Clusterin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: Ensembl
• chaperone binding Source: ParkinsonsUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells."
    Bando Y., Ogawa S., Yamauchi A., Kuwabara K., Ozawa K., Hori O., Yanagi H., Tamatani M., Tohyama M.
    Am J Physiol Cell Physiol 278:C1172-82(2000) [PubMed] [Europe PMC] [Abstract]
• low-density lipoprotein particle receptor binding Source: Ensembl
• misfolded protein binding Source: UniProtKB
• protein-containing complex binding Source: Ensembl
• tau protein binding Source: Ensembl
• ubiquitin protein ligase binding Source: UniProtKB
• unfolded protein binding Source: UniProtKB

GO - Biological processⁱ

• cell morphogenesis Source: Ensembl
• central nervous system myelin maintenance Source: Ensembl
• chaperone-mediated protein complex assembly Source: Ensembl
• chaperone-mediated protein folding Source: UniProtKB
• immune complex clearance Source: UniProtKB
• intrinsic apoptotic signaling pathway Source: UniProtKB
• microglial cell activation Source: Ensembl
• microglial cell proliferation Source: Ensembl
• negative regulation of amyloid-beta formation Source: Ensembl
• negative regulation of amyloid fibril formation Source: UniProtKB
• negative regulation of cellular response to thapsigargin Source: Ensembl
• negative regulation of cellular response to tunicamycin Source: Ensembl
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
• negative regulation of protein-containing complex assembly Source: BHF-UCL
• negative regulation of response to endoplasmic reticulum stress Source: Ensembl
• positive regulation of amyloid-beta formation Source: Ensembl
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
• positive regulation of neurofibrillary tangle assembly Source: Ensembl
• positive regulation of neuron death Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
• positive regulation of nitric oxide biosynthetic process Source: Ensembl
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
• positive regulation of protein-containing complex assembly Source: Ensembl
• positive regulation of receptor-mediated endocytosis Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.3

    "Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes."
    Bartl M.M., Luckenbach T., Bergner O., Ullrich O., Koch-Brandt C.
    Exp. Cell Res. 271:130-141(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of tau-protein kinase activity Source: Ensembl
• positive regulation of tumor necrosis factor production Source: Ensembl
• positive regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
• protein import Source: Ensembl
• protein stabilization Source: UniProtKB
• regulation of amyloid-beta clearance Source: Ensembl
• regulation of apoptotic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: UniProtKB
• regulation of neuronal signal transduction Source: Ensembl
• response to misfolded protein Source: UniProtKB
• response to virus Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• chaperone binding Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells."
    Bando Y., Ogawa S., Yamauchi A., Kuwabara K., Ozawa K., Hori O., Yanagi H., Tamatani M., Tohyama M.
    Am J Physiol Cell Physiol 278:C1172-82(2000) [PubMed] [Europe PMC] [Abstract]
• low-density lipoprotein particle receptor binding Source: Ensembl
• misfolded protein binding Source: UniProtKB
• tau protein binding Source: Ensembl
• ubiquitin protein ligase binding Source: UniProtKB
• unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MMKTLLLLVG LLLTWDNGRV LGDQAVSDTE LQEMSTEGSK YINKEIKNAL 
        60         70         80         90        100
KGVKQIKTLI EQTNEERKSL LSNLEEAKKK KEDALNDTKD SETKLKASQG 
       110        120        130        140        150
VCNDTMMALW EECKPCLKQT CMKFYARVCR SGSGLVGHQL EEFLNQSSPF 
       160        170        180        190        200
YFWMNGDRID SLLENDRQQT HALDVMQDSF NRASSIMDEL FQDRFFTREP 
       210        220        230        240        250
QDTYHYSPFS LFQRRPFFNP KFRIARNIIP FPRFQPLNFH DMFQPFFDMI 
       260        270        280        290        300
HQAQQAMDVN LHRIPYHFPI EFPEEDNRTV CKEIRHNSTG CLKMKDQCEK 
       310        320        330        340        350
CQEILSVDCS SNNPAQVQLR QELSNSLQIA EKFTKLYDEL LQSYQEKMFN 
       360        370        380        390        400
TSSLLKQLNE QFSWVSQLAN LTQSEDPFYL QVTTVGSQTS DSNVPVGFTK 
       410        420        430        440 
VVVKLFDSDP ITVMIPEAVS RNNPKFMETV AEKALQEYRQ KHREE      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families