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Entry version 180 (13 Feb 2019)
Sequence version 3 (12 Dec 2006)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II

Gene

Plc21C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei333PROSITE-ProRule annotation1
Active sitei378PROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei464SubstrateBy similarity1
Binding sitei466SubstrateBy similarity1
Binding sitei628SubstrateBy similarity1
Binding sitei655SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • phosphatidylinositol phospholipase C activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112043 PLC beta mediated events
R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DME-416476 G alpha (q) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plc21C
Synonyms:plc-21
ORF Names:CG4574
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004611 Plc21C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000885111 – 13181-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and IIAdd BLAST1318

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25455

PRoteomics IDEntifications database

More...
PRIDEi
P25455

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia in adults, and the brain of larvae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004611 Expressed in 30 organ(s), highest expression level in crop (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25455 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59460, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P25455, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0089226

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P25455

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25455

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini318 – 466PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST149
Domaini599 – 715PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini722 – 820C2PROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi469 – 478His-rich10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169 Eukaryota
ENOG410XPSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25455

KEGG Orthology (KO)

More...
KOi
K05858

Identification of Orthologs from Complete Genome Data

More...
OMAi
PHHHGCS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25455

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13361 PH_PLC_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09279 EF-hand_like, 1 hit
PF17787 PH_14, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000956 PLC-beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform D (identifier: P25455-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSAGGTYIS TASVEVPQAL QDGEKFIRWD DDSGTGTPVT MRVDAKGFFL
60 70 80 90 100
YWVDQNNELD ILDIATIRDV RTGQYAKRPK DNKLRQIVTL GPQDTLEEKT
110 120 130 140 150
VTVCHGSDFV NMTFVNFCCT RRDIAQLWTD GLIKLAYSLA QLNGSAIMFL
160 170 180 190 200
QKAHTKLCLQ VDKSGRIPVK NIIKLFAQNK EDRKRVEKAL DVTGLPSGKV
210 220 230 240 250
DSISVSKFQF EDFYNLYKYL TQRSEVERLF DSIVGNSKRK CMSIAQLVEF
260 270 280 290 300
LNKTQRDPRL NEILYPYANP ARAKELIQQY EPNKFNAQKG QLSLDGFLRY
310 320 330 340 350
LMGDDNPIMA PSKLDLCDDM DQPMSHYFIN SSHNTYLTGH QLTGKSSVEI
360 370 380 390 400
YRQCLLAGCR CVELDFWNGR TEEPVIVHGY TFVPEIFAKD VLEAIAESAF
410 420 430 440 450
KTSEYPVILS FENHCNPRQQ AKIANYCREI FGDMLLDKPL DSHPLEPNMD
460 470 480 490 500
LPPPAMLRRK IIIKNKKKHH HHHHHHHHKK PAQVGTPAAN NKLTTANSVD
510 520 530 540 550
AKAAQQVGLS ASHEDGGVTR STANGDVATG TGTGSAAGTA GHAPPLQQIR
560 570 580 590 600
QSSKDSTGSS DSDSSSEDES LPNTTPNLPS GNEPPPEKAQ KETEAGAEIS
610 620 630 640 650
ALVNYVQPIH FSSFENAEKK NRCYEMSSFD EKQATTLLKE RPIEFVNYNK
660 670 680 690 700
HQLSRVYPAG TRFDSSNFMP QLFWNAGCQL VALNFQTLDL AMQLNLGIFE
710 720 730 740 750
YNARSGYLLK PEFMRRSDRR LDPFAESTVD GIIAGTVSIT VLSGQFLTDK
760 770 780 790 800
RANTFVEVDM YGLPADTVRK KFRTKTVRDN GMNPLYDEEP FVFKKVVLPE
810 820 830 840 850
LASIRIAAYE EGGKLIGHRV LPVIGLCPGY RHVNLRSEVG QPIALASLFL
860 870 880 890 900
CVVVKDYVPD DLSNFAEALA NPIKYQSELE KRDIQLSVLT DEAEALGSAD
910 920 930 940 950
EDLSKSFVFV QVGGQKKELR PVESLATSPK HRPSISAAAA MSVDVTVDRT
960 970 980 990 1000
DGGRGEDSIS IVAPSIQHQH SLDQSVSTSI RQVESSQFDV DLVLAEPLEK
1010 1020 1030 1040 1050
ILDHKSVKEK RLEMEKKLES LRKKHDKEKI KIAGQKSSPL EGKKPKFAIT
1060 1070 1080 1090 1100
NKLVKRLSNK SLNCLSPHSE PGVEIPACPL DLGDSSEESA AADAGEDLAG
1110 1120 1130 1140 1150
GSSSLDGRTQ ESRLRSACRE YTSQYRELQE KYHEAIYSAA EKVLKTSQTG
1160 1170 1180 1190 1200
QTKQLKASLD KVTGEVMHQL QEARRNEVKN LATVHRDRDE LIRMKREVAS
1210 1220 1230 1240 1250
SVVERGVAER VRLKQTFDRR TDELQKQHDS VRNALAEHRS KARQILDKEA
1260 1270 1280 1290 1300
ESRSCVSSNG FLVLFHGPHH HGCTGSGSSA LSGNNLTLNL DAGAAGSHSA
1310
ISPAKSHNSI AAAAEMKT
Note: No experimental confirmation available.
Length:1,318
Mass (Da):146,391
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95C14A73843A325E
GO
Isoform 1 (identifier: P25455-2) [UniParc]FASTAAdd to basket
Also known as: Class-I

The sequence of this isoform differs from the canonical sequence as follows:
     907-913: FVFVQVG → C
     1063-1069: Missing.

