Tumor necrosis factor receptor superfamily member 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calmodulin binding Source: UniProtKB
• identical protein binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis."
    Chu K., Niu X., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract]
• kinase binding Source: MGI
• protease binding Source: MGI
• protein-containing complex binding Source: MGI
• tumor necrosis factor-activated receptor activity Source: MGI

GO - Biological processⁱ

• activation-induced cell death of T cells Source: MGIInferred from direct assayⁱ
  • "Fas is not essential for lamina propria T lymphocyte homeostasis."
    Boone D.L., Dassopoulos T., Chai S., Chien M., Lodolce J., Ma A.
    Am J Physiol Gastrointest Liver Physiol 285:G382-8(2003) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract."
    Suzuki A., Matsuzawa A., Iguchi T.
    Oncogene 13:31-37(1996) [PubMed] [Europe PMC] [Abstract]
• apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand."
    Takahashi T., Tanaka M., Brannan C.I., Jenkins N.A., Copeland N.G., Suda T., Nagata S.
    Cell 76:969-976(1994) [PubMed] [Europe PMC] [Abstract]
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
• B cell mediated immunity Source: MGIInferred from mutant phenotypeⁱ
  • "The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation."
    Haraldsson M.K., Louis-Dit-Sully C.A., Lawson B.R., Sternik G., Santiago-Raber M.L., Gascoigne N.R., Theofilopoulos A.N., Kono D.H.
    Immunity 28:40-51(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid starvation Source: MGI
• cellular response to hyperoxia Source: MGI
• cellular response to lithium ion Source: MGIInferred from mutant phenotypeⁱ
  • "NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy."
    Gomez-Sintes R., Lucas J.J.
    J Clin Invest 120:2432-2445(2010) [PubMed] [Europe PMC] [Abstract]
• circadian rhythm Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.14

