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UniProtKB - P25573 (MGR1_YEAST)
Protein
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1
Gene
MGR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. Together with MGR3, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.
2 PublicationsMiscellaneous
Present with 3410 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- misfolded protein binding Source: SGD
GO - Biological processi
- protein catabolic process Source: ComplexPortal
- protein quality control for misfolded or incompletely synthesized proteins Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1Alternative name(s): Mitochondrial genome-required protein 1 |
Gene namesi | Name:MGR1 Ordered Locus Names:YCL044C ORF Names:YCL314, YCL44C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000549, MGR1 |
VEuPathDBi | FungiDB:YCL044C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 3 Publications; Multi-pass membrane protein 3 Publications
Mitochondrion
- i-AAA complex Source: SGD
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | Mitochondrial intermembrane1 PublicationAdd BLAST | 56 | |
Transmembranei | 57 – 73 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 74 – 151 | Mitochondrial matrix1 PublicationAdd BLAST | 78 | |
Transmembranei | 152 – 169 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 170 – 417 | Mitochondrial intermembrane1 PublicationAdd BLAST | 248 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202546 | 1 – 417 | Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1Add BLAST | 417 |
Proteomic databases
MaxQBi | P25573 |
PaxDbi | P25573 |
PRIDEi | P25573 |
Interactioni
Subunit structurei
Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. With MGR3, forms a subcomplex that binds to YME1 and to substrates to facilitate proteolysis.
Interacts directly with YME1.
2 PublicationsBinary interactionsi
P25573
With | #Exp. | IntAct |
---|---|---|
YME1 [P32795] | 3 | EBI-21740,EBI-27785 |
GO - Molecular functioni
- misfolded protein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 30940, 357 interactors |
ComplexPortali | CPX-1655, i-AAA complex |
DIPi | DIP-5031N |
IntActi | P25573, 2 interactors |
MINTi | P25573 |
STRINGi | 4932.YCL044C |
Miscellaneous databases
RNActi | P25573, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 387 – 417 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 387 – 406 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the MGR1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QR67, Eukaryota |
HOGENOMi | CLU_039216_0_0_1 |
InParanoidi | P25573 |
OMAi | FYHEGID |
Family and domain databases
InterProi | View protein in InterPro IPR013911, i-AAA_Mgr1 |
Pfami | View protein in Pfam PF08602, Mgr1, 2 hits |
i Sequence
Sequence statusi: Complete.
P25573-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVFTPPSGN SNSTDHTHTQ DDHDKDDNDI KKFYIRPSLG LKLWGPLVPA
60 70 80 90 100
PDNLPGLYTL ITIQSAVGFF ALWRLRRLYK LPPPRRIATG THSDLSFGEL
110 120 130 140 150
PSEMIVNGKT KIKKDIADFP TLNRFSTTHG DIVLAPPPII PRQSRFVSVR
160 170 180 190 200
KLLWGLFGSL LLSQSLLELT RLNFLKYDPW CDEMKSVRDK KFFNNIVKYY
210 220 230 240 250
HEGIDPTKIK VKDAMNGTPL STNIPEVKQS VALARAQVEA QNPIIKWFGP
260 270 280 290 300
LEYKPMSFNE YLNRMEFHLD MFEFFQNKRN IRENSIELIN SISHNPQSSS
310 320 330 340 350
TGLEGLSESK KLHLQNVEKR LHFLASSGDS ISAPVKKRSS TTLSRGVILP
360 370 380 390 400
HDTKGPQDID LDTIRSLYDP WMTLALETSL SIKFIPTTMP SHTKTPTSTD
410
QPLPGPTPKA LTNEKTH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42372.1 BK006937 Genomic DNA Translation: DAA07441.1 |
PIRi | S19373 |
RefSeqi | NP_009886.1, NM_001178689.1 |
Genome annotation databases
EnsemblFungii | YCL044C_mRNA; YCL044C; YCL044C |
GeneIDi | 850313 |
KEGGi | sce:YCL044C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42372.1 BK006937 Genomic DNA Translation: DAA07441.1 |
PIRi | S19373 |
RefSeqi | NP_009886.1, NM_001178689.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 30940, 357 interactors |
ComplexPortali | CPX-1655, i-AAA complex |
DIPi | DIP-5031N |
IntActi | P25573, 2 interactors |
MINTi | P25573 |
STRINGi | 4932.YCL044C |
Proteomic databases
MaxQBi | P25573 |
PaxDbi | P25573 |
PRIDEi | P25573 |
Genome annotation databases
EnsemblFungii | YCL044C_mRNA; YCL044C; YCL044C |
GeneIDi | 850313 |
KEGGi | sce:YCL044C |
Organism-specific databases
SGDi | S000000549, MGR1 |
VEuPathDBi | FungiDB:YCL044C |
Phylogenomic databases
eggNOGi | ENOG502QR67, Eukaryota |
HOGENOMi | CLU_039216_0_0_1 |
InParanoidi | P25573 |
OMAi | FYHEGID |
Miscellaneous databases
PROi | PR:P25573 |
RNActi | P25573, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013911, i-AAA_Mgr1 |
Pfami | View protein in Pfam PF08602, Mgr1, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MGR1_YEAST | |
Accessioni | P25573Primary (citable) accession number: P25573 Secondary accession number(s): D6VQX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names - SIMILARITY comments
Index of protein domains and families