Fas

Functionⁱ

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
identical protein binding Source: MGI
kinase binding Source: MGI
protease binding Source: MGI
protein-containing complex binding Source: MGI
tumor necrosis factor-activated receptor activity Source: MGI
tumor necrosis factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation-induced cell death of T cells
Source: MGI
Inferred from direct assayⁱ
- 12702495
apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 8700551
apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 7511063
- 8666928
B cell mediated immunity
Source: MGI
Inferred from mutant phenotypeⁱ
- 18199416
cellular response to amino acid starvation Source: MGI
cellular response to hyperoxia Source: MGI
cellular response to lithium ion
Source: MGI
Inferred from mutant phenotypeⁱ
- 20530871
circadian rhythm
Source: UniProtKB
Inferred from expression patternⁱ
- 23785138
dendrite regeneration Source: MGI
extrinsic apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 17980593
extrinsic apoptotic signaling pathway in absence of ligand
Source: MGI
Inferred from mutant phenotypeⁱ
- 13679421
extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Inferred from direct assayⁱ
- 10950869
Fas signaling pathway Source: MGI
gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 7602121
hepatocyte apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 20436477
immunoglobulin production
Source: MGI
Inferred from mutant phenotypeⁱ
- 18199416
inflammatory cell apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 12801066
inflammatory response Source: GO_Central
motor neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 13679421
necroptotic signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 21052097
negative regulation of apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 7595210
negative regulation of B cell activation
Source: MGI
Inferred from mutant phenotypeⁱ
- 6610701
negative thymic T cell selection
Source: MGI
Inferred from mutant phenotypeⁱ
- 10429671
neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 20530871
positive regulation of apoptotic process Source: MGI
positive regulation of apoptotic signaling pathway Source: MGI
positive regulation of cell death Source: MGI
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI
positive regulation of extrinsic apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 15632112
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: MGI
Inferred from mutant phenotypeⁱ
- 15039234
positive regulation of lymphocyte apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 15632112
positive regulation of neuron apoptotic process Source: MGI
positive regulation of protein homooligomerization
Source: BHF-UCL
Inferred from direct assayⁱ
- 10950869
positive regulation of protein phosphorylation Source: MGI
positive regulation of release of cytochrome c from mitochondria
Source: BHF-UCL
Inferred by curatorⁱ
- 10950869
protein homooligomerization
Source: MGI
Inferred from direct assayⁱ
- 8524870
regulation of apoptotic process Source: MGI
regulation of cell proliferation Source: MGI
regulation of gene expression Source: MGI
regulation of lymphocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 6610701
regulation of myeloid cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9697835
regulation of stress-activated MAPK cascade Source: MGI
renal system process
Source: MGI
Inferred from mutant phenotypeⁱ
- 8640868
response to glucocorticoid
Source: MGI
Inferred from mutant phenotypeⁱ
- 7602121
- 8640868
response to lipopolysaccharide Source: GO_Central
response to toxic substance
Source: MGI
Inferred from mutant phenotypeⁱ
- 8557033
spleen development
Source: MGI
Inferred from mutant phenotypeⁱ
- 18199416
T cell homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 8640868

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371378 Regulation by c-FLIP R-MMU-5213460 RIPK1-mediated regulated necrosis R-MMU-5218900 CASP8 activity is inhibited R-MMU-69416 Dimerization of procaspase-8 R-MMU-75157 FasL/ CD95L signaling

Reactomeⁱ

R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 6 Alternative name(s): Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor CD_antigen: CD95
Gene namesⁱ	Name:Fas Synonyms:Apt1, Tnfrsf6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:95484 Fas

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 169	ExtracellularSequence analysisAdd BLAST	148
Transmembraneⁱ	170 – 186	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	187 – 327	CytoplasmicSequence analysisAdd BLAST	141

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.

Keywords - Diseaseⁱ

Disease mutation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000034567	22 – 327	Tumor necrosis factor receptor superfamily member 6Add BLAST		306

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	44 ↔ 55	PROSITE-ProRule annotation
Disulfide bondⁱ	56 ↔ 69	PROSITE-ProRule annotation
Disulfide bondⁱ	59 ↔ 78	PROSITE-ProRule annotation
Disulfide bondⁱ	81 ↔ 97	PROSITE-ProRule annotation
Disulfide bondⁱ	100 ↔ 115	PROSITE-ProRule annotation
Disulfide bondⁱ	103 ↔ 123	PROSITE-ProRule annotation
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	125 ↔ 139	PROSITE-ProRule annotation
Disulfide bondⁱ	142 ↔ 153	PROSITE-ProRule annotation
Disulfide bondⁱ	145 ↔ 161	PROSITE-ProRule annotation
Modified residueⁱ	206	PhosphothreonineCombined sources	1
Modified residueⁱ	217	PhosphoserineCombined sources	1
Modified residueⁱ	220	PhosphoserineCombined sources	1
Modified residueⁱ	314	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25446
PaxDbⁱ	P25446
PeptideAtlas More...PeptideAtlasⁱ	P25446
PRIDEⁱ	P25446

