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UniProtKB - P25490 (TYY1_HUMAN)

Entry version 231 (07 Apr 2021)
Sequence version 2 (15 Dec 1998)
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Protein

Transcriptional repressor protein YY1

Gene

YY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647).4 Publications
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi298Zinc 11
Metal bindingi303Zinc 11
Metal bindingi316Zinc 11
Metal bindingi320Zinc 11
Metal bindingi327Zinc 21
Metal bindingi330Zinc 21
Metal bindingi343Zinc 21
Metal bindingi347Zinc 21
Metal bindingi355Zinc 31
Metal bindingi360Zinc 31
Metal bindingi373Zinc 31
Metal bindingi377Zinc 31
Metal bindingi385Zinc 41
Metal bindingi390Zinc 41
Metal bindingi403Zinc 41
Metal bindingi407Zinc 41

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri325 – 347C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 377C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri383 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, DNA damage, DNA recombination, DNA repair, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25490

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER
R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P25490

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25490

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional repressor protein YY1
Alternative name(s):
Delta transcription factor
INO80 complex subunit S
NF-E1
Yin and yang 1
Short name:
YY-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YY1
Synonyms:INO80S
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12856, YY1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600013, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25490

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100811.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Gabriele-de Vries syndrome (GADEVS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by delayed psychomotor development and intellectual disability. Most patients have behavioral and feeding problems, movement abnormalities, mild distal skeletal anomalies, and dysmorphic facial features.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079202179 – 414Missing in GADEVS. 1 PublicationAdd BLAST236
Natural variantiVAR_079203320H → Y in GADEVS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079204339K → Q in GADEVS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555370868EnsemblClinVar.1
Natural variantiVAR_079205344 – 414Missing in GADEVS. 1 PublicationAdd BLAST71
Natural variantiVAR_079206366L → P in GADEVS; reduced DNA-binding; reduced transcription regulator activity. 1 PublicationCorresponds to variant dbSNP:rs1131692163EnsemblClinVar.1
Natural variantiVAR_079207366L → V in GADEVS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1131692044EnsemblClinVar.1
Natural variantiVAR_065086380D → Y in GADEVS; reduced DNA-binding; reduced transcription regulator activity. 2 PublicationsCorresponds to variant dbSNP:rs1131692043EnsemblClinVar.1
Natural variantiVAR_079208393Missing in GADEVS; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		7528

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		YY1

MalaCards human disease database

More...MalaCardsi		YY1
MIMi617557, phenotype

Open Targets

More...OpenTargetsi		ENSG00000100811

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		506358, Gabriele-de Vries syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25490, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YY1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3915889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471901 – 414Transcriptional repressor protein YY1Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei187PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei247PhosphoserineCombined sources1
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei378PhosphothreonineCombined sources1
Cross-linki409Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
Ubiquitinated.1 Publication

Keywords - PTMi

ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P25490

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25490

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25490

MaxQB - The MaxQuant DataBase

More...MaxQBi		P25490

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25490

PeptideAtlas

More...PeptideAtlasi		P25490

PRoteomics IDEntifications database

More...PRIDEi		P25490

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54279

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25490

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25490

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100811, Expressed in amniotic fluid and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P25490, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25490, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100811, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636).

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910).

Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321).

Interacts with SFMBT2 (PubMed:23385818).

Found in a complex with SMAD1 and SMAD4 (PubMed:15329343).

