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Protein

Chromatin structure-remodeling complex protein RSC6

Gene

RSC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.7 Publications

Miscellaneous

Present with 2470 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: UniProtKB
  • nucleosome disassembly Source: SGD
  • nucleosome positioning Source: SGD
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29361-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin structure-remodeling complex protein RSC6
Alternative name(s):
Remodel the structure of chromatin complex subunit 6
Gene namesi
Name:RSC6
Ordered Locus Names:YCR052W
ORF Names:YCR52W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR052W
SGDiS000000648 RSC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974741 – 483Chromatin structure-remodeling complex protein RSC6Add BLAST483

Proteomic databases

MaxQBiP25632
PaxDbiP25632
PRIDEiP25632

PTM databases

iPTMnetiP25632

Interactioni

Subunit structurei

Interacts directly with RSC8. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31032, 399 interactors
ComplexPortaliCPX-1888 RSC complex variant RSC2
CPX-1889 RSC complex variant RSC1
DIPiDIP-4999N
IntActiP25632, 56 interactors
MINTiP25632
STRINGi4932.YCR052W

Structurei

3D structure databases

ProteinModelPortaliP25632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast SNF12.Curated

Phylogenomic databases

GeneTreeiENSGT00730000114141
HOGENOMiHOG000000860
InParanoidiP25632
KOiK11760
OMAiAMANTEE
OrthoDBiEOG092C2KJN

Family and domain databases

InterProiView protein in InterPro
IPR036885 SWIB_MDM2_dom_sf
SUPFAMiSSF47592 SSF47592, 2 hits

Sequencei

Sequence statusi: Complete.

P25632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTQTNPVPV TYPTDAYIPT YLPDDKVSNL ADLKKLIEMD SRLDLYLTRR
60 70 80 90 100
RLDTSINLPT NTKTKDHPPN KEMLRIYVYN TTESSPRSDS GTPADSGKTT
110 120 130 140 150
WTLRIEGKLL HESANGKHPF SEFLEGVAVD FKRLKPLGMG KKRKRDSSLS
160 170 180 190 200
LPLNLQQPEY NDQDSTMGDN DNGEDEDSAE AESREEIVDA LEWNYDENNV
210 220 230 240 250
VEFDGIDIKR QGKDNLRCSI TIQLRGVDGG KVQYSPNLAT LIGMQTGSVN
260 270 280 290 300
DAVYSIYKYI LINNLFVTEQ TEAQDGSNDA EDSSNENNNK NGAGDDDGVE
310 320 330 340 350
GSTPKDKPEL GEVKLDSLLQ KVLDTNAAHL PLMNVVQTVN KLVSPLPPII
360 370 380 390 400
LDYTIDLSKD TTYGATTLDV DVSHILHQPQ PQPNLQKEEE TDAEDTAKLR
410 420 430 440 450
EITKLALQLN SSAQKYQFFH ELSLHPRETL THYLWSSKQN ELVLQGDQYF
460 470 480
NEDAARTSDI YSNNNNDRSL MGNISLLYSQ GRL
Length:483
Mass (Da):54,165
Last modified:May 1, 1992 - v1
Checksum:i6A9998BDBC4D24B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42283.1
AY692985 Genomic DNA Translation: AAT93004.1
BK006937 Genomic DNA Translation: DAA07529.1
PIRiS19466
RefSeqiNP_009981.1, NM_001178766.1

Genome annotation databases

EnsemblFungiiCAA42283; CAA42283; CAA42283
YCR052W; YCR052W; YCR052W
GeneIDi850419
KEGGisce:YCR052W

Similar proteinsi

Entry informationi

Entry nameiRSC6_YEAST
AccessioniPrimary (citable) accession number: P25632
Secondary accession number(s): D6VR60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 18, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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