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UniProtKB - P25536 (NTPPA_ECOLI)

Entry version 139 (02 Jun 2021)
Sequence version 1 (01 May 1992)
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Protein

dTTP/UTP pyrophosphatase

Gene

yhdE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP (PubMed:24210219, PubMed:25658941, PubMed:28811554).

Can also hydrolyze TTP and the modified nucleotides 5-methyl-UTP (m5UTP), pseudo-UTP and 5-methyl-CTP (m5CTP). Has weak activity with CTP (PubMed:24210219, PubMed:25658941).

May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219, PubMed:25658941).

Important in maintenance of cell shape (PubMed:25658941).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationUniRule annotation1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 15.4 sec(-1) with dTTP as substrate. kcat is 15.2 sec(-1) with UTP as substrate. kcat is 4.9 sec(-1) with CTP as substrate. kcat is 18.2 sec(-1) with m5UTP as substrate. kcat is 9.2 sec(-1) with m5CTP as substrate. kcat is 10.5 sec(-1) with pseudo-UTP as substrate (PubMed:24210219). kcat is 43 sec(-1) with dTTP as substrate. kcat is 95 sec(-1) with UTP as substrate (PubMed:25658941).2 Publications
  1. KM=53.0 µM for dTTP1 Publication
  2. KM=0.09 mM for dTTP1 Publication
  3. KM=69.1 µM for UTP1 Publication
  4. KM=0.5 mM for UTP1 Publication
  5. KM=105.9 µM for CTP1 Publication
  6. KM=32.0 µM for m5UTP1 Publication
  7. KM=44.8 µM for m5CTP1 Publication
  8. KM=47.2 µM for pseudo-UTP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei12Important for substrate specificityUniRule annotation1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei70Proton acceptorUniRule annotation1 Publication1
    Sitei71Important for substrate specificityUniRule annotation1 Publication1
    Sitei153Important for substrate specificityUniRule annotation1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		EcoCyc:EG11298-MONOMER
    MetaCyc:EG11298-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.6.1.9, 2026

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    dTTP/UTP pyrophosphataseUniRule annotationCurated (EC:3.6.1.9UniRule annotation3 Publications)
    Short name:
    dTTPase/UTPase1 PublicationUniRule annotation
    Alternative name(s):
    Nucleoside triphosphate pyrophosphatase1 PublicationUniRule annotation
    Nucleotide pyrophosphatase1 PublicationUniRule annotation
    Short name:
    Nucleotide PPase1 PublicationUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:yhdE
    Ordered Locus Names:b3248, JW3217
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Knockout mutant grows faster than the wild-type and exhibits a more spherical shape.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8S → A: Loss of activity. 1 Publication1
    Mutagenesisi10S → A: Decrease in activity. 1 Publication1
    Mutagenesisi12R → A: Slight decrease in activity. 1 Publication1
    Mutagenesisi13R → A: Loss of activity. 1 Publication1
    Mutagenesisi32E → A: Loss of activity. 1 Publication1
    Mutagenesisi33E → A: Loss of activity. Has weak pyrophosphatase activity when assayed using PPi fluorescence sensor. 2 Publications1
    Mutagenesisi52K → A: Loss of activity. 1 Publication1
    Mutagenesisi70D → A: Loss of activity. 1 Publication1
    Mutagenesisi81E → A: Strong decrease in activity. 1 Publication1
    Mutagenesisi82K → A: Strong decrease in activity. 1 Publication1
    Mutagenesisi150Y → A: Loss of activity. 1 Publication1
    Mutagenesisi153Q → A: Strong decrease in activity. 1 Publication1
    Mutagenesisi153Q → E: Loss of activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001229811 – 197dTTP/UTP pyrophosphataseAdd BLAST197

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P25536

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P25536

    PRoteomics IDEntifications database

    More...    PRIDEi    		P25536

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:24210219, PubMed:25658941, PubMed:26252214). Can also form homotetramers (PubMed:24210219).

