UniProtKB - P25446 (TNR6_MOUSE)
Tumor necrosis factor receptor superfamily member 6
Fas
Functioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: MGI
- kinase binding Source: MGI
- protease binding Source: MGI
- protein-containing complex binding Source: MGI
- tumor necrosis factor-activated receptor activity Source: MGI
GO - Biological processi
- activation-induced cell death of T cells Source: MGI
- apoptotic process Source: MGI
- apoptotic signaling pathway Source: MGI
- B cell mediated immunity Source: MGI
- cellular response to amino acid starvation Source: MGI
- cellular response to hyperoxia Source: MGI
- cellular response to lithium ion Source: MGI
- circadian rhythm Source: UniProtKB
- dendrite regeneration Source: MGI
- extrinsic apoptotic signaling pathway Source: MGI
- extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- Fas signaling pathway Source: MGI
- gene expression Source: MGI
- hepatocyte apoptotic process Source: MGI
- immunoglobulin production Source: MGI
- inflammatory cell apoptotic process Source: MGI
- lymphocyte apoptotic process Source: MGI
- motor neuron apoptotic process Source: MGI
- necroptotic signaling pathway Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of B cell activation Source: MGI
- negative regulation of Schwann cell migration Source: MGI
- negative regulation of Schwann cell proliferation Source: MGI
- negative thymic T cell selection Source: MGI
- neuron apoptotic process Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of cell death Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI
- positive regulation of neuron apoptotic process Source: MGI
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
- regulation of apoptotic process Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of gene expression Source: MGI
- regulation of lymphocyte differentiation Source: MGI
- regulation of myeloid cell differentiation Source: MGI
- regulation of stress-activated MAPK cascade Source: MGI
- response to glucocorticoid Source: MGI
- response to toxic substance Source: MGI
- spleen development Source: MGI
- T cell homeostasis Source: MGI
Keywordsi
Molecular function | Calmodulin-binding, Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-3371378, Regulation by c-FLIP R-MMU-5218900, CASP8 activity is inhibited R-MMU-69416, Dimerization of procaspase-8 R-MMU-75157, FasL/ CD95L signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 6Alternative name(s): Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor CD_antigen: CD95 |
Gene namesi | Name:Fas Synonyms:Apt1, Tnfrsf6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95484, Fas |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Membrane raft By similarity
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Nucleus
- nuclear body Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- CD95 death-inducing signaling complex Source: UniProtKB
- death-inducing signaling complex Source: MGI
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
- sarcolemma Source: MGI
Other locations
- apical dendrite Source: MGI
- cell surface Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
- secretory granule Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 169 | ExtracellularSequence analysisAdd BLAST | 148 | |
Transmembranei | 170 – 186 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 187 – 327 | CytoplasmicSequence analysisAdd BLAST | 141 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Keywords - Diseasei
Disease variantPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000034567 | 22 – 327 | Tumor necrosis factor receptor superfamily member 6Add BLAST | 306 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 44 ↔ 55 | PROSITE-ProRule annotation | ||
Disulfide bondi | 56 ↔ 69 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 78 | PROSITE-ProRule annotation | ||
Disulfide bondi | 81 ↔ 97 | PROSITE-ProRule annotation | ||
Disulfide bondi | 100 ↔ 115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 103 ↔ 123 | PROSITE-ProRule annotation | ||
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 125 ↔ 139 | PROSITE-ProRule annotation | ||
Disulfide bondi | 142 ↔ 153 | PROSITE-ProRule annotation | ||
Disulfide bondi | 145 ↔ 161 | PROSITE-ProRule annotation | ||
Lipidationi | 194 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 206 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 | |
Modified residuei | 314 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | P25446 |
jPOSTi | P25446 |
MaxQBi | P25446 |
PaxDbi | P25446 |
PeptideAtlasi | P25446 |
PRIDEi | P25446 |
PTM databases
GlyGeni | P25446, 2 sites |
iPTMneti | P25446 |
PhosphoSitePlusi | P25446 |
SwissPalmi | P25446 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000024778, Expressed in granulocyte and 204 other tissues |
ExpressionAtlasi | P25446, baseline and differential |
Genevisiblei | P25446, MM |
Interactioni
Subunit structurei
Binds DAXX (PubMed:9215629).
Interacts with HIPK3 (PubMed:11034606).
Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2.
Interacts with BABAM2 and FEM1B.
Interacts with FADD (By similarity).
Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280).
Interacts with CALM (By similarity). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity).
