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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila mayaguana (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
Synonyms:Adh2
OrganismiDrosophila mayaguana (Fruit fly)
Taxonomic identifieri7268 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilamayaguana subcluster

Organism-specific databases

FlyBaseiFBgn0012519 Dmay\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544832 – 254Alcohol dehydrogenaseAdd BLAST253

Proteomic databases

PRIDEiP25721

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP25721
SMRiP25721
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25721-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIANKNIIF VAGLGGIGFD TSREIVKSGP KNLVILDRIE NPAAIAELKA
60 70 80 90 100
LNPKVIVTFY PYDVTVPVAE TTKLLKIIFD KLKTVDLLIN GAGILDDYQI
110 120 130 140 150
ERTIAVNFTG TVNTTTAIMS FWDKRKGGPG GVIANICSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLAKLAP ITGVTAYSIN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,667
Last modified:January 23, 2007 - v2
Checksum:i0106CBB7384FB9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62742 Genomic DNA Translation: AAA28327.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62742 Genomic DNA Translation: AAA28327.1

3D structure databases

ProteinModelPortaliP25721
SMRiP25721
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP25721

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012519 Dmay\Adh

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROMY
AccessioniPrimary (citable) accession number: P25721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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