PTM databases

iPTMnetⁱ	P25446
PhosphoSitePlusⁱ	P25446
SwissPalmⁱ	P25446

Expressionⁱ

Tissue specificityⁱ

Detected in various tissues including thymus, liver, lung, heart, and adult ovary.1 Publication

Inductionⁱ

Expression oscillates in a circadian manner in the liver with peak levels seen at CT12.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000024778 Expressed in 185 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_FAS
ExpressionAtlasⁱ	P25446 baseline and differential
Genevisibleⁱ	P25446 MM

Interactionⁱ

Subunit structureⁱ

Binds DAXX (PubMed:9215629). Interacts with HIPK3 (PubMed:11034606). Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (PubMed:15383280). Interacts with CALM (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Casp8	O89110	3	EBI-296206,EBI-851690
DAXX	Q9UER7	4	EBI-296206,EBI-77321	From Homo sapiens.
Daxx	O35613	2	EBI-296206,EBI-77304
FADD	Q13158	8	EBI-296206,EBI-494804	From Homo sapiens.
Fadd	Q61160	3	EBI-296206,EBI-524415
Hipk3	Q9ERH7	3	EBI-296206,EBI-524356
Pml	Q60953	6	EBI-296206,EBI-3895605

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
identical protein binding Source: MGI
kinase binding Source: MGI
protease binding Source: MGI
tumor necrosis factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199594, 8 interactors
Database of interacting proteins More...DIPⁱ	DIP-31093N
IntActⁱ	P25446, 11 interactors
Molecular INTeraction database More...MINTⁱ	P25446
STRINGⁱ	10090.ENSMUSP00000025691

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	170 – 179	Combined sources		10
Helixⁱ	181 – 189	Combined sources		9

Show more details

3D structure databases

ProteinModelPortalⁱ	P25446
SMRⁱ	P25446
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P25446

EvolutionaryTraceⁱ

P25446

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	43 – 79	TNFR-Cys 1Add BLAST	37
Repeatⁱ	80 – 123	TNFR-Cys 2Add BLAST	44
Repeatⁱ	124 – 162	TNFR-Cys 3Add BLAST	39
Domainⁱ	222 – 306	DeathPROSITE-ProRule annotationAdd BLAST	85

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	204 – 309	Interaction with HIPK31 PublicationAdd BLAST		106
Regionⁱ	222 – 246	Interaction with CALMBy similarityAdd BLAST		25

Domainⁱ

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J23A Eukaryota ENOG4112ADB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111280
HOGENOMⁱ	HOG000139681
HOVERGENⁱ	HBG004091
InParanoidⁱ	P25446
KEGG Orthology (KO) More...KOⁱ	K04390
OMAⁱ	CTTCEHG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DU6
TreeFamⁱ	TF333916

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08316 Death_FAS_TNFRSF6, 1 hit cd10579 TNFRSF6, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR008063 Fas_rcpt IPR001368 TNFR/NGFR_Cys_rich_reg IPR033998 TNFRSF6_death IPR033999 TNFRSF6_N
PANTHERⁱ	PTHR23097:SF114 PTHR23097:SF114, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01680 TNFACTORR6
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 3 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P25446-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ 
        60         70         80         90        100
GGPFCCQPCQ PGKKKVEDCK MNGGTPTCAP CTEGKEYMDK NHYADKCRRC 
       110        120        130        140        150
TLCDEEHGLE VETNCTLTQN TKCKCKPDFY CDSPGCEHCV RCASCEHGTL 
       160        170        180        190        200
EPCTATSNTN CRKQSPRNRL WLLTILVLLI PLVFIYRKYR KRKCWKRRQD 
       210        220        230        240        250
DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK 
       260        270        280        290        300
IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD 
       310        320 
KFQDMVQKDL GKSTPDTGNE NEGQCLE

Length:327

Mass (Da):37,437

Last modified:July 27, 2011 - v2

Checksum:ⁱD8DA95CA525CED56

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8C350	Q8C350_MOUSE		Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 6	Fas	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	38	R → H in AAA37593 (PubMed:1371136).Curated	1
Sequence conflictⁱ	38	R → H in CAC00638 (Ref. 2) Curated	1
Sequence conflictⁱ	38	R → H in AAB25700 (PubMed:7680478).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	246	I → N in lpr. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83649 mRNA Translation: AAA37593.1 AK002590 mRNA Translation: BAB22211.1 AJ295702, AJ295703, AJ295704 Genomic DNA Translation: CAC00638.1 DQ846748 mRNA Translation: ABI24112.1 CH466534 Genomic DNA Translation: EDL41748.1 BC061160 mRNA Translation: AAH61160.1 S56490, S56485, S56486 Genomic DNA Translation: AAB25700.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29758.1
PIRⁱ	A46484
NCBI Reference Sequences More...RefSeqⁱ	NP_032013.2, NM_007987.2
UniGeneⁱ	Mm.1626

