UniProtKB - P25670 (3L21_ASPSC)
Protein
Long neurotoxin 1
Gene
N/A
Organism
Aspidelaps scutatus (Shield-nose snake)
Status
Functioni
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Long neurotoxin 1Alternative name(s): Toxin S4C6 |
Organismi | Aspidelaps scutatus (Shield-nose snake) |
Taxonomic identifieri | 8607 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Acanthophiinae › Aspidelaps |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 0.13 mg/kg by intravenous injection.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093529 | 1 – 68 | Long neurotoxin 1Add BLAST | 68 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 20 | By similarity | ||
Disulfide bondi | 13 ↔ 41 | By similarity | ||
Disulfide bondi | 26 ↔ 30 | By similarity | ||
Disulfide bondi | 45 ↔ 56 | By similarity | ||
Disulfide bondi | 57 ↔ 62 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
ProteinModelPortali | P25670 |
SMRi | P25670 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.Curated
Phylogenomic databases
HOVERGENi | HBG006553 |
Family and domain databases
CDDi | cd00206 snake_toxin, 1 hit |
InterProi | View protein in InterPro IPR003571 Snake_3FTx IPR018354 Snake_toxin_con_site IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
PROSITEi | View protein in PROSITE PS00272 SNAKE_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P25670-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RICYIAPYDH KTCAAGENIC YLKAWCDAWC SSRGKKLEFG CAATCPTVKP
60
GVDISCCDTD NCNPHPKL
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P25670 |
SMRi | P25670 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Phylogenomic databases
HOVERGENi | HBG006553 |
Family and domain databases
CDDi | cd00206 snake_toxin, 1 hit |
InterProi | View protein in InterPro IPR003571 Snake_3FTx IPR018354 Snake_toxin_con_site IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
PROSITEi | View protein in PROSITE PS00272 SNAKE_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | 3L21_ASPSC | |
Accessioni | P25670Primary (citable) accession number: P25670 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | November 22, 2017 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families