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UniProtKB - P25527 (GABP_ECOLI)

Entry version 168 (02 Dec 2020)
Sequence version 1 (01 May 1992)
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Protein

GABA permease

Gene

gabP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter for GABA.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • gamma-aminobutyric acid transmembrane transporter activity Source: EcoCyc
  • secondary active transmembrane transporter activity Source: EcoCyc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:GABP-MONOMER
MetaCyc:GABP-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00733

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.1.4, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GABA permease
Alternative name(s):
4-amino butyrate transport carrier
Gamma-aminobutyrate permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gabP
Ordered Locus Names:b2663, JW2638
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 96CytoplasmicSequence analysisAdd BLAST34
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118PeriplasmicSequence analysis1
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 153CytoplasmicSequence analysisAdd BLAST14
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 199PeriplasmicSequence analysisAdd BLAST25
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 286PeriplasmicSequence analysisAdd BLAST19
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 334CytoplasmicSequence analysisAdd BLAST27
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 359PeriplasmicSequence analysis4
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 402CytoplasmicSequence analysisAdd BLAST22
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428PeriplasmicSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 466CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542021 – 466GABA permeaseAdd BLAST466

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25527

PRoteomics IDEntifications database

More...PRIDEi		P25527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by RpoS, but not in response to multiple stress conditions.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261470, 22 interactors

Database of interacting proteins

More...DIPi		DIP-9724N

Protein interaction database and analysis system

More...IntActi		P25527, 2 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2663

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1113, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_9_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25527

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25527

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS
IPR011265, GABA_permease

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00324, AA_permease, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01773, GABAperm, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQSSQPHEL GGGLKSRHVT MLSIAGVIGA SLFVGSSVAI AEAGPAVLLA 
        60         70         80         90        100
YLFAGLLVVM IMRMLAEMAV ATPDTGSFST YADKAIGRWA GYTIGWLYWW 
       110        120        130        140        150
FWVLVIPLEA NIAAMILHSW VPGIPIWLFS LVITLALTGS NLLSVKNYGE 
       160        170        180        190        200
FEFWLALCKV IAILAFIFLG AVAISGFYPY AEVSGISRLW DSGGFMPNGF 
       210        220        230        240        250
GAVLSAMLIT MFSFMGAEIV TIAAAESDTP EKHIVRATNS VIWRISIFYL 
       260        270        280        290        300
CSIFVVVALI PWNMPGLKAV GSYRSVLELL NIPHAKLIMD CVILLSVTSC 
       310        320        330        340        350
LNSALYTASR MLYSLSRRGD APAVMGKINR SKTPYVAVLL STGAAFLTVV 
       360        370        380        390        400
VNYYAPAKVF KFLIDSSGAI ALLVYLVIAV SQLRMRKILR AEGSEIRLRM 
       410        420        430        440        450
WLYPWLTWLV IGFITFVLVV MLFRPAQQLE VISTGLLAIG IICTVPIMAR 
       460 
WKKLVLWQKT PVHNTR
Length:466
Mass (Da):51,080
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87998A83C80BA4EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72T → R in CAA46229 (Ref. 2) Curated1
Sequence conflicti385 – 386MR → IG in CAA46229 (Ref. 2) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M88334 Genomic DNA Translation: AAC36833.1
X65104 Genomic DNA Translation: CAA46229.1
U00096 Genomic DNA Translation: AAC75710.1
AP009048 Genomic DNA Translation: BAA16526.1

Protein sequence database of the Protein Information Resource

More...PIRi		H65045

NCBI Reference Sequences

More...RefSeqi		NP_417149.1, NC_000913.3
WP_001295173.1, NZ_STEB01000042.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75710; AAC75710; b2663
BAA16526; BAA16526; BAA16526

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948049

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2638
eco:b2663

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.4078

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88334 Genomic DNA Translation: AAC36833.1
X65104 Genomic DNA Translation: CAA46229.1
U00096 Genomic DNA Translation: AAC75710.1
AP009048 Genomic DNA Translation: BAA16526.1
PIRiH65045
RefSeqiNP_417149.1, NC_000913.3
WP_001295173.1, NZ_STEB01000042.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261470, 22 interactors
DIPiDIP-9724N
IntActiP25527, 2 interactors
STRINGi511145.b2663

Protein family/group databases

TCDBi2.A.3.1.4, the amino acid-polyamine-organocation (apc) family

Proteomic databases

PaxDbiP25527
PRIDEiP25527

Genome annotation databases

EnsemblBacteriaiAAC75710; AAC75710; b2663
BAA16526; BAA16526; BAA16526
GeneIDi948049
KEGGiecj:JW2638
eco:b2663
PATRICifig|1411691.4.peg.4078

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1306

Phylogenomic databases

eggNOGiCOG1113, Bacteria
HOGENOMiCLU_007946_9_3_6
InParanoidiP25527
PhylomeDBiP25527

Enzyme and pathway databases

UniPathwayiUPA00733
BioCyciEcoCyc:GABP-MONOMER
MetaCyc:GABP-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P25527

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS
IPR011265, GABA_permease
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
TIGRFAMsiTIGR01773, GABAperm, 1 hit
PROSITEiView protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGABP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25527
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: December 2, 2020
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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