UniProtKB - P25527 (GABP_ECOLI)
Protein
GABA permease
Gene
gabP
Organism
Escherichia coli (strain K12)
Status
Functioni
Transporter for GABA.
: 4-aminobutanoate degradation Pathwayi
This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.
GO - Molecular functioni
- gamma-aminobutyric acid transmembrane transporter activity Source: EcoCyc
- secondary active transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- cellular response to nitrogen starvation Source: EcoCyc
- gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway
- gamma-aminobutyric acid transport Source: EcoCyc
- response to carbon starvation Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GABP-MONOMER MetaCyc:GABP-MONOMER |
UniPathwayi | UPA00733 |
Protein family/group databases
TCDBi | 2.A.3.1.4, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: GABA permeaseAlternative name(s): 4-amino butyrate transport carrier Gamma-aminobutyrate permease |
Gene namesi | Name:gabP Ordered Locus Names:b2663, JW2638 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 96 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 118 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 153 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 175 – 199 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 246 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 286 | PeriplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 334 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 359 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 360 – 380 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 381 – 402 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 403 – 423 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 428 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 429 – 449 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 450 – 466 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054202 | 1 – 466 | GABA permeaseAdd BLAST | 466 |
Proteomic databases
PaxDbi | P25527 |
PRIDEi | P25527 |
Expressioni
Inductioni
Induced by RpoS, but not in response to multiple stress conditions.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261470, 22 interactors |
DIPi | DIP-9724N |
IntActi | P25527, 2 interactors |
STRINGi | 511145.b2663 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1113, Bacteria |
HOGENOMi | CLU_007946_9_3_6 |
InParanoidi | P25527 |
PhylomeDBi | P25527 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS IPR011265, GABA_permease |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR01773, GABAperm, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P25527-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQSSQPHEL GGGLKSRHVT MLSIAGVIGA SLFVGSSVAI AEAGPAVLLA
60 70 80 90 100
YLFAGLLVVM IMRMLAEMAV ATPDTGSFST YADKAIGRWA GYTIGWLYWW
110 120 130 140 150
FWVLVIPLEA NIAAMILHSW VPGIPIWLFS LVITLALTGS NLLSVKNYGE
160 170 180 190 200
FEFWLALCKV IAILAFIFLG AVAISGFYPY AEVSGISRLW DSGGFMPNGF
210 220 230 240 250
GAVLSAMLIT MFSFMGAEIV TIAAAESDTP EKHIVRATNS VIWRISIFYL
260 270 280 290 300
CSIFVVVALI PWNMPGLKAV GSYRSVLELL NIPHAKLIMD CVILLSVTSC
310 320 330 340 350
LNSALYTASR MLYSLSRRGD APAVMGKINR SKTPYVAVLL STGAAFLTVV
360 370 380 390 400
VNYYAPAKVF KFLIDSSGAI ALLVYLVIAV SQLRMRKILR AEGSEIRLRM
410 420 430 440 450
WLYPWLTWLV IGFITFVLVV MLFRPAQQLE VISTGLLAIG IICTVPIMAR
460
WKKLVLWQKT PVHNTR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | T → R in CAA46229 (Ref. 2) Curated | 1 | |
Sequence conflicti | 385 – 386 | MR → IG in CAA46229 (Ref. 2) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88334 Genomic DNA Translation: AAC36833.1 X65104 Genomic DNA Translation: CAA46229.1 U00096 Genomic DNA Translation: AAC75710.1 AP009048 Genomic DNA Translation: BAA16526.1 |
PIRi | H65045 |
RefSeqi | NP_417149.1, NC_000913.3 WP_001295173.1, NZ_STEB01000042.1 |
Genome annotation databases
EnsemblBacteriai | AAC75710; AAC75710; b2663 BAA16526; BAA16526; BAA16526 |
GeneIDi | 948049 |
KEGGi | ecj:JW2638 eco:b2663 |
PATRICi | fig|1411691.4.peg.4078 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88334 Genomic DNA Translation: AAC36833.1 X65104 Genomic DNA Translation: CAA46229.1 U00096 Genomic DNA Translation: AAC75710.1 AP009048 Genomic DNA Translation: BAA16526.1 |
PIRi | H65045 |
RefSeqi | NP_417149.1, NC_000913.3 WP_001295173.1, NZ_STEB01000042.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4261470, 22 interactors |
DIPi | DIP-9724N |
IntActi | P25527, 2 interactors |
STRINGi | 511145.b2663 |
Protein family/group databases
TCDBi | 2.A.3.1.4, the amino acid-polyamine-organocation (apc) family |
Proteomic databases
PaxDbi | P25527 |
PRIDEi | P25527 |
Genome annotation databases
EnsemblBacteriai | AAC75710; AAC75710; b2663 BAA16526; BAA16526; BAA16526 |
GeneIDi | 948049 |
KEGGi | ecj:JW2638 eco:b2663 |
PATRICi | fig|1411691.4.peg.4078 |
Organism-specific databases
EchoBASEi | EB1306 |
Phylogenomic databases
eggNOGi | COG1113, Bacteria |
HOGENOMi | CLU_007946_9_3_6 |
InParanoidi | P25527 |
PhylomeDBi | P25527 |
Enzyme and pathway databases
UniPathwayi | UPA00733 |
BioCyci | EcoCyc:GABP-MONOMER MetaCyc:GABP-MONOMER |
Miscellaneous databases
PROi | PR:P25527 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS IPR011265, GABA_permease |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR01773, GABAperm, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GABP_ECOLI | |
Accessioni | P25527Primary (citable) accession number: P25527 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families