Found in a complex with YY1, SIN3A and HDAC1 (By similarity).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P25490
With#Exp.IntAct
ACTL6A [O96019]6EBI-765538,EBI-355018
ALOXE3 [Q9BYJ1]3EBI-765538,EBI-6925949
ARRB1 [P49407]4EBI-765538,EBI-743313
CBX5 [P45973]3EBI-765538,EBI-78219
CEP76 [Q8TAP6]3EBI-765538,EBI-742887
CYSRT1 [A8MQ03]3EBI-765538,EBI-3867333
DMWD [G5E9A7]3EBI-765538,EBI-10976677
ESM1 [Q9NQ30]3EBI-765538,EBI-12260294
FHL2 [Q14192]5EBI-765538,EBI-701903
GMCL1 [Q96IK5]5EBI-765538,EBI-2548508
GPR37 [O15354]3EBI-765538,EBI-15639515
GRN [P28799]4EBI-765538,EBI-747754
GRN - isoform 2 [P28799-2]3EBI-765538,EBI-25860013
IL10 [P22301]3EBI-765538,EBI-1031632
INO80 [Q9ULG1]7EBI-765538,EBI-769345
KRTAP1-5 [Q9BYS1]3EBI-765538,EBI-11741292
KRTAP10-5 [P60370]3EBI-765538,EBI-10172150
KRTAP10-8 [P60410]3EBI-765538,EBI-10171774
KRTAP10-9 [P60411]3EBI-765538,EBI-10172052
KRTAP12-2 [P59991]3EBI-765538,EBI-10176379
KRTAP12-3 [P60328]3EBI-765538,EBI-11953334
KRTAP17-1 [Q9BYP8]3EBI-765538,EBI-11988175
KRTAP2-4 [Q9BYR9]3EBI-765538,EBI-14065470
KRTAP4-2 [Q9BYR5]3EBI-765538,EBI-10172511
KRTAP4-5 [Q9BYR2]3EBI-765538,EBI-11993254
KRTAP5-6 [Q6L8G9]3EBI-765538,EBI-10250562
KRTAP9-3 [Q9BYQ3]3EBI-765538,EBI-1043191
KRTAP9-8 [Q9BYQ0]5EBI-765538,EBI-11958364
LHX3 - isoform B [Q9UBR4-2]3EBI-765538,EBI-12039345
LHX4 [Q969G2]3EBI-765538,EBI-2865388
MDFI [Q99750]3EBI-765538,EBI-724076
MED20 [Q9H944]3EBI-765538,EBI-394644
PLEKHF2 [Q9H8W4]3EBI-765538,EBI-742388
PRKDC [P78527]2EBI-765538,EBI-352053
RAD23A [P54725]3EBI-765538,EBI-746453
RUVBL1 [Q9Y265]6EBI-765538,EBI-353675
RUVBL2 [Q9Y230]7EBI-765538,EBI-352939
SERPINH1 [P50454]3EBI-765538,EBI-350723
SF3A2 [Q15428]5EBI-765538,EBI-2462271
SPRED1 [Q7Z699]3EBI-765538,EBI-5235340
TGFBR2 [P37173]3EBI-765538,EBI-296151
TRIM42 [Q8IWZ5]3EBI-765538,EBI-5235829
VWC2 [Q2TAL6]3EBI-765538,EBI-11957238
WFS1 [O76024]3EBI-765538,EBI-720609
XAGE1B [Q9HD64]3EBI-765538,EBI-2340004
YY1AP1 [Q9H869]5EBI-765538,EBI-946122
YY1AP1 - isoform 2 [Q9H869-2]4EBI-765538,EBI-12150045
ZNF85 [Q49A12]3EBI-765538,EBI-18141506
E1A [Q8JSK4] from Human adenovirus B serotype 3.4EBI-765538,EBI-7453955
Rybp [Q8CCI5] from Mus musculus.2EBI-765538,EBI-929290
P03259 from Human adenovirus A serotype 12.3EBI-765538,EBI-6947456

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113360, 189 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-846, INO80 chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P25490

Database of interacting proteins

More...DIPi		DIP-150N

Protein interaction database and analysis system

More...IntActi		P25490, 122 interactors

Molecular INTeraction database

More...MINTi		P25490

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262238

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25490, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25490

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P25490

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 170Interaction with the SMAD1/SMAD4 complexAdd BLAST170
Regioni257 – 341Involved in nuclear matrix associationAdd BLAST85
Regioni295 – 414Binding to DNAAdd BLAST120
Regioni333 – 371Involved in repression of activated transcriptionAdd BLAST39
Regioni371 – 397Involved in masking transactivation domainAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 53Asp/Glu-rich (acidic)Add BLAST11
Compositional biasi54 – 69Gly-richAdd BLAST16
Compositional biasi70 – 80Poly-HisAdd BLAST11
Compositional biasi159 – 170Gly/Ser-richAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YY transcription factor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri325 – 347C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 377C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri383 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154763