Genome annotation databases

Ensemblⁱ	ENSMUST00000025691; ENSMUSP00000025691; ENSMUSG00000024778
GeneIDⁱ	14102
KEGGⁱ	mmu:14102
UCSC genome browser More...UCSCⁱ	uc008hgi.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25446	Fas		MOUSE		327	UniRef90_P25446
UPI000A3186AE		MUSCR		327
UPI0001E5ECDF		MOUSE		86
UPI0005AB980A		MOUSE		302

Protein	Similar proteins		Species	Score	Length	Source
P25446	Tumor necrosis factor receptor superfamily member 6		RAT		324	UniRef50_P25446
Fas		MOUSE		327
UPI000A3186AE		MUSCR		327
UPI000454647B		CRIGR		333
Tumor necrosis factor receptor superfamily member 6		RAT		324
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83649 mRNA Translation: AAA37593.1 AK002590 mRNA Translation: BAB22211.1 AJ295702, AJ295703, AJ295704 Genomic DNA Translation: CAC00638.1 DQ846748 mRNA Translation: ABI24112.1 CH466534 Genomic DNA Translation: EDL41748.1 BC061160 mRNA Translation: AAH61160.1 S56490, S56485, S56486 Genomic DNA Translation: AAB25700.1
CCDSⁱ	CCDS29758.1
PIRⁱ	A46484
RefSeqⁱ	NP_032013.2, NM_007987.2
UniGeneⁱ	Mm.1626

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2NA6	NMR	-	A/B/C	167-193	[»]
	3OQ9	X-ray	6.80	A/B/C/D/E	223-308	[»]
ProteinModelPortalⁱ	P25446
SMRⁱ	P25446
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199594, 8 interactors
DIPⁱ	DIP-31093N
IntActⁱ	P25446, 11 interactors
MINTⁱ	P25446
STRINGⁱ	10090.ENSMUSP00000025691

PTM databases

iPTMnetⁱ	P25446
PhosphoSitePlusⁱ	P25446
SwissPalmⁱ	P25446

Proteomic databases

MaxQBⁱ	P25446
PaxDbⁱ	P25446
PeptideAtlasⁱ	P25446
PRIDEⁱ	P25446

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025691; ENSMUSP00000025691; ENSMUSG00000024778
GeneIDⁱ	14102
KEGGⁱ	mmu:14102
UCSCⁱ	uc008hgi.2 mouse

Organism-specific databases

CTDⁱ	355
MGIⁱ	MGI:95484 Fas

Phylogenomic databases

eggNOGⁱ	ENOG410J23A Eukaryota ENOG4112ADB LUCA
GeneTreeⁱ	ENSGT00730000111280
HOGENOMⁱ	HOG000139681
HOVERGENⁱ	HBG004091
InParanoidⁱ	P25446
KOⁱ	K04390
OMAⁱ	CTTCEHG
OrthoDBⁱ	EOG091G0DU6
TreeFamⁱ	TF333916

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371378 Regulation by c-FLIP R-MMU-5213460 RIPK1-mediated regulated necrosis R-MMU-5218900 CASP8 activity is inhibited R-MMU-69416 Dimerization of procaspase-8 R-MMU-75157 FasL/ CD95L signaling

Reactomeⁱ

R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling

Miscellaneous databases

ChiTaRSⁱ	Fas mouse
EvolutionaryTraceⁱ	P25446
Protein Ontology More...PROⁱ	PR:P25446
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024778 Expressed in 185 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_FAS
ExpressionAtlasⁱ	P25446 baseline and differential
Genevisibleⁱ	P25446 MM

Family and domain databases

CDDⁱ	cd08316 Death_FAS_TNFRSF6, 1 hit cd10579 TNFRSF6, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR008063 Fas_rcpt IPR001368 TNFR/NGFR_Cys_rich_reg IPR033998 TNFRSF6_death IPR033999 TNFRSF6_N
PANTHERⁱ	PTHR23097:SF114 PTHR23097:SF114, 1 hit
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01680 TNFACTORR6
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 3 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR6_MOUSE
Accessionⁱ	P25446Primary (citable) accession number: P25446 Secondary accession number(s): Q6GT31, Q9DCQ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	July 27, 2011
	Last modified:	October 10, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Help

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UniProtKB - P25446 (TNR6_MOUSE)

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Tumor necrosis factor receptor superfamily member 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