DNAJB1

Functionⁱ

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).2 Publications

GO - Molecular functionⁱ

ATPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24318877
ATPase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
chaperone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21231916
Hsp70 protein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9499401
unfolded protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chaperone cofactor-dependent protein refolding
Source: UniProtKB
Inferred from direct assayⁱ
- 18620420
forebrain development Source: Ensembl
negative regulation of inclusion body assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916
negative regulation of transcription from RNA polymerase II promoter in response to stress
Source: UniProtKB
Inferred from direct assayⁱ
- 9499401
positive regulation of ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 23921388
regulation of cellular response to heat Source: Reactome
response to unfolded protein
Source: ProtInc
Traceable author statementⁱ
- 8975727

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Stress response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-3371568 Attenuation phase R-HSA-3371571 HSF1-dependent transactivation R-HSA-5687128 MAPK6/MAPK4 signaling
SIGNORⁱ	P25685

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily B member 1 Alternative name(s): DnaJ protein homolog 1 Heat shock 40 kDa protein 1 Short name: HSP40 Short name: Heat shock protein 40 Human DnaJ protein 1 Short name: hDj-1
Gene namesⁱ	Name:DNAJB1 Synonyms:DNAJ1, HDJ1, HSPF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132002.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5270 DNAJB1
MIMⁱ	604572 gene
neXtProtⁱ	NX_P25685

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3337
MalaCards human disease database More...MalaCardsⁱ	DNAJB1
Open Targets More...OpenTargetsⁱ	ENSG00000132002
Orphanetⁱ	401920 Fibrolamellar hepatocellular carcinoma
PharmGKBⁱ	PA27412

Polymorphism and mutation databases

BioMutaⁱ	DNAJB1
DMDMⁱ	1706473

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000071016	2 – 340	DnaJ homolog subfamily B member 1Add BLAST		339

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	307	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P25685
PaxDbⁱ	P25685
PeptideAtlas More...PeptideAtlasⁱ	P25685
PRIDEⁱ	P25685
ProteomicsDBⁱ	54280

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00015947

REPRODUCTION-2DPAGEⁱ

IPI00015947

PTM databases

iPTMnetⁱ	P25685
PhosphoSitePlusⁱ	P25685

Expressionⁱ

Inductionⁱ

By heat shock.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000132002
CleanExⁱ	HS_DNAJB1
ExpressionAtlasⁱ	P25685 baseline and differential
Genevisibleⁱ	P25685 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017450 HPA063247

HPAⁱ

CAB017450
HPA063247

Interactionⁱ

Subunit structureⁱ

Interacts with DNAJC3 (PubMed:9920933). Interacts with HSF1 (via transactivation domain); this interaction results in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUDC	Q9Y266	3	EBI-357034,EBI-357298
Phlda1	Q62392	2	EBI-357034,EBI-309727	From Mus musculus.
TERF1	P54274	2	EBI-357034,EBI-710997

Show more details

GO - Molecular functionⁱ

ATPase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
chaperone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21231916
Hsp70 protein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 23921388
unfolded protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109569, 108 interactors
CORUMⁱ	P25685
Database of interacting proteins More...DIPⁱ	DIP-41180N
IntActⁱ	P25685, 54 interactors
Molecular INTeraction database More...MINTⁱ	P25685
STRINGⁱ	9606.ENSP00000254322

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 9	Combined sources	5
Helixⁱ	17 – 31	Combined sources	15
Turnⁱ	33 – 35	Combined sources	3
Helixⁱ	41 – 55	Combined sources	15
Helixⁱ	58 – 70	Combined sources	13
Beta strandⁱ	166 – 170	Combined sources	5
Helixⁱ	172 – 177	Combined sources	6
Beta strandⁱ	179 – 190	Combined sources	12
Turnⁱ	191 – 193	Combined sources	3
Beta strandⁱ	197 – 208	Combined sources	12
Beta strandⁱ	217 – 220	Combined sources	4
Beta strandⁱ	228 – 230	Combined sources	3
Beta strandⁱ	235 – 241	Combined sources	7
Beta strandⁱ	248 – 250	Combined sources	3
Beta strandⁱ	253 – 261	Combined sources	9
Helixⁱ	262 – 267	Combined sources	6
Beta strandⁱ	269 – 274	Combined sources	6
Beta strandⁱ	280 – 285	Combined sources	6
Beta strandⁱ	294 – 297	Combined sources	4
Beta strandⁱ	305 – 307	Combined sources	3
Beta strandⁱ	314 – 321	Combined sources	8
Helixⁱ	328 – 337	Combined sources	10

