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UniProtKB - P25568 (ATG22_YEAST)

Entry version 147 (23 Feb 2022)
Sequence version 1 (01 May 1992)
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Protein

Autophagy-related protein 22

Gene

ATG22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • amino acid transmembrane export from vacuole Source: SGD
  • autophagy Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Autophagy, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-879518, Transport of organic anions

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.24.1, the major facilitator superfamily (mfs)
9.A.15.1.1, the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG22
Synonyms:AUT4
Ordered Locus Names:YCL038C
ORF Names:YCL38C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000000543, ATG22

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YCL038C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 130VacuolarSequence analysisAdd BLAST11
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 153CytoplasmicSequence analysis2
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 210VacuolarSequence analysisAdd BLAST36
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 241CytoplasmicSequence analysis10
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 318VacuolarSequence analysisAdd BLAST56
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 352CytoplasmicSequence analysisAdd BLAST13
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 388VacuolarSequence analysisAdd BLAST15
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 417CytoplasmicSequence analysis8
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 485VacuolarSequence analysisAdd BLAST47
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 528CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076291 – 528Autophagy-related protein 22Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei278PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P25568

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25568

PRoteomics IDEntifications database

More...PRIDEi		P25568

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25568

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		30945, 104 interactors

Database of interacting proteins

More...DIPi		DIP-4976N

Protein interaction database and analysis system

More...IntActi		P25568, 4 interactors

Molecular INTeraction database

More...MINTi		P25568

STRING: functional protein association networks

More...STRINGi		4932.YCL038C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25568, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QR9I, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017518_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25568

Identification of Orthologs from Complete Genome Data

More...OMAi		MYPLGAV

Family and domain databases

Conserved Domains Database

More...CDDi		cd17483, MFS_Atg22_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044738, Atg22
IPR024671, Atg22-like
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11700, ATG22, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL 
        60         70         80         90        100
LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV 
       110        120        130        140        150
FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN 
       160        170        180        190        200
DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV 
       210        220        230        240        250
DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW 
       260        270        280        290        300
WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS 
       310        320        330        340        350
YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM 
       360        370        380        390        400
STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP 
       410        420        430        440        450
FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK 
       460        470        480        490        500
ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV 
       510        520 
LNCLDVKRGR REAEELSQVL PESERRLD
Length:528
Mass (Da):58,844
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC26CAFD581A66DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42378.1
BK006937 Genomic DNA Translation: DAA07446.1

Protein sequence database of the Protein Information Resource

More...PIRi		S19366

NCBI Reference Sequences

More...RefSeqi		NP_009892.1, NM_001178683.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YCL038C_mRNA; YCL038C; YCL038C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YCL038C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42378.1
BK006937 Genomic DNA Translation: DAA07446.1
PIRiS19366
RefSeqiNP_009892.1, NM_001178683.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi30945, 104 interactors
DIPiDIP-4976N
IntActiP25568, 4 interactors
MINTiP25568
STRINGi4932.YCL038C

Protein family/group databases

TCDBi2.A.1.24.1, the major facilitator superfamily (mfs)
9.A.15.1.1, the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiP25568

Proteomic databases

MaxQBiP25568
PaxDbiP25568
PRIDEiP25568

Genome annotation databases

EnsemblFungiiYCL038C_mRNA; YCL038C; YCL038C
GeneIDi850319
KEGGisce:YCL038C

Organism-specific databases

SGDiS000000543, ATG22
VEuPathDBiFungiDB:YCL038C

Phylogenomic databases

eggNOGiENOG502QR9I, Eukaryota
HOGENOMiCLU_017518_1_0_1
InParanoidiP25568
OMAiMYPLGAV

Enzyme and pathway databases

ReactomeiR-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-879518, Transport of organic anions

Miscellaneous databases

Protein Ontology

More...PROi		PR:P25568
RNActiP25568, protein

Family and domain databases

CDDicd17483, MFS_Atg22_like, 1 hit
Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR044738, Atg22
IPR024671, Atg22-like
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF11700, ATG22, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG22_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25568
Secondary accession number(s): D6VQX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 23, 2022
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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