Cell division control protein 48

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 7492595
• ATP binding Source: UniProtKB-KW
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 25215493
• protein phosphatase regulator activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23418575
• ubiquitin binding Source: SGDInferred from direct assayⁱ
  • 11733065

GO - Biological processⁱ

• ATP metabolic process Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • 12847084
• cellular protein complex disassembly Source: SGDInferred from mutant phenotypeⁱ
  • 25342810
  • 26255844
• cytoplasm protein quality control by the ubiquitin-proteasome system Source: SGDInferred from mutant phenotypeⁱ
  • 18812321
• endoplasmic reticulum membrane fusion Source: SGDInferred from mutant phenotypeⁱ
  • 7553849
• ER-associated misfolded protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 11740563
  • 11813000
• macroautophagy Source: SGDInferred from mutant phenotypeⁱ
  • 20855502
• mitochondria-associated ubiquitin-dependent protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 21070972
• mitotic spindle disassembly Source: SGDInferred from mutant phenotypeⁱ
  • 14636562
• negative regulation of telomerase activity Source: SGDInferred from mutant phenotypeⁱ
  • 26365526
• nonfunctional rRNA decay Source: SGDInferred from mutant phenotypeⁱ
  • 22505030
• nuclear protein quality control by the ubiquitin-proteasome system Source: SGDInferred from mutant phenotypeⁱ
  • 22718752
• piecemeal microautophagy of the nucleus Source: SGDInferred from mutant phenotypeⁱ
  • 20855502
• positive regulation of histone H2B ubiquitination Source: SGDInferred from mutant phenotypeⁱ
  • 25183520
• positive regulation of protein localization to nucleus Source: SGDInferred from mutant phenotypeⁱ
  • 11598205
  • 11733065
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 20206597
• protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: SGDInferred from mutant phenotypeⁱ
  • 29444958
• retrograde protein transport, ER to cytosol Source: SGDInferred from mutant phenotypeⁱ
  • 11740563
• ribophagy Source: SGDInferred from mutant phenotypeⁱ
  • 20508643
• ribosome-associated ubiquitin-dependent protein catabolic process Source: SGDInferred from mutant phenotypeⁱ
  • 23358411
  • 23479637
• SCF complex disassembly in response to cadmium stress Source: SGDInferred from mutant phenotypeⁱ
  • 23000173
• sister chromatid biorientation Source: SGDInferred from mutant phenotypeⁱ
  • 20483956
• stress-induced homeostatically regulated protein degradation pathway Source: SGDInferred from mutant phenotypeⁱ
  • 29861160
• ubiquitin-dependent ERAD pathway Source: SGDInferred from mutant phenotypeⁱ
  • 11739805
  • 11756557

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 25215493
• ubiquitin binding Source: SGDInferred from direct assayⁱ
  • 11733065

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGEEHKPLLD ASGVDPREED KTATAILRRK KKDNMLLVDD AINDDNSVIA 
        60         70         80         90        100
INSNTMDKLE LFRGDTVLVK GKKRKDTVLI VLIDDELEDG ACRINRVVRN 
       110        120        130        140        150
NLRIRLGDLV TIHPCPDIKY ATRISVLPIA DTIEGITGNL FDVFLKPYFV 
       160        170        180        190        200
EAYRPVRKGD HFVVRGGMRQ VEFKVVDVEP EEYAVVAQDT IIHWEGEPIN 
       210        220        230        240        250
REDEENNMNE VGYDDIGGCR KQMAQIREMV ELPLRHPQLF KAIGIKPPRG 
       260        270        280        290        300
VLMYGPPGTG KTLMARAVAN ETGAFFFLIN GPEVMSKMAG ESESNLRKAF 
       310        320        330        340        350
EEAEKNAPAI IFIDEIDSIA PKRDKTNGEV ERRVVSQLLT LMDGMKARSN 
       360        370        380        390        400
VVVIAATNRP NSIDPALRRF GRFDREVDIG IPDATGRLEV LRIHTKNMKL 
       410        420        430        440        450
ADDVDLEALA AETHGYVGAD IASLCSEAAM QQIREKMDLI DLDEDEIDAE 
       460        470        480        490        500
VLDSLGVTMD NFRFALGNSN PSALRETVVE SVNVTWDDVG GLDEIKEELK 
       510        520        530        540        550
ETVEYPVLHP DQYTKFGLSP SKGVLFYGPP GTGKTLLAKA VATEVSANFI 
       560        570        580        590        600
SVKGPELLSM WYGESESNIR DIFDKARAAA PTVVFLDELD SIAKARGGSL 
       610        620        630        640        650
GDAGGASDRV VNQLLTEMDG MNAKKNVFVI GATNRPDQID PAILRPGRLD 
       660        670        680        690        700
QLIYVPLPDE NARLSILNAQ LRKTPLEPGL ELTAIAKATQ GFSGADLLYI 
       710        720        730        740        750
VQRAAKYAIK DSIEAHRQHE AEKEVKVEGE DVEMTDEGAK AEQEPEVDPV 
       760        770        780        790        800
PYITKEHFAE AMKTAKRSVS DAELRRYEAY SQQMKASRGQ FSNFNFNDAP 
       810        820        830 
LGTTATDNAN SNNSAPSGAG AAFGSNAEED DDLYS                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