3D structure databases

ProteinModelPortalⁱ	P25685
SMRⁱ	P25685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P25685

EvolutionaryTraceⁱ

P25685

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 70	JPROSITE-ProRule annotationAdd BLAST		69

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118947
HOGENOMⁱ	HOG000226718
HOVERGENⁱ	HBG066727
InParanoidⁱ	P25685
KEGG Orthology (KO) More...KOⁱ	K09507
OMAⁱ	GAYTYQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLS
PhylomeDBⁱ	P25685
TreeFamⁱ	TF105141

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 2 hits
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P25685-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE 
        60         70         80         90        100
AYDVLSDPRK REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHA 
       110        120        130        140        150
MFAEFFGGRN PFDTFFGQRN GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR 
       160        170        180        190        200
SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE 
       210        220        230        240        250
DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD 
       260        270        280        290        300
GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 
       310        320        330        340
GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Length:340

Mass (Da):38,044

Last modified:January 23, 2007 - v4

Checksum:ⁱ17545098B0C196DF

GO

Isoform 2 (identifier: P25685-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-100: Missing.

« Hide

        10         20         30         40         50
MFAEFFGGRN PFDTFFGQRN GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR 
        60         70         80         90        100
SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE 
       110        120        130        140        150
DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD 
       160        170        180        190        200
GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 
       210        220        230        240
GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Note: No experimental confirmation available.

Show »

Length:240

Mass (Da):27,016

Checksum:ⁱ760FFA819B48174B

GO

Sequence cautionⁱ

The sequence CAA44287 differs from that shown. Reason: Frameshift at positions 11, 28, 81 and 136.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	68	G → L in CAA44287 (PubMed:1754405).Curated	1
Sequence conflictⁱ	150	R → C in CAA44287 (PubMed:1754405).Curated	1
Sequence conflictⁱ	183	M → T in CAA44287 (PubMed:1754405).Curated	1
Sequence conflictⁱ	320	V → A in CAA44287 (PubMed:1754405).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056414	1 – 100	Missing in isoform 2. 1 PublicationAdd BLAST		100

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62421 mRNA Translation: CAA44287.1 Frameshift. D49547 mRNA Translation: BAA08495.1 D85429 Genomic DNA Translation: BAA12819.1 AK301817 mRNA Translation: BAG63264.1 AC009004 Genomic DNA No translation available. AC012318 Genomic DNA No translation available. BC002352 mRNA Translation: AAH02352.1 BC019827 mRNA Translation: AAH19827.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12312.1 [P25685-1] CCDS74295.1 [P25685-2]
PIRⁱ	JN0912 S20062
NCBI Reference Sequences More...RefSeqⁱ	NP_001287843.1, NM_001300914.1 [P25685-2] NP_001300893.1, NM_001313964.1 [P25685-2] NP_006136.1, NM_006145.2 [P25685-1] XP_006722796.1, XM_006722733.1 [P25685-2] XP_006722797.1, XM_006722734.3 [P25685-2] XP_011526258.1, XM_011527956.2 [P25685-2]
UniGeneⁱ	Hs.515210

Genome annotation databases

Ensemblⁱ	ENST00000254322; ENSP00000254322; ENSG00000132002 [P25685-1] ENST00000396969; ENSP00000444212; ENSG00000132002 [P25685-2]
GeneIDⁱ	3337
KEGGⁱ	hsa:3337
UCSC genome browser More...UCSCⁱ	uc010xnr.2 human [P25685-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P25685	DNAJB1 protein (Fragment)		HUMAN		340
DNAJB1 isoform 9		PANTR		340
DNAJB1 isoform 9		PONAB		340
UPI0001FB33C3		HUMAN		190
DnaJ homolog subfamily B member 1 (Fragment)		HUMAN		183
+9

Protein	Similar proteins		Species	Score	Length
P25685	DNAJB1 protein (Fragment)		HUMAN		340
DNAJB1 isoform 9		PANTR		340
DNAJB1 isoform 9		PONAB		340
UPI00038ED451		CHILA		341
UPI000C9E398F		HORSE		341
+123

Protein	Similar proteins		Species	Score	Length
P25685	DNAJB1 protein (Fragment)		HUMAN		340
DNAJB1 isoform 9		PANTR		340
DNAJB1 isoform 9		PONAB		340
UPI00038ED451		CHILA		341
UPI000C9E398F		HORSE		341
+1000