By similarity3 PublicationsBinary interactionsi
Hide detailsP25446
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: MGI
- kinase binding Source: MGI
- protease binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199594, 9 interactors |
DIPi | DIP-31093N |
IntActi | P25446, 11 interactors |
MINTi | P25446 |
STRINGi | 10090.ENSMUSP00000025691 |
Miscellaneous databases
RNActi | P25446, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P25446 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25446 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 79 | TNFR-Cys 1Add BLAST | 37 | |
Repeati | 80 – 123 | TNFR-Cys 2Add BLAST | 44 | |
Repeati | 124 – 162 | TNFR-Cys 3Add BLAST | 39 | |
Domaini | 222 – 306 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 204 – 309 | Interaction with HIPK31 PublicationAdd BLAST | 106 | |
Regioni | 222 – 246 | Interaction with CALMBy similarityAdd BLAST | 25 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0SV, Eukaryota |
GeneTreei | ENSGT00950000183126 |
HOGENOMi | CLU_067123_1_0_1 |
InParanoidi | P25446 |
OMAi | QDTKCRC |
OrthoDBi | 993446at2759 |
TreeFami | TF333916 |
Family and domain databases
CDDi | cd08316, Death_FAS_TNFRSF6, 1 hit cd10579, TNFRSF6, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR008063, Fas_rcpt IPR001368, TNFR/NGFR_Cys_rich_reg IPR033998, TNFRSF6_death IPR033999, TNFRSF6_N |
PANTHERi | PTHR46874, PTHR46874, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01680, TNFACTORR6 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 3 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ
60 70 80 90 100
GGPFCCQPCQ PGKKKVEDCK MNGGTPTCAP CTEGKEYMDK NHYADKCRRC
110 120 130 140 150
TLCDEEHGLE VETNCTLTQN TKCKCKPDFY CDSPGCEHCV RCASCEHGTL
160 170 180 190 200
EPCTATSNTN CRKQSPRNRL WLLTILVLLI PLVFIYRKYR KRKCWKRRQD
210 220 230 240 250
DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK
260 270 280 290 300
IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD
310 320
KFQDMVQKDL GKSTPDTGNE NEGQCLE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BBP5 | A0A494BBP5_MOUSE | Apo-1 antigen | Fas | 309 | Annotation score: | ||
Q8C350 | Q8C350_MOUSE | Tumor necrosis factor receptor supe... | Fas | 63 | Annotation score: | ||
A0A494BBE8 | A0A494BBE8_MOUSE | Tumor necrosis factor receptor supe... | Fas | 123 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | R → H in AAA37593 (PubMed:1371136).Curated | 1 | |
Sequence conflicti | 38 | R → H in CAC00638 (Ref. 2) Curated | 1 | |
Sequence conflicti | 38 | R → H in AAB25700 (PubMed:7680478).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 246 | I → N in lpr. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83649 mRNA Translation: AAA37593.1 AK002590 mRNA Translation: BAB22211.1 AJ295702, AJ295703, AJ295704 Genomic DNA Translation: CAC00638.1 DQ846748 mRNA Translation: ABI24112.1 CH466534 Genomic DNA Translation: EDL41748.1 BC061160 mRNA Translation: AAH61160.1 S56490, S56485, S56486 Genomic DNA Translation: AAB25700.1 |
CCDSi | CCDS29758.1 |
PIRi | A46484 |
RefSeqi | NP_032013.2, NM_007987.2 |
Genome annotation databases
Ensembli | ENSMUST00000025691; ENSMUSP00000025691; ENSMUSG00000024778 |
GeneIDi | 14102 |
KEGGi | mmu:14102 |
UCSCi | uc008hgi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83649 mRNA Translation: AAA37593.1 AK002590 mRNA Translation: BAB22211.1 AJ295702, AJ295703, AJ295704 Genomic DNA Translation: CAC00638.1 DQ846748 mRNA Translation: ABI24112.1 CH466534 Genomic DNA Translation: EDL41748.1 BC061160 mRNA Translation: AAH61160.1 S56490, S56485, S56486 Genomic DNA Translation: AAB25700.1 |
CCDSi | CCDS29758.1 |
PIRi | A46484 |
RefSeqi | NP_032013.2, NM_007987.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2NA6 | NMR | - | A/B/C | 167-193 | [»] | |
3OQ9 | X-ray | 6.80 | A/B/C/D/E | 223-308 | [»] | |
SMRi | P25446 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 199594, 9 interactors |
DIPi | DIP-31093N |
IntActi | P25446, 11 interactors |
MINTi | P25446 |
STRINGi | 10090.ENSMUSP00000025691 |
PTM databases
GlyGeni | P25446, 2 sites |
iPTMneti | P25446 |
PhosphoSitePlusi | P25446 |
SwissPalmi | P25446 |
Proteomic databases
EPDi | P25446 |
jPOSTi | P25446 |
MaxQBi | P25446 |
PaxDbi | P25446 |
PeptideAtlasi | P25446 |
PRIDEi | P25446 |
Protocols and materials databases
ABCDi | P25446, 16 sequenced antibodies |
Antibodypediai | 4525, 2841 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025691; ENSMUSP00000025691; ENSMUSG00000024778 |
GeneIDi | 14102 |
KEGGi | mmu:14102 |
UCSCi | uc008hgi.2, mouse |
Organism-specific databases
CTDi | 355 |
MGIi | MGI:95484, Fas |
Phylogenomic databases
eggNOGi | ENOG502S0SV, Eukaryota |
GeneTreei | ENSGT00950000183126 |
HOGENOMi | CLU_067123_1_0_1 |
InParanoidi | P25446 |
OMAi | QDTKCRC |
OrthoDBi | 993446at2759 |
TreeFami | TF333916 |
Enzyme and pathway databases
Reactomei | R-MMU-3371378, Regulation by c-FLIP R-MMU-5218900, CASP8 activity is inhibited R-MMU-69416, Dimerization of procaspase-8 R-MMU-75157, FasL/ CD95L signaling |
Miscellaneous databases
BioGRID-ORCSi | 14102, 0 hits in 17 CRISPR screens |
ChiTaRSi | Fas, mouse |
EvolutionaryTracei | P25446 |
PROi | PR:P25446 |
RNActi | P25446, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024778, Expressed in granulocyte and 204 other tissues |
ExpressionAtlasi | P25446, baseline and differential |
Genevisiblei | P25446, MM |
Family and domain databases
CDDi | cd08316, Death_FAS_TNFRSF6, 1 hit cd10579, TNFRSF6, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR008063, Fas_rcpt IPR001368, TNFR/NGFR_Cys_rich_reg IPR033998, TNFRSF6_death IPR033999, TNFRSF6_N |
PANTHERi | PTHR46874, PTHR46874, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01680, TNFACTORR6 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 3 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR6_MOUSE | |
Accessioni | P25446Primary (citable) accession number: P25446 Secondary accession number(s): Q6GT31, Q9DCQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references