Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallothionein-3

Gene

MT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi64Divalent metal cation; cluster ABy similarity1
Metal bindingi66Divalent metal cation; cluster ABy similarity1
Metal bindingi67Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
GIFB
Short name:
GIF
Growth inhibitory factor
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000087250.8
HGNCiHGNC:7408 MT3
MIMi139255 gene
neXtProtiNX_P25713

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4504
OpenTargetsiENSG00000087250
PharmGKBiPA31216

Polymorphism and mutation databases

BioMutaiMT3
DMDMi127404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972501 – 68Metallothionein-3Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP25713
PeptideAtlasiP25713
PRIDEiP25713
ProteomicsDBi54284

PTM databases

iPTMnetiP25713
PhosphoSitePlusiP25713

Expressioni

Tissue specificityi

Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.

Gene expression databases

BgeeiENSG00000087250 Expressed in 111 organ(s), highest expression level in amygdala
CleanExiHS_MT3
ExpressionAtlasiP25713 baseline and differential

Organism-specific databases

HPAiCAB017779
HPA004011

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110610, 2 interactors
IntActiP25713, 2 interactors
MINTiP25713
STRINGi9606.ENSP00000200691

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25713
SMRiP25713
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25713

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 30BetaAdd BLAST30
Regioni31 – 68AlphaAdd BLAST38

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KFJ7 Eukaryota
ENOG4110T98 LUCA
GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
InParanoidiP25713
KOiK14740
PhylomeDBiP25713

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P25713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV
60
CKGGEAAEAE AEKCSCCQ
Length:68
Mass (Da):6,927
Last modified:May 1, 1992 - v1
Checksum:i59801ECF5BC8A406
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQX6H3BQX6_HUMAN
Metallothionein
MT3
81Annotation score:
H3BTG5H3BTG5_HUMAN
Metallothionein
MT3
92Annotation score:
H3BPK2H3BPK2_HUMAN
Metallothionein-3
MT3
113Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93311 Genomic DNA Translation: AAA36214.1
D13365 mRNA No translation available.
S72043 Genomic DNA Translation: AAB31396.1
X89604 mRNA Translation: CAA61763.1
BT007030 mRNA Translation: AAP35677.1
DQ297144 Genomic DNA Translation: ABB84467.1
BC013081 mRNA Translation: AAH13081.1
CCDSiCCDS10762.1
PIRiB46034
RefSeqiNP_005945.1, NM_005954.2
UniGeneiHs.73133

Genome annotation databases

EnsembliENST00000200691; ENSP00000200691; ENSG00000087250
GeneIDi4504
KEGGihsa:4504
UCSCiuc002ejf.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93311 Genomic DNA Translation: AAA36214.1
D13365 mRNA No translation available.
S72043 Genomic DNA Translation: AAB31396.1
X89604 mRNA Translation: CAA61763.1
BT007030 mRNA Translation: AAP35677.1
DQ297144 Genomic DNA Translation: ABB84467.1
BC013081 mRNA Translation: AAH13081.1
CCDSiCCDS10762.1
PIRiB46034
RefSeqiNP_005945.1, NM_005954.2
UniGeneiHs.73133

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F5HNMR-A32-68[»]
2FJ4NMR-A32-68[»]
2FJ5NMR-A32-68[»]
ProteinModelPortaliP25713
SMRiP25713
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110610, 2 interactors
IntActiP25713, 2 interactors
MINTiP25713
STRINGi9606.ENSP00000200691

PTM databases

iPTMnetiP25713
PhosphoSitePlusiP25713

Polymorphism and mutation databases

BioMutaiMT3
DMDMi127404

Proteomic databases

PaxDbiP25713
PeptideAtlasiP25713
PRIDEiP25713
ProteomicsDBi54284

Protocols and materials databases

DNASUi4504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000200691; ENSP00000200691; ENSG00000087250
GeneIDi4504
KEGGihsa:4504
UCSCiuc002ejf.4 human

Organism-specific databases

CTDi4504
DisGeNETi4504
EuPathDBiHostDB:ENSG00000087250.8
GeneCardsiMT3
HGNCiHGNC:7408 MT3
HPAiCAB017779
HPA004011
MIMi139255 gene
neXtProtiNX_P25713
OpenTargetsiENSG00000087250
PharmGKBiPA31216
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KFJ7 Eukaryota
ENOG4110T98 LUCA
GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
InParanoidiP25713
KOiK14740
PhylomeDBiP25713

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

EvolutionaryTraceiP25713
GeneWikiiMT3
GenomeRNAii4504
PROiPR:P25713
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087250 Expressed in 111 organ(s), highest expression level in amygdala
CleanExiHS_MT3
ExpressionAtlasiP25713 baseline and differential

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_HUMAN
AccessioniPrimary (citable) accession number: P25713
Secondary accession number(s): Q2V574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again