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62421 mRNA Translation: CAA44287.1 Frameshift. D49547 mRNA Translation: BAA08495.1 D85429 Genomic DNA Translation: BAA12819.1 AK301817 mRNA Translation: BAG63264.1 AC009004 Genomic DNA No translation available. AC012318 Genomic DNA No translation available. BC002352 mRNA Translation: AAH02352.1 BC019827 mRNA Translation: AAH19827.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12312.1 [P25685-1] CCDS74295.1 [P25685-2]
PIRⁱ	JN0912 S20062
NCBI Reference Sequences More...RefSeqⁱ	NP_001287843.1, NM_001300914.1 [P25685-2] NP_001300893.1, NM_001313964.1 [P25685-2] NP_006136.1, NM_006145.2 [P25685-1] XP_006722796.1, XM_006722733.1 [P25685-2] XP_006722797.1, XM_006722734.3 [P25685-2] XP_011526258.1, XM_011527956.2 [P25685-2]
UniGeneⁱ	Hs.515210

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HDJ	NMR	-	A	1-76	[»]
	2QLD	X-ray	2.70	A	158-340	[»]
	3AGX	X-ray	1.85	A/B	161-340	[»]
	3AGY	X-ray	1.85	A/B	161-340	[»]
	3AGZ	X-ray	2.51	A/B	151-340	[»]
	4WB7	X-ray	1.90	A/B	2-70	[»]
ProteinModelPortalⁱ	P25685
SMRⁱ	P25685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109569, 108 interactors
CORUMⁱ	P25685
Database of interacting proteins More...DIPⁱ	DIP-41180N
IntActⁱ	P25685, 54 interactors
Molecular INTeraction database More...MINTⁱ	P25685
STRINGⁱ	9606.ENSP00000254322

PTM databases

iPTMnetⁱ	P25685
PhosphoSitePlusⁱ	P25685

Polymorphism and mutation databases

BioMutaⁱ	DNAJB1
DMDMⁱ	1706473

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00015947

REPRODUCTION-2DPAGEⁱ

IPI00015947

Proteomic databases

EPDⁱ	P25685
PaxDbⁱ	P25685
PeptideAtlas More...PeptideAtlasⁱ	P25685
PRIDEⁱ	P25685
ProteomicsDBⁱ	54280

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3337
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000254322; ENSP00000254322; ENSG00000132002 [P25685-1] ENST00000396969; ENSP00000444212; ENSG00000132002 [P25685-2]
GeneIDⁱ	3337
KEGGⁱ	hsa:3337
UCSC genome browser More...UCSCⁱ	uc010xnr.2 human [P25685-1]

Organism-specific databases

CTDⁱ	3337
DisGeNET More...DisGeNETⁱ	3337
EuPathDBⁱ	HostDB:ENSG00000132002.7
GeneCardsⁱ	DNAJB1
H-InvDBⁱ	HIX0014838
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5270 DNAJB1
Human Protein Atlas More...HPAⁱ	CAB017450 HPA063247
MalaCards human disease database More...MalaCardsⁱ	DNAJB1
MIMⁱ	604572 gene
neXtProtⁱ	NX_P25685
Open Targets More...OpenTargetsⁱ	ENSG00000132002
Orphanetⁱ	401920 Fibrolamellar hepatocellular carcinoma
PharmGKBⁱ	PA27412
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118947
HOGENOMⁱ	HOG000226718
HOVERGENⁱ	HBG066727
InParanoidⁱ	P25685
KEGG Orthology (KO) More...KOⁱ	K09507
OMAⁱ	GAYTYQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DLS
PhylomeDBⁱ	P25685
TreeFamⁱ	TF105141

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-3371568 Attenuation phase R-HSA-3371571 HSF1-dependent transactivation R-HSA-5687128 MAPK6/MAPK4 signaling
SIGNORⁱ	P25685

Miscellaneous databases

ChiTaRSⁱ	DNAJB1 human
EvolutionaryTraceⁱ	P25685
GeneWikiⁱ	DNAJB1
GenomeRNAiⁱ	3337
Protein Ontology More...PROⁱ	PR:P25685
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132002
CleanExⁱ	HS_DNAJB1
ExpressionAtlasⁱ	P25685 baseline and differential
Genevisibleⁱ	P25685 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR002939 DnaJ_C IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR008971 HSP40/DnaJ_pept-bd IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit PF01556 DnaJ_C, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit SSF49493 SSF49493, 2 hits
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNJB1_HUMAN
Accessionⁱ	P25685Primary (citable) accession number: P25685 Secondary accession number(s): B4DX52
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	July 18, 2018
	This is version 193 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25685 (DNJB1_HUMAN)

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DnaJ homolog subfamily B member 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