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UniProtKB - P25638 (TAH1_YEAST)
Protein
TPR repeat-containing protein associated with Hsp90
Gene
TAH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 1660 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- chaperone binding Source: SGD
- Hsp70 protein binding Source: InterPro
- Hsp90 protein binding Source: InterPro
GO - Biological processi
- box C/D snoRNP assembly Source: SGD
- protein folding Source: SGD
- protein stabilization Source: ComplexPortal
Names & Taxonomyi
Protein namesi | Recommended name: TPR repeat-containing protein associated with Hsp90 |
Gene namesi | Name:TAH1 Ordered Locus Names:YCR060W ORF Names:YCR60W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000656, TAH1 |
VEuPathDBi | FungiDB:YCR060W |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
- R2TP complex Source: SGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000106352 | 2 – 111 | TPR repeat-containing protein associated with Hsp90Add BLAST | 110 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P25638 |
PRIDEi | P25638 |
PTM databases
iPTMneti | P25638 |
Interactioni
Subunit structurei
Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1.
Interacts also with HSP90.
1 PublicationBinary interactionsi
P25638
With | #Exp. | IntAct |
---|---|---|
HSP82 [P02829] | 10 | EBI-21956,EBI-8659 |
PIH1 [P38768] | 17 | EBI-21956,EBI-24499 |
GO - Molecular functioni
- chaperone binding Source: SGD
- Hsp70 protein binding Source: InterPro
- Hsp90 protein binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 31037, 113 interactors |
ComplexPortali | CPX-1814, R2TP co-chaperone complex |
DIPi | DIP-5000N |
IntActi | P25638, 8 interactors |
MINTi | P25638 |
STRINGi | 4932.YCR060W |
Miscellaneous databases
RNActi | P25638, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P25638 |
BMRBi | P25638 |
SMRi | P25638 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 37 | TPR 1Add BLAST | 34 | |
Repeati | 39 – 71 | TPR 2Add BLAST | 33 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1124, Eukaryota |
HOGENOMi | CLU_132745_0_0_1 |
InParanoidi | P25638 |
OMAi | PIGYSNK |
Family and domain databases
DisProti | DP01243 |
Gene3Di | 1.25.40.10, 1 hit |
IDEALi | IID50204 |
InterProi | View protein in InterPro IPR045248, Sti1-like IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR22904, PTHR22904, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P25638-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK
60 70 80 90 100
LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE
110
VDELPEGYDR S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42288.1 AY558151 Genomic DNA Translation: AAS56477.1 BK006937 Genomic DNA Translation: DAA07534.1 |
PIRi | S19475 |
RefSeqi | NP_009986.1, NM_001178771.1 |
Genome annotation databases
EnsemblFungii | YCR060W_mRNA; YCR060W; YCR060W |
GeneIDi | 850424 |
KEGGi | sce:YCR060W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42288.1 AY558151 Genomic DNA Translation: AAS56477.1 BK006937 Genomic DNA Translation: DAA07534.1 |
PIRi | S19475 |
RefSeqi | NP_009986.1, NM_001178771.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L6J | NMR | - | A | 1-111 | [»] | |
2LSU | NMR | - | A | 2-111 | [»] | |
2LSV | NMR | - | A | 2-111 | [»] | |
2MNJ | NMR | - | A | 93-111 | [»] | |
4CGQ | X-ray | 2.00 | A | 1-111 | [»] | |
4CGU | X-ray | 2.11 | A | 1-111 | [»] | |
AlphaFoldDBi | P25638 | |||||
BMRBi | P25638 | |||||
SMRi | P25638 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 31037, 113 interactors |
ComplexPortali | CPX-1814, R2TP co-chaperone complex |
DIPi | DIP-5000N |
IntActi | P25638, 8 interactors |
MINTi | P25638 |
STRINGi | 4932.YCR060W |
PTM databases
iPTMneti | P25638 |
Proteomic databases
PaxDbi | P25638 |
PRIDEi | P25638 |
Genome annotation databases
EnsemblFungii | YCR060W_mRNA; YCR060W; YCR060W |
GeneIDi | 850424 |
KEGGi | sce:YCR060W |
Organism-specific databases
SGDi | S000000656, TAH1 |
VEuPathDBi | FungiDB:YCR060W |
Phylogenomic databases
eggNOGi | KOG1124, Eukaryota |
HOGENOMi | CLU_132745_0_0_1 |
InParanoidi | P25638 |
OMAi | PIGYSNK |
Miscellaneous databases
ChiTaRSi | TAH1, yeast |
PROi | PR:P25638 |
RNActi | P25638, protein |
Family and domain databases
DisProti | DP01243 |
Gene3Di | 1.25.40.10, 1 hit |
IDEALi | IID50204 |
InterProi | View protein in InterPro IPR045248, Sti1-like IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR22904, PTHR22904, 2 hits |
SMARTi | View protein in SMART SM00028, TPR, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50293, TPR_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAH1_YEAST | |
Accessioni | P25638Primary (citable) accession number: P25638 Secondary accession number(s): D6VR65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references