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25490

Identification of Orthologs from Complete Genome Data

More...OMAi		MWASDDN

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25490

TreeFam database of animal gene trees

More...TreeFami		TF106493

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00234

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017114, YY1-like
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037113, TF_Yin_yang, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P25490-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD 
        60         70         80         90        100
DEDGGGGDHG GGGGHGHAGH HHHHHHHHHH PPMIALQPLV TDDPTQVHHH 
       110        120        130        140        150
QEVILVQTRE EVVGGDDSDG LRAEDGFEDQ ILIPVPAPAG GDDDYIEQTL 
       160        170        180        190        200
VTVAAAGKSG GGGSSSSGGG RVKKGGGKKS GKKSYLSGGA GAAGGGGADP 
       210        220        230        240        250
GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE QIIGENSPPD 
       260        270        280        290        300
YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH 
       310        320        330        340        350
KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE 
       360        370        380        390        400
KPFQCTFEGC GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL 
       410 
KSHILTHAKA KNNQ
Length:414
Mass (Da):44,713
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i058C05A0AD2D04E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJV7H0YJV7_HUMAN
Transcriptional repressor protein Y...
YY1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJU4H0YJU4_HUMAN
Transcriptional repressor protein Y...
YY1
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C032A0A494C032_HUMAN
Transcriptional repressor protein Y...
YY1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3M8G3V3M8_HUMAN
Transcriptional repressor protein Y...
YY1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65H → R in AAA59926 (PubMed:1946405).Curated1
Sequence conflicti196G → R in AAA59467 (PubMed:1655281).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079202179 – 414Missing in GADEVS. 1 PublicationAdd BLAST236
Natural variantiVAR_079203320H → Y in GADEVS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079204339K → Q in GADEVS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555370868EnsemblClinVar.1
Natural variantiVAR_079205344 – 414Missing in GADEVS. 1 PublicationAdd BLAST71
Natural variantiVAR_079206366L → P in GADEVS; reduced DNA-binding; reduced transcription regulator activity. 1 PublicationCorresponds to variant dbSNP:rs1131692163EnsemblClinVar.1
Natural variantiVAR_079207366L → V in GADEVS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1131692044EnsemblClinVar.1
Natural variantiVAR_074172372T → R Found in patients with late onset insulinomas; alters DNA-binding motif; increases transactivation activity; produces a constitutive activation of cAMP and Ca2+ signaling pathways involved in insulin secretion. 2 PublicationsCorresponds to variant dbSNP:rs386834266EnsemblClinVar.1
Natural variantiVAR_065086380D → Y in GADEVS; reduced DNA-binding; reduced transcription regulator activity. 2 PublicationsCorresponds to variant dbSNP:rs1131692043EnsemblClinVar.1
Natural variantiVAR_079208393Missing in GADEVS; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M77698 mRNA Translation: AAA59467.1
M76541 mRNA Translation: AAA59926.1
Z14077 mRNA Translation: CAA78455.1
BC037308 mRNA Translation: AAH37308.1
BC065366 mRNA Translation: AAH65366.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9957.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40350

NCBI Reference Sequences

More...RefSeqi		NP_003394.1, NM_003403.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262238; ENSP00000262238; ENSG00000100811

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7528

UCSC genome browser

More...UCSCi		uc001ygy.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77698 mRNA Translation: AAA59467.1
M76541 mRNA Translation: AAA59926.1
Z14077 mRNA Translation: CAA78455.1
BC037308 mRNA Translation: AAH37308.1
BC065366 mRNA Translation: AAH65366.1
CCDSiCCDS9957.1
PIRiA40350
RefSeqiNP_003394.1, NM_003403.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UBDX-ray2.50C291-414[»]
1ZNMNMR-A352-379[»]
4C5IX-ray2.59C199-228[»]
SMRiP25490
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113360, 189 interactors
ComplexPortaliCPX-846, INO80 chromatin remodeling complex
CORUMiP25490
DIPiDIP-150N
IntActiP25490, 122 interactors
MINTiP25490
STRINGi9606.ENSP00000262238

PTM databases

iPTMnetiP25490
PhosphoSitePlusiP25490

Genetic variation databases

BioMutaiYY1
DMDMi3915889

Proteomic databases

EPDiP25490
jPOSTiP25490
MassIVEiP25490
MaxQBiP25490
PaxDbiP25490
PeptideAtlasiP25490
PRIDEiP25490
ProteomicsDBi54279

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9, 578 antibodies

The DNASU plasmid repository

More...DNASUi		7528

Genome annotation databases

EnsembliENST00000262238; ENSP00000262238; ENSG00000100811
GeneIDi7528
KEGGihsa:7528
UCSCiuc001ygy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7528
DisGeNETi7528

GeneCards: human genes, protein and diseases

More...GeneCardsi		YY1
GeneReviewsiYY1
HGNCiHGNC:12856, YY1
HPAiENSG00000100811, Low tissue specificity
MalaCardsiYY1
MIMi600013, gene
617557, phenotype
neXtProtiNX_P25490
OpenTargetsiENSG00000100811
Orphaneti506358, Gabriele-de Vries syndrome
PharmGKBiPA37445
VEuPathDBiHostDB:ENSG00000100811.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000154763
InParanoidiP25490
OMAiMWASDDN
OrthoDBi1318335at2759
PhylomeDBiP25490
TreeFamiTF106493

Enzyme and pathway databases

PathwayCommonsiP25490
ReactomeiR-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER
R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkiP25490
SIGNORiP25490

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7528, 592 hits in 1030 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YY1, human
EvolutionaryTraceiP25490

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YY1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7528
PharosiP25490, Tbio

Protein Ontology

More...PROi		PR:P25490
RNActiP25490, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100811, Expressed in amniotic fluid and 252 other tissues
ExpressionAtlasiP25490, baseline and differential
GenevisibleiP25490, HS

Family and domain databases

IDEALiIID00234
InterProiView protein in InterPro
IPR017114, YY1-like
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
PIRSFiPIRSF037113, TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 4 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYY1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25490
Secondary accession number(s): Q14935
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 15, 1998
Last modified: April 7, 2021
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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