    "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
    Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
    J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• dendrite regeneration Source: MGI
• extrinsic apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • "YAP1 increases organ size and expands undifferentiated progenitor cells."
    Camargo F.D., Gokhale S., Johnnidis J.B., Fu D., Bell G.W., Jaenisch R., Brummelkamp T.R.
    Curr Biol 17:2054-2060(2007) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from mutant phenotypeⁱ
  • "Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo."
    Ugolini G., Raoul C., Ferri A., Haenggeli C., Yamamoto Y., Salaun D., Henderson C.E., Kato A.C., Pettmann B., Hueber A.O.
    J Neurosci 23:8526-8531(2003) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCLInferred from direct assayⁱ
  • "tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c."
    Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J.
    Genes Dev 14:2060-2071(2000) [PubMed] [Europe PMC] [Abstract]
• Fas signaling pathway Source: MGI
• gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice."
    Tamura A., Yui K.
    J Immunol 155:499-507(1995) [PubMed] [Europe PMC] [Abstract]
• hepatocyte apoptotic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria."
    Zaltsman Y., Shachnai L., Yivgi-Ohana N., Schwarz M., Maryanovich M., Houtkooper R.H., Vaz F.M., De Leonardis F., Fiermonte G., Palmieri F., Gillissen B., Daniel P.T., Jimenez E., Walsh S., Koehler C.M., Roy S.S., Walter L., Hajnoczky G., Gross A.
    Nat Cell Biol 12:553-562(2010) [PubMed] [Europe PMC] [Abstract]
• inflammatory cell apoptotic process Source: MGIInferred from direct assayⁱ
  • "Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody."
    Yokota A., Oikawa A., Matsuda C., Shinohara N., Eshima K.
    Microbiol Immunol 47:285-293(2003) [PubMed] [Europe PMC] [Abstract]
• lymphocyte apoptotic process Source: MGIInferred from direct assayⁱ
  • "The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain."
    Song Y., Jacob C.O.
    J Biol Chem 280:9618-9626(2005) [PubMed] [Europe PMC] [Abstract]
• motor neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo."
    Ugolini G., Raoul C., Ferri A., Haenggeli C., Yamamoto Y., Salaun D., Henderson C.E., Kato A.C., Pettmann B., Hueber A.O.
    J Neurosci 23:8526-8531(2003) [PubMed] [Europe PMC] [Abstract]
• necroptotic signaling pathway Source: MGIInferred from genetic interactionⁱ
  • "cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production."
    Vanlangenakker N., Vanden Berghe T., Bogaert P., Laukens B., Zobel K., Deshayes K., Vucic D., Fulda S., Vandenabeele P., Bertrand M.J.
    Cell Death Differ 18:656-665(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • "A naturally occurring soluble isoform of murine Fas generated by alternative splicing."
    Hughes D.P., Crispe I.N.
    J Exp Med 182:1395-1401(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of B cell activation Source: MGIInferred from mutant phenotypeⁱ
  • "Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice."
    Davidson W.F., Roths J.B., Holmes K.L., Rudikoff E., Morse H.C.
    J Immunol 133:1048-1056(1984) [PubMed] [Europe PMC] [Abstract]
• negative regulation of Schwann cell migration Source: MGI
• negative regulation of Schwann cell proliferation Source: MGI
• negative thymic T cell selection Source: MGIInferred from mutant phenotypeⁱ
  • "Several different cell surface molecules control negative selection of medullary thymocytes."
    Kishimoto H., Sprent J.
    J Exp Med 190:65-73(1999) [PubMed] [Europe PMC] [Abstract]
• neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy."
    Gomez-Sintes R., Lucas J.J.
    J Clin Invest 120:2432-2445(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGI
• positive regulation of apoptotic signaling pathway Source: MGI
• positive regulation of cell death Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI
• positive regulation of neuron apoptotic process Source: MGI
• positive regulation of protein-containing complex assembly Source: BHF-UCLInferred from direct assayⁱ
  • "tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c."
    Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J.
    Genes Dev 14:2060-2071(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: MGI
• positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c."
    Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J.
    Genes Dev 14:2060-2071(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGI
• regulation of cell population proliferation Source: MGI
• regulation of gene expression Source: MGI
• regulation of lymphocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice."
    Davidson W.F., Roths J.B., Holmes K.L., Rudikoff E., Morse H.C.
    J Immunol 133:1048-1056(1984) [PubMed] [Europe PMC] [Abstract]
• regulation of myeloid cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia."
    Traver D., Akashi K., Weissman I.L., Lagasse E.
    Immunity 9:47-57(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of stress-activated MAPK cascade Source: MGI
• response to glucocorticoid Source: MGIInferred from mutant phenotypeⁱ
  • "Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice."
    Tamura A., Yui K.
    J Immunol 155:499-507(1995) [PubMed] [Europe PMC] [Abstract]
  • "Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice."
    Tamura A., Katsumata M., Greene M.I., Yui K.
    Cell Immunol 168:220-228(1996) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: MGIInferred from mutant phenotypeⁱ
  • "Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis."
    Strasser A., Harris A.W., Huang D.C., Krammer P.H., Cory S.
    EMBO J 14:6136-6147(1995) [PubMed] [Europe PMC] [Abstract]
• spleen development Source: MGIInferred from mutant phenotypeⁱ
  • "The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation."
    Haraldsson M.K., Louis-Dit-Sully C.A., Lawson B.R., Sternik G., Santiago-Raber M.L., Gascoigne N.R., Theofilopoulos A.N., Kono D.H.
    Immunity 28:40-51(2008) [PubMed] [Europe PMC] [Abstract]
• T cell homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice."
    Tamura A., Katsumata M., Greene M.I., Yui K.
    Cell Immunol 168:220-228(1996) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• calmodulin binding Source: UniProtKB
• identical protein binding Source: MGIInferred from direct assayⁱ
  • "A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis."
    Chu K., Niu X., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract]
• kinase binding Source: MGI
• protease binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ 
        60         70         80         90        100
GGPFCCQPCQ PGKKKVEDCK MNGGTPTCAP CTEGKEYMDK NHYADKCRRC 
       110        120        130        140        150
TLCDEEHGLE VETNCTLTQN TKCKCKPDFY CDSPGCEHCV RCASCEHGTL 
       160        170        180        190        200
EPCTATSNTN CRKQSPRNRL WLLTILVLLI PLVFIYRKYR KRKCWKRRQD 
       210        220        230        240        250
DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK 
       260        270        280        290        300
IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD 
       310        320 
KFQDMVQKDL GKSTPDTGNE NEGQCLE                          

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references