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UniProtKB - P25568 (ATG22_YEAST)
Protein
Autophagy-related protein 22
Gene
ATG22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
3 PublicationsGO - Biological processi
- amino acid transmembrane export from vacuole Source: SGD
- autophagy Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Autophagy, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-352230, Amino acid transport across the plasma membrane R-SCE-879518, Transport of organic anions |
Protein family/group databases
TCDBi | 2.A.1.24.1, the major facilitator superfamily (mfs) 9.A.15.1.1, the autophagy-related phagophore-formation transporter (apt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Autophagy-related protein 22 |
Gene namesi | Name:ATG22 Synonyms:AUT4 Ordered Locus Names:YCL038C ORF Names:YCL38C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000543, ATG22 |
VEuPathDBi | FungiDB:YCL038C |
Subcellular locationi
Vacuole
- Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Vacuole and punctate structures.
Vacuole
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 98 | CytoplasmicSequence analysisAdd BLAST | 98 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 130 | VacuolarSequence analysisAdd BLAST | 11 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 153 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 175 – 210 | VacuolarSequence analysisAdd BLAST | 36 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 241 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 318 | VacuolarSequence analysisAdd BLAST | 56 | |
Transmembranei | 319 – 339 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 340 – 352 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 374 – 388 | VacuolarSequence analysisAdd BLAST | 15 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 417 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 439 – 485 | VacuolarSequence analysisAdd BLAST | 47 | |
Transmembranei | 486 – 506 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 507 – 528 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207629 | 1 – 528 | Autophagy-related protein 22Add BLAST | 528 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 278 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P25568 |
PaxDbi | P25568 |
PRIDEi | P25568 |
PTM databases
iPTMneti | P25568 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 30945, 104 interactors |
DIPi | DIP-4976N |
IntActi | P25568, 4 interactors |
MINTi | P25568 |
STRINGi | 4932.YCL038C |
Miscellaneous databases
RNActi | P25568, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the ATG22 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QR9I, Eukaryota |
HOGENOMi | CLU_017518_1_0_1 |
InParanoidi | P25568 |
OMAi | MYPLGAV |
Family and domain databases
CDDi | cd17483, MFS_Atg22_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR044738, Atg22 IPR024671, Atg22-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF11700, ATG22, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
i Sequence
Sequence statusi: Complete.
P25568-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL
60 70 80 90 100
LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV
110 120 130 140 150
FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN
160 170 180 190 200
DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV
210 220 230 240 250
DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW
260 270 280 290 300
WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS
310 320 330 340 350
YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM
360 370 380 390 400
STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP
410 420 430 440 450
FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK
460 470 480 490 500
ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV
510 520
LNCLDVKRGR REAEELSQVL PESERRLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42378.1 BK006937 Genomic DNA Translation: DAA07446.1 |
PIRi | S19366 |
RefSeqi | NP_009892.1, NM_001178683.1 |
Genome annotation databases
EnsemblFungii | YCL038C_mRNA; YCL038C; YCL038C |
GeneIDi | 850319 |
KEGGi | sce:YCL038C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59720 Genomic DNA Translation: CAA42378.1 BK006937 Genomic DNA Translation: DAA07446.1 |
PIRi | S19366 |
RefSeqi | NP_009892.1, NM_001178683.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 30945, 104 interactors |
DIPi | DIP-4976N |
IntActi | P25568, 4 interactors |
MINTi | P25568 |
STRINGi | 4932.YCL038C |
Protein family/group databases
TCDBi | 2.A.1.24.1, the major facilitator superfamily (mfs) 9.A.15.1.1, the autophagy-related phagophore-formation transporter (apt) family |
PTM databases
iPTMneti | P25568 |
Proteomic databases
MaxQBi | P25568 |
PaxDbi | P25568 |
PRIDEi | P25568 |
Genome annotation databases
EnsemblFungii | YCL038C_mRNA; YCL038C; YCL038C |
GeneIDi | 850319 |
KEGGi | sce:YCL038C |
Organism-specific databases
SGDi | S000000543, ATG22 |
VEuPathDBi | FungiDB:YCL038C |
Phylogenomic databases
eggNOGi | ENOG502QR9I, Eukaryota |
HOGENOMi | CLU_017518_1_0_1 |
InParanoidi | P25568 |
OMAi | MYPLGAV |
Enzyme and pathway databases
Reactomei | R-SCE-352230, Amino acid transport across the plasma membrane R-SCE-879518, Transport of organic anions |
Miscellaneous databases
PROi | PR:P25568 |
RNActi | P25568, protein |
Family and domain databases
CDDi | cd17483, MFS_Atg22_like, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR044738, Atg22 IPR024671, Atg22-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF11700, ATG22, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATG22_YEAST | |
Accessioni | P25568Primary (citable) accession number: P25568 Secondary accession number(s): D6VQX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names - SIMILARITY comments
Index of protein domains and families