Show »
Length:1,305
Mass (Da):144,979
Checksum:iCB5B3ED60B5C1ACC
GO
Isoform A (identifier: P25455-1) [UniParc]FASTAAdd to basket
Also known as: B, Class-II

The sequence of this isoform differs from the canonical sequence as follows:
     907-913: FVFVQVG → C

Show »
Length:1,312
Mass (Da):145,718
Checksum:iB8DD0EF5A48C2665
GO
Isoform C (identifier: P25455-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1063-1069: Missing.

Note: No experimental confirmation available.
Show »
Length:1,311
Mass (Da):145,653
Checksum:i906B2BF56240A89E
GO
Isoform H (identifier: P25455-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     907-912: FVFVQV → L
     1063-1069: Missing.

Note: No experimental confirmation available.
Show »
Length:1,306
Mass (Da):145,046
Checksum:i5439E23B80AA5974
GO
Isoform G (identifier: P25455-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-360: Missing.
     1063-1069: Missing.

Note: No experimental confirmation available.
Show »
Length:1,250
Mass (Da):138,774
Checksum:i039C4E8C9E785417
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti508G → A in AAA28819 (PubMed:2061323).Curated1
Sequence conflicti508G → A in AAA28820 (PubMed:2061323).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053949300 – 360Missing in isoform G. CuratedAdd BLAST61
Alternative sequenceiVSP_021970907 – 913FVFVQVG → C in isoform 1 and isoform A. 1 Publication7
Alternative sequenceiVSP_053950907 – 912FVFVQV → L in isoform H. Curated6
Alternative sequenceiVSP_0047271063 – 1069Missing in isoform 1, isoform C, isoform G and isoform H. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60452 mRNA Translation: AAA28819.1
M60453 mRNA Translation: AAA28820.1
AE014134 Genomic DNA Translation: AAN10493.1
AE014134 Genomic DNA Translation: AAS64631.1
AE014134 Genomic DNA Translation: AAS64632.2
AE014134 Genomic DNA Translation: AAS64633.1
AE014134 Genomic DNA Translation: AGB92355.1
AY051657 mRNA Translation: AAK93081.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40879
B40879

NCBI Reference Sequences

More...
RefSeqi
NP_001259818.1, NM_001272889.1 [P25455-6]
NP_476851.2, NM_057503.5 [P25455-1]
NP_476852.1, NM_057504.5 [P25455-1]
NP_995604.2, NM_205882.2 [P25455-5]
NP_995605.1, NM_205883.2 [P25455-3]
NP_995606.1, NM_205884.3 [P25455-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.4674

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078047; FBpp0077710; FBgn0004611 [P25455-1]
FBtr0078048; FBpp0077711; FBgn0004611 [P25455-1]
FBtr0078049; FBpp0089225; FBgn0004611 [P25455-4]
FBtr0078050; FBpp0089226; FBgn0004611 [P25455-3]
FBtr0330673; FBpp0303523; FBgn0004611 [P25455-6]
FBtr0330674; FBpp0303524; FBgn0004611 [P25455-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4574

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60452 mRNA Translation: AAA28819.1
M60453 mRNA Translation: AAA28820.1
AE014134 Genomic DNA Translation: AAN10493.1
AE014134 Genomic DNA Translation: AAS64631.1
AE014134 Genomic DNA Translation: AAS64632.2
AE014134 Genomic DNA Translation: AAS64633.1
AE014134 Genomic DNA Translation: AGB92355.1
AY051657 mRNA Translation: AAK93081.1
PIRiA40879
B40879
RefSeqiNP_001259818.1, NM_001272889.1 [P25455-6]
NP_476851.2, NM_057503.5 [P25455-1]
NP_476852.1, NM_057504.5 [P25455-1]
NP_995604.2, NM_205882.2 [P25455-5]
NP_995605.1, NM_205883.2 [P25455-3]
NP_995606.1, NM_205884.3 [P25455-4]
UniGeneiDm.4674

3D structure databases

ProteinModelPortaliP25455
SMRiP25455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59460, 3 interactors
IntActiP25455, 4 interactors
STRINGi7227.FBpp0089226

Proteomic databases

PaxDbiP25455
PRIDEiP25455

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078047; FBpp0077710; FBgn0004611 [P25455-1]
FBtr0078048; FBpp0077711; FBgn0004611 [P25455-1]
FBtr0078049; FBpp0089225; FBgn0004611 [P25455-4]
FBtr0078050; FBpp0089226; FBgn0004611 [P25455-3]
FBtr0330673; FBpp0303523; FBgn0004611 [P25455-6]
FBtr0330674; FBpp0303524; FBgn0004611 [P25455-5]
GeneIDi33204
KEGGidme:Dmel_CG4574

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
33204
FlyBaseiFBgn0004611 Plc21C

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00940000173822
InParanoidiP25455
KOiK05858
OMAiPHHHGCS
PhylomeDBiP25455

Enzyme and pathway databases

ReactomeiR-DME-112043 PLC beta mediated events
R-DME-1855204 Synthesis of IP3 and IP4 in the cytosol
R-DME-416476 G alpha (q) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plc21C fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33204

Protein Ontology

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PROi
PR:P25455

Gene expression databases

BgeeiFBgn0004611 Expressed in 30 organ(s), highest expression level in crop (Drosophila)
GenevisibleiP25455 DM

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF09279 EF-hand_like, 1 hit
PF17787 PH_14, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIP1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25455
Secondary accession number(s): A4UZX5
, M9PC05, Q0E8V1, Q7KTZ7, Q961D5, Q9VPN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 12, 2006
Last modified: February 13, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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