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Protein

Lactaldehyde dehydrogenase

Gene

aldA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts on lactaldehyde as well as other aldehydes.

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.
Glycolaldehyde + NAD+ + H2O = glycolate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei251By similarity1
Active sitei285By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 213NADBy similarity7

GO - Molecular functioni

  • glycolaldehyde dehydrogenase activity Source: EcoCyc
  • identical protein binding Source: EcoCyc
  • lactaldehyde dehydrogenase activity Source: EcoCyc
  • succinate-semialdehyde dehydrogenase (NAD+) activity Source: EcoCyc
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: GO_Central

GO - Biological processi

  • L-fucose catabolic process Source: EcoCyc
  • protein homotetramerization Source: EcoCyc
  • rhamnose catabolic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:LACTALDDEHYDROG-MONOMER
MetaCyc:LACTALDDEHYDROG-MONOMER
BRENDAi1.2.1.22 2026
SABIO-RKiP25553

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Alternative name(s):
Aldehyde dehydrogenase A
Glycolaldehyde dehydrogenase (EC:1.2.1.21)
Gene namesi
Name:aldA
Synonyms:ald
Ordered Locus Names:b1415, JW1412
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10035 aldA

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

DrugBankiDB03619 Deoxycholic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000565642 – 479Lactaldehyde dehydrogenaseAdd BLAST478

Proteomic databases

EPDiP25553
PaxDbiP25553
PRIDEiP25553

2D gel databases

SWISS-2DPAGEiP25553

Expressioni

Inductioni

By growth on fucose, rhamnose, arabinose and amino acids such as glutamate.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4260173, 13 interactors
850044, 1 interactor
DIPiDIP-9081N
IntActiP25553, 5 interactors
STRINGi316385.ECDH10B_1541

Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25553
SMRiP25553
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25553

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271509
InParanoidiP25553
KOiK07248
PhylomeDBiP25553

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVPVQHPMY IDGQFVTWRG DAWIDVVNPA TEAVISRIPD GQAEDARKAI
60 70 80 90 100
DAAERAQPEW EALPAIERAS WLRKISAGIR ERASEISALI VEEGGKIQQL
110 120 130 140 150
AEVEVAFTAD YIDYMAEWAR RYEGEIIQSD RPGENILLFK RALGVTTGIL
160 170 180 190 200
PWNFPFFLIA RKMAPALLTG NTIVIKPSEF TPNNAIAFAK IVDEIGLPRG
210 220 230 240 250
VFNLVLGRGE TVGQELAGNP KVAMVSMTGS VSAGEKIMAT AAKNITKVCL
260 270 280 290 300
ELGGKAPAIV MDDADLELAV KAIVDSRVIN SGQVCNCAER VYVQKGIYDQ
310 320 330 340 350
FVNRLGEAMQ AVQFGNPAER NDIAMGPLIN AAALERVEQK VARAVEEGAR
360 370 380 390 400
VAFGGKAVEG KGYYYPPTLL LDVRQEMSIM HEETFGPVLP VVAFDTLEDA
410 420 430 440 450
ISMANDSDYG LTSSIYTQNL NVAMKAIKGL KFGETYINRE NFEAMQGFHA
460 470
GWRKSGIGGA DGKHGLHEYL QTQVVYLQS
Length:479
Mass (Da):52,273
Last modified:January 23, 2007 - v2
Checksum:iDA7819EA0C05C32F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64541 Genomic DNA Translation: AAA23427.1
U00096 Genomic DNA Translation: AAC74497.1
AP009048 Genomic DNA Translation: BAA15032.1
PIRiA38165
RefSeqiNP_415933.1, NC_000913.3
WP_000115943.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74497; AAC74497; b1415
BAA15032; BAA15032; BAA15032
GeneIDi945672
KEGGiecj:JW1412
eco:b1415
PATRICifig|1411691.4.peg.856

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64541 Genomic DNA Translation: AAA23427.1
U00096 Genomic DNA Translation: AAC74497.1
AP009048 Genomic DNA Translation: BAA15032.1
PIRiA38165
RefSeqiNP_415933.1, NC_000913.3
WP_000115943.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HG2X-ray2.20A1-479[»]
2ILUX-ray2.70A1-479[»]
2IMPX-ray2.10A1-479[»]
2OPXX-ray2.53A1-479[»]
ProteinModelPortaliP25553
SMRiP25553
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260173, 13 interactors
850044, 1 interactor
DIPiDIP-9081N
IntActiP25553, 5 interactors
STRINGi316385.ECDH10B_1541

Chemistry databases

DrugBankiDB03619 Deoxycholic Acid

2D gel databases

SWISS-2DPAGEiP25553

Proteomic databases

EPDiP25553
PaxDbiP25553
PRIDEiP25553

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74497; AAC74497; b1415
BAA15032; BAA15032; BAA15032
GeneIDi945672
KEGGiecj:JW1412
eco:b1415
PATRICifig|1411691.4.peg.856

Organism-specific databases

EchoBASEiEB0034
EcoGeneiEG10035 aldA

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271509
InParanoidiP25553
KOiK07248
PhylomeDBiP25553

Enzyme and pathway databases

BioCyciEcoCyc:LACTALDDEHYDROG-MONOMER
MetaCyc:LACTALDDEHYDROG-MONOMER
BRENDAi1.2.1.22 2026
SABIO-RKiP25553

Miscellaneous databases

EvolutionaryTraceiP25553
PROiPR:P25553

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALDA_ECOLI
AccessioniPrimary (citable) accession number: P25553
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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