    3 Publications

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		4262448, 147 interactors
    852065, 1 interactor

    Protein interaction database and analysis system

    More...    IntActi    		P25536, 4 interactors

    STRING: functional protein association networks

    More...    STRINGi    		511145.b3248

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1197
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P25536

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Maf family. YhdE subfamily.UniRule annotation1 Publication

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		COG0424, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_040416_2_1_6

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P25536

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P25536

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd00555, Maf, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.90.950.10, 1 hit

    HAMAP database of protein families

    More...    HAMAPi    		MF_00528, Maf, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029001, ITPase-like_fam
    IPR003697, Maf-like

    The PANTHER Classification System

    More...    PANTHERi    		PTHR43213, PTHR43213, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF02545, Maf, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF006305, Maf, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF52972, SSF52972, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00172, maf, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P25536-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTSLYLASGS PRRQELLAQL GVTFERIVTG IEEQRQPQES AQQYVVRLAR 
            60         70         80         90        100
    EKARAGVAQT AKDLPVLGAD TIVILNGEVL EKPRDAEHAA QMLRKLSGQT 
           110        120        130        140        150
    HQVMTAVALA DSQHILDCLV VTDVTFRTLT DEDIAGYVAS DEPLDKAGAY 
           160        170        180        190 
    GIQGLGGCFV RKINGSYHAV VGLPLVETYE LLSNFNALRE KRDKHDG
    Length:197
    Mass (Da):21,515
    Last modified:May 1, 1992 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD023A366FB71DA87
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA58051 differs from that shown. Reason: Erroneous initiation.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		X57166 Genomic DNA Translation: CAA40456.1
    U18997 Genomic DNA Translation: AAA58051.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76280.1
    AP009048 Genomic DNA Translation: BAE77290.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JQ1271

    NCBI Reference Sequences

    More...    RefSeqi    		NP_417714.1, NC_000913.3
    WP_000203105.1, NZ_SSZK01000034.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...    EnsemblBacteriai    		AAC76280; AAC76280; b3248
    BAE77290; BAE77290; BAE77290

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		947753

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		ecj:JW3217
    eco:b3248

    Pathosystems Resource Integration Center (PATRIC)

    More...    PATRICi    		fig|1411691.4.peg.3481

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		X57166 Genomic DNA Translation: CAA40456.1
    U18997 Genomic DNA Translation: AAA58051.1 Different initiation.
    U00096 Genomic DNA Translation: AAC76280.1
    AP009048 Genomic DNA Translation: BAE77290.1
    PIRiJQ1271
    RefSeqiNP_417714.1, NC_000913.3
    WP_000203105.1, NZ_SSZK01000034.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4P0EX-ray2.30A/B2-190[»]
    SMRiP25536
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi4262448, 147 interactors
    852065, 1 interactor
    IntActiP25536, 4 interactors
    STRINGi511145.b3248

    Proteomic databases

    jPOSTiP25536
    PaxDbiP25536
    PRIDEiP25536

    Genome annotation databases

    EnsemblBacteriaiAAC76280; AAC76280; b3248
    BAE77290; BAE77290; BAE77290
    GeneIDi947753
    KEGGiecj:JW3217
    eco:b3248
    PATRICifig|1411691.4.peg.3481

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...    EchoBASEi    		EB1275

    Phylogenomic databases

    eggNOGiCOG0424, Bacteria
    HOGENOMiCLU_040416_2_1_6
    InParanoidiP25536
    PhylomeDBiP25536

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11298-MONOMER
    MetaCyc:EG11298-MONOMER
    BRENDAi3.6.1.9, 2026

    Miscellaneous databases

    Protein Ontology

    More...    PROi    		PR:P25536

    Family and domain databases

    CDDicd00555, Maf, 1 hit
    Gene3Di3.90.950.10, 1 hit
    HAMAPiMF_00528, Maf, 1 hit
    InterProiView protein in InterPro
    IPR029001, ITPase-like_fam
    IPR003697, Maf-like
    PANTHERiPTHR43213, PTHR43213, 1 hit
    PfamiView protein in Pfam
    PF02545, Maf, 1 hit
    PIRSFiPIRSF006305, Maf, 1 hit
    SUPFAMiSSF52972, SSF52972, 1 hit
    TIGRFAMsiTIGR00172, maf, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTPPA_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25536
    Secondary accession number(s): Q2M8W6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: June 2, 2021
    This is version 139 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
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