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Entry version 147 (02 Jun 2021)
Sequence version 2 (01 Mar 2004)
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Protein

Factor-induced gene 2 protein

Gene

FIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Cell shape, Cell wall biogenesis/degradation, Conjugation, Pheromone response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Factor-induced gene 2 protein
Alternative name(s):
Cell wall adhesin FIG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FIG2
Ordered Locus Names:YCR089W
ORF Names:YCR1102, YCR89W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000685, FIG2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YCR089W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002126423 – 1588Factor-induced gene 2 proteinAdd BLAST1566
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00003724521589 – 1609Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi661N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi713N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi889N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi907N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1400N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1588GPI-anchor amidated glycineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25653

PRoteomics IDEntifications database

More...
PRIDEi
P25653

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mating pheromones. By cells of the opposite mating type.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31061, 83 interactors

Protein interaction database and analysis system

More...
IntActi
P25653, 1 interactor

Molecular INTeraction database

More...
MINTi
P25653

STRING: functional protein association networks

More...
STRINGi
4932.YCR089W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P25653, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25653

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 165DisorderedSequence analysisAdd BLAST37
Regioni196 – 243DisorderedSequence analysisAdd BLAST48
Regioni266 – 312DisorderedSequence analysisAdd BLAST47
Regioni846 – 876DisorderedSequence analysisAdd BLAST31
Regioni1231 – 1259DisorderedSequence analysisAdd BLAST29

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S8X9, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_244733_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25653

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITEYVTW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025928, Flocculin_t3_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13928, Flocculin_t3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P25653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES
60 70 80 90 100
SSTGEVQYSS SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS
110 120 130 140 150
DTFSSYSDIF DEETSSLIST SAASSEKASS TLSSTAQPHR TSHSSSSFEL
160 170 180 190 200
PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF NSEKSSALSS TIDFTSSEIS
210 220 230 240 250
GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE PLSSSSGDLI
260 270 280 290 300
LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT
310 320 330 340 350
SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA
360 370 380 390 400
SIASTPFGTD SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST
410 420 430 440 450
ASGSSQYQDW SSSSLPLSQT TWVVINTTNT QGSVTSTTSP AYVSTATKTV
460 470 480 490 500
DGVITEYVTW CPLTQTKSQA IGVSSSISSV PQASSFSGSS ILSSNSSTLA
510 520 530 540 550
ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ GSVTSTTSPA
560 570 580 590 600
YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT
610 620 630 640 650
LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV
660 670 680 690 700
NLASSLSSYP NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV
710 720 730 740 750
SSSVNSLTDF TSNSTETIAV ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL
760 770 780 790 800
STVTTTVNGA ATEYTTWCPA SSIAYTTSIS YKTLVLTTEV CSHSECTPTV
810 820 830 840 850
ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI NTQVSATSEA
860 870 880 890 900
TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA
910 920 930 940 950
LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ
960 970 980 990 1000
TLQTEAVEVT LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS
1010 1020 1030 1040 1050
TSSSSLASTK KSSLEASSEM STFSVSTQSL PLAFTSSEKR STTSVSQWSN
1060 1070 1080 1090 1100
TVLTNTIMSS SSNVISTNEK PSSTTSPYNF SSGYSLPSSS TPSQYSLSTA
1110 1120 1130 1140 1150
TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS KPSSSLSQTS
1160 1170 1180 1190 1200
IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS
1210 1220 1230 1240 1250
ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP
1260 1270 1280 1290 1300
SVSTSSSSSF STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP
1310 1320 1330 1340 1350
SPAFTSSTLP TATAVSSSTF IASSLPLSSK SSLSLSPVSS SILMSQFSSS
1360 1370 1380 1390 1400
SSSSSSLASL PSLSISPTVD TVSVLQPTTS IATLTCTDSQ CQQEVSTICN
1410 1420 1430 1440 1450
GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY SCKVSETYKS
1460 1470 1480 1490 1500
SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI
1510 1520 1530 1540 1550
SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP
1560 1570 1580 1590 1600
TTTTYVEQRL SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM

IMVMVINFI
Length:1,609
Mass (Da):166,036
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9B6E08F98996B54
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42254.2
BK006937 Genomic DNA Translation: DAA07558.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25345

NCBI Reference Sequences

More...
RefSeqi
NP_010013.2, NM_001178795.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YCR089W_mRNA; YCR089W; YCR089W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YCR089W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42254.2
BK006937 Genomic DNA Translation: DAA07558.1
PIRiS25345
RefSeqiNP_010013.2, NM_001178795.1

3D structure databases

SMRiP25653
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi31061, 83 interactors
IntActiP25653, 1 interactor
MINTiP25653
STRINGi4932.YCR089W

Proteomic databases

PaxDbiP25653
PRIDEiP25653

Genome annotation databases

EnsemblFungiiYCR089W_mRNA; YCR089W; YCR089W
GeneIDi850451
KEGGisce:YCR089W

Organism-specific databases

SGDiS000000685, FIG2
VEuPathDBiFungiDB:YCR089W

Phylogenomic databases

eggNOGiENOG502S8X9, Eukaryota
HOGENOMiCLU_244733_0_0_1
InParanoidiP25653
OMAiITEYVTW

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P25653
RNActiP25653, protein

Family and domain databases

InterProiView protein in InterPro
IPR025928, Flocculin_t3_rpt
PfamiView protein in Pfam
PF13928, Flocculin_t3, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIG2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25653
Secondary accession number(s): D6VR89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 1, 2004
Last modified: June 2, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names
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