We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P25656 (CDC50_YEAST)
Protein
Cell division control protein 50
Gene
CDC50
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for polarized cell growth.
Miscellaneous
Present with 589 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- actin cortical patch localization Source: SGD
- aminophospholipid translocation Source: GOC
- endocytosis Source: SGD
- intracellular protein transport Source: SGD
- phospholipid translocation Source: SGD
- retrograde transport, endosome to Golgi Source: SGD
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation |
Protein family/group databases
TCDBi | 8.A.27.1.2, the cdc50 p-type atpase lipid flippase subunit (cdc50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division control protein 50 |
Gene namesi | Name:CDC50 Ordered Locus Names:YCR094W ORF Names:YCR94W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000690, CDC50 |
VEuPathDBi | FungiDB:YCR094W |
Subcellular locationi
Endosome
- Late endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication
Cytosol
- cytosol Source: GOC
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Endosome
- late endosome membrane Source: SGD
Golgi apparatus
- Golgi apparatus Source: GO_Central
- trans-Golgi network Source: SGD
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- Cdc50p-Drs2p complex Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | CytoplasmicSequence analysisAdd BLAST | 44 | |
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 66 – 331 | LumenalSequence analysisAdd BLAST | 266 | |
Transmembranei | 332 – 352 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 391 | CytoplasmicSequence analysisAdd BLAST | 39 |
Keywords - Cellular componenti
Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207670 | 1 – 391 | Cell division control protein 50Add BLAST | 391 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 216 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 237 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 288 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P25656 |
PaxDbi | P25656 |
PRIDEi | P25656 |
Interactioni
Subunit structurei
Interacts with DRS2. Might function as an essential subunit for this protein.
1 PublicationBinary interactionsi
P25656
With | #Exp. | IntAct |
---|---|---|
DRS2 [P39524] | 10 | EBI-22014,EBI-3106 |
Protein-protein interaction databases
BioGRIDi | 31066, 434 interactors |
ComplexPortali | CPX-1018, DRS2-CDC50 P4-ATPase complex |
DIPi | DIP-5138N |
IntActi | P25656, 7 interactors |
MINTi | P25656 |
STRINGi | 4932.YCR094W |
Miscellaneous databases
RNActi | P25656, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P25656 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the CDC50/LEM3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2952, Eukaryota |
GeneTreei | ENSGT00390000004660 |
HOGENOMi | CLU_025025_0_1_1 |
InParanoidi | P25656 |
OMAi | WEELQVW |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam |
PANTHERi | PTHR10926, PTHR10926, 1 hit |
Pfami | View protein in Pfam PF03381, CDC50, 1 hit |
PIRSFi | PIRSF015840, DUF284_TM_euk, 1 hit |
i Sequence
Sequence statusi: Complete.
P25656-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSLFKRGKA PPLTKEGPTS KKPPNTAFRQ QRLKAWQPIL SPQSVLPLLI
60 70 80 90 100
FVACIFTPIG IGLIVSATKV QDLTIDYSHC DTKASTTAFE DIPKKYIKYH
110 120 130 140 150
FKSKVENKPQ WRLTENENGE QSCELQFEIP NDIKKSIFIY YKITNFYQNH
160 170 180 190 200
RRYVQSFDTK QILGEPIKKD DLDTSCSPIR SREDKIIYPC GLIANSMFND
210 220 230 240 250
TFSQVLSGID DTEDYNLTNK HISWSIDRHR FKTTKYNASD IVPPPNWMKK
260 270 280 290 300
YPDGYTDENL PDIHTWEEFQ VWMRTAAFPK FYKLTLKNES ASLPKGKYQM
310 320 330 340 350
NIELNYPISL FGGTKSFVLT TNGAIGGRNM SLGVLYLIVA GLCALFGIIF
360 370 380 390
LVKLIFQPRA MGDHTYLNFD DEENEDYEDV HAENTTLREI L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42249.1 BK006937 Genomic DNA Translation: DAA07563.1 |
PIRi | S19510 |
RefSeqi | NP_010018.1, NM_001178800.1 |
Genome annotation databases
EnsemblFungii | YCR094W_mRNA; YCR094W; YCR094W |
GeneIDi | 850456 |
KEGGi | sce:YCR094W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42249.1 BK006937 Genomic DNA Translation: DAA07563.1 |
PIRi | S19510 |
RefSeqi | NP_010018.1, NM_001178800.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6PSX | electron microscopy | 3.30 | E | 1-391 | [»] | |
6PSY | electron microscopy | 2.80 | E | 1-391 | [»] | |
6ROH | electron microscopy | 2.80 | C | 1-391 | [»] | |
6ROI | electron microscopy | 3.70 | C | 1-391 | [»] | |
6ROJ | electron microscopy | 2.90 | C | 1-391 | [»] | |
7OH4 | electron microscopy | 3.00 | C | 1-391 | [»] | |
7OH5 | electron microscopy | 2.90 | C | 1-391 | [»] | |
7OH6 | electron microscopy | 3.00 | C | 1-391 | [»] | |
7OH7 | electron microscopy | 3.80 | C | 1-391 | [»] | |
SMRi | P25656 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31066, 434 interactors |
ComplexPortali | CPX-1018, DRS2-CDC50 P4-ATPase complex |
DIPi | DIP-5138N |
IntActi | P25656, 7 interactors |
MINTi | P25656 |
STRINGi | 4932.YCR094W |
Protein family/group databases
TCDBi | 8.A.27.1.2, the cdc50 p-type atpase lipid flippase subunit (cdc50) family |
Proteomic databases
MaxQBi | P25656 |
PaxDbi | P25656 |
PRIDEi | P25656 |
Genome annotation databases
EnsemblFungii | YCR094W_mRNA; YCR094W; YCR094W |
GeneIDi | 850456 |
KEGGi | sce:YCR094W |
Organism-specific databases
SGDi | S000000690, CDC50 |
VEuPathDBi | FungiDB:YCR094W |
Phylogenomic databases
eggNOGi | KOG2952, Eukaryota |
GeneTreei | ENSGT00390000004660 |
HOGENOMi | CLU_025025_0_1_1 |
InParanoidi | P25656 |
OMAi | WEELQVW |
Enzyme and pathway databases
Reactomei | R-SCE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P25656 |
RNActi | P25656, protein |
Family and domain databases
InterProi | View protein in InterPro IPR005045, CDC50/LEM3_fam |
PANTHERi | PTHR10926, PTHR10926, 1 hit |
Pfami | View protein in Pfam PF03381, CDC50, 1 hit |
PIRSFi | PIRSF015840, DUF284_TM_euk, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC50_YEAST | |
Accessioni | P25656Primary (citable) accession number: P25656 Secondary accession number(s): D6VR94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families