UniProtKB - P25489 (AT1A1_CATCO)
Sodium/potassium-transporting ATPase subunit alpha-1
atp1a1
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
By similarityCatalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 379 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Binding sitei | 490 | ATPBy similarity | 1 | |
Metal bindingi | 721 | MagnesiumBy similarity | 1 | |
Metal bindingi | 725 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha-1 (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha-1 subunit Alternative name(s): Sodium pump subunit alpha-1 |
Gene namesi | Name:atp1a1 |
Organismi | Catostomus commersonii (White sucker) (Cyprinus commersonnii) |
Taxonomic identifieri | 7971 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Catostomoidei › Catostomidae › Catostomus |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 6 – 90 | CytoplasmicSequence analysisAdd BLAST | 85 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 134 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 156 – 291 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 292 – 311 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 312 – 323 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 324 – 341 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 342 – 776 | CytoplasmicSequence analysisAdd BLAST | 435 | |
Transmembranei | 777 – 796 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 797 – 806 | ExtracellularSequence analysis | 10 | |
Transmembranei | 807 – 827 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 828 – 847 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 848 – 870 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 871 – 922 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 923 – 942 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 943 – 955 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 956 – 974 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 975 – 989 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 990 – 1010 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1011 – 1027 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000002497 | 1 – 5 | By similarity | 5 | |
ChainiPRO_0000002498 | 6 – 1027 | Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST | 1022 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 947 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
CuratedFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 85 – 87 | Interaction with phosphoinositide-3 kinaseBy similarity | 3 | |
Regioni | 217 – 238 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 39 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGVGDGRDQY ELAAMSEQSG KKKSKNKKEK KEKDMDELKK EVDLDDHKLS
60 70 80 90 100
LEELHHKYGT DLSKGLSNSR AEEILARDGP NALTPPPTTP EWVKFCKQMF
110 120 130 140 150
GGFSMLLWTG AVLCFLAYGI LAAMEDEPAN DNLYLGVVLS AVVIITGCFS
160 170 180 190 200
YYQDAKSSKI MDSFKNLVPQ QALVVRDGEK KQINAEEVVI GDLVEVKGGD
210 220 230 240 250
RIPADLRIIS SHGCKVDNSS LTGESEPQTR SPDFSNDNPL ETKNIAFFST
260 270 280 290 300
NCVEGTARGI VISTGDRTVM GRIATLASGL EVGRTPISIE IEHFIHIITG
310 320 330 340 350
VAVFLGVSFL LLSLVLGYSW LEAVIFLIGI IVANVPEGLL ATVTVCLTLT
360 370 380 390 400
AKRMAKKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI
410 420 430 440 450
HEADTTENQS GTSFDRSSDT WASLARIAGL CNRAVFLAEQ IDVPILKRDV
460 470 480 490 500
AGDASESALL KCIELCCGSV KEMREKFTKV AEIPFNSTNK YQLSVHKIPS
510 520 530 540 550
GGKESQHLLV MKGAPERILD RCATIMIQGK EQLLDDEIKE SFQNAYLELG
560 570 580 590 600
GLGERVLGFC HFYLPDEQFP EGFQFDADDV NFPTENLCFV GLMSMIDPPR
610 620 630 640 650
AAVPDAVGKC RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA
660 670 680 690 700
RLNIPVNEVN PRDAKACVVH GGDLKDLSCE QLDDILKYHT EIVFARTSPQ
710 720 730 740 750
QKLIIVEGCQ RTGAIVAVTG DGVNDSPALK KADIGVAMGI AGSDVSKQAA
760 770 780 790 800
DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLFFIIA
810 820 830 840 850
NIPLPLGTVT ILCIDLGTDM LPAISLAYEA AESDIMKRQP RNPKTDKLVN
860 870 880 890 900
ERLISIAYGQ IGMIQALAGF FTYFVILAEN GFLPPRLLGI RMNWDDKYIN
910 920 930 940 950
DLEDSYGQQW TYEQRKIVEF TCHTAFFTSI VIVQWADLII CKTRRNSVFQ
960 970 980 990 1000
QGMKNKILIF GLFEETALAA FLSYCPGMDV ALRMYPLKPN WWFCAFPYSL
1010 1020
LIFIYDEIRK LILRRNPGGW MERETYY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58629 mRNA Translation: CAA41483.1 |
PIRi | S14740, PWCCNM |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58629 mRNA Translation: CAA41483.1 |
PIRi | S14740, PWCCNM |
3D structure databases
SMRi | P25489 |
ModBasei | Search... |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A1_CATCO | |
Accessioni | P25489Primary (citable) accession number: P25489 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | June 2, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |