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UniProtKB - P25646 (PDP2_YEAST)
Protein
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Gene
PTC6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Protein phosphatase that shows typical type 2C protein phosphatase (PP2C) activity (PubMed:17002782).
Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex (PubMed:18180296).
Required for efficient mitophagy in stationary phase cells (PubMed:17166847).
3 PublicationsMiscellaneous
Present with 432 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 α subunit] = L-seryl-[pyruvate dehydrogenase E1 α subunit] + phosphate1 PublicationEC:3.1.3.431 Publication
- EC:3.1.3.161 Publication
- EC:3.1.3.161 Publication
Cofactori
GO - Molecular functioni
- [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: SGD
- protein serine/threonine phosphatase activity Source: SGD
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- autophagy of mitochondrion Source: SGD
- macroautophagy Source: SGD
- peptidyl-serine dephosphorylation Source: SGD
- positive regulation of pyruvate dehydrogenase activity Source: SGD
- protein dephosphorylation Source: SGD
- regulation of mitophagy Source: SGD
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Autophagy |
Ligand | Magnesium, Manganese |
Names & Taxonomyi
Protein namesi | Recommended name: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialCurated (EC:3.1.3.161 Publication, EC:3.1.3.431 Publication)Short name: PDP 2Curated Alternative name(s): Autophagy-related protein phosphatase 11 Publication Phosphatase two C protein 61 Publication Protein phosphatase 2C homolog 6Curated Short name: PP2C-6Curated Protein phosphatase of PDH protein 2 Pyruvate dehydrogenase complex phosphatase 21 Publication Short name: PDC phosphatase 2Curated |
Gene namesi | Ordered Locus Names:YCR079WImported ORF Names:YCR79CImported, YCR79WImported |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002133, PTC6 |
VEuPathDBi | FungiDB:YCR079W |
Subcellular locationi
Mitochondrion
- Mitochondrion intermembrane space 2 Publications
- Mitochondrion matrix 2 Publications
Mitochondrion
- mitochondrial intermembrane space Source: SGD
- mitochondrial matrix Source: SGD
- mitochondrion Source: SGD
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Disruption phenotypei
Confers rapamycin-sensitivity.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | MitochondrionSequence analysisAdd BLAST | 34 | |
ChainiPRO_0000057788 | 35 – 442 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialAdd BLAST | 408 |
Proteomic databases
PaxDbi | P25646 |
PRIDEi | P25646 |
PTM databases
iPTMneti | P25646 |
Interactioni
Subunit structurei
Interacts with PRO2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 31053, 219 interactors |
DIPi | DIP-2963N |
IntActi | P25646, 30 interactors |
MINTi | P25646 |
STRINGi | 4932.YCR079W |
Miscellaneous databases
RNActi | P25646, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 411 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 377 |
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00940000156633 |
HOGENOMi | CLU_021251_0_0_1 |
InParanoidi | P25646 |
OMAi | LPNWGNW |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P25646-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLGNAYAYC KPSQNVGLKL DLLRGLPGYV GHATSRINRL ENQDNYSIKM
60 70 80 90 100
MRSWPNAYGS ALNCSVFDGH GEKGAQLSQL LADKLCSSLD FPEPSWDKQD
110 120 130 140 150
LKKLVQEYAR RFPEGNYWKH KLSTFEKFYN KFIKNCNSKQ ELLLMKEGDS
160 170 180 190 200
AILGQNGGRM IFDKMGNIID KIALLTELDR LRLFYGFARF DLDQCCGLGT
210 220 230 240 250
AAGSTASSIF LYPYDDPNAP IDEGKDDDSW IISHSGLLKL IVTQVGDSKI
260 270 280 290 300
ILCDQDGIAH ALTTTHHINS SRERHRLSID PSRLDPDAFG ETRFLNNFAN
310 320 330 340 350
TRSFGDVAGK PYGISSEPDI FSFLVGNTLH LPRSERSKLP FNGDECFLAL
360 370 380 390 400
VTDGITNKLA DQEVVDLITS TVNSWGLKKA TPQFVAEETI KFIQAIATKH
410 420 430 440
SDNATCVVVR LSNWGNWPNV DRTGPQRETK LMNAQSNETK LN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAC42991.1 BK006937 Genomic DNA Translation: DAA07550.1 |
PIRi | S19493 |
RefSeqi | NP_010003.2, NM_001180034.1 |
Genome annotation databases
EnsemblFungii | YCR079W_mRNA; YCR079W; YCR079W |
GeneIDi | 850441 |
KEGGi | sce:YCR079W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAC42991.1 BK006937 Genomic DNA Translation: DAA07550.1 |
PIRi | S19493 |
RefSeqi | NP_010003.2, NM_001180034.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 31053, 219 interactors |
DIPi | DIP-2963N |
IntActi | P25646, 30 interactors |
MINTi | P25646 |
STRINGi | 4932.YCR079W |
PTM databases
iPTMneti | P25646 |
Proteomic databases
PaxDbi | P25646 |
PRIDEi | P25646 |
Genome annotation databases
EnsemblFungii | YCR079W_mRNA; YCR079W; YCR079W |
GeneIDi | 850441 |
KEGGi | sce:YCR079W |
Organism-specific databases
SGDi | S000002133, PTC6 |
VEuPathDBi | FungiDB:YCR079W |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00940000156633 |
HOGENOMi | CLU_021251_0_0_1 |
InParanoidi | P25646 |
OMAi | LPNWGNW |
Miscellaneous databases
PROi | PR:P25646 |
RNActi | P25646, protein |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDP2_YEAST | |
Accessioni | P25646Primary (citable) accession number: P25646 Secondary accession number(s): D6VR81, Q8NIL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | October 10, 2003 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names