(s):
Endonuclease I
Short name:
Endo I
Gene namesi
Name:endA
Ordered Locus Names:b2945, JW2912
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11336 endA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000782723 – 235Endonuclease-1Add BLAST213

Proteomic databases

PaxDbiP25736
PRIDEiP25736

Interactioni

Protein-protein interaction databases

BioGridi4262350, 55 interactors
STRINGi316407.85675755

Structurei

3D structure databases

ProteinModelPortaliP25736
SMRiP25736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EndA/NucM nuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105RWS Bacteria
COG2356 LUCA
HOGENOMiHOG000281182
InParanoidiP25736
KOiK01150
OMAiADQYGQC
PhylomeDBiP25736

Family and domain databases

InterProiView protein in InterPro
IPR007346 Endonuclease-I
PANTHERiPTHR33607 PTHR33607, 1 hit
PfamiView protein in Pfam
PF04231 Endonuclease_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRYLSIAAV VLSAAFSGPA LAEGINSFSQ AKAAAVKVHA DAPGTFYCGC
60 70 80 90 100
KINWQGKKGV VDLQSCGYQV RKNENRASRV EWEHVVPAWQ FGHQRQCWQD
110 120 130 140 150
GGRKNCAKDP VYRKMESDMH NLQPSVGEVN GDRGNFMYSQ WNGGEGQYGQ
160 170 180 190 200
CAMKVDFKEK AAEPPARARG AIARTYFYMR DQYNLTLSRQ QTQLFNAWNK
210 220 230
MYPVTDWECE RDERIAKVQG NHNPYVQRAC QARKS
Length:235
Mass (Da):26,709
Last modified:May 1, 1992 - v1
Checksum:iEB0C355ADEF91EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65169 Genomic DNA Translation: CAA46287.1
U28377 Genomic DNA Translation: AAA69112.1
U00096 Genomic DNA Translation: AAC75982.1
AP009048 Genomic DNA Translation: BAE77008.1
PIRiA38966
RefSeqiNP_417420.1, NC_000913.3
WP_000286500.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75982; AAC75982; b2945
BAE77008; BAE77008; BAE77008
GeneIDi949092
KEGGiecj:JW2912
eco:b2945
PATRICifig|1411691.4.peg.3788

Similar proteinsi

Entry informationi

Entry nameiEND1_ECOLI
AccessioniPrimary (citable) accession number: P25736
Secondary accession number(s): Q2M